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Conjugates in Medical News

SAFC Pharma's St. Louis HPAPI Conjugates Facility Receives SafeBridge Certification

ST. LOUIS, June 1 /PRNewswire-FirstCall/ -- SAFC Pharma (R) ( www.safcpharma.com ), a business segment of SAFC(R), a member of the Sigma-Aldrich (R) Group (Nasdaq: SIAL ), today announced the certification of its highly potent active pharmaceutical ingredient (HPAPI) conjugation suite, by ...

SAFC Pharma Commissions HPAPI Conjugates Facility at St. Louis

ST. LOUIS, Sept. 29 /PRNewswire-FirstCall/ -- SAFC Pharma(TM), a focus area within SAFC(R), a member of the Sigma-Aldrich Group (Nasdaq: SIAL ), today announced details of a new suite that has been commissioned at its St. Louis campus that will produce high-potency active pharmaceutical ingre...

CEL-SCI Corporation Reports 2009 Second Fiscal Quarter Financial Results

...ould potentially induce protection against illnesses such as swine influenza. In pre-clinical studies using mouse models, several different L.E.A.P.S. conjugates focused on different diseases induced protection and disease improvement. In addition, it was recently presented that the L.E.A.P.S. vaccines work on ...

Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting

...linical pipeline also includes proprietary targeting moieties employed with conjugates for delivery of siRNA and anti-cancer agents. The key component of Mer...ith "biological stealth" properties, making Fleximer(R) materials and their conjugates long-circulating and non-immunotoxic. Fleximer(R) molecules are characteri...

Carestream Molecular Imaging Releases Western Blot Kits For Added Convenience, Better Performance

...step protocols designed to deliver peak performance from X-SIGHT Nanosphere conjugates in western blots. "The X-SIGHT Nanosphere Conjugates, when u... Accessory Kit is also available for use with any of the X-SIGHT Nanosphere conjugates or any other commercially available fluorescently-labeled secondary antibod...

CCNY researchers demonstrate effectiveness of contrast agent Cytate in detectcing prostate cancer

... and optical imaging studies that demonstrate the efficacy of Cytate as a fluorescence marker to detect prostate cancer. Cytate, a contrast agent that conjugates to receptors on prostate cancer cells, exhibited greater fluorescence when applied to cancerous prostate tissue as opposed to normal prostate tissue. ...

Cato Research Ltd. and Advanced Targeting Systems, Inc. Partner to Develop SP-SAP for Chronic Pain

...ts required for marketing approval. About Advanced Targeting Systems A San Diego-based biotechnology company, ATS is a pioneer in the use of toxin conjugates targeted to eliminate specific cells through a powerful technique called Molecular Neurosurgery. Since 1994, Dr. Douglas Lappi, the leading expert in ...

Novel Technique For Targeting Small-Cell Lung Cancer

...bone cyclic peptides, and conjugated them with fluorescent agents. Nineteen conjugates differing in core peptide, length of alkyl linker and fluorescence moiety (...ed in vitro, using a receptor binding assay, and nine of the more promising conjugates were tested in vivo by fiber-optic spectrofluorimetry and quantitative spec...

Gold Nanoparticles: Agents For Noninvasive Cancer Therapy

...uction was observed for all types of cells in the absence of nanoparticles at four times energy required to kill the malignant cells with anti-EGFR/Au conjugates bonded. Gold nanoparticles thus offer a novel class of selective photothermal agents using a CW laser at low powers. Photodynamic therapy for the...
Conjugates in Medical Technology

Medarex Presents Preclinical Data Demonstrating Potent Anti-Tumor Activity of Anti-CD19 and Anti-CD70 Antibody-Drug Conjugates in Cancer Animal Models

- Data presentations at American Association for Cancer Research annual meeting - PRINCETON, N.J., April 17, 2007 /PRNewswire-FirstCall/ -- Medarex, Inc. today presented preclinical data demonstrating potent anti- tumor activity from two separate studies exploring the efficacy and safety in animal...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

