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Cyclosporine in Medical News

Inhaled Cyclosporine Results In Rejection Free Survival among Lung Transplant Patients

Patients who undergo lung transplants suffer from rejection of the organ. Hence according to a study researchers have found that inhaled anti-rejection drug, cyclosporine significantly reduces// rejection and results in better lung function. The study results were presented at the American Thoracic...

Post-transplant combo can replace toxic immune-suppressing drugs in monkeys

...o prevent graft rejection, but at the cost of serious side effects. The class of immunosuppressive drugs known as calcineurin inhibitors (examples are cyclosporine and tacrolimus) can damage patients' kidneys and lead to high blood pressure, among other problems. A combination of treatments can effectively rep...

American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications

...y used traditional systemic agents - methotrexate, cyclosporine and acitretin - were outlined. Published onl...th immunodeficiency syndromes, among others. cyclosporine cyclosporine is one of the most effective treatments for psoria...

PARI Pharma Receives 2nd ODD From EMEA; Moves Inhaled Tobramycin - eFlow Technology Program Forward

... the second ODD designation that PARI Pharma has received for a product in its proprietary drug pipeline; the first ODD was granted for PARI's inhaled cyclosporine delivered via an eFlow Technology device. "In clinical trials, we have seen a reduction to one fourth of the inhalation time for PARI Tobramycin ...

Licorice May Block Absorption of Organ Transplant Drug

... Study finds potential interaction with cyclosporine could lead to fatal complications TUE...thDay News) -- People taking the immunosuppressant cyclosporine should avoid consuming licorice because it may wea... Chemists in Taiwan report that lab rats taking cyclosporine -- commonly used to help prevent organ rejection i...

Cyclosporine Eye Drops a Good Deal for Dry Eye

... Eye drops that contain the immunosuppressant drug cyclosporine may be a cost-effective treatment for dry eye synd... according to background information in the study. cyclosporine is used to treat arthritis and psoriasis, and to r...ave eye drops containing a 0.5 percent emulsion of cyclosporine to patients with moderate to severe dry eye syndro...

January 2009 Mayo Clinic Health Letter Highlights Improved PSA Tests, Dry Eyes and Colds

... with tiny silicone plugs or cauterizing the tissues of the tear drainage area so scarring closes the tear ducts. Other options are prescription cyclosporine (Restasis) drops and corticosteroid drops or contact lenses that cover the white of the eye to help retain moisture. For impaired blinking, surgery ma...

Watson Enters Into Agreement to Acquire Products Related to Teva's Proposed Acquisition of Barr

...cts consists of 17 products, including 15 FDA-approved products and 2 development-stage products. Key products in the portfolio include: cyclosporine Capsules and Liquid Desmopressin Acetate Tablets Glipizide/Metformin HCl Tablets Mirtazapine Orally Disintegrating Tablets ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...or of p-glycoprotein, on the pharmacokinetics of sitagliptin. Co-administration of a single 100mg oral dose of JANUVIA and a single 600mg oral dose of cyclosporine increased the AUC and Cmax of sitagliptin by approximately 29% and 68%, respectively. These modest changes in sitagliptin pharmacokinetics were not co...

Researchers Find Link Between Organ Transplants, Cancer

...t untreated. But the researchers also found a potential solution to the problem: Giving targeted anti-VEGF therapy reduced the pace of growth. cyclosporine seems to promote the growth of cancer by activating different forms of protein kinase C, which, in turn, stimulates VEGF production, the researchers s...
Cyclosporine in Medical Technology

PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine A and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans

MONTEREY, Calif., June 2 /PRNewswire/ -- This month's Journal of Aerosol Medicine and Pulmonary Drug Delivery features positive Phase Ib clinical trial results for PARI Pharma's L-CsA, inhaled liposomal cyclosporine A. In May, PARI Pharma received Orphan Drug Designation from the Food and Drug Ad...

Fovea Reports Positive Results with Prednisporin(TM) in Persistent Allergic Conjunctivitis

...'s Enviro-CAC(TM) clinical technology. The combination therapy of low doses cyclosporine A and prednisolone acetate was compared to PredForte(TM) alone or vehicle a...mulation of lower than the usual therapeutic doses prednisolone acetate and cyclosporine A, to retain the efficacy of a very potent steroid with an improved safety ...

Novagali Pharma Completed a New Phase II With Cyclokat(R) in Dry Eye

... Europe and patient recruitment has been already completed. Cyclokat(R) is a proprietary ophthalmic emulsion enabling an optimal penetration of cyclosporine in tissues of the eye surface that benefit from Novasorb(R), Novagali(R) cationic emulsion technology. About Novagali Pharma : http://www.nova...

CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI

...cent of grafts. Eighty-two percent received tacrolimus (Tac) and 18 percent cyclosporine (CyA). CNI doses and levels were significantly lower in the reduced level o... cardiac or hepatic transplants. CellCept should be used concomitantly with cyclosporine and corticosteroids. Important Safety Information: WARNING: Immunosup...

Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function

... the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. CellCept should be used concomitantly with cyclosporine and corticosteroids. Important Safety Information: WARNING: Immunosuppression may lead to increased susceptibility to infection and possible dev...

Isotechnika's independent data monitoring committee conducts review of phase 2b kidney transplant trial

...that will result in efficacy (lack of acute rejection) with minimal side effects that are typically seen with other calcineurin inhibitors such as cyclosporine and tacrolimus. A total of 332 de novo (newly transplanted) kidney transplant patients will be enrolled in this trial. Patients will be placed i...

