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Conformational in Medical News

ImQuest Presents New Anti-HIV Drug and Topical Microbicide Development Results on Lead Pyrimidinedione Products IQP-0410 and IQP-0528

...se. Dr. Buckheit presented detailed mechanism of action evaluations performed with IQP-0410, demonstrating that the compound targets a newly defined conformational cell surface target formed upon attachment of the virus to prevent the entry of HIV into the cells. This molecular target will be exploited by ImQuest...

Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells

...lular SRC-3 protein levels by inducing phosphorylation of a particular region of SRC-3. Specifically, phosphorylation of C-terminal residues induced a conformational change that made SRC-3 more resistant to degradation by the core proteasome. This effect of aPKC required estrogen and estrogen receptor and was not s...

Engineering chimeric polypeptides to illuminate cellular redox states

...optical technique called Frster resonance energy transfer (FRET). The absence of polypeptide linkers able to sense the redox state by undergoing a conformational change was the major obstacle to a FRET-based redox sensor. The researchers designed the linker sequence such that in its reduced state the linker is ...

First look at an enzyme target for antibacterial and cancer drugs

...t where it is cleaved. The near folding-in-half of the DNA segment helps enable topo II to recognize where it should disentangle DNA strands. Large conformational changes in the topo II accompany the DNA deformation, creating a bipartite catalytic site that positions the DNA backbone near a reactive tyrosine and...

Caught in the act: The dynamic dance of enzymes

...ing toward the active state, Kern and co-workers were able to detect picosecond (one millionth of one millionth of a second) changes, the fast smaller conformational motions, as well as the millisecond large-scale motions that are a result of the many fast motions. This work will lead to understanding the physic...

In the Forefront of Research into Protein Folding and Macromolecular Complex Assembly

...ys Ashcroft. The full reference for Dr. Ashcroft's article in the Journal of the American Society of Mass Spectrometry is: Monitoring co-populated conformational states during protein folding events using ESI-IMS-MS, D. P. Smith, K. Giles, R. H. Bateman, S. E. Radford, A. E Ashcroft, J. Am. Soc. Mass Spectrom.,...

Journal of Alzheimer's Disease special issue explores multifaceted aspects of AD

...ently used. Cristina Lanni and colleagues from the University of Pavia (Italy) discuss the methodologies that have been used to identify an altered conformational status of p53 in fibroblasts of AD patients. They explain that this alteration may be related to exposure to low amounts of soluble A peptide, not res...

The structural basis of familial hypertrophic cardiomyopathy is revealed

...angles at the attachment sites, thus demonstrating a structural basis for the change in function of the mutant myosin. Dr. Hanein illustrates how the conformational instability within the sarcomere affects ability of the heart to function properly and may lead to compensatory hypertrophy in cardiac muscle tissue, ...

Adlyfe Appoints Roxanne Duan as Vice President of Research

... are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with amyloid aggregation (and eventual amyloid plaque formation). These aggregates are associated wit...

Kerala Institute to Hold International Seminar on Drug Discovery

...en receptor. Modulators using combinatorial docking method, quantum mechanics in structure based drug design, novel methods to predict protein conformational changes during ligand binding are included for deliberations. Jorg Weiser, vice president, Schrdinger, Germany; Shashidhar Rao, senior applica...
Conformational in Medical Technology

Adlyfe Strikes Translational Medicine Partnership With Wyeth Pharmaceuticals for Alzheimer's Biomarker Assay

... are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with amyloid aggregation (and eventual amyloid plaque formation). These aggregates are associated wit...

New Insight Into the Controls on a Go-To Enzyme

...formation renders it a target of calpastatin attachment and thus inhibition. "This new structural information on calpastatin and on calpain's conformational changes not only explains a lot about calpain's regulation," Green said. "It also gives us information we can use to develop targets for drugs that co...

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

... "And in many cases, this process is probably regulated by just the kind of conformational change that our findings reveal. So, we believe that these findings offer overall insight into how conformational change can activate these kinds of ligases." Other authors of this paper ...

Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion

...tein with Adlyfe's proprietary peptides produces a conformational change that transduces a fluorescent signal. Furth... signal is generated as additional ligands undergo conformational changes. This is the basis for the tests' sensitiv... on regions of the target protein known to undergo conformational changes (structural changes in shape) associated w...

YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy

...ors noted that, "According to our models, nimotuzumab inhibits the EGFr signaling both by inhibiting the binding of EGF to domain III of EGFr and by a conformational change of EGFr that is necessary to shape the EGF binding site." "These two studies provide independent confirmation of earlier research indicati...
Conformational in Medical Definition

Proteopathy

...isease , type 2 diabetes , amyloidosis , and a wide range of other disorders (see Table). [3] [4] The proteopathies are also called protein conformational diseases , [5] because a change in the 3-dimensional folding (conformation) of a protein increases the tendency of the protein to misfold and polym...
Conformational in Medical Dictionary

Alpha1-antitrypsin deficiency

...ital alpha1 - antitrypsin deficiency . ... Congenital Alpha1 - Antitrypsin Deficiency ... Alpha1 - antitrypsin deficiency --a model for conformational diseases. N Engl J Med. ... Luisetti M, Seersholm N. Alpha1 - antitrypsin deficiency . ... ...
Conformational in Biological News

Flexible neck in cell-receptor DC-SIGN targets more pathogens

...ein binds to a pathogen, binding sites on the cell receptor rearrange slightly, to adapt to the target surface and maximize the bond. This 5 nanometer conformational change is binding-induced, and made possible by a flexible linker in the neck, the researchers report. "The protein neck region acts as a stiff, but...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

...ism has lots of clinical implications," Deniz says. "Small mutations in proteins could throw off the delicate balance of energy that is needed between conformational structures of proteins in a cell, leading to disease. If so, a drug might be able to reverse those kinds of imbalances." ...

New research helps explain how connexin hemichannels are kept closed

...y Tang et al. in the June issue of JGP (2). The report, along with a recent publication from Verselis et al. (3), provides new information about the conformational changes that occur within the loop gate. In addition, the concurrent unveiling of a high-resolution structure of a connexin channel has been a long-aw...

6 young ASU faculty earn NSF Career awards

...ion initiation and DNA replication. Their binding is characterized by large conformational changes, involving the (partial) folding or unfolding of the protein and th...ll give insight into how the molecular recognition processes are coupled to conformational dynamics. The knowledge gained is expected to lead to a better understandin...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... hemaglutinin (HA). Binding to the stem prevents a conformational change in the protein that is necessary for viral ...s highly conserved because it undergoes a dramatic conformational change to allow entry of viral RNA into the host c...ly conserved pocket in the HA stem, inhibiting the conformational change required for membrane fusion and viral entr...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... hemaglutinin (HA). Binding to the stem prevents a conformational change in the protein that is necessary for viral ...s highly conserved because it undergoes a dramatic conformational change to allow entry of viral RNA into the host c...ly conserved pocket in the HA stem, inhibiting the conformational change required for membrane fusion and viral entr...

The Burnham Buzz, February 2009

...ion and found that protein-protein interactions between Fas and FADD mechanistically control DISC formation. The structure showed that Fas undergoes a conformational change, creating an open structure that acts as a site for FADD binding, as well as bridging between the Fas molecules in the clustered complex. Dr. R...

Burnham researchers discover 'on switch' for cell death signaling mechanism

...domain complex revealed a particular arrangement of four FADD death domains bound to four Fas death domains. The structure showed that Fas undergoes a conformational change, creating an open form of the protein that acts as a site for FADD binding and also participates in the association of other Fas molecules in t...

New insight into the controls on a go-to enzyme

... transformation renders it a target of calpastatin attachment and thus inhibition. "This new structural information on calpastatin and on calpain's conformational changes not only explains a lot about calpain's regulation," Green said. "It also gives us information we can use to develop targets for drugs that co...

Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye

...inds, the GAF domain closes and becomes less dynamic. In this state it looks more like a closed fist. Further analysis of the consequences of this conformational change may lead to a better understanding of how the photoreceptor PDE helps regulate the path of signals that enable us to see, as well as provide ge...
Conformational in Biological Technology

First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes

...pectrometry (JASMS). Prof. Ashcroft's paper titled, Monitoring Copopulated conformational States During Protein Folding Events Using Electrospray Ionization-Ion Mobi...the American Society of Mass Spectrometry is: Monitoring co-populated conformational states during protein folding events using ESI -IMS-MS, D. P. Smith, K. ...

Sandia researchers construct carbon nanotube device that can detect colors of the rainbow

... of chemical and electrical impulses that ultimately trigger nerve impulses. In the nanoscale color detector, light strikes a chromophore and causes a conformational change in the molecule, which in turn causes a threshold shift on a transistor made from a single-walled carbon nanotube. "In our eyes the neuron ...

