Millennium Pharmaceuticals Inc./Lymphoma Research Foundation funds lymphoma research
...d below the diaphragm and in most cases involves the gastrointestinal tract and bone marrow.
MCL is characterized by over expression of the gene cyclin
D1 due to a chromosomal translocation. A subset of MCL also expresses higher levels of a group of small RNA molecules, called miR-17~92. Dr. Fu and ...
Vaporized viral vector shows promise in anti-cancer gene therapy
The researchers also found that CTMP increased apoptosis, inhibited angiogenesis and suppressed production of several proteins, such as cyclin
D1, CDK4 and CDK2, which are important in cancer cell growth.
"Our results demonstrated that lentivirus-mediated CTMP overexpression suppressed Ak...
LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth
... Zinc Finger Transcription Factor INSM1 Interrupts cyclin
D1 and CDK4 Binding and Induces Cell Cycle Arrest,...bition was due to an interaction between INSM1 and cyclin
D1, an important cell growth promoting protein. T...we provide evidence to support that INSM1 binds to cyclin
D1, a critical factor in cell growth, and interrup...
CSHL scientists discover link between control of chromosome duplication and segregation
...he centrosomes by the action of a protein known as cyclin
A. This protein is found at high levels in cells a...opy of their DNA.
But a related protein called cyclin
E may be the target of Orc1. cyclin
E, which was also found to associate with Orc1, is...
Broccoli compound targets key enzyme in late-stage cancer
...se is an enzyme that shortens a cellular chemical, cyclin
E, that is involved in controlling the cell cycle. The shortened version of cyclin
E accelerates the cell cycle, making cancer cells ...howed that I3C prevents the elastase shortening of cyclin
E, thereby arresting development of breast cancer ...
Therapy may block expansion of breast cancer cells
... and finds that therapy targeting a protein called cyclin
D1 may block the expansion of cancerous stem cells...s Jefferson University, was the first to show that cyclin
d1 is required for breast cancer growth in mice. As cyclin
d1 is known to be over-expressed in human breast c...
Penn researchers identify natural tumor suppressor
...e in stopping production of another protein called cyclin
D1, which is thought to contribute to the early st...ment.
When mutations block production of Fbx4, cyclin
D1 is not broken down, and subsequently contribute...stopping trouble before it starts by breaking down cyclin
D1 before it can affect the body.
"Cyclin D1 w...
Sound Pharmaceuticals Receives Additional DoD Funding for Its Hearing Regeneration Product
... regeneration. SPI has
developed a proprietary technology for regenerating auditory sensory cells
within the inner ear of mammals involving p27Kip1, a cyclin
kinase inhibitor or CKI. CKIs shut down cell division or proliferation in
many developing cells and tissues and are often expressed in adult...
Also in the July 8 JNCI
..., firstname.lastname@example.org , (646) 227-3573
A1 Expression Promotes Prostate Cancer Invasion and Metastases
A1 promotes prostate cancer invasion and metastasi... signaling proteins and extracellular proteins.
A1 is a cell cycle regulatory protein and is thoug...
Bacterial peptide provides new insight into common tumor suppressor
... and provides new insight into the regulation of the complex process of cellular protein degradation under normal and pathological conditions.
kinase inhibitor p27kip1 is one of the most frequently dysregulated tumor suppressor proteins in human cancers and it correlates directly with patient...
Cyclin in Medical Technology
Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia To Be Presented at ASH
...oreloxin in combination with cytarabine for relapsed/refractory AML. In addition, results from the Phase 1 study of SNS-032, a selective inhibitor of cyclin
dependent kinases 2, 7 and 9, in both chronic lymphocytic leukemia and multiple myeloma will be presented. Following are the details on each of these...
TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)
...s in Chicago on June 1, 2008 (J Clin Oncol 26:3077, 2008).
Rexin-G and Reximmune-C are pathotropic (disease-seeking) nanoparticles
bearing a cytocidal cyclin
G1 gene and a granulocyte-macrophage colony
stimulating factor (GM-CSF) gene, respectively. When injected
intravenously, these targeted vectors seek o...
Sunesis Pharmaceuticals Reports Data from Nonclinical Studies of SNS-032 at the Annual Meeting of the American Association for Cancer Research
...s lymphoma driven by the
over-expression of certain oncoproteins, including cyclin
D1, Mcl-1 and
Myc. SNS-032's targeted inhibition of CDKs 7 and 9 blocks tra... inhibitor of cyclin-dependent kinases 2, 7,
and 9, blocks transcription of cyclin
D1 and Mcl-1, causing cell death in
mantle cell lymphoma cell lines" (Abstr...
Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research
...NS-032 Poster Presentation Sunday, April 13, 2008 -- SNS-032, a novel inhibitor of cyclin-dependent kinases 2, 7, and 9, blocks transcription of cyclin
D1 and Mcl-1, causing cell death in mantle cell lymphoma cell lines Session: Histone Deacetylase Inhibitors and Cell Cycle Inhibitors Abst...
Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine
...d so far only
targeted vector that has been tested in the clinic: the retroviral vector
Rexin-G, which expresses a cytocidal dominant-negative form of cyclin
The article goes as far as to mention the fact that a number of clinical
studies have "demonstrated the effectiveness of the vector" in the cruci...
Sunesis Pharmaceuticals to Present Data on Two Product Candidates at the 49th Annual Meeting of the American Society of Hematology
...-dependent kinase (CDK) inhibitor, during poster session "CLL:
Salvage Therapies and New Agents." The poster, "Mechanism of Action of
SNS-032, a Novel cyclin
Dependent Kinase Inhibitor, in Chronic Lymphocytic
Leukemia: Comparison with Flavopiridol" (Abstract no. 3112) will be
presented in Hall B4 of the Geo...
Cyclacel Pharmaceuticals to Present Preclinical Data on
Sapacitabine and Seliciclib at AACR
... Seliciclib is the most advanced
dependent kinase (CDK) inhibitor in Phase
II clini...valuating seliciclib (CYC202),
an orally-available cyclin
dependent kinase inhibitor, in Phase II
clinical t...out seliciclib
Seliciclib is an orally-available cyclin
dependent kinase (CDK)
inhibitor that selectively ...
Onconova Therapeutics Announces Presentation of Clinical and
Non-Clinical Results for Its Lead Compound ON 01910.Na at American
Association of Cancer Research Conference in Los Angeles
...Y. Cho, J. Roboz, T. Ohnuma and J. F.
Holland (abstract 3182); and "Evaluation of ON 01910.Na, a novel
modulator of PLK-1 pathway and development of a cyclin
predictive assay in pancreatic cancer" by A. Jimeno, A. Chan, G.
Cusatis, X. Zhang, J. Wheelhouse, A. Solomon, F. Chan, M. Zhao, S.
VioQuest Pharmaceuticals Announces Data Presentation for Its Akt
Inhibitor VQD-002, at American Association for Cancer Research
androgen-dependent to androgen-independent disease. Therapeutics
for these aggressive forms of cancers are lacking. Previously, we
reported that the cyclin
dependent kinase inhibitor (CDK)
roscovitine down- regulates the expression of X-linked Inhibitor of
Apoptosis (XIAP) in metastatic PCas and can induc...
Cyclin in Biological News
Pitt researchers find promising candidate protein for cancer prevention vaccines
...e response against this cell cycle protein, called cyclin
B1, were able to reject a tumor challenge in which...ch like tumor cells because they, too, overproduce cyclin
B1. The virus actually packages the host protein, ...infected cells that must be destroyed.
B1 is a 'self' protein, there have been concerns t...
Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
...e detected OGF and OGFr in both the cytoplasmic and the nuclear compartments. The OGF-OGFr axis is known to regulate cell proliferation by modulating cyclin
dependent kinase inhibitors, resulting in a retardation of cells at the G1-S interface of the cell cycle. To address the question of the location and...
JDRF-funded researchers discover proteins regulating human beta cell replication
...They examined 34 different proteins and found that cyclin
dependent kinase- 6 (cdk6) alone or with cyclin
D, when injected into human islets by viral delive...weeks. The transplanted islet cells with cdk6 and cyclin
D performed better than control (non-modified) hum...
Human beta cells can be easily induced to replicate, according to study in Diabetes
... vector carrying the cdk-6 gene, the cells replicated. Stimulation was further enhanced by increasing production of another cell cycle molecule called cyclin
D1. Untreated human islets did not replicate.
"After we transplanted some of these engineered human beta cells under the outer layer of a kidney in...
Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway
...imulates the interaction of the OGF-OGFr axis. This native, tonically active inhibitory pathway is known to regulate cell proliferation by modulating cyclin
dependent kinase inhibitors, resulting in a retardation of cells at the G1-S interface of the cell cycle. Neutralization of OGF or knockdown of OGFr ...
Argyrin: Natural substance raises hope for new cancer therapies
...can be tested for their biological activity in a fast, automated procedure. The two agreed to develop a special cell line in which the quantity of the cyclin
kinase inhibitor can be measured using simple optical methods. Ronald Frank: "We adapted this cell based assay system to allow automated screening of ...
Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
... are thought to help turn on certain genes such as cyclin
D1, which in turn promote cancer development. "We'...re, we could say that estrogen receptors turned on cyclin
D1, which was enough to cause mammary tumorigenesi...e first initiation step."
The team found that cyclin
D1 activity in human breast cancer samples was inc...
New cellular flaw found in some virulent breast cancers
...ar events. The overproduction of a common protein, cyclin
D1, hyperstimulates a growth switch, CDK4 kinase, ...composed of cells that contain both the overactive cyclin
D1-CDK4 switch and a mutated cancer-causing gene E...ofessor of pathology at Harvard Medical School.
D1 is one of a family of proteins that help regula...
New binding target for oncogenic viral protein
...ll division, cell growth, differentiation, and cell death.