Novagali Pharma Announces Positive Vekacia Clinical Results From Pivotal Phase III Trial in Vernal Keratoconjunctivitis

...irst reported on the use and potential efficacy of cyclosporine A for the treatment of VKC. Vekacia(R) is a topical cyclosporine A cationic emulsion enabling an efficient and unma... efficacy. This proprietary ophthalmic emulsion of cyclosporine A will be the first therapeutic product dedicated ...

New Anti-Rejection Medication 6-Month Results for Heart Transplant Recipients to Be Released at International Heart and Lung Transplant Meeting

... be presented includes: -- Six Month Data on cyclosporine Reduction and Impact on Renal Function wi...12 Month Study of Everolimus with Reduced cyclosporine Exposure vs. MMF and Conventional cyclosporine in De Novo Heart Transplant Recipients wi...

Lux Biosciences' Investigational Therapy for Uveitis, LX211, is Subject of Two Presentations at Key Ophthalmology Meeting, ARVO 2007

...ls in the first two groups received daily subcutaneous injections of either cyclosporine A (CsA) at 40 mg/kg or LX211 at 2.5 mg/kg, 10 mg/kg or 40 mg/kg, with the p...rix ocular (episcleral) implant that steadily releases therapeutic doses of cyclosporine A locally to the eye. Both the LUMINATE pivotal clinical program for LX211 ...

Isotechnika Announces Interim Three Month Data from Phase 2b Kidney Transplant Trial

...ose that will result in efficacy (lack of acute rejection) with minimal side effects that are typically seen with other calcineurin inhibitors such as cyclosporine and tacrolimus. A total of 332 de novo (newly transplanted) kidney transplant patients will be enrolled in this trial. Patients will be placed into ...
Cyclosporine in Medical Products

Lyphochek Elevated Immunosuppressant Control

Description:...ek Elevated Immunosuppressant Control is a bilevel cyclosporine control product, prepared from human whole blood. ... for use with assay methods that monitor very high cyclosporine levels, such as C2 monitoring, which measures cyclosporine levels in transplant patients at two hours post-do...
Company:Bio-Rad Laboratories
Cyclosporine in Biological News

Researchers discover link between organ transplantation and increased cancer risk

...ts that the anti-rejection, immunosuppressive drug cyclosporine ramps up expression of vascular endothelial growth...ltaneously administering an anti-VEGF therapy with cyclosporine in mice repressed this tumor growth. Several inhib...as unclear. The Harvard team tested the ability of cyclosporine to promote growth of pre-existing tumors in mice i...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

...ived MultiStem TM without immunosuppression of any kind did just as well as animals that received MultiStem TM treatment along with daily doses of cyclosporine A, a drug typically given to transplant recipients to prevent rejection. Such drugs can cause undesired side effects, and may be problematic if admin...

Cyclosporine inhibits hepatitis C virus in vitro

...l response when taking the immunosuppressive agent cyclosporine along with interferon-ribavirin combination therapy. cyclosporine also showed efficacy against Hepatitis C virus in ... anti-rejection medication is Tacrolimus, although cyclosporine is also used. The latter drug has been shown to ha...

New type of rejection blocker protects kidneys after transplant

...d in NEJM, 218 patients were randomized to receive cyclosporine or either a less-intensive or more-intensive cours...e in the intensive belatacept group and one in the cyclosporine group. After 12 months of post-transplant treat...and less intensive belatacept regimens compared to cyclosporine patients. Another indicator of kidney health, chro...
Cyclosporine in Biological Technology

Investigational Urine NGAL Biomarker Shows Promise to Monitor Cyclosporine Toxicity in Cardiac Transplant Patients

CHICAGO, July 22 /PRNewswire-FirstCall/ -- Research presented at the American Association for Clinical Chemistry (AACC) annual meeting today indicates that monitoring cardiac transplant patients with the Urine NGAL assay on Abbott's ARCHITECT immunoassay analyzer may help clinicians to m...

Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients

...4 kidney transplant recipients received Prograf or cyclosporine in combination with MMF, basiliximab induction and...e Prograf/MMF group was similar to the rate in the cyclosporine (CyA)/MMF group. There was, however, an imbalance ... used simultaneously with cyclosporine. Prograf or cyclosporine should be discontinued at least 24 hours prior to ...

Barr Reports First Quarter 2008 GAAP Earnings of $0.21 Per Share; Adjusted Earnings of $0.57 Per Share

...r year period. The $46 million decrease in sales is primarily related to lower sales of several of the Company's products including Ondansetron ODT, cyclosporine Capsules and Desmopressin. These decreases were partially offset by increases in sales of Fentanyl Citrate and the launch of the Company's Alendrona...

Video and Photo: Tekturna HCT(R), a Single-tablet Combination of Tekturna(R)* and a Diuretic, Receives US Approval for Treatment of High Blood Pressure

...f you have a history of reduced urine output, or have allergic reactions to certain drugs called sulfonamides. Tell your doctor if you take lithium or cyclosporine or if you have ever had a reaction called angioedema to ACE inhibitor medicine. In clinical studies, the most common side effect experienced by more...

High-throughput gene expression analysis to screen for anti-asthma drugs

...used this approach to screen for asthma drugs that inhibit expression of Th2-specific cytokines (1). Figure 1 shows an example using cyclosporine A (CSA), which was used as a control compound during the screening process. CSA is an immunosuppressive agent known to inhibit trans...
Cyclosporine in Biological Dictionary

Polymorphisms

... Polymorphisms : Evaluating polymorphisms in renal transplant recipients may help achieve better outcomes. ... Next: Polymorphisms to predict cyclosporine and ... The Environmental Genome Project: Functional Analysis of Polymorphisms , analysis of function in genes, cytochrome P450, Environmental Gen...
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