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

...nder and Chief Scientific officer. "Since a number of years we have been working on developing our CLIPS technology through which we can synthesize 3D conformational mimics of protein active sites , allowing us to do site-specific immunization to come up with functional antibodies against very difficult targets suc...

New force-fluorescence device measures motion previously undetectable

...ap, we now have a technique that can detect subtle conformational changes of a biomolecule at an extremely low appli...ance energy transfer, we can measure the resulting conformational changes with nanometer precision. By probing the ...ucture of the transient species present during the conformational changes. Based on our previous studies, we knew t...

Ca++-Induced G Protein Coupled Receptor (GPCR) Activation Monitored via Aequorin Luminescence in the LMax Microplate Luminometer (MaxLine Application Note #42)

...n, and the luminophore coelenterazine 1,2 emits blue light (469 nm) upon binding calcium ions (Figure 1). The binding of Ca ++ to aequorin induces a conformational change resulting in the oxidation ofcoelenterazine through an intramolecular reaction. This bioluminescent processpresents an advantage over Ca ++ -se...

Measurement of Molecular Beacons in the SpectraMax Gemini Spectrofluorometer (MaxLine Application Note #36)

...er are held in close proximity by the arms and thefluorescence is internally quenched. When the probe hybridizes to the targetmolecule, it undergoes a conformational change resulting in separation of thefluorophore and quencher, and restoration of fluorescence. Molecular beacons areappealing because they can be use...

Rapid, High Throughput Mutation Discovery Using Fluorescent SSCP on the ABI PRISM 3100 and 3100Avant Genetic Analyzers

...s, single-stranded DNA molecules assume unique conformations that vary depending on their nucleotide sequence. The change of only one base may cause a conformational change in the DNA molecule that is sufficient to be detected on a non-denaturing polymer, e.g., electrophoretic mobility differences compared with wil...

Monitoring fluorescence resonance energy transfer (FRET) between GFP fusions in lysates of the yeast Saccharomyces cerevisiae using the Varian Cary Eclipse

...come a powerful tool to monitor interactions at the protein level, within an intact cell or organism. It is possible to use FRET to measure conformational changes in a molecule tagged with two GFP variants in response to the binding of ligands such as calcium1, or the interaction be...

Protein Truncation Tests Using the DCode System

... Summary The versatile DCode system can be used for multiple mutation detection techniques, including single-stranded conformational polymorphism (SSCP), conformation-sensitive gel electrophoresis (CSGE) and denaturing gradient gel electrophoresis (DGGE). Prote...

Heteroduplex Analysis Using the DCode System

...ction Heteroduplex Analysis (HA) is a commonly used mutation screening method due to its simplicity. The technique is based on conformational differences in double-stranded DNA caused by the formation of heteroduplex molecules. 1 Heteroduplex molecules have a mismatch ...
Conformational in Biological Products

MDR1 Shift Assay from CHEMICON

Description:... The CHEMICON MDR1 Shift Assay provides a convenient method to probe conformational changes in MDR1 that occur upon transport of MDR1 substrates. Thus, the kit...trol (DMSO) are provided as positive and negative controls for inducing the conformational change in MDR1. Concentrated PBS (10x) and a BSA solution are included as c...
Company:CHEMICON
Conformational in Biological Definition

Allostery

...enzyme subunits are connected in such a way that a conformational change in one subunit is necessarily conferred to ...at subunits are not connected in such a way that a conformational change in one induces a similar change in the othe...tensed to relaxed state, it does not propagate the conformational change to adjacent subunits. Instead, substrate bi...

Allostery

...enzyme subunits are connected in such a way that a conformational change in one subunit is necessarily conferred to ...at subunits are not connected in such a way that a conformational change in one induces a similar change in the othe...tensed to relaxed state, it does not propagate the conformational change to adjacent subunits. Instead, substrate bi...

ATP synthase

...ch postulated that ATP synthesis is coupled with a conformational change in the ATP synthase generated by rotation o...TP synthase and was able to determine that Boyer's conformational model was essentially correct. In the crystal stru...ubunits are fixed in place. This rotation forces a conformational change in the F 1 particle, eventually leading to...

Ion gradient

...h the help of the solar driven enzyme bacteriorhodopsin , here it is used for driving the molecular motor enzyme ATP synthase to make the necessary conformational changes required to synthesize ATP. Proton gradients are also be made by bacteria by running ATP synthase in reverse, this is used to drive flagell...

