Navigation Links
Crystallize in Medical News

Cancer cells need normal, nonmutated genes to survive

...vides a much more direct path to new anti-cancer drug targets," adds Luo. "The genes that are critical for maintaining the malignant state will really crystallize when we combine forces." ...

DIA to host Patient Recruitment and Retention Forum April 20-21, 2009

...dham and Company. Sponsors, CROs, service providers, and clinical research team thought leaders will lead interactive group discussions to further crystallize the topics discussed in the more formal sessions. About the Drug Information Association (DIA) DIA serves more than 30,000 professionals in the...

Microwave synthesis connects with the (quantum) dots

...king good quantum dots for biological research is complex. First a semiconductor compoundtypically a mixture of cadmium and seleniummust be induced to crystallize into discrete nanocrystals of just the right size. Cadmium is toxic, and the compound also can oxidize easily (ruining the effect), so the nanocrystal...

Penn researchers discover 'modus operandi' of heart muscle protein

...ly studying how the heart regulates the level of Lmod and how Lmod might be relevant to cardiac muscle disease. In addition, the team is attempting to crystallize Lmod in order to study its structure directly. ...

University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein

...rane and keep it in an active form to ensure that their studies revealed a physiologically relevant enzyme structure. The team then used detergents to crystallize the enzyme and screened the protein crystals in Pitts new state-of-the-art X-ray crystallography facility, directed by Dr. Yeh. Next, they applied ...

Scientists solve structure of gene regulator that plays key role in cancer

...rotein crystal. Marmorstein and his colleagues spent years attempting to crystallize p300/CBP a process made excruciatingly difficult by the proteins tendency ...ct the enzymes flexible and floppy nature, the scientists were then able to crystallize it. Studies of the structure show that p300/CBP contains a binding pocke...

How one virus uses mimicry to replicate successfully

...lexible, it needs binding partners to crystallize, Liu says. By forming a complex with pRb and these binding partners, the researchers were able to crystallize the protein and then analyze its structure using a technique called X-ray crystallography. Their studies revealed how each component of the complex wo...

Does Aspirin Crystallize?

...t? “We can now clear this matter up,” say Bond, Boese and Desiraju, after very careful examination of aspirin crystals. “Aspirin has a tendency to crystallize with an unusual intergrown structure. The same single crystal contains domains with both arrangements lying side by side.” The distribution and ratio ...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

...roteins that form a dimer. In seeking to determine the structure of p53 bound to DNA, the challenge for the scientists was that their efforts to crystallize the p53 dimer bound to DNA consistently resulted in structures that could not bind to DNA. (Crystallization is a prerequisite for obtaining the type o...
Crystallize in Medical Technology

New Insight Into the Controls on a Go-To Enzyme

...lography, with help from nuclear magnetic resonance (NMR) spectroscopy. In this widely used method of determining protein structure, researchers first crystallize a protein to be studied. Then, they direct X-rays through the crystal and deduce the protein structure from the diffraction pattern of those X-rays. T...

VAI Finding Could Lead to New Drugs for Anxiety, Depression

...ound to the receptor, and one that shows how the receptor binds to other proteins in the same family. To determine the structure, researchers had to crystallize the hormone and receptor in these different scenarios, a process similar to letting salty water evaporate to form salt crystals but much more difficul...
Crystallize in Medical Products

Immersion oil UV-transparent

Description:... Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
Company:Sigma-Aldrich

Immersion oil UV-transparent, fluorescence-free

Description:... Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
Company:Sigma-Aldrich
Crystallize in Medical Dictionary

Salivary duct stones

...re a type of salivary gland disorder. ... The chemicals in saliva can crystallize into a stone that can block the salivary ducts . ... Salivary d... Salivary duct stones are crystallized minerals ... in saliva can crystallize into a stone that can block the salivary ducts . ... Salivary d...
Crystallize in Biological News

New clues to how proteins dissolve and crystallize

BERKELEY, CA -- In the late 19th century the Czech scientist Franz Hofmeister observed that some salts (ionic compounds) aided the solution of proteins in egg white, some caused the proteins to destabilize and precipitate, and others ranged in activity between these poles. Hofmeister proceeded...

