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Contractile in Medical News

Chemical can reproduce complications for some patients

...easure cardiac output, heart rate, stroke volume, blood pressure, and heart contractile function. Measurements were made at baseline and again 60 minutes after in...n the CHX rats. Stroke volume, in turn, was depressed because the inherent contractile ability of the heart was significantly reduced. CHX exposure also resulted...

Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers

...n the management of heart failure. It targets the redox-nitiric oxide imbalance, which is increasingly recognized as a major factor in poor myocardial contractile efficiency, the hallmark manifestation of this disorder. About Heart Failure Heart failure, a condition characterized by the inability of the...

Cardium Reports on Recent Highlights, Financial Results and 2009 Outlook

...moting angiogenesis within the heart and that the zone of heart attack related tissue damage (the infarct zone) was significantly reduced, and cardiac contractile function significantly improved - further highlighting the potential value of these therapeutic approaches. Financial Report For the qua...

UNT Health Science Center Researchers Discover Eating Less May Not Increase Life Expectancy

...e Miller School of Medicine, University of Miami , and the Institute of Physics at the Marie Curie-Sklodowska University to study activity in cardiac contractile fibrils of skeletal muscle using fluorescence. They found the lifetime of a fluorescent marker was high in the presence of actin, a component of muscl...

From mother to daughters: A central mystery in cell division solved

...ancer. Their work describing the mechanism of the contractile ring a structure that pinches the mother cell int...vision of one cell into two is accomplished by the contractile ring, which is assembled from two protein filament...indle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle. ...

Saving teeth by using periodontal ligament regeneration

...igament could be generated in this way. The composition of the collagen network in which the cells are located has a considerable influence on the contractile properties of the cells. Contraction of the cells creates internal tension in the network which keeps the cells active. The network must be well attac...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology Meeting

...romised resulting in blindness in that region. When scars occur on the vitreal surface, termed proliferative vitreoretinopathy (PVR), the cells become contractile and cause re-detachment of the retina, again resulting in blindness. We show here using an animal model of retinal detachment that a single intravitre...

Stem cells from hair follicles may help 'grow' new blood vessels

...oth muscle cells that grow new vasculature. The group recently produced data showing that stem cells from human hair follicles also differentiate into contractile smooth muscle cells. We have demonstrated that engineered blood vessels prepared with smooth muscle progenitor cells from hair follicles are capabl...

Researchers find new way to block destructive rush of immune cells

...t is migrating across by breaking integrin-ICAM bonds. The results provide the first evidentiary support of the longstanding theory that cell skeleton contractile force is used to drive T cell migration, with MyH9 as the mechanical link. Captured images show fluorescently tagged actin (which partners with LFA-1...

JCI online early table of contents: Jan. 10 2008

...lated genes, which make proteins that manifest the contractile phenotype of SMCs. As elimination of myocardin in ...the expression of proteins responsible for the SMC contractile phenotype, the authors suggested that myocardin has a central role in maintaining the SMC contractile phenotype and that this probably explains, in part...
Contractile in Medical Technology

Leading Experts Endorse Bioheart's Muscle Stem Cell MyoCell Therapy

...oming muscle, and they are the only progenitor cell in the human body that normally develop the ability to contract making them more likely to restore contractile function of the damaged heart. About Bioheart, Inc. Bioheart, Inc. is committed to delivering intelligent devices and biologics that help mon...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

...ent the recovery of photoreceptor cells even though the retina is reattached. When such cells grow on the vitreal surface of the retina, they can form contractile scar tissue leading to re-detachment of the retina. Together, these conditions are termed proliferative vitreoretinopathy (PVR). PVR remains the most ...

FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function

...s that affect heart cell differentiation and regulation of the synthesis of contractile proteins within cardiac muscle cells that allows cells to contract. Identif... rescuing mutant hearts by promoting the development and differentiation of contractile cardiac muscle cells from non-contractile, pre-cardiac, non-muscle cells. ...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

...ated using non-conditioned, serum-free media and a directed differentiation protocol that produces cells with the phenotypic, electrophysiological and contractile properties of human immature cardiomyocytes. The new protocol produces cardiomyocytes with high efficiency, yielding 10-100 fold more cardiomyocytes p...
Contractile in Medical Dictionary

Smooth muscle

...mooth muscle cells line the walls of various organs and tubes in the ... contractile activity in smooth muscle is initiated by a Ca2+-calmodulin ... Sm...gh quality peer-reviewed full-text publications in ... ERK1/2-Dependent contractile Protein Expression in Vascular Smooth Muscle Cells ... The 2.3 kb smoo...

Muscle twitching

...s, the majority of which are benign, but can also be... Muscle is the contractile tissue of the body and is derived from the mesodermal layer of embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They a...

