Navigation Links
Cyclophilin in Medical News

New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report

...ses II-11 Immunomodulators in Pipeline by Company, and Development Stage II-11 Adjuvant Therapies to Compete with Mainline Therapies II-12 cyclophilin Analogs and Fibrosis/Inflammation Inhibitors in Pipeline by Company II-12 Vaccine Development Remains at Low Scale II-12 HCV Vaccines in P...

Study in Nature Medicine establishes major new treatment target in diseased arteries

...l Nature Medicine . By eliminating the gene for a signaling protein called cyclophilin A (CypA) from a strain of mice, researchers were able to provide complete p... protein to provide absolute protection, but it makes perfect sense because cyclophilin A promotes three of the most destructive forces in blood vessels oxidative...

Study in Circulation provides detail on how low blood flow promotes vascular disease

...of the journal Circulation . The work establishes cyclophilin A as an exciting target in the design of drugs aga...hree discoveries by providing strong evidence that cyclophilin A, a protein involved in the immune response, has ...e results because they provide solid evidence that cyclophilin A is at the center of it all." Study Details ...

Protein that provides innate defense against HIV could lead to new treatments

...am from Emory University School of Medicine, Vanderbilt University School of Medicine, and Mayo Medical School has identified CAML (calcium-modulating cyclophilin ligand) as the cellular protein that inhibits the release of HIV particles. CAML works by inhibiting a very late step in the virus lifecycle, lead...

Investigational drug tested for preventing muscle fiber death in muscular dystrophy

...ug, Debio-025, is a known inhibitor of the protein cyclophilin D, which regulates the swelling of mitochondria in...n alpha2. Similar to deleting the gene encoding cyclophilin D, we found that treatment with Debio-025 reduced ...cular dystrophy. This is why we believe inhibiting cyclophilin D could be a new treatment strategy, said Jeff Mol...

HIV Becomes More Infectious Due To Human Immune-system Protein

...ound that the human form of immune-system protein, cyclophilin A, changes the shape of HIV particles to make them...ells from Old World monkeys with HIV-1, found that cyclophilin A changed the shape of the virus particles, report...ith HIV-1. They found that the human form of cyclophilin A still changed the shape of the virus particles, ...
Cyclophilin in Medical Technology

Clinical Update - Debio 025 Cyclophilin Inhibitor for the Treatment of HCV

A Unique Viral Kinetics Profile LAUSANNE, Switzerland, April 19, 2007 /PRNewswire/ -- Debiopharm Group (Debiopharm), a global independent biopharmaceutical development specialist in oncology and serious medical conditions, presented additional results of a previous phase Ib, 15 day study with cycl...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

...trick Aebischer, MD, Ecole Polytechnique Federale de Lausanne (Switzerland) and Deniz Kirik, MD, PhD, Lund University (Sweden) Validation of cyclophilin D, a protein involved in the mitochondrial permeability transi tion, as a target for Parkinson' s disease therapy Mathieu Lesort, PhD, Universi...

Clinical Update - Debio 025 in Hepatitis C

...conditions and particularly oncology, announced today the randomisation of its first patient in a phase IIb clinical study with Debio 025, a selective cyclophilin (Cyp) inhibitor with a potent anti-hepatitis C (HCV) effect. This multinational, double blind, placebo-controlled, parallel-group study will investiga...

Biotica Strikes Significant Collaboration Deal With GlaxoSmithKline

...ical validation. Biotica's programmes include rapamycin-based mTOR inhibitors (partnered with Wyeth), novel FK506 analogues for inhaled use in asthma, cyclophilin inhibitors and erythromycin macrolides (in collaboration with GlaxoSmithKline). All of Biotica's projects employ its proprietary technology, polyketid...

Clinical Update - Debio 025 in Hepatitis C

...5 days induced a strong anti-HCV effect (3.6 log10 reduction) in HIV-1/HCV co-infected patients. (Hepatology, Vol. 47, No 3, 2008, Flisiak et al. "The cyclophilin Inhibitor Debio-025 Shows Potent Anti-Hepatitis C Effect in Patients Coinfected with Hepatitis C and Human Immunodeficiency Virus)." About HCV HCV...
Cyclophilin in Biological News

Tips from the American Journal of Pathology

...mmation. Am J Pathol 2009, 174:177-183 cyclophilin B Is a Possible New Target for Treating Breast Can...ues at Northwestern University have uncovered that cyclophilin B may contribute to progression in breast cancer. ...The American Journal of Pathology . The protein cyclophilin B affects cell division, motility, and death, all ...

Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients

...ase patients. These new findings reveal that blocking this molecule, called cyclophilin D (CypD), and development of surrounding mitochondrial targets may be viabl...l death mediators and enhances production of reactive oxygen species (ROS). cyclophilin D (CypD), a type of enzyme called a prolyl isomerase that is located within...

