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CpG in Medical News

Orochem Technologies Acquires Oligonet, a Custom Oligo Synthesis Business

...ligo synthesis market having already been supporting oligonucleotide synthesis establishment with several products that range from synthesis plates to cpg (controlled pore glass) columns as well as having proprietary technologies for the purification of small and large scale oligonucleotides. "We sa...

Hormone therapy offers potential protective effect against colon cancer in older women

...colorectal cancer patients, specifically looking for associations between self-reported hormone use and a specific DNA methylation pattern, called the cpg island methylator phenotype, or BRAF gene mutations. No associations were detected between hormone use and these molecular markers. Of note, the inves...

Cold Spring Harbor Protocols features high-throughput methods for analyzing gene activity

...cribes a rapid, genome-wide method for identifying regions where methylation, an epigenetic control mechanism, is occurring. This method, "Methylated cpg Island Amplification and Microarray (MCAM) for High-Throughput Analysis of DNA Methylation," was developed by Marcos Estecio and Jean-Pierre Issa of t...

New Guidelines to Address Growing Obesity Epidemic

...image issue," says Dr. David Lau, President of Obesity Canada, Chair of the cpg Steering Committee and a professor medicine at the University of Calgary. "...r of Family Medicine at Laval University in Québec City and a member of the cpg Expert Panel. "Canadians must be alerted to the fact that their weig...

Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses

...sease CPGs are applied to a hypothetical 79-year-old woman with 5 common chronic diseases. Two investigators independently assessed whether each cpg addressed older patients with co-morbidities, goals of treatment, interactions between recommendations, burden to patients and caregivers, patient pre...
CpG in Medical Technology

Use of PressureWire(R) Yields a More Accurate Assessment of Translesion Pressure Gradients in Peripheral Vasculature, Two New Studies Report

...ements, according to a paper published in the Journal of Interventional Cardiology (2008; Vol. 20, Issue 1: 63-65). The authors report that although cpg measurements derived from both a catheter and PressureWire correlated with anatomic stenosis, PressureWire gradient was more accurate in estimating th...

Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus

... -- cpg 52364, Coley's First Orally-Available, Small Molec...stemic Lupus Erythematosus, or SLE. The candidate, cpg 52364, is a small molecule Toll- Like Receptor (TL...development in SLE and other autoimmune disorders. cpg 52364 has been designed to interfere at an early s...

Major Manufacturer of Unapproved and Adulterated Drugs

...o;Marketed Unapproved Drugs—Compliance Policy Guide” (CPG). The cpg makes clear that firms may not market drugs that require approval without f...ons that the products are safe and effective. One of the priorities in this cpg is enforcement actions against manufacturers that violate other provisions ...
CpG in Biological News

The evolutionary foundation of genomic imprinting in lower vertebrates

...iang University, has shown that, as mammalian Igf2 cpg island, goldfish Igf2 cpg island has a parental differentially methylated re...esis. Their results showed that, as mammalian Igf2 cpg island, goldfish Igf2...

Rett Syndrome Research Trust advisor makes significant discovery

... A paper published online today in Nature Neuroscience reveals the presence of methyl cpg binding protein 2 (MeCP2) in glia. MeCP2 is a protein associated with a variety of neurological disorders, including Rett Syndrome, the most physicall...

DNA component can stimulate and suppress the immune response

...immune system, depending on the dosage, may hold hope for treating cancer and infection, Medical College of Georgia researchers say. Low levels of cpg increase inflammation, part of the body's way of eliminating invaders. But high doses block inflammation by increasing expression of the enzyme indole...

Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome

...ow. The long-time focus in methylation has been cpg islands, regions of the genome rich in the DNA bui...using a new method that searches all DNA, not just cpg islands. To their surprise, the researchers dis...6 percent of methylated sites were situated inside cpg islands. Because of the newly discovered sites' pr...

Salk researchers make fast strides towards understanding how our body controls walking

...s the control and command center for these rhythmic movements. As such, the cpg lies at the heart of all locomotion. Remarkably, this circuitry functions w...run away from the butcher's block. "Although people have known about the cpg for a long time, they haven't been able to identify the nerve cells that a...

