NIH multicenter AIDS cohort study commemorates 25 years of discovery
The longest U.S. study of people with HIV/AIDS will be honored at a 25th anniversary commemoration on May 12, 2009, at the Carnegie Institution for Science in Washington, D.C. The Multicenter AIDS Cohort
Study (MACS) has significantly contributed to the scientific understanding of HIV, AIDS and th...
Decreasing access to cigarettes for youth in the Minnesota Adolescent Community Cohort Study
New York, 10 December 2007 New research in the December issue of Preventive Medicine, published by Elsevier, shows that there was a decline in access to cigarettes from commercial venues from 2000 to 2003.These findings are specific to the Minnesota Adolescent Community Cohort
study, a longitudin...
Ninety-one Percent of BARACLUDE(R) (entecavir) Treated Patients in a Four-Year Cohort Demonstrated Virologic Suppression to Undetectable Levels
- In this Cohort
of Nucleoside-Naive Chronic Hepatitis B e-Antigen (HBeAg) Positive Patients, Resistance Monitoring Identified One Patient with Genotypic Resistance to BARACLUDE -
BOSTON, Nov. 2 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb Company
(NYSE: BMY ) today announc...
News briefs from the August issue of Chest
...health services utilization and cost outcomes in 4,723 AA patients and 4,021 Caucasians with COPD, asthma, or both. After controlling for age, gender, cohort
allocation, and comorbidities, results showed that AA adults with COPD, asthma, or coexisting asthma and COPD used fewer medical services and accounte...
Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer
... a favorable tolerability profile and encouraging clinical activity among a cohort
of patients with metastatic breast cancer who had been heavily pretreated w...lable chemotherapeutic agents, and shows encouraging clinical activity in a cohort
of women who have been heavily pretreated for metastatic breast cancer," sa...
Hip and back fractures increase mortality rates in people older than 50
...e conditions are usually difficult to recruit and thus under-represented in cohort
studies. "If this was the case in this Canadian cohort
(and it most likely was), the mortality data may contain "healthy volunteer...
Long-term health and social outcomes for neuroblastoma survivors
...Study (CCSS). Late mortality, second malignant tumors, and chronic health conditions were analyzed. The researchers also compared participants with a cohort
of 3,899 siblings of children with cancer for risk of chronic health conditions and sociodemographic outcomes.
Neuroblastoma survivors were less li...
Cancer treatment controls macular edema related to diabetes and to cataract surgery
...coemulsification method has reduced cataract surgery complications in general, but the impact on diabetic retinopathy has been unclear. A clinic-based cohort
study (2004 to 2006) led by Jie Jin Wang, MMed, PhD, at the Centre for Vision Research, University of Sydney, Australia, followed 169 diabetic patient...
BioMarin Announces Second Quarter 2009 Financial Results
3Q09: Initiation of PEG-PAL Phase II trial
3Q09: International Congress of Inborn Errors of Metabolism (ICIEM)
meeting - Data on first cohort
of patients from trial evaluating the
impact of Kuvan on executive function
2H09: Decision on 6R-BH4 PAH program
1Q10: Initiation of Pha...
QuatRx Announces Further Positive Phase 3 Results For Ophena(TM) (Ospemifene Tablets) in Postmenopausal Vaginal Atrophy
...al pain). The results announced today focus on the cohort
of 314 patients from this study identifying vagina...ate that Ophena(TM) was well-tolerated. A second cohort
of the study, consisting of 605 patients with the ...l as additional efficacy data from the dyspareunia cohort
of the second Phase 3 study, are expected in the t...
Cohort in Medical Technology
ThromboGenics and BioInvent Start Recruitment of Second 100 Patient Cohort in Phase II DVT Prophylaxis Study With TB-402
LEUVEN, Belgium and LUND, Sweden, July 3 /PRNewswire-FirstCall/ --
ThromboGenics NV (Euronext Brussels: THR) and co-development partner
BioInvent International (OMXS: BINV) announce that they have started
recruitment of a second cohort
of patients for their Phase II trial of
TB-402. This follo...
