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Crystallize in Medical News

Cancer cells need normal, nonmutated genes to survive

...vides a much more direct path to new anti-cancer drug targets," adds Luo. "The genes that are critical for maintaining the malignant state will really crystallize when we combine forces." ...

DIA to host Patient Recruitment and Retention Forum April 20-21, 2009

...dham and Company. Sponsors, CROs, service providers, and clinical research team thought leaders will lead interactive group discussions to further crystallize the topics discussed in the more formal sessions. About the Drug Information Association (DIA) DIA serves more than 30,000 professionals in the...

Microwave synthesis connects with the (quantum) dots

...king good quantum dots for biological research is complex. First a semiconductor compoundtypically a mixture of cadmium and seleniummust be induced to crystallize into discrete nanocrystals of just the right size. Cadmium is toxic, and the compound also can oxidize easily (ruining the effect), so the nanocrystal...

Penn researchers discover 'modus operandi' of heart muscle protein

...ly studying how the heart regulates the level of Lmod and how Lmod might be relevant to cardiac muscle disease. In addition, the team is attempting to crystallize Lmod in order to study its structure directly. ...

University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein

...rane and keep it in an active form to ensure that their studies revealed a physiologically relevant enzyme structure. The team then used detergents to crystallize the enzyme and screened the protein crystals in Pitts new state-of-the-art X-ray crystallography facility, directed by Dr. Yeh. Next, they applied ...

Scientists solve structure of gene regulator that plays key role in cancer

...rotein crystal. Marmorstein and his colleagues spent years attempting to crystallize p300/CBP a process made excruciatingly difficult by the proteins tendency ...ct the enzymes flexible and floppy nature, the scientists were then able to crystallize it. Studies of the structure show that p300/CBP contains a binding pocke...

How one virus uses mimicry to replicate successfully

...lexible, it needs binding partners to crystallize, Liu says. By forming a complex with pRb and these binding partners, the researchers were able to crystallize the protein and then analyze its structure using a technique called X-ray crystallography. Their studies revealed how each component of the complex wo...

Does Aspirin Crystallize?

...t? “We can now clear this matter up,” say Bond, Boese and Desiraju, after very careful examination of aspirin crystals. “Aspirin has a tendency to crystallize with an unusual intergrown structure. The same single crystal contains domains with both arrangements lying side by side.” The distribution and ratio ...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

...roteins that form a dimer. In seeking to determine the structure of p53 bound to DNA, the challenge for the scientists was that their efforts to crystallize the p53 dimer bound to DNA consistently resulted in structures that could not bind to DNA. (Crystallization is a prerequisite for obtaining the type o...
Crystallize in Medical Technology

New Insight Into the Controls on a Go-To Enzyme

...lography, with help from nuclear magnetic resonance (NMR) spectroscopy. In this widely used method of determining protein structure, researchers first crystallize a protein to be studied. Then, they direct X-rays through the crystal and deduce the protein structure from the diffraction pattern of those X-rays. T...

VAI Finding Could Lead to New Drugs for Anxiety, Depression

...ound to the receptor, and one that shows how the receptor binds to other proteins in the same family. To determine the structure, researchers had to crystallize the hormone and receptor in these different scenarios, a process similar to letting salty water evaporate to form salt crystals but much more difficul...
Crystallize in Medical Products

Immersion oil UV-transparent

Description:... Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
Company:Sigma-Aldrich

Immersion oil UV-transparent, fluorescence-free

Description:... Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
Company:Sigma-Aldrich
Crystallize in Medical Dictionary

Salivary duct stones

...re a type of salivary gland disorder. ... The chemicals in saliva can crystallize into a stone that can block the salivary ducts . ... Salivary d... Salivary duct stones are crystallized minerals ... in saliva can crystallize into a stone that can block the salivary ducts . ... Salivary d...
Crystallize in Biological News

New clues to how proteins dissolve and crystallize

BERKELEY, CA -- In the late 19th century the Czech scientist Franz Hofmeister observed that some salts (ionic compounds) aided the solution of proteins in egg white, some caused the proteins to destabilize and precipitate, and others ranged in activity between these poles. Hofmeister proceeded...

Jet-propelled imaging for an ultrafast light source

... by computers how the electrons, and thus the atoms, are arranged. But many proteins can't be crystallized at all, and others are so difficult to crystallize it's virtually impossible to obtain crystals large enough to use in today's light sources. Ultrafast, ultrabright x-rays offer a way past this dil...

