Waters Drives Efficiency in the Clinical and Research Laboratory and Showcases New MassTrak Systems at AACC 2009

... clinical and research laboratories including a new research use only (RUO) kit for quantitative measurement of Tacrolimus, Sirolimus, Everolimus, and cyclosporin A. A highlight of the AACC meeting, the Waters(R) MassTrak(TM) Immunosuppressants XE RUO Kit provides laboratories an alternative to immunoassay tes...

Chronic Kidney Disease Related To Mutant Gene

...e four. Five children progressed to end-stage renal disease before age 5. But surprisingly, two children who received early treatment with steroids or cyclosporin A were still alive and healthy, with no symptoms of the disease. Hildebrandt and his research team couldn't believe children with the most seve...

Cyclosporin A Treats Leukemia Complications

...ytopenia can be treated effectively with the drug, cyclosporin A. Anemia is a decrease in red cells in the blood ...ssue. The patients were treated with 300 mg/day of cyclosporin A. While on the drug, more than 60 percent of the ...ree weeks of treatment. Researchers conclude cyclosporin A is an effective alternative treatment for CLL pa...

Cyclosporin in Biological News

Burnham researchers present at 100th AACR Meeting

...n Garrison, Ph.D., who will discuss ARTS and Siah Collaborate in a Novel Pathway for XIAP Degradation Shi Ranxin, Ph.D., who will present two papers: cyclosporin A Sensitizes Cancer Cells to Death Receptor-Mediated Apoptosis and Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NFκB Activati...

Tips from the American Journal of Pathology

...atinocytes. Only the keratinocyte-restricted Tie-2 mice developed symptoms similar to human psoriasis. These symptoms were reduced by treatment with cyclosporin A, a common psoriasis therapy. Keratinocyte-restricted Tie-2 mice, therefore, may serve as an animal model for human psoriasis. The psoriasis mode...

Mutant gene causes severe kidney disease in infants

... four. Five children progressed to end-stage renal disease before age 5. But surprisingly, two children who received early treatment with steroids or cyclosporin A were still alive and healthy, with no symptoms of the disease. Hildebrandt and his research team couldn't believe children with the most severe...

Cyclosporin in Biological Technology

A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)

...ous determination of four immunosuppressant drugs: cyclosporin A (CsA), Tacrolimus (TAC, aka FK-506), Sirolimus (...ring the MRM measurements. This permits the use of cyclosporin D (CsD) as an internal standard for quantitation o...ted of 80% methanol with 1% ZnSO4 and 200 ng/mL of cyclosporin D as internal standard. 20 ng/mL Ascomycin is adde...

Cis-Reporting System Monitors Intracellular Calcium Mobilization

...ase. NFAT proteins, as substrates for calcineurin, mediate the effects of cyclosporin A (CsA) and FK506, two immunosuppresive drugs that revolutionized transpl... previous reports. 2 Fig.2 cyclosporin is an immunosuppressive drug that was introduced in 1983 and revolutionized...

Cis-Reporting System Monitors Intracellular Calcium Mobilization

...ase. NFAT proteins, as substrates for calcineurin, mediate the effects of cyclosporin A (CsA) and FK506, two immunosuppresive drugs that revolutionized transpl... previous reports. 2 Fig.2 cyclosporin is an immunosuppressive drug that was introduced in 1983 and revolutionized...