Jennerex Completes the Treatment of First Patient Cohort in Phase 1 Trial With Intravenous Delivery of JX-594 Oncolytic Virus
12 Patient Trial Targets Advanced Solid Tumors, Including Lung Cancer
SAN FRANCISCO, Oct. 15 /PRNewswire/ -- Jennerex, Inc. (San Francisco,
CA and Ottawa, Canada) today announced the completion of treatment for the
first patient cohort
in the Phase 1 cancer clinical trial of its targeted
Nventa Completes Safety Evaluation on Final Cohort in HspE7 Phase 1 Cervical Dysplasia Trial
- HspE7 Phase 2 Trial for Cervical Dysplasia to Begin Mid-2008 -
SAN DIEGO, April 24 /PRNewswire-FirstCall/ -- Nventa Biopharmaceuticals
Corporation (TSX: NVN) today announced the completion of the safety and
tolerability assessment of the fourth and final cohort
of patients in its
Nventa Enrolls and Initiates Dosing of Final Cohort in HspE7 Phase 1 Cervical Dysplasia Trial
SAN DIEGO, March 11 /PRNewswire-FirstCall/ -- Nventa Biopharmaceuticals
Corporation (TSX: NVN) today announced that the Company has completed
enrollment and initiated dosing of the fourth and final cohort
in its Phase 1 dose escalation trial. This study examines the safety of its
Baraclude (entecavir) Therapy Resulted in Undetectable Levels of
Hepatitis B Virus in Cohort of Patients Who Re-Started Treatment
93 Percent of Nucleoside-Naive Chronic Hepatitis B e-Antigen
(HBeAg)-Negative Patients Achieved Undetectable Viral Load by Week
48 of Re-Treatment
PRINCETON, N.J., April 13, 2007 /PRNewswire-FirstCall/ --
Bristol-Myers Squibb Company today announced data from a cohort
OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer
...vels. Patients were treated in 21-day cycles, with cohort
one receiving 135 mg/m2 of paclitaxel poliglumex and 500 mg/m2 of pemetrexed, and cohort
two receiving 175 mg/m2 of paclitaxel poliglumex a...d 500 mg/m2 of pemetrexed. None of the patients in cohort
one had an initial dose-limiting toxicity (IDLT) w...
Diabetes Gene Raises Odds of Lower Birth Weight
...er for Applied Genomics at Children's Hospital, investigated 20 gene locations previously reported to be associated with type 2 diabetes. Drawing on a cohort
of some 5,700 Caucasian children in an ongoing genome-wide association study of childhood obesity at Children's Hospital, the researchers compared bir...
Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)
... End of Treatment Mean Patients with 1 log10 or
Change in HCV RNA Greater Reduction in HCV
Dose (log10) RNA at End of Treatment
------ ---- --------------------- --------------------------
Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM)
...tres in North America are participating in this trial and recruitment of 105 evaluable patients was completed in March, 2009.
Data from the full cohort
of evaluable patients from this trial, coupled with additional safety information to be collected from a second registration trial, will be used to su...
Landmark Study for GSK's Cervical Cancer Vaccine Published in The Lancet
... with HPV 16 or 18. A further analysis of the same cohort
which excluded lesions not likely to be caused by ...llowing cohorts:
for efficacy (ATP-E; vaccine=8093; control=8069)
Total vaccinated cohort
(TVC; vaccine=9319, control=9325)
Cohort in Medical Definition
European Prospective Investigation into Cancer and Nutrition
...ion into Cancer and Nutrition (EPIC) study is a Europe -wide prospective cohort
study of the relationships between diet and cancer , as well as other c... et al . Modified Mediterranean diet and survival: EPIC-elderly prospective cohort
study. BMJ (2005) 330: 991
van Gils CH, Peeters PH, Bueno-de-Mesquita ...