Genetic switch potential key to new class of antibiotics

... at extreme temperatures and was first found in a Chinese hot spring. The team suspected that the hot spring preQ1 riboswitch must be stable enough to crystallize due to its need to function at high temperatures. The more stable the riboswitch, the easier it is to capture and map its molecular structure. The tea...

A splice of life

...smitted to action in the human cell and frequently at which point genetic disease develops in humans. The scientists report that they were able to crystallize a very large complex of a macromolecular "machine" in the human cell and determine its structure or what it actually looks like, thereby zeroing in on...

Long-sought protein structure may help reveal how 'gene switch' works

...cterium Escherichia coli, researchers were able to crystallize the protein in its active ("on") state and examine...ive ("off") E. coli CRP eluded them as attempts to crystallize it repeatedly failed. With only the structure of t...hen they are not needed. "Our next step is to crystallize M. tuberculosis CRP in the active state and define...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

...titute (RPCI), said. "Scientists worldwide have been trying for 35 years to crystallize this membrane-bound enzyme and we are the first to succeed. Now that we kno...ng the enzyme," Ghosh said. "Using a 'secret recipe,' we have been able to crystallize it and identify the structure knowledge which will be used to make much be...

New insight into the controls on a go-to enzyme

...lography, with help from nuclear magnetic resonance (NMR) spectroscopy. In this widely used method of determining protein structure, researchers first crystallize a protein to be studied. Then, they direct X-rays through the crystal and deduce the protein structure from the diffraction pattern of those X-rays. T...

The structure of the Mre11 protein bound to DNA

...ner, leader of SIBYLS, says "You get information from every protein crystal you analyze if only what not to try crystallizing. Sometimes you can only crystallize a small part of a large protein or complex. It's the synergy with SAXS, which can show you how these pieces fit together or provide experimental evide...

Argonne scientists peer into heart of compound that may detect chemical, biological weapons

... went undiscovered. The material, (A)ZrPSe6, where A can be potassium, rubidium or cesium, has a unique and difficult chemical structure that does not crystallize very well. It grows lengthwise, but not in other directions. This creates long, thin crystals--perfect for fiber optics but a headache to study by con...

Argonne scientists use lasers to align molecules

...he most important challenge facing structural biology," Young said. "A method for structure determination at atomic resolution without the need to crystallize would be revolutionary." Young and her team have successfully aligned molecules using a laser, probed the aligned ensemble with x-rays and shown th...
Crystallize in Biological Technology

New nanocluster to boost thin films for semiconductors

...on, allowing for reaction yields up to 95 percent. Comparable compounds traditionally made under caustic conditions often take months or even years to crystallize and result in low yields. "The benefit is that we can predictably control the ratio of gallium and indium in these structures at molecular levels, ...

Penn engineers design computer memory in nanoscale form that retrieves data 1,000 times faster

...ces unusable materials with space, size and efficiency limitations. Instead, researchers used self-assembly, a process by which chemical reactants crystallize at lower temperatures mediated by nanoscale metal catalysts to spontaneously form nanowires that were 30-50 nanometers in diameter and 10 micrometers ...

Penn engineers design computer memory in nanoscale form that retrieves data 1,000 times faster

...ces unusable materials with space, size and efficiency limitations. Instead, researchers used self-assembly, a process by which chemical reactants crystallize at lower temperatures mediated by nanoscale metal catalysts to spontaneously form nanowires that were 30-50 nanometers in diameter and 10 micrometers ...

Impact of research park firms pegged at $680M

...ecdotal stories about the extent to which the research park has an impact in this community, but we wanted to get it in black and white and be able to crystallize it in one easy document." The more than a half-billion dollars in economic contribution was "frankly surprising to me," Bugher said. "We are pleasa...
Crystallize in Biological Definition

X-ray crystallography

...allographic database such as the Protein Databank or the Cambridge Structure Database . Many structures obtained in private commercial ventures to crystallize medicinally relevant proteins, are not deposited in public crystallographic databases. Visit the X-factors webzine for the latest X-ray crystallogr...
Crystallize in Biological Dictionary

Uric acid

...ls than men. ... Uric acid is made in the liver and excreted by the kidneys. ... Supersaturated uric acid in the urine (uricosuria) can crystallize to form ... uric acid gout food high in uric acid level danger and side effects uric acid diet ... Uric acid is the end product of ...

Transferrin receptor

...sferrin receptor 1 was established as a gatekeeper for ... The first involves receptor -mediated endocytosis of transferrin . ... Efforts to crystallize transferrin receptor protein are underway. ... This test measures the concentration of soluble transferrin receptor in blood. When body ...
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