Jet-propelled imaging for an ultrafast light source

... by computers how the electrons, and thus the atoms, are arranged. But many proteins can't be crystallized at all, and others are so difficult to crystallize it's virtually impossible to obtain crystals large enough to use in today's light sources. Ultrafast, ultrabright x-rays offer a way past this dil...

Genetic switch potential key to new class of antibiotics

... at extreme temperatures and was first found in a Chinese hot spring. The team suspected that the hot spring preQ1 riboswitch must be stable enough to crystallize due to its need to function at high temperatures. The more stable the riboswitch, the easier it is to capture and map its molecular structure. The tea...

A splice of life

...smitted to action in the human cell and frequently at which point genetic disease develops in humans. The scientists report that they were able to crystallize a very large complex of a macromolecular "machine" in the human cell and determine its structure or what it actually looks like, thereby zeroing in on...

Long-sought protein structure may help reveal how 'gene switch' works

...cterium Escherichia coli, researchers were able to crystallize the protein in its active ("on") state and examine...ive ("off") E. coli CRP eluded them as attempts to crystallize it repeatedly failed. With only the structure of t...hen they are not needed. "Our next step is to crystallize M. tuberculosis CRP in the active state and define...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

...titute (RPCI), said. "Scientists worldwide have been trying for 35 years to crystallize this membrane-bound enzyme and we are the first to succeed. Now that we kno...ng the enzyme," Ghosh said. "Using a 'secret recipe,' we have been able to crystallize it and identify the structure knowledge which will be used to make much be...

New insight into the controls on a go-to enzyme

...lography, with help from nuclear magnetic resonance (NMR) spectroscopy. In this widely used method of determining protein structure, researchers first crystallize a protein to be studied. Then, they direct X-rays through the crystal and deduce the protein structure from the diffraction pattern of those X-rays. T...

The structure of the Mre11 protein bound to DNA

...ner, leader of SIBYLS, says "You get information from every protein crystal you analyze if only what not to try crystallizing. Sometimes you can only crystallize a small part of a large protein or complex. It's the synergy with SAXS, which can show you how these pieces fit together or provide experimental evide...

Argonne scientists peer into heart of compound that may detect chemical, biological weapons

... went undiscovered. The material, (A)ZrPSe6, where A can be potassium, rubidium or cesium, has a unique and difficult chemical structure that does not crystallize very well. It grows lengthwise, but not in other directions. This creates long, thin crystals--perfect for fiber optics but a headache to study by con...

Argonne scientists use lasers to align molecules

...he most important challenge facing structural biology," Young said. "A method for structure determination at atomic resolution without the need to crystallize would be revolutionary." Young and her team have successfully aligned molecules using a laser, probed the aligned ensemble with x-rays and shown th...
Crystallize in Biological Technology

New nanocluster to boost thin films for semiconductors

...on, allowing for reaction yields up to 95 percent. Comparable compounds traditionally made under caustic conditions often take months or even years to crystallize and result in low yields. "The benefit is that we can predictably control the ratio of gallium and indium in these structures at molecular levels, ...

Penn engineers design computer memory in nanoscale form that retrieves data 1,000 times faster

...ces unusable materials with space, size and efficiency limitations. Instead, researchers used self-assembly, a process by which chemical reactants crystallize at lower temperatures mediated by nanoscale metal catalysts to spontaneously form nanowires that were 30-50 nanometers in diameter and 10 micrometers ...

Penn engineers design computer memory in nanoscale form that retrieves data 1,000 times faster

...ces unusable materials with space, size and efficiency limitations. Instead, researchers used self-assembly, a process by which chemical reactants crystallize at lower temperatures mediated by nanoscale metal catalysts to spontaneously form nanowires that were 30-50 nanometers in diameter and 10 micrometers ...