JCI table of contents: Aug. 9, 2007

...e enhanced by agonists of beta-adrenergic receptors and abrogated by inhibitors of beta-adrenergic receptors. They were also abrogated in mice lacking cyclophilin D, which is the regulator of the mitochondrial permeability pore. This demonstration that Ca2+- and mitochondrial-dependent necrotic cardiomyocyte dea...
Cyclophilin in Biological Technology

Measuring siRNA-mediated knockdown of IL-8 mRNA

...ental results (data not shown), we determined that cyclophilin B (PPIB) demonstrated more stable expression than ...knockdown). To normalize the results, the IL-8 and cyclophilin B measurements made from the same replicate ( i.e....ysed cells) were converted to a ratio (IL-8 RLU to cyclophilin B RLU). This ratio was calculated for each of the ...

Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions

...foam cells. Real-time quantitative RT-PCR for CD68 was performed on equivalent amounts of RNA (100 pg) and the results normalized to the control gene, cyclophilin A. As shown in Fig. 3C, the LCM-derived RNA was significantly enriched in the mRNA for the macrophage specific marker, CD68, compared to whole section...

Real-Time PCR: General Considerations, Rev A

...monstrates the importance of primer optimization using the human cyclophilin 40 gene. Two sets of primers, differing in location, were designed to amplify the same region of the human cyclophilin 40 gene (IMAGE Consortium clone 71154, ATCC). Figure 1 illustrat...

Nuclease Protection Assays: The Basics

...MAXIscript Kit with [- 32 P]UTP (800 Ci/mmol, 10 Ci/ml) and gel purified prior to hybridization. The specific activities of the cyclophilin and -actin probes were reduced twenty and 200-fold, respectively, by adding appropriate amounts of non-radioactive UTP to the tr...

Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation

...ame gel hybridized to radiolabeled probes for -actin, GAPDH, and cyclophilin (Note that the specific activity of the cyclophilin probe was lower than that of the other probes). For each tissue,...

Selecting siRNA Sequences to Incorporate into the pSilencer Vectors

...ed plasmids and siRNAs targeting four different sequences in the cyclophilin and GAPDH genes. These nucleic acids were transfected into HeLa ...3' 45% 63% cyclophilin None 100% 100% ...

Enhanced siRNA Delivery and Long-term Gene Silencing

...n. For example, mRNA levels for ATM and cyclophilin were more strongly reduced when their r... negative control siRNA or an siRNA targeting cyclophilin were generated and used to in...n of the cells was harvested to analyze cyclophilin expression in cells that received the...

GENE SILENCING WITH PCR PRODUCTS

...y 500 ng of total RNA from each sample was assessed by Northern analysis. Radiolabeled RNA probes targeting 28S rRNA, GAPDH, and cyclophilin were used to detect target genes and normalize levels of input RNA. Films were exposed to the blots for 16 hours with a single i...

Control Your siRNA Research

...idated for use in human cell lines and each lot is functionally tested in an siRNA experiment. The GAPDH and cyclophilin siRNAs are also validated for use in mouse cell lines. These siRNA controls are ideal for developing and opt...

QuantiTect SYBR Green RT-PCR Kit

...ucibility and Sensitivity of the QuantiTect SYBR Green RT-PCR Kit One-step RT-PCR of a cyclophilin fragment from 100 ng, 1 ng, and 10 pg of total HeLa RNA. Twelve samples were amplified in parallel from each template amount. Coeffi...
Other Tags
(Date:3/28/2015)... Bellingham, WA (PRWEB) March 28, 2015 ... for athletes, recently announced the release of their new natural ... ounce and 3 ounce packages. Both options come with ... be purchased at RocketPure.com or on Amazon. Click ... product description states that the natural sunscreen is made with ...
(Date:3/28/2015)... AZ. (PRWEB) March 28, 2015 Could ... to a new study by researchers at ... , Produced with the support of the Coffee and ... journal Molecular Psychiatry this past fall, the study—one of ... meta-analysis of genomic data from more than 120,000 regular ...
(Date:3/28/2015)... Take a bite of warm, gooey pepperoni pizza, ... into the stomach, ready to break down your meal. ... acids run amok, triggering a burning sensation in the ... 60 million Americans have heartburn at least once a ... how it can be stopped. , Heartburn or acid ...
(Date:3/28/2015)... New York, New York (PRWEB) March 28, 2015 ... ( http://www.vaginalmeshlawsuit2015.com/ ) involving devices manufactured by C.R. ... multidistrict litigation underway in U.S. District Court, Southern ... Jeffrey S. Grand, is serving on the Plaintiffs’ ... March 24th, the Court has granted certain defendants ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Emergency Medical ... urgent care in Manhattan, recently commemorated its three-year anniversary ... in Manhattan. In addition to 24-hour urgent care, Emergency ... , At this time, Emergency Medical Care’s ... pain, asthma, chest pain, eye injuries, ear infections, fevers, ...
Breaking Medicine News(10 mins):Health News:Rocket Pure Releases New Natural Sunscreens For Athletes 2Health News:Rocket Pure Releases New Natural Sunscreens For Athletes 3Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 3Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 3Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 4Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ... - Global Strategic Business Report" report to their offering. ... Geometry in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Rest of World. Annual estimates and forecasts are ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
Other Contents