...hat the data presented by Dr. Borthakur's group will also be beneficial in developing more improved TB vaccines, perhaps ones including the L.E.A.P.S. conjugates known to elicit protective cytokines such as IL-12, a precursor to producing gamma interferon, and gamma interferon itself. The L.E.A.P.S. tech...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...inding alkylating agent (MGBA) based antibody-drug conjugates (Abstract #1722) The effectiveness of a cleavab...ble linker when used with MGBA-based antibody-drug conjugates was examined using fully human anti-CD70 antibody-...ancer xenograft models, single dose treatment with conjugates using the cleavable linker demonstrated selective ...

AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Ovarian Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108

... is followed by internalization and retention of the cytotoxic drug, doxorubicin, in the cells. Therefore, since they target specific cells, cytotoxic conjugates are postulated to be less toxic, have less side-effects and are more effective in vivo than the respective non-conjugated/non-linked cytotoxic agents ...

Access Pharmaceuticals Presents New Data on the Company's Cobalamin(TM) Technology at an International Polymer Therapeutics Symposium

...mer Therapeutics: Laboratory to Clinical Practice, taking place from May 26-28 in Valencia, Spain. The presentations are entitled "Vitamin B12-Polymer conjugates as Constructs for Targeted Tumor Delivery and for Oral Drug Delivery." Cobalamin is Access' proprietary technology based upon the use of vitamin B12...

UM Maryland Industrial Partnerships Program Approves 18 Collaborative Research Projects, Worth $4.4 Million, Between University Faculty, State Technology Companies

...sion for Future Ready Basestations; $195,700. -- Rockville-based Rexahn Pharmaceuticals Inc. and the University of Maryland, Baltimore: Polymer-drug conjugates for Cancer Therapy; $217,761. -- Crisfield-based Sherwin Williams and the University of Maryland, College Park: Automation of the Brush-Knot Manufac...

Raptor Pharmaceuticals Provides Update of Product Programs

...lectively to liver cells or to infected liver cells in preclinical studies. conjugates of HepTide and antiviral agents could significantly improve accumulation of...Factor ("NGF") across the BBB, and to investigate the potential for RAP-NGF conjugates to prevent or reverse neuronal injury in preclinical models. Preclinical T...

Alfacell's Onconase Highlighted in Latest Edition of Handbook of Therapeutic Antibodies

...N.J., March 20, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation's ONCONASE (ranpirnase) has shown potential to act as a potent payload in antibody conjugates for cancer therapy, according to the latest edition of the Handbook of Therapeutic Antibodies. In a chapter of the text that reviews immunotoxins, S...

Isotechnika's independent data monitoring committee conducts review of phase 2b kidney transplant trial

...e Inc. signed an option agreement on April 25, 2006, granting Isotechnika the option to obtain an exclusive license to develop and commercialize conjugates consisting of Cellgate's patented transporter technology for the topical delivery of ISA247 in patients suffering from mild to moderate psoriasis....

Enzon to Present Preclinical Data From PEG-SN38 and PEGylation Technology Studies at AACR Meeting

...2007, 1:00 PM - 5:00 PM, PT, Poster Section 25, Poster Board 14.) -- Abstract #4726: In vitro and in vivo evaluation of PEGylated anti-Bcl2 siRNA conjugates in a Bcl-2 over-expressing lung cancer model (Poster displayed on Tuesday, April 17, 2007, 1:00 PM - 5:00 PM, PT, Poster Section 25, Poster Board 9.) ...
Conjugates in Medical Products

Anti-Thyroid Antibody (TA) Test Kit - Monkey Thyroid Substrate

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Autoantibody Screen (AAS) Test Kit - Rat Kidney/Stomach Substrate

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Anti-Nuclear Antibodies (ANA) Hep-2 Substrate

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Anti-Smooth Muscle Antibody (ASMA) Test Kit