Cohort in Medical Dictionary
...Detecting the Prodrome . Certain types of ' prodrome ' have been identified. ... Comment: This study provides a portrait of prodrome in a large cohort
of patients, and it draws attention to the potential of preventing the headache phase of the ... Register today for a free trial, credit card re...
...In 1999, she set about trying to find a way ... Lactation causes significant hypoestrogenemia, which has negative effects on ... The lactation cohort
included women who intended to breast feed for at least six ... Offers breastfeeding products including Medela breast pumps, nursing bras,...
Acquired Immunodeficiency Syndrome
... immunodeficiency virus (HIV) is diagnosed as having ... International Epidemiologic Databases to Evaluate AIDS (IeDEA) ... Pediatric HIV/AIDS cohort
Study (PHACS) Women's HIV Interdisciplinary Network (WHIN) ... AIDS ( acquired immune deficiency syndrome ) is the final and most serious st...
Cohort in Biological News
Forsyth scientists suggest linkages between obesity and oral bacterial infection
... to metabolic changes. In the next phase of this research, Dr. Goodson plans to further examine this relationship by initially conducting a controlled cohort
study to see if this initial observation can be reproduced. In addition, he hopes to conduct longitudinal studies in children to see if oral infection...
Chemicals in common consumer products may play a role in pre-term births
...e of Public Health in Mexico and the U.S. Centers for Disease Control and Prevention analyzed data from a larger study directed by Hu, which follows a cohort
of Mexican women recruited during pre-natal visits at one of four clinics of the Mexican Institute of Social Security in Mexico City.
Meeker and c...
Study characterizes eczema patients most at risk for dangerous viral infections
...t be able to identify eczema patients at high risk for these infections and to obtain clues about the mechanisms of susceptibility by studying a large cohort
of patients who had suffered eczema herpeticum, the herpes simplex viral skin infections. They examined a wide variety of demographic, pathologic and ...
Biolex presents Locteron US Phase 2a hepatitis C data at EASL
...re for flu-like symptoms for patients in the 320 g cohort
of Locteron was 80 percent lower than the severity score for the PEG-Intron control cohort
(severity score was based on number of occurrences...The total severity score for patients in the 640 g cohort
of Locteron was 30 percent lower than the severity...
Early administration of antiretroviral therapy can improve survival
... published in The Lancet , in the framework of the Antiretroviral Therapy cohort
Collaboration , includes information from 15 international cohorts. Data we...he best time to begin antiretroviral treatment.
The Catalan and Balearic cohort
PISCIS (Project for the Computerization and Clinical Epidemiological Monito...
Exposure to insecticide may play role in obesity epidemic among some women
... The mothers who were studied are part of a larger cohort
of Michigan fish eaters along Lake Michigan who we...n 2000, Osuch and research partners approached the cohort
and began to identify daughters aged 20 to 50 year...gs not only apply to the offspring of women in our cohort
but to any woman who has been exposed to high leve...
New tumor markers determine therapy intensity
...preserved in paraffin.
BMBF promotes the search for other tumor markers
The prospective validation of these markers in an independent patient cohort
and the search for the simplest and most reliable methods of analysis is now the goal of a project promoted by the Federal Ministry for Education and ...
AJCN study shows moderate alcohol consumption related to stronger bones
... of alcoholic beverages (beer, wine, and liquor). To explore this issue further, an international team of experts headed by Katherine Tucker studied a cohort
of adults in the Framingham Offspring Study. Their results are published in the April 2009 issue of The American Journal of Clinical Nutrition . In a...
Harmonizing biobank research: An achievable world-wide goal
...PHOEBE identifies and explores key issues to help to ensure that Europe makes best use of its rich array of population-based biobanks and longitudinal cohort
studies. The ultimate aim is to harmonise those features that will help to: (1) promote communication between major biobanking initiatives; (2) enhanc...
