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Conserved in Medical News

Researchers Discover the Tale Behind Short Dogs

...rised to find that just one retrogene inserted at one point during the evolution of a species could yield such a dramatic physical trait that has been conserved over time." Retrogenes occur when a transcription error in the creation of DNA code causes a functional, but imperfect duplicate of a gene to be i...

Insmed Provides Update on Supply of IPLEX(TM)

...ime. The Company has determined that its limited inventory on hand must be conserved for the treatment of existing patients. Following the previously a...rrently receiving IPLEX(TM) to ensure that our current limited inventory is conserved in order to maintain their drug supply as long as possible, while allowing ...

Premiere Fibers Unveils New Logo, Names for Innovative Brands

... Earth-Color(TM) Fiber is also Earth-friendly. Since there is no separate dyeing process, thousands of gallons of water, resources and chemicals are conserved each year. Earth-Color(TM) Fiber has numerous potential applications including hosiery, apparel, military, upholstery and industrial market segments....

Wistar Institute team finds key target of aging regulator

... Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature , provides fundamental knowledge about key mechanisms of aging th...

Fate Therapeutics Adds Pratik Multani, M.D., M.S., as Vice President Clinical Development to Advance Upcoming Clinical Programs of Stem Cell Modulators

...ntiate to become some or all of the major specialized cell types of the particular tissue or organ in which it is found. The discovery of a number of conserved mechanisms from developmental biology and tissue repair has led to the identification of small molecules and biologics that can direct stem cell proli...

Study Links Sugar Production in Yeast Cells to Longevity

...acetyl group and which other studies have strongly link to the aging process and several diseases in mammals. "Because the NuA4 complex is highly conserved among species, what we've found in yeast translates to humans as well," researcher Heng Zhu, a Johns Hopkins assistant professor of pharmacology and m...
Conserved in Medical Technology

Intercell Starts a Phase I Clinical Trial for a New Streptococcus pneumoniae Vaccine

...ll's vaccine candidate is a recombinant subunit vaccine consisting of three conserved surface proteins from Streptococcus pneumoniae . Two of these proteins wer...nst the pathogen. Intercell's novel vaccine candidate is composed of highly conserved proteins of Streptococcus pneumoniae that have the potential to protect aga...

Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans

... responses against the matching H5 antigen and the conserved NP and M2 antigens were detected in a majority of ...receiving the trivalent vaccine. Responses against conserved antigens could provide protection against serious ...lasmids encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

...site www.supergen.com . About SGI-1776 SGI-1776 inhibits the three human PIM kinases (PIM-1, PIM-2 and PIM-3). PIM kinases are highly conserved serine-threonine kinases that are key regulators in many signaling pathways implicated in cancer. When expressed, PIM kinases are strong survival fact...

Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor

...d active-site atoms of HIV protease representing a conserved atomic substructure that cannot be altered by mutations. This conserved substructure then served as the target for a serie...ing a structure-based approach that targets highly conserved regions of the protease enzyme while minimizing in...

Intercell Announces Initiation of Further Phase II Clinical Trial of V710 an Investigational Vaccine to Prevent S. aureus Infection

...rial. We look forward to continued progress of the program building on clinical data obtained so far." The S. aureus vaccine candidate is based on a conserved protein antigen discovered by Intercell and licensed to Merck & Co., Inc. in 2004 on an exclusive worldwide basis. Merck is responsible for clinical d...

Strategic Diagnostics Launches Initial Oncology-Targeted Antibody Reagent Catalog

...to stain disease-associated proteins across thousands of clinical biopsy samples. More targeted studies have shown the ability to differentiate highly conserved proteins in cell sorting assays, the ability to react with traditionally elusive proteins of interest, and be directed through SDI's design algorithms...
Conserved in Medical Products

QualiTrace

Description:..., and prints a calibration report The audit trail feature records entries by the user and any changes in key setup options. Complete device history is conserved intact ...
Company:Gilson, Inc
Conserved in Medical Dictionary

Innate

...ion that funds the most promising research worldwide focused ... The innate immune system evolved to ... Innate immunity is an ancient and conserved defense mechanism. ... With regard to regulating innate immune responses, Serpent functions in ... to innate (third-person singular simple p...

