Lilly to Unveil More Than 30 Studies at Premier Lung Cancer Meeting
...patients with nonsquamous non-small cell lung cancer (NSCLC) histology: An analysis of three large, randomized, phase III trials (* vs. the respective comparators
in these three trials)
D2.6: Oral Presentation: Aug. 4, 2009, 1:30 p.m. PDT
Final results of a randomized phase II trial...
Non-Hormonal Therapies Aid Breast Cancer Patients
...ensus regarding the best dosage, timing, sequence or combination of therapies for treatment of metastatic breast cancer, due to the fact that standard comparators
haven't been available, Dr. Philippe Bedard and Dr. Martine Piccart-Gebhart, of the Jules Bordet Institute in Brussels, Belgium, wrote in an accompany...
GSK Revises US Labeling for Avandia(R)
...ludes data from ADOPT and RECORD plus
a third long-term trial in pre-diabetic patients (DREAM) which show there
was no increased risk of Avandia over comparators
with regard to myocardial infarction,
mortality, or other non-heart failure cardiovascular events. GSK believes data from ongoing and future clinical...
GlaxoSmithKline Responds to JAMA Articles
...Actos meta-analysis shows no statistical difference between Avandia and comparators
(a hazard ratio of 1.03). In RECORD, a study specifically designed to ... cardiovascular events, no real difference was seen between Avandia and comparators
(HR 0.96). In all of these analyses, the Avandia and the Actos hazard r...
Comparators in Medical Technology
New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria
Beta-lactamase producing Enterobacteriaceae (ESBLE) and
ciprofloxacin-resistant Enterobacteriaceae (CIPRE) to doripenem and
was evaluated. The data analyzed was pooled from six
large, multi-national Phase III clinical trials, including trials that
focused on complicated uri...
FDA Updates Label for AVANDIA(R) to Include Clinical Findings Demonstrating Sustained Glycemic Control for Up to Five Years
...ontrol at five years was 34
percent with glyburide, 21 percent with metformin and only 15 percent with
AVANDIA. The difference between AVANDIA and the comparators
"GSK is pleased that the FDA has approved inclusion of the results from
ADOPT, an important clinical trial that provi...
Vanda Presents Phase III Iloperidone Efficacy Data
.../day to 20-24 mg/day; similar reductions in BPRS
scores were observed at six weeks for iloperidone in doses of 20-24 mg/day,
as compared to the active comparators
risperidone and haloperidol. The
analysis further demonstrated that iloperidone had a favorable safety
profile, most notably with regard to extrapyram...
Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria
...Staphylococcus aureus In
Vitro," researchers detailed the antibacterial efficacy of physiologically
attainable concentrations of oritavancin and other comparators
against in vitro models of slow-growing and biofilm S. aureus. Slow-growing
bacteria and biofilms are notoriously tolerant to antibiotics. In t...
July Issue of Journal of Antimicrobial Chemotherapy Highlights
Study of Factive Tablets for Five-Day Treatment of
...aximum-labeled duration of 7 days. In clinical trials, the
discontinuation rate due to drug-related adverse events was similar
for FACTIVE tablets and comparators
(2.2% versus 2.1%,
FACTIVE is contraindicated in patients with a history of
hypersensitivity to gemifloxacin, fluoroquinolone antibio...
Comparators in Biological News
Prednisone tablets less variable than marketed drugs
...ts, said William Koch, Ph.D, chief reference materials officer for USP. USP Prednisone yielded an average variability of less than five percent, while comparators
averaged about 13 percent. Established metrological principles were followed to ensure the tests objectivity, and it is clear that USP Prednisone Refe...
Comparators in Biological Technology