Granulocyte

...izing granulocyte colony-stimulating factor to enhance vascular graft ... Granulocyte colony-stimulating factor and stem cell factor improve contractile ... ... GRANULOCYTES , AND ... High levels of granulocyte /macrophage–colony -stimulating ... Granulocyte -macrophage colony-stimulating factor...

Cardiomyopathy

...and prevention information. Cardiomyopathy represents a group of diseases of the heart, which involve the heart muscle itself resulting in contractile and relaxation dysfunction of both ventricles Hypertrophic cardiomyopathy is a genetic disease in which the heart muscle thickens abnorm...
Contractile in Biological News

Study may aid efforts to prevent uncontrolled cell division in cancer

...dicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate devel...even though both cell volume and the length of the contractile ring are reduced during successive rounds of embry...

Heart attacks: The tipping point

...blished last year in the Biophysical Journal . Keeping His Eye on the Balance "Seventy percent of the heart is made up of myocytes, which are contractile muscle cells. The remaining 30% is mostly rigid structural cells called fibroblasts that work to hold the muscle in place," Dr. Zlochiver explains. "A...

Studies point to novel target for treating arrhythmias

...n the role of calcium inside heart muscle cells. Calcium is central to the contractile cycle. After it is released from its storage sites in heart muscle cells, it interacts with proteins called troponins, part of the cell's myofilament contractile apparatus. The interaction of calcium with troponins regulates myofilament ...

Caltech scientists show function of helical band in heart

...plications for the surgical treatment of heart disease, Gharib says. "It's going to change the way we repair the heart," he explains. Knowing that the contractile wave travels along the helical pathway--instead of occurring throughout the heart all at once--has implications for which parts of the heart will be m...

Dense tissue promotes aggressive cancers

...e team examined how cells convert a sense of matrix rigidity into intracellular signals, a process called mechanotransduction. Proteins that generate contractile forces, such as myosin "motors," are important players in mechanotransduction. Weaver and colleagues confirmed that myosin motors are involved in spar...

New mechanical insights into wound healing and scar tissue formation

...p migrating and, like Popeye, change into powerful contractile cells, anchoring themselves to the matrix and pull...anism is crucial for this switch from migrating to contractile cells. To make this change, the fibroblasts need t... factor is available, the fibroblast expresses the contractile proteins, sticks more firmly to the matrix and sta...

How molecular muscles help cells divide

...odel and then observe the way a cell assembles the contractile ring, the short-lived force-producing structure th...ely between the two daughter cell nuclei. This contractile ring is thought to operate like an old-fashioned p...works. Since the 1970s, it has been known that the contractile ring is made up of muscle-like actin and myosin ...

'Smart' flower bulbs pull themselves to deeper ground

...ive growth is very rare in plants, and the sort of contractile proteins that are so well known to drive contracti...cused on the "Nelly White" variety of Easter lily. contractile roots were found to respond to light signals perce...Exposure to certain types of blue light forced new contractile roots to be formed on the bulbs and helped initiat...

Study: Fountain of youth for your heart?

... has shown that a protein that is responsible for transporting fat into the contractile cells of the heart actually increases. Based on this finding, Dyck proposed...findings suggest that the protein responsible for transporting fat into the contractile cells of the heart may be a candidate for drug inhibition and that this dru...

Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction

...raphic and MRI evidence of significant improvement in cardiac structure and contractile function. Gerons scientists conducted the study in collaboration with Charl... vessel formation, possibly contributing to both cell survival and improved contractile function. The scalable production system allows for production runs at suf...
Contractile in Biological Technology

United States FDA Clears the REGEN Trial to Test Bioheart's Combination Gene and Stem Cell Therapy in Heart Failure Patients

...ering from heart failure, the cells are injected into the scar tissue that has formed in the patient's heart. The goal of MyoCell SDF-1 is to grow new contractile muscle within the scar tissue that will have the ability to release additional beneficial proteins to assist in the tissue repair process and improve ...

Cordex Pharma Forms Heart Failure Medical Advisory Board

... the management of heart failure. It targets the redox-nitiric oxide imbalance, which is increasingly recognized as a major factor in poor myocardial contractile efficiency, the hallmark manifestation of this disorder. The Medical Advisory Board is chaired by Joshua M. Hare, M.D., the Louis Lemberg Profess...
Contractile in Biological Definition

Actin

... helix . Bundles There are two types of actin bundles: parallel and contractile bundles. In parallel bundles, the filaments are spaced 14 nm apart by the ... actin filament in a relaxing or contracting movement by usage of ADP. In contractile bundles, the actin-bundling protein actinin separates each filament by 40 ...