Enterotoxin

...? ... Enterotoxin ... enterotoxin ... The European Bioinformatics Institute ... Staphylococcal enterotoxin /Streptococcal pyrogenic exotoxin, conserved site. Toxin, bacterial ... Enterotoxin . Contents of this page: Definition. Definition Return to top. An enterotoxin is a harmful substance p...
Conserved in Biological News

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

First-of-its-kind analysis published in the Feb. 8 PNAS supports the concept of a basic wiring diagram for all eukaryotes. Researchers in California, Israel, and Germany have compared three distantly related species ?baker's yeast, a worm, and the fruit fly ?and reported that protein "wiring" co...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

...dividuals with PGL2 from a previously described Dutch lineage. They identified a single DNA nucleotide change which resulted in a mutation in the most conserved region of the protein. Of the 45 individuals within the affected lineage who inherited the mutation, 33 have developed PGL2, providing strong evidence...

International research team seeks to unravel flatworm regeneration

...m cells. Many planaria genes resemble those of humans, and also many genes specifically linked to planarian stem cell biology and regeneration are conserved in humans. Understanding planarian regeneration therefore promises to yield important insights into human regeneration and stem cell biology, the rese...

Dogs, humans, put heads together to find cure for brain cancer

...tead of looking at 50 million base pairs that contain several hundred genes, we can focus on the portion of human chromosome 22 that is evolutionarily conserved with dog chromosome 27," Breen says. "By looking at dog and human meningiomas together we reduce the amount of searching we need to do 50-fold. It's t...

The battle for CRTC2: How obesity increases the risk for diabetes

...ndency to become diabetic. When ER stress signaling is abnormal glucose output is actually increased." "It is possible that mutations in the highly conserved CRTC2 lead to a predisposition to inappropriate gluconeogenesis," says Montminy, who is now trying to identify natural mutations in CRTC2 that may lea...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

...worm broadly used as a model for studying basic biological systems. Ruvkun and other researchers discovered that simple mutations in genetic pathways conserved throughout evolution can double or triple the lifespan of C. elegans , and that similar mutations in the corresponding pathways also dramatically ext...
Conserved in Biological Technology

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...uch more lethal new virus. That is what happened in the case of the Spanish flu pandemic. CEL-SCI's efforts to fight this virus are focused on using conserved epitopes from essential proteins to be found in the A influenza virus for H1N1, H1N5, swine, bird flu and Spanish influenza to create an effective vac...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...people in their prime more severely. In addition, LEAPS conjugates may be used to potentially overcome the virus' mutations by focusing on more conserved and common epitopes critical for critical viral function. The L.E.A.P.S. technology is a novel T-cell modulation platform technology that enables...

Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital

...ntiate to become some or all of the major specialized cell types of the particular tissue or organ in which it is found. The discovery of a number of conserved mechanisms from developmental biology and tissue repair has led to the identification of small molecules and biologics that can direct stem cell proli...

Avian Adenovirus Genotyping Diagnostic Service

...ein is the major capsid protein of the non-enveloped virion on which type, group and subgroup specific determinants are located. The hexon consists of conserved regions (pedestals), which are located inside the virion, and variable loops which protrude from the surface containing the type-specific neutralizing...

First H1N1 Swine Flu Vaccine, Replikins-Based, Is Ready Now for Testing Worldwide

...y's chairman, Dr. Samuel Bogoch, found that some of these regions have been conserved for decades. In H1N1 last year the company detected the highest concentrati...nd that H1N1 would strike this year, has been used to manufacture synthetic conserved Replikin vaccines against both these influenza strains, Replikins H5N1 Bird...

H1N1 Influenza "Swine Flu" Peptide Vaccine Now Available For Testing Worldwide

...specific regions in virus genes that have been linked with past epidemics. The company's chairman, Dr. Samuel Bogoch, found that the regions have been conserved for decades. In H1N1 last year the company detected the highest concentrations of these specific regions ever seen, except for those from the 1918 flu...
Conserved in Biological Products

Rabbit Anti-Evolutionarily conserved signaling intermediate in Toll pathway Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description: Evolutionarily conserved signaling intermediate in Toll pathway...
Company:GenWay Biotech, Inc.