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Anti-Mitochondrial Antibody (AMA) Test Kit

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Anti-Native Deoxyribonucleic Acid (nDNA) Test Kit

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Fluorescent Treponemal Antibody Absorption (FTA-ABS) Test Kits

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Toxoplasma gondii (Toxo) Antibody IgM

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Mycoplasma Pneumoniae (IgM)(Crown Titer Substrate)

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations

Toxoplasma gondii (Toxo) Antibody IgG

Description:...ence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a wide assortment of substrates and kit sizes to choose from. Kit components include substrate sl...
Company:Inverness Medical Innovations
Conjugates in Biological News

American Chemical Society's Weekly PressPac -- Nov. 14, 2007

... the researchers demonstrated that a good electrical connection was established using photoluminescence spectroscopy measurements. These new biohybrid conjugates could reduce the cost of fuel cells by reducing or eliminating the need for platinum and other costly metal components, they say. ARTICLE #5 FOR ...

Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes

...in A, a protein from a species of bacteria that infects people with weakened immune systems, and ovalbumin, a protein found in egg whites. All of the conjugates produced high levels of antibodies in mice. Adsorbing the conjugate molecules to the surface of molecules of aluminum hydroxide produced even higher ...

Berkeley researchers lay groundwork for cell version of DNA chip

...ess. As a bonus, the researchers are even able to bind their phosphine-DNA conjugates to cells that are not naturally sticky, providing the first known method fo...ial therapies," said Chandra. To test the ability of their phosphine-DNA conjugates to bind to cells, Chandra and his colleagues conducted a series of experime...

New tool reveals secrets of migrating cells

...entirely different universe to us," Witt said. Images and videos : Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile conjugates with Helper T Cells Directed Migration of Positively Selected Thymocytes Visualized in Real Time ...
Conjugates in Biological Technology

Mersana Reports Preliminary Phase 1 Results of XMT-1001 in Patients with Advanced Solid Tumors

...peutic index of existing compounds by uniquely combining biodegradability with "biological stealth" properties, making Fleximer(R) materials and their conjugates long-circulating and non-immunotoxic. Fleximer(R) molecules are characterized by solubility in water, with stability in common manufacturing procedur...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...animals. In addition, several different L.E.A.P.S. conjugates induced protection and/or improvement in diseases ...ainst the H1N1 flu virus is because the L.E.A.P.S. conjugates induce an effective and powerful immune response w...eir prime more severely. In addition, LEAPS conjugates may be used to potentially overcome the virus' mut...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

...ould potentially induce protection against illnesses such as swine influenza. In pre-clinical studies using mouse models, several different L.E.A.P.S. conjugates focused on different diseases induced protection and disease improvement. In addition, it was recently presented that the L.E.A.P.S. vaccines work on...

Medarex Announces Allowance of Investigational New Drug Application for Company's First Antibody-Drug Conjugate, MDX-1203

...dy will evaluate MDX-1203 for the treatment of advanced/recurrent RCC and relapsed/refractory B-cell non-Hodgkin's lymphoma (NHL). "Antibody-drug conjugates are another important and innovative therapeutic approach used to fight cancer by effectively and selectively killing tumor cells over-expressing spec...

First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer

... technology platform. NKTR-102 is the first oncolytic that leverages Nektar's polymer conjugate technology. Using a proprietary approach that directly conjugates the drug to a unique polymer architecture, Nektar is the first company to have created a PEGylated small molecule with a unique pharmacokinetic profil...

Technical Note: E-PAGE(TM) 48- and 96-Well Gels on the Odyssey(R) Infrared Imaging System

...r blots processed in this manner can be performed using IRDye(R) Infrared Secondary Antibodies and the Odyssey Infrared Imaging System. IRDye antibody conjugates are available in two spectrally-distinct wavelengths; therefore, multiplex detection can be accomplished, increasing the number of analytes to as many...

AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108

... is followed by internalization and retention of the cytotoxic drug, doxorubicin, in the cells. Therefore, since they target specific cells, cytotoxic conjugates are postulated to be less toxic, have less side-effects and are more effective in vivo than the respective non-conjugated/non-linked cytotoxic agents ...

Significant Anti-Tumor Activity and Extended Half-Life of NKTR-102 (PEG-irinotecan) Highlighted in Phase 1 Data Presented at EORTC-NCI-AACR Symposium

...NKTR-102 is the first PEG-oncolytic that leverages Nektar's innovative small molecule PEGylation chemistry. Using a proprietary approach that directly conjugates the drug to a unique PEG structure, Nektar is the first company to have created a PEGylated small molecule with a unique pharmacokinetic profile that ...

Medarex Announces Presentations at Annual Meeting of the American Association for Cancer Research

...ion scheduled for Tuesday, April 15, 2008 at 2:25 p.m. -- "Human antibody conjugates of potential utility for prostate cancer therapy: a comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific memb...

AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers

... is followed by internalization and retention of the cytotoxic drug, doxorubicin, in the cells. Therefore, since they target specific cells, cytotoxic conjugates are postulated to be less toxic, have less side-effects and are more effective in vivo than the respective non-conjugated/non-linked cytotoxic agents ...
Conjugates in Biological Products

Captivate magnetic separator for six microtubes from Molecular Probes (Invitrogen)

Description:... The Captivate magnetic separator for six microtubes can be used in conjunction with the Captivate ferrofluid conjugates (C-21473, C-21474, C-21476) or other magnetic particles and can accommodate six 1.5 mL microcentrifuge tubes. Cell Biology Cell Separation Captivate M...
Company:Molecular Probes (Invitrogen)

Captivate disposable sample chamber - for Captivate magnetic yoke - set of 10 from Molecular Probes (Invitrogen)

Description:...ivate Disposable Sample Chamber is designed for use with the Captivate magnetic yoke assembly (C-24700) and can be used with our Captivate ferrofluid conjugates (C-21473 C-21474 C-21476) or with other magnetic particles....
Company:Molecular Probes (Invitrogen)

Captivate magnetic separator for 96-well microplates from Molecular Probes (Invitrogen)

Description:... The Captivate magnetic separator for 96-well microplates can be used in conjunction with the Captivate ferrofluid conjugates (C-21473, C-21474, C-21476) or other magnetic particles and is compatible with most 96-well microplates. Cell Biology Cell Separation Captivate Magnet...
Company:Molecular Probes (Invitrogen)

Mouse IgE ELISA Kit from Bethyl Laboratories

Description:... Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Company:Bethyl Laboratories

Cat IgA ELISA Kit from Bethyl Laboratories

Description:... Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Company:Bethyl Laboratories

Chicken IgG ELISA Kit from Bethyl Laboratories

Description:... Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Company:Bethyl Laboratories

Cat IgG ELISA Kit from Bethyl Laboratories

Description:... Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Company:Bethyl Laboratories

Cat IgM ELISA Kit from Bethyl Laboratories

Description:... Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Company:Bethyl Laboratories

Bovine IgM ELISA Kit from Bethyl Laboratories

Description:... Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Company:Bethyl Laboratories

Horse IgGa ELISA Kit from Bethyl Laboratories

Description:... Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Company:Bethyl Laboratories
Conjugates in Biological Dictionary

Streptavidin

... Streptavidin products that produce high quality results. ... to avidin, streptavidin has no carbohydrate ... High Sensitivity Streptavidin HRP conjugates ... Streptavidin . Streptavidin is a tetrameric protein which binds very tightly to the small ... Stefanie Freitag has also organized a strep...

Oligodeoxyribonucleotide

... Nature Protocols is an interactive online resource for all laboratory protocols ... Versatile synthesis of oligodeoxyribonucleotide –oligo spermine conjugates ... An antisense oligonucleotide phosphorothioate, previously shown to inhibit HIV-1 viral expression in chronically infected H9 cells, was f...
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