Biological tissue

...the name suggests, connective tissue holds everything together. Blood is considered a connective tissue. Muscle tissue - Muscle cells contain contractile filaments that move past each other and change the size of the cell. Nervous tissue - cells forming the brain , spinal cord and peripheral ...

Eukaryote

...zymes that break down the contents of food vacuoles, and peroxisomes are used to break down peroxide which is toxic otherwise. Many protozoa have contractile vacuoles, which collect and expel excess water, and extrusomes , which expel material used to deflect predators or capture prey. In multicellular or...

Actin

... helix . Bundles There are two types of actin bundles: parallel and contractile bundles. In parallel bundles, the filaments are spaced 14 nm apart by the ... actin filament in a relaxing or contracting movement by usage of ADP. In contractile bundles, the actin-bundling protein actinin separates each filament by 40 ...

Muscle

... Muscle is a contractile form of tissue . It is one of the four major tissue types, the other three being epithelium , connective tissue and nervous tissue . Muscle con...

Myosin

...wn. The Muscle is composed of single muscle cells (sometimes known as "muscle fibers"). Within the cells are myofibrils ; the basic unit of a the contractile apparatus of a myofibril is the sarcomere , which is composed of three different filament systems, the thin filaments assembled by actin proteins...

Osmoregulation

...he sand-dune marran grass has rolled leaves with stomata on the inner surface. Osmoregulation in protoctists and animals Amoeba makes us of a contractile vacuole to collect excretory waste, such as ammonia , from the intracellular fluid by both diffusion and active transport. As osmotic action pushes ...

Vacuole

...olecules, particles, or even other cells, by the cell for digestion . A contractile vacuole is used to pump excess water out of the cell to reduce osmotic pressure and keep the cell from bursting. contractile vacuoles are found in some freshwater protozoa . Vacuoles in plant c...
Contractile in Biological Dictionary

Vacuoles

... with 7 pages of encyclopedia entries, essays, summaries, research information, and more. ... Vacuoles are organelles of plant, fungal, and ... contractile vacuole n. A membrane-bound organelle found in certain protists that pumps fluid in a cyclical manner from within the cell to the outside va...

Vacuole

... and containing water, food, or metabolic waste contractile vacuole n. A membrane-bound organelle found in...the harmony seen in the natural ... Basically, the contractile vacuole stores extra water. ... Vacuole sum... ... information on Vacuole ... They also use contractile vacuole s to pump out excess water so ... This ...

Transport vesicle

...edes the ... The European Bioinformatics Institute ... vesicle -mediated transport ... GO:0048489 synaptic vesicle transport . I. GO:0070177 contractile vacuole discharge ... Transport vesicles . Definition(s) Vesicles that are involved in shuttling cargo from the ... Definition from: Unified ...

Skeletal muscle

... Muscle is the contractile tissue of the body and is derived from the mesodermal layer of embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They a...

Sarcoplasm

...adder of the oyster toadfish Opsanus tau proliferate ... surround a central core of sarcoplasm . ... The sarcoplasm of the cell is filled with contractile myofibrils and this ... 4) Ca+2 is pumped out of the sarcoplasm by the SR and another stimulus will be ... ...

Sarcolemma

...le in a patchy distribution along the sarcolemma in our patients. ... disturbance of sarcolemma -extracellular matrix interaction leading to ... contractile function, sarcolemma integrity, and the loss of dystrophin after skeletal ... Costameres at the sarcolemma of keratin-19-null muscle, visualized w...

Pyrenoid

...diminish, and quantities of starch not ... A single circular pyrenoid , which is the centre for starch production, is ... P = pyrenoid , PV = contractile (pulsing) vacuole, S = stigma. ... Chloroplasts 1 per cell without pyrenoid . ... Pyrenoid present or absent. ... Chloroplasts 1 (–3) per cel...

Purkinje fibers

...ed to be Editor-In-Chief to add or edit content to WikiDoc. ... Purkinje fibers . Section of the heart showing the ventricular septum. ... ... contractile myocytes to form Purkinje fibers in ... Purkinje fibers of the cardiac conduction system ... In the avian heart, Purkinje fiber differentiat...

Proteins

...associate together to ... 1 The structure of proteins . 1.1 Components and synthesis ... Motion and locomotion of cells and organisms depends on contractile proteins . ... Translation: How proteins are synthesized using the genetic code. ... Proteins are essential to the structure and function of a...

Oral groove

...formation on Oral Groove , check out the band at http://www.crossrecords.com. ... ... on the video: cilia, oral groove , food vacuoles, and contractile vacuoles. ... The cilia along the oral groove move food substances to its base where they are ... Cilia- help paramecium move and sweep foo...
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