Enzyme

...e Catalysis. These works demonstrated the role of conformational transformations in catalytic reactions. Ribo...ov, Z.D. Urushadze, Yu.I. Kharkats. Electronic and conformational Interactions in Enzyme Catalysis.- In: E.L. Andron...lation of Kinetic Parameters of Reactions with the conformational Transformations.- In: E.L. Andronikashvili (Ed.), ...

Myosin

... muscle tissue . Together with actin filaments, myosin provides the mechanism for muscle contraction , utilizing energy from ATP . The specific conformational rearrangements throughout the chemo-mechanical transduction process are still not known. The Muscle is composed of single muscle cells (sometimes ...

Protein

...ctional rearrangements, these tertiary or quaternary structures are usually referred to as " conformations ," and transitions between them are called conformational changes. The primary structure is held together by covalent peptide bonds , which are made during the process of translation . The secondary s...

Quaternary structure

...tiprotein complexes also possess quaternary structure. Examples include nucleosomes and microtubules . Changes in quaternary structure are called conformational changes . It is through such changes, which underlie cooperativity and allostery in "multimeric" enzymes, that many proteins undergo regulation an...

Signal transduction

...on of the hormone. Transport of the hormone to the target cell. Recognition of the hormone by the hormone receptor protein, leading to a conformational change. Relay and amplification of the signal that leads to defined biochemical reactions within the target cell. The reactions of the target c...

Transmembrane receptor

...ropriate ligand, the pore becomes accessible to ions, which then pass through. In other receptors, the transmembrane domains are presumed to undergo a conformational change upon binding, which exerts an effect intracellularly. In some receptors, such as members of the 7TM superfamily, the transmembrane domain may c...
Conformational in Biological Dictionary

Sequential Epitope

...ucture. In contrast, most antibodies recognize a conformational epitope that has a specific three-dimensional sh...unique to T cell epitopes, a B in ... 7_may be a conformational epitope rather than a sequential epitope ...... ... usage bias - competent - complementary - conformational epitope - congenital ... tagged site - sequen...

RNA polymerase

...TIAL REVERSIBLE BINDING OF RNA POLYMERASE TO PROMOTER SITES. REVERSIBLE conformational CHANGES IN RNA POLYMERASE . conformational CHANGES IN THE DNA ... Transcription Is Catalyzed by RNA Polymerase ...

Pseudoknot

...seudoknot ," indicated by the presence of crossed arcs in ... Of the 43 sequences, 11 are pseudoknot -free (namely the tRNA sequences and five ... conformational loops that we call pseudoknot core units, using the theory of ... We also find that the entropy of a pseudoknot loop depends not only on its .....

Okazaki fragments

...e I uses. its exonuclease ... discontinuous units called Okazaki fragments . The polymerase moves in the 5'Ë3' direction. ... Energetic and conformational contributions to the stability of Okazaki fragments . ... It uses material from the Wikipedia article " Okazaki fragments " ... Definition and...

DNA gyrase

...nverted to ... Quinolone binding to the gyrase - DNA complex induces a conformational change that ... DNA gyrase is the intracellular target of the quinolone group of ... ... have used limited proteolysis to identify conformational changes in DNA gyrase . ... DNA gyrase is a type II topoisomerase ...

C-terminus

...ng.pdf' target='_blank'>Full article >>> Role of conformational change in the C-terminus of β2-microglobulin in dialysis ... Conclusions: conformational changes in the C-terminus of β2m may play an ...... ... of 6 histidines at the C-terminus led to conformational ... cated from the C-terminus of the MSP, or aft...

Conformational epitope

... A conformational epitope is a sequence of subunits composing a...cture. In contrast, most antibodies recognize a conformational epitope that has a specific three-dimensional shape and its protein... conformational epitopes are an important form of epitope forme...

Carboxyl Terminus

...s usage examples and terminus quotes. ... the negatively charged carboxyl termini of the rhinovirus coat ... carboxyl terminus undergoes conformational ... tional changes that occur at the carboxyl terminus of G ... carboxyl terminus is highly mobile in its GDP-bound ... ... occurring dystr...

Beta sheet

...to build beta - sheet unobserved yet in PDB, as long ... The strands of the beta sheet are not fully extended due to the constraints of ... conformational and geometrical properties of beta - sheets in proteins. ... Paper Sculpture installation at the Stamp Staircase, Somerset House, London. 7-19 Oc...
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