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Cyclase in Medical News

Ironwood and Forest to Present Additional Phase 2b Data for Novel Gastrointestinal Agent Linaclotide

...rally delivered peptide that acts locally in the gut with no detectable systemic exposure at therapeutic doses. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. An issued composition of matter patent for linaclotide provides protection to 2025. In Septem...

DiagnoCure announces first quarter 2009 results

...Previstage(TM) GCC Colorectal Cancer Staging Test. This major prospective 5-year multicenter study of 425 enrolled patients demonstrated that guanylyl cyclase C ("GCC" or "GUCY2C") is the strongest independent predictor of colorectal cancer recurrence in patients considered low risk by current assessment met...

Biomarker predicts disease recurrence in colorectal cancer

...in regional lymph nodes is an independent predictor of disease recurrence in patients with colorectal cancer. Detection of the biomarker, guanylyl cyclase 2C (GUCY2C), indicates the presence of occult metastases in lymph nodes that may not have been identified by current cancer staging methods, according...

Major study on DiagnoCure's GCC biomarker published in Jama

...multicenter study of over 400 enrolled patients demonstrating that guanylyl cyclase C (GCC) is the strongest independent predictor of colorectal cancer recurre...ents experience disease recurrence and face greater risk of death. Guanylyl cyclase C is the first validated marker useful in detecting the presence or absence...

Gene Test May Help Predict Colon Cancer's Return

...heir risk of recurrence, a new study finds. A report in the Feb. 18 issue of the Journal of the American Medical Association finds that guanylyl cyclase C (GUCY2C) -- an intestinal tumor-suppressing receptor in the lymph nodes -- may better reveal the chance of metastatic colorectal cancer. Accordin...

Sanofi-aventis Delivers 2008 Results Above Guidance

...e NHE3 inhibitor (AVE0657) in sleep apnea; the monoclonal antibody (AVE1642) in the treatment of breast cancer; ataciguat, a guanylate cyclase activator, in neuropathic pain; SAR97276 in the treatment of malaria; a therapeutic vaccine against melanoma; anti-rabies mono...

Also in the June 24 JNCI

...a and colleagues immunized mice with a viral vector that expressed guanylyl cyclase C protein, which is normally only expressed in the intestinal lining and is... animals with colon cancer cells before or after immunization with guanylyl cyclase C. The vaccinated animals developed fewer metastases in the liver and lu...

Different type of colon cancer vaccine reduces disease spread, Jefferson scientists show

...dman, postdoctoral fellow Adam Snook, Ph.D., and their colleagues engineered viruses adenovirus, vaccinia and rabies to express the protein guanylyl cyclase C (GCC), which is normally found in the intestinal lining (and in metastatic colon cancer). The researchers injected the animals with colon cancer cel...

Vaccine Stops Colon Cancer's Spread in Mice

...aid. By targeting this immune system, a vaccine could develop antibodies to the cancer, he explained. The vaccine targets a protein called guanylyl cyclase C (GCC), which is normally made in the intestines, Waldman said. "This protein is actually over expressed when cells lining the intestines transform f...

DiagnoCure's molecular diagnostic tests - PCA3 and GCC - discussed at scientific meetings

...e sessions at the 34th Annual International Clinical Ligand Assay Society Meeting, held in Coral Springs, Florida, with a presentation on its guanylyl cyclase C (GCC) testing research. Timothy J. Holzer, Ph.D., Vice President, R&D and Production at DiagnoCure, presented research data on "Molecular Detectio...
Cyclase in Medical Technology

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

...rally delivered peptide that acts locally in the gut with no detectable systemic exposure at therapeutic doses. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. An issued composition of matter patent for linaclotide provides protection to 2025. In Septem...

Ironwood Announces Linaclotide European Licensing Agreement with Almirall

...rally delivered peptide that acts locally in the gut with no detectable systemic exposure at therapeutic doses. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. Issued composition of matter patents for linaclotide in the United States and Europe provide ...

Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

...stinal disorders. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. Linaclotide demonstrated proof of concept in a comprehensive Phase 2b program, comprised of t...

Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain

...crease intracellular and extracellular cGMP levels by stimulating guanylate cyclase C. Linaclotide is currently being evaluated in a comprehensive Phase 3 prog...tine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. Linaclotide demons...

Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference

...nce in San Diego. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing, linaclotide was shown to decrease visceral pain, increase fluid secre...

Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results

...-class compound currently being evaluated for the treatment of IBS-C, CC, and other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing linaclotide was shown to decrease visceral pain, increase fluid secret...

Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies

...-in-class compound currently being tested for the treatment of IBS-C, CC, and other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing linaclotide was shown to increase fluid secretion into the intestine, ...

Callisto Reports on Second-Quarter 2007 Milestones

... design of a pivotal trial in this disease indication. Dr. Jacob continued, "We also have implemented a plan to develop Guanilib, Callisto's guanylyl cyclase C receptor agonist, to treat gastrointestinal disorders such as chronic constipation and irritable bowel syndrome. We plan to file an Investigational ...

Callisto Intends to Move Guanilib into Clinical Trials in Ulcerative Colitis

...ieves that Guanilib is presently the best physiological ligand of guanylate cyclase receptor with the potential to provide a new way to treat gastrointestinal ...l inflammation, and cancer. Guanilib is the lead candidate of our Guanylate cyclase Receptor Agonist (GCRA) platform. Callisto own worldwide patent coverage fo...