MIT researcher finds neuron growth in adult brain

...ch remodeling was ever detected in excitatory cells. Yet evidence points to the fact that adult brains can be functionally plastic. In response to the cpg data, Nedivi and Lee revisited this question with the help of So and Huang. By applying an innovative new imaging technology that allows monitorin...

Modification of program enables prediction of gene transcription

...TRs on genes that weren't even known to exist before," Brent said. The system takes advantage of the scarcity of the CG sequence, finding so-called cpg "islands" known to be more common near the transcription-start site. It also has a knack for recognizing sequences that indicate splice sites. Over th...

Scripps research scientists solve structure of a critical innate immune system protein

...in bacteria like Neisseria meningitides--one of the leading causes of bacterial meningitis. TLR9 recognizes bacterial DNA that contains distinguishing cpg dinucleotides motifs . TLR3 in Detail Likewise, TLR3 recognizes double-stranded RNA, which is the form of genetic information carried by many vi...

Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy

...ne combining the synthetic bacterial DNA sequence, cpg 7909 (ProMuneTM, Coley Pharmaceutical), with a pep...f Clinical Investigation. The paper shows that the cpg 7909 DNA sequence is safe, and increases the immun...n the cancer cells." The vaccine, combining the cpg 7909 adjuvant and Incomplete Freund's Adjuvant (IF...
CpG in Biological Technology

Biotage Launches New 24 Well Pyrosequencing(R) System

...Systems. This new high-performance platform includes a complete software package for the study of genetic and epigenetic variation of genes, providing cpg methylation allele quantification and mutation analysis. These studies are used for a wide range of clinical research, for example the identification ...

Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice

... delivered using a helium pressure of 400 psi. For intramuscular delivery, 100 g of pCMV-S DNA in endotoxin-free water with 0.2 M cpg oligonucleotide was administered into the quadriceps muscle using a 1 ml insulin syringe. Mice were not anesthetized and the muscle ...

siRNA Design: It's All in the Algorithm

...ences known to mediate regulatory processes through binding to protein factors are similarly avoided, as are cpg motifs. Concentrate on Your Experiments, Not on your siRNA Design Experiments ...

Organize Your Data from the Big Blue Mutation Assay

...tra based on the occurrence of each mutation type. Specialized computations are also performed, such as calculating the percentage of mutations at cpg sites and correcting for possible clonal effects. In addition to the standard reports, an ad-hoc reporting feature enables users to create customi...
CpG in Biological Products

CpG WIZ® DAP-KINASE AMPLIFICATION KIT from CHEMICON

Description:...he reagents necessary to perform the initial bisulfite reactions, while the cpg WIZ® DAP-kinase Amplification Kit contains the reagents required for the PCR amplification reactions. The cpg WIZ® DAP-kinase Amplification Kit contains primers that can be used for...
Company:CHEMICON
CpG in Biological Definition

Barr body

...fications, such as histone H3 methylation and histone H2A ubiquitylation , as well as direct modification of the DNA itself, via the methylation of cpg sites . These changes help inactivate gene expression on the inactive X-chromosome and to bring about its compaction to form the Barr body. See...
CpG in Biological Dictionary

Methylation

...ently, another method has been adopted to study promoter methylation . ... Role of changes in patterns of DNA methylation in cancer ... When cpg island methylation and transcriptional silencing occurs at tumor ... ...

Loci

...arrower but ill-defined ... A guide to Illumina's method for unambiguous cpg loci identification and tracking for the ... vide accurate cpg loci identifiers and strand orientation, ... LOCI serves the LADAR...

Genomic DNA

.... Pricing Info. Request Info ... Human DNA (cytosine-5) Methyltransferase (Dnmt3A) Amino-terminal Ab ... 5-Aza-dc Treated Jurkat Genomic DNA . cpg Methylated HeLa Genomic DNA ... ...

CpG island

... ... formal definition of a cpg island is a region with ... cpg islands in vertebrate genomes" ... cpg Island Searcher using the updated rules from...

Chromosome jumping

...chromosome jumping library, with application to ... Cosmid walking and chromosome jumping in the region of PKD1 reveal a locus ... A third cpg island was detected and cloned by directional chromosome jumping . Full text ... The use of chromosome jumping should now be applicable to a...
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