Impact of research park firms pegged at $680M

...ecdotal stories about the extent to which the research park has an impact in this community, but we wanted to get it in black and white and be able to crystallize it in one easy document." The more than a half-billion dollars in economic contribution was "frankly surprising to me," Bugher said. "We are pleasa...
Crystallize in Biological Definition

X-ray crystallography

...allographic database such as the Protein Databank or the Cambridge Structure Database . Many structures obtained in private commercial ventures to crystallize medicinally relevant proteins, are not deposited in public crystallographic databases. Visit the X-factors webzine for the latest X-ray crystallogr...
Crystallize in Biological Dictionary

Uric acid

...ls than men. ... Uric acid is made in the liver and excreted by the kidneys. ... Supersaturated uric acid in the urine (uricosuria) can crystallize to form ... uric acid gout food high in uric acid level danger and side effects uric acid diet ... Uric acid is the end product of ...

Transferrin receptor

...sferrin receptor 1 was established as a gatekeeper for ... The first involves receptor -mediated endocytosis of transferrin . ... Efforts to crystallize transferrin receptor protein are underway. ... This test measures the concentration of soluble transferrin receptor in blood. When body ...
Other Tags
(Date:7/9/2014)... most common type of lung cancer, researchers have uncovered ... in forming tumors. The new knowledge may expand treatments ... changes already are available or are in clinical trials. ... from The Cancer Genome Atlas (TCGA), including researchers at ... Medical School and other institutions, studied tumors from 230 ...
(Date:7/9/2014)... policing injection drug users in Russia might contribute ... A study, conducted by researchers from Boston University ... with St. Petersburg Pavlov State University, sought to ... health outcomes of a cohort of HIV-positive people ... who were arrested by police were more likely ...
(Date:7/9/2014)... July 9, 2014 There has been a sharp ... Southwestern Medical Center using MyChart, the online, interactive service ... communicate with their healthcare providers, schedule appointments, and renew ... patients actively using MyChart each year increased ... increased more than 10-fold, according to a study by ...
(Date:7/9/2014)... It may smell of flatulence and have a reputation for ... dosage, hydrogen sulfide is now being being found to offer ... to stroke, heart attacks and dementia. A new compound (AP39), ... the key to future therapies, by targeting delivery of very ... places inside cells. , Scientists in Exeter have already ...
(Date:7/9/2014)... print and poor printing on prescription labels handed ... lead to errors in taking medication, according to ... CNIB (Canadian National Institute for the Blind)., The ... Journal , found that labels on prescription medications ... recommended guidelines for legibility. , By simply following ...
Breaking Medicine News(10 mins):Health News:Lung cancer study hints at new treatments 2Health News:BU researchers relate arrests with HIV risk environment 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:Rotten egg gas holds key to healthcare therapies 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
(Date:7/9/2014)... of Guelph scientist that involved fitting bumblebees with ... a neonicotinoid pesticide hampers bees, ability to forage ... a professor in Guelph,s School of Environmental Sciences, ... published July 9 in the British Ecological Society,s ... shows how long-term pesticide exposure affects individual bees, ...
(Date:7/9/2014)... may be able to cope with the rising salinity of ... Arctic today is best known for its tundra and polar ... to 38 million years ago during what is known as ... huge temperate forest with brackish water, home to a variety ... and giant tortoises. Much of what is known about the ...
(Date:7/9/2014)... first-ever global census of Adlie penguins shows that ... 53 percent larger than previously estimated. Adlie penguins ... to monitor and understand the effects of climate ... By using high-resolution satellite imagery, researchers from Stony ... a new method that permits regular monitoring of ...
Breaking Biology News(10 mins):Bee foraging chronically impaired by pesticide exposure: Study 2Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3
Other Contents