Microbia Announces Positive Phase 2 Results for Its Investigational Compound Linaclotide

...ther gastrointestinal disorders. Linaclotide is an agonist of the guanylate cyclase type-C receptor and acts by a different mechanism than agents targeting the...nd other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical tes...
Cyclase in Medical Dictionary

Smooth muscle

... Predicted smooth muscle NO concentrations are as high as 430 nM, which is ... In smooth muscle cells, NO activates enzyme soluble guanylate cyclase (sGC) ... Loss of vascular smooth muscle SG-SSPN complex was only detected in Sgcd null ... Administration of a vascular smooth muscle ...
Cyclase in Biological News

Creation of antibiotic in test tube holds promise for better antibiotics

... The researchers synthesized nisin simply in a test tube by using a single cyclase enzyme to re-create the process that normally occurs in a strain of the bac...7 steps to make it, while nature uses just two enzymes. One of these is the cyclase whose activity we have demonstrated in this paper." The thioether rings ...

CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts

...ification of a link between CO2 sensing and fungal virulence may have broad implications for the study of microbial pathogens and the role of adenylyl cyclase in virulence trait regulation by CO2. Furthermore, it may in time facilitate the development of a new class of antimicrobial agents. ...
Cyclase in Biological Technology

Microbia and Forest Laboratories Announce Linaclotide Co-Development and Co-Marketing Collaboration

...low incidence of adverse events. Linaclotide is an agonist of the guanylate cyclase type-C receptor found in the intestine and acts by a mechanism distinct fro...nd other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical tes...

cAMP DataFile: Homogenous Cyclic AMP detection using High Efficiency Fluorescence Polarization

...ctivation of the enzyme adenylyl cyclase. Adenylyl cyclase converts ATP into cyclic AMP that in turn activate...ual assays of cell lysates or of purified adenylyl cyclase will require optimization and validation based upo... Measurement of adenylyl cyclase activity 1 Monitoring ph...

In Vitro Measurement of the Second Messenger cAMP: RIA vs. FlashPlate

...racellular changes in the level of cAMP can then initiate a cascade of other cellular events. We have been investigating changes of adenylyl cyclase activity, induced by receptor stimulation in recombinant cell lines, by measuring the accumulation of cAMP. Until recently, we used the commercially a...

Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors

... is monitoring the activity of the enzyme adenylyl cyclase by measuring cAMP accumulation. Until re...owever the recent introduction of a novel adenylyl cyclase FlashPlate assay (SMP004, SMP004A) has provided a ...e technology to measure the activation of adenylyl cyclase in Chinese Hamster Ovary (CHO) cells expressing hu...

Development of a CRF1 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System

...ceptor subtypes (CRF 1 and CRF 2 , which includes CRF 2 α and CRF 2 β ) (1). These receptor subtypes are positively coupled to adenylyl cyclase and show distinct expression patterns and binding characteristics. CRF 1 receptors, for instance, are widely expressed in the brain, the anterior pit...

Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells

... cAMP assay Adrenergic receptors are linked to adenylate cyclase via either inhibitory or stimulatory G proteins. These receptors, when acti...ntracellular generation of cAMP. In response to receptor binding, adenylate cyclase converts AMP to cAMP, which exerts its effect by activating a protein kinas...

In Vivo Signal Transduction Pathway Reporting Systems

... be activated by ultraviolet irradiation, and the PathDetect CREB system was activated by known PKA-activating agents such as the adenylate cyclase toxin from Bordetella pertussis and forskolin (data not shown). Applications of the PathDetect Systems The PathDetect c-Jun, Elk1 a...

Enzyme Immunoassay for Studying Intracellular Levels of cAMP

...ctivation of a G protein, which, in turn, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAM...or Increased Intracellular cAMP Levels Stratagene is offering adenylate cyclase (AC) toxin, a useful reagent for increasing intracellular cAMP levels in ...
Cyclase in Biological Products

Guanylate Cyclase Blocking Peptide from Cayman Chemical

Description: Peptide sequences: Two separate vials containing 200 g of peptide corresponding to the same sequence used as antigens for guanylate cyclase polyclonal antiserum (Catalog No. 160890) To be used in conjunction with Cayman's guanylate cyclase polyclonal antiserum (Catalog No. 160890) to block pro...
Company:Cayman Chemical

Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)

Description:... pyrophosphate (PPi ) produced by a number of biochemical reactions, such as DNA and RNA polymerizations, cyclic AMP formation by the enzyme adenylate cyclase and the enzymatic activation of fatty acids to form their coenzyme A esters.1 The EnzChek Pyrophosphate Assay Kit is a modification of our EnzChek Pho...
Company:Molecular Probes (Invitrogen)
Cyclase in Biological Definition

Enzyme

...t bonds The complete nomenclature can be browsed at http://www.chem.qmul.ac.uk/iubmb/enzyme/ Enzymes and classes of enzyme Adenylate cyclase : participate in signal transduction by converting ATP into cyclic AMP Alcohol dehydrogenase : breaks down alcohols to aldehydes in human...

Signal transduction

... the enzyme NO synthase , with citrulline as a by-product. NO works mainly through activation of its target receptor, the enzyme soluble guanylate cyclase , which when activated, produces the second messenger cyclic guanosine monophosphate (cGMP). NO can also act through covalent modification of prote...
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