Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... absence of adenoviral binding sites on pancreatic cancer cells such as the coxsackie and adenovirus receptor (CAR). Circumventing CAR-mediated entry therefore s...cificity of this vector, binding sites for native adenoviral receptors, the coxsackie and adenovirus receptor (CAR) and integrin, were ablated from the viral cap...

Researchers from 5 countries to test hygiene hypothesis with EU funding

...ften, and hepatitis A antibodies 12 times more often than Finnish children. Karelian children also have considerably more often antibodies against the coxsackie B4 virus, belonging to the enterovirus group, than Finnish children have. The differences in the frequency of autoimmune phenomena and allergic res...

China Claims Viral Outbreak Contained

...in early May that 26 children had died in the outbreak. However, authorities have dismissed the reports as rumours. The disease, also known as coxsackie virus, is characterized by mouth sores, rashes, blisters and fever. Highly contagious among children, it is not normally fatal. It is not rel...

Scientists Explore Ways to Lure Viruses to Their Death

...ey would bait their traps with a surface protein called CAR. A virus called coxsackie virus B attaches to CAR, using it to invade cells in the pancreas. The new ...oduce CAR on their red blood cells and then compared how they fared against coxsackie virus B compared with normal mice. In the engineered mice, viruses reached ...

Eastern UP hit by killer virus – Coxsacki

...8 samples contained coxsackie-B virus and only 4 samples tested positive for Japanese Encephalitis. Giving a detailed account, Dr. Dhole said that coxsackie virus is a variant of the enterovirus that caused polio.”The entero virus and its variants are present in the human intestine and are hyperactive in t...

Infection in pregnancy can lead to congenital eye defects

...defects. Now studies have shown that infections such as from Parvovirus and coxsackie virus may also be responsible for birth defects in newborns. The res...f Parvovirus B19 and influenza with development of eyes in the fetus, while coxsackie virus had showed a positive effect on development of eyes in unborn babies....

Coxsackie in Medical Technology

ViroDefense Inc Announces Selection of Poliovirus Antiviral Preclinical Candidate

...s on sales. Schering-Plough Research Institute had been developing the series for treatment of diseases caused by non-polio enteroviruses, such as the coxsackie viruses. ViroDefense Inc determined in laboratory tests that compounds of the series had promising anti-poliovirus activity. The licensed compounds ...

Coxsackie in Medical Dictionary

Herpangina

...mouth blisters, is the name of a painful mouth infection caused by coxsackieviruses. Usually, herpangina is produced by one particular strain of coxsackie virus A, but it can also be caused by coxsackievirus B or echoviruses. It is most common in... The number of cases of herpangina is unknown,...

Hand-foot-and-mouth disease

...es of the Picornaviridae family. The most common strains causing HFMD are coxsackie A virus and Enterovirus 71 (EV71). Foot - and - mouth disease , FM... associated with outbreaks in child care settings. It is usually caused by coxsackie virus or ... Communicable Disease Fact Sheet, hand , foot and ...

Coxsackievirus

...ecently, Eastern China has been affected with the coxsackie virus . ... Adaptation of Group B coxsackie virus to adult mouse pancreas". J. Exp. Med....... Coxsackievirus was first found in the town coxsackie south of Albany, New York. ... Coxsackievirus...

Aseptic meningitis

... Aseptic meningitis - Overview, Aseptic meningitis is an illness that appears ... About half of aseptic meningitis cases are caused by the coxsackie virus and ... ... diagnostic guides, medical books excerpts online about Aseptic meningitis . ... Misdiagnosis and Aseptic meningitis . Di...

Coxsackie in Biological News

New mechanism for cardiac arrhythmia discovered

...ntacts (tight junctions) of the specialized heart fibres. CAR was discovered as the critical protein responsible for virus entry during infection with coxsackie and Adenoviruses. Its role in the adult heart was previously unknown. To investigate CAR's task in a healthy organism, the MDC-scientists switched ...

Common cold virus may kill breast cancer cells

...he said. Debilitating symptoms associated with conventional treatments (such as nausea, vomiting and hair loss) could also be avoided by using the coxsackie virus. "If this research is successful we could have something that produces side effects as harmless as a mild, common cold-like infection yet it...

Anti cancer virotherapy well tolerated in first human administration, research finds

... only were approved to receive this virotherapy. Professor Shafren reported to the conference that this research team had injected a single dose of coxsackie A21 (CVA21) virus directly into the advanced melanoma tumours of these patients with end stage disease. Both patients had many sites of spread mela...

Coxsackie in Biological Definition

Diabetes mellitus

...fficiently to reduce insulin production. The autoimmune attack may be triggered by reaction to an infection, for example by one of the viruses of the coxsackie virus family. A subtype of type 1 (identifiable by the presence of antibodies against beta cells) develops slowly and so is often confused with Type ...

Foot and mouth disease

...ntly in humans, especially in young children; this disease is caused by a different virus of the family Picornaviridae, namely, an Enterovirus called coxsackie A . Because FMD rarely infects humans but spreads rapidly among animals, it is a much greater threat to the agriculture industry than to human health...