Anti-Sodium Channel, NaB2 (B2 subunit of Voltate-Gated Na+ Channel, Scn2b) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Nabeta2 is not present in any other known proteins. SPECIES REACTIVITIES: It is expected to work on human because the immunogen sequence is highly conserved (17/19 residues). Reactivity with other species has not yet been tested....
Company:CHEMICON

Rabbit Anti-Fruit fly (Drosophila melanogaster) SARA Polyclonal Antibody, Unconjugated from Abcam

Description:...tigen: Synthetic peptide: PVPKEMEQPV QTEEEDVELP conjugated to KLH, corresponding to amino acids 281-300 of Fruit fly (Drosophila melanogaster) SARA. conserved sequence unique to SARA. Entrez Gene ID: 9372 Swiss Protein ID: O95405...
Company:Abcam

Human BMP-5 ELISA development Kit, DuoSet Economy Pack from R&D Systems

Description:...pes, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similar to other TGF-beta family proteins, BMPs are highly conserved across animal species. This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure nat...
Company:R&D Systems

Anti-Potassium Channel, TASK (TWIK-Related Acid Sensitive, TASK-1, cTBAK, Kcnk3) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... The epitope is specific for TASK and is not present in any other known proteins tested so far. SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues identical) but other species have not been tested....
Company:CHEMICON

Anti-K+-Cl- Cotransporter 1 (KCC1) Polyclonal Antibody, Unconjugated from CHEMICON

Description:...nsporter-1 (KCC1). The immunogen shows no significant sequence homology with other KCCs or CCC. SPECIES REACTIVITIES: The immunogen sequence is 100% conserved in human, mouse, porcine and rabbit. Reactivity with other species has not been confirmed....
Company:CHEMICON
Conserved in Biological Definition

Actin

...can also bind to ADP . An ATP-actin complex polymerizes faster and dissociates slower than an ADP-actin complex. Actin is also one of the most highly conserved proteins, differing by no more than 5% in species as diverse as algae and humans. Contents showTocToggle("show","hide") 1 Microfilamen...

Enzyme

...ive region widely dispersed, instead tending to keep the amino acids involved in each active region compacted fairly closely together in the chain and conserved against mutation, separating these regions by long stretches of 'spacer' amino acids where mutation is much less critical (although some mutations in ...

Genomics

...ising biological discoveries. If a particular DNA sequence or pattern is present among many members of a clade , that sequence is said to have been conserved among the species. Evolutionary conservation of a DNA sequence may imply that it confers a relative selective advantage to the organisms that posses...

Insulin

... to human insulin (2 amino acid difference for bovine insulin, 1 amino acid difference for porcine). Insulin is a protein which has been very strongly conserved across evolutionary time. Differences in suitability of beef, pork, or fish insulin preparations for particular patients have been primarily the resul...

Intron

...t of a gene. Intron evolution There are two competing theories as to the evolutionary origin of introns, which is usually studied in a highly conserved family of genes such as the actins . In the introns-early model ancestral genes are believed to have included a large number of introns, some of whic...

Actin

...can also bind to ADP . An ATP-actin complex polymerizes faster and dissociates slower than an ADP-actin complex. Actin is also one of the most highly conserved proteins, differing by no more than 5% in species as diverse as algae and humans. Contents showTocToggle("show","hide") 1 Microfilamen...
Conserved in Biological Dictionary

Evolutionarily conserved

In biology, conserved sequences are similar or identical sequences that occur within nucleic acid sequences, protein sequences, protein structures or polymeric carbohydrates across species or within different molecules produced by the same organism . In the case of... Conservation g...

Ubiquitin

...iquitin ( yü′bikwə′tin ) ( biochemistry ) A small, 76-amino-acid, highly conserved protein present in the cytoplasm and nucleus of all eukaryotes Ub...ar functions degradation by covalent ligation to ubiquitin , a highly conserved small protein. Ubiquitin -mediated degradation of regulatory proteins pl...

Transposase

...s (<a href ... λ DNA and 4 µl of TnsABC* Transposase in 1X GPS Buffer supplemented with 15 mM ... Asterisks indicate the amino acid residues conserved in all of the transposase segments. ... Inhibition of cell growth by ISY100 transposase . ... ...

Synteny

... A disrupted synteny refers to circumstances where a pair of genes are located on ... Synteny map. Human NCBI build 31 vs. Mouse NCBI build 30. conserved ... http://kp03.iis.sinica.edu .tw/ synteny /supplement/ (Website author: Yu-Jung Chang) ... What is synteny ? Meaning of synteny medical term. ...

Supergene

...; film students ... tidylikerecords go live supergene ... In an intriguing example of adaptive evolution, genetic linkage analysis identifies a conserved region in distantly related Heliconius butterfly species that ... This ASTER image covers 30 by 37 km in the Atacama Desert, Chile and was ... A ...

SnRNA

...ed evidence that the snRNA -(guanosine-N2)-methyltra nsferase is a non ... U4atac snRNA forms a base-paired complex with U6atac snRNA . ... The conserved 3' end domain of U6atac snRNA can direct U6 snRNA to the minor spliceosome ... U1 and U2 snRNA are RNA polymerase II transcripts, and U...
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