"These proteins are also some of the most broadly acting cellular oncogenes, and include cyclin
E, c-Myc, Notch, and c-Jun," noted Dr. Clurman. "When Fbw7 is mutated in cancers, deregulation of these oncogenic Fbw7 targets is thought to contribut...
Cyclin in Biological Technology
ScienceFirst Staff Expansion
...tical industry. He earned a PhD from the Technion-Israel Institute of Technology, completing his thesis on the "Role of cyclosome in the regulation of cyclin
Brian Burns was recently named account director at ScienceFirst. Before joining ScienceFirst, Burns held the position of associate...
JCI table of contents: April 22, 2008
...tumor cells is their reliance on just one of three cyclin
Unlike normal cells, which have three cyclin
D proteins that can each cover for the others, the...cancers such as multiple myeloma, express only one cyclin
D protein. This has led to the suggestion that tar...
Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040
...-small cell lung cancer, and has an excellent therapeutic
window due to its low toxicity. The mode of action of LOR-253 involves the
downregulation of cyclin
D1, an important regulator of cell cycle
progression and cell proliferation, and induction of the tumor suppressor
Kruppel like factor 4 (KLF-4). Alte...
Three Astex Drug Candidates to be Presented at the 2007 American Society of Hematology Annual Meeting
...re clinical trials,
including a Phase I/II study in patients with refractory haematological
AT7519 is a selective inhibitor of certain cyclin
(CDKs), currently in two multi-centre Phase 1 clinical trials.
AT9311 (also known as NVP-LCQ195) is also an inhibitor of CDKs, but...
Astex Drug Candidates to be Featured at the 2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
Conference on Molecular Targets and Cancer Therapeutics, to be held October
22-26, 2007 in San Francisco. AT7519 is a potent and selective cyclin
Dependent Kinase (CDK)
inhibitor currently in multi-centre Phase 1 clinical trials. AT13148 is a
potent and selective inhibitor of AKT and certain oth...
siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)
...radation of an EGFP sensor that shadows endogenous cyclin
B1 levels. The G2/M cell cycle phase marker (CCPM)...ciency was confirmed using an siRNA pool targeting cyclin
B1 sequences in the region of cyclin
B1 used to construct the G2/M CCPM fusion protein ...
RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs
...selectively inhibit FASE.
E is overexpressed in a number of
... drug target, Li et al (6) used siRNAs to reduce cyclin
expression in hepatocellula...(HCC) cells. As
expected, the cyclin
E siRNA promoted apoptosis of HCC cells
Deliver siRNAs Into Primary Cells
...GAPDH, uPAR, PKR, as
well as a negative control siRNA, were electroporated into hMSC cells
(A) . Seven siRNAs (1.5 g) targeting cyclin
D1, NFκBp65, STAT1,
PKCα, JAK1, RAF1, MMP-2, and a negative control siRNA were individually
electroporated into NHDF-n...
Isolate Total RNA and Protein From the Same Sample
as each independent replicate contained the same relative proportion of
long RNA (18S rRNA, GAPDH, and/or cyclin
D1 mRNA), small RNA (5S rRNA),
and protein (GAPDH). Quantitative analysis by real time PCR showed variations
of less than 10% (F...
Assessing Gene Function with siRNA Libraries
A validated siRNA targeting cyclin
B1 was used as a positive control.
B1 is a well-studied cell cycle regulator known to...fter 48 hours (Figure 2).
Inhibition of cyclin
B1, which is known to be critical for initiation
Cyclin in Biological Products
Cyclin in Biological Definition
...tes metaphase (M-phase) activity by cleaving and inactivating the M-phase cyclin
required for the function of M-phase cyclin
dependent kinases (M-Cdks). It also cleaves securin , a protein that had ...
Cyclin in Biological Dictionary
...se in the degradation of p21Cip1 in S phase . ... ... activity is restricted to the G1- S phase of the cell cycle. ... During S phase , cyclin
A forms a complex with Cdk2, the pRB-related protein p107 ... ' s Phase I Environmental Site Assessment for this site are. as follows: ... '...
... posted to reproduction ovogenesis oogenesis oocyte invertebrate gigas by altotor ... posted to vertebrate spermatogenesis oogenesis molecular cyclin
cell-cycle by ... Oogenesis ) ... Postnatal Oogenesis ... Search NLM Online Textbooks- " oogenesis " : Molecular Biology of the Cell ... Labo...
... mammalian cell cycle is the oldest, ... Cells stopped growth and were arrested with a G1 phase amount of DNA. ... (10 , 11) also showed that cyclin
B1 accumulated at the G1 phase in human leukemic cell lines. ... sort subgroups in the G1 phase , the cells were first labeled ... G1...
...he cell moves onto the G2 phase . G2 Phase ... Oncogene is one of the world's leading cancer journals. ... Once induced in G2 phase , cyclin
D1 expression became Ras independent through the next G1 phase . ... Oncogene is one of the world's leading cancer journals. ... UV radiation ...