Novel veterinary procedure detecting life-threatening injuries touted
...ns. He stated: "This is a wonderful paper that evaluates an incredibly useful bedside technique that empowers the physical examination in a good sized cohort
of animals with very good results. It is wonderful to see this technique come back to the veterinary world, as the very first description of using ult...
Cohort in Biological Technology
YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB COLORECTAL CANCER TRIAL FIRST COHORT IS CLOSED TO ACCRUAL
MISSISSAUGA, ON, Dec. 20 /PRNewswire-FirstCall/ - YM BioSciences Inc.
(AMEX: YMI , TSX: YM, AIM: YMBA), an oncology company that identifies,
develops and commercializes differentiated products for patients worldwide,
today announced that it has completed accrual in the first 50-patient
Nventa completes enrollment and initial dosing of second cohort in Phase 1 HspE7 safety trial
SAN DIEGO, CA, Dec. 6 /PRNewswire-FirstCall/ - Nventa
Biopharmaceuticals Corporation (TSX: NVN) today announced that the Company
has completed enrollment and initiated dosing of the second cohort
patients in its Phase 1 dose escalation trial examining the safety of its
lead candidate, HspE7...
Nile Therapeutics, Inc. Announces Dosing of First Patient in Phase 2 Study of CD-NP for the Treatment of Acute Heart Failure
... failure patients showed that CD-NP infusion was associated with an improvement in renal function. Previously reported interim results from the first cohort
of a Phase 2a study in patients hospitalized for acute heart failure also showed that CD-NP infusion was associated with clinically meaningful improve...
Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease
Poster #P2-071: Increased Risk of Serious Comorbidities in a cohort
of AD Patients Compared to a Similar Non-AD cohort
(Malone D, et al.)
A retrospective data analysis showed that AD patien...
MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus
... study of MGAWN1 in healthy volunteers, with the last patient having completed treatment in late 2008. This randomized, double-blind, dose-escalation cohort
study was designed to evaluate the safety, tolerability, and pharmacokinetics of a single infusion of MGAWN1 in healthy adults. The study demonstrate...
Schering-Plough Announces Phase II and III Data for Corifollitropin Alfa
Fatemi HM et al, The first pilot study with corifollitropin alfa in a long GnRH agonist protocol indicates the development of a large cohort
of follicles during the first week of ovarian stimulation. Oral presentation at 25th European Society of Human Reproduction and Embryology (ESHRE) on ...
Novo Nordisk Convenes Policy and Clinical Experts at Diabetes Media Summit
...are legislation scoring.
"Diabetes has the best data, the best modeling and the best studies," said O'Grady. "If we can intervene with a certain cohort
of patients and figure out what that intervention will cost during the progression of the disease, then we can bring together the clinical trial data ...
Proteolix Presents Clinical Data from Two Clinical Studies of Carfilzomib in Multiple Myeloma at the 14th Congress of the European Hematology Association
...duration of response of 8.5 months. The median time to progression in this cohort
has not been reached.
Among patients with prior bortezomib exposure, 1...ed in this population. The median time to progression for patients in this cohort
was 8.9 months. Ten additional patients achieved stable disease.
Peregrine Pharmaceuticals Presents Promising Data From Its Phase II Bavituximab Breast Cancer Trial at 2009 ASCO Annual Meeting
... Median Progression Free Survival in Initial Study cohort
ORLANDO, Fla. and TUSTIN, Calif., June 1 /P...ates that 10 of 14 evaluable patients in the first cohort
of the trial achieved an objective tumor response ... vessels.
"The preliminary data in this first cohort
of advanced breast cancer patients treated with ba...
Ascenta Therapeutics Announces Presentation of Promising Results From Clinical Trials of AT-101 in Prostate, Brain, and Lung Cancers at 2009 ASCO Annual Meeting
...o confirming this in larger studies."
Complementing these findings from the chemotherapy-naive setting, another presentation reported data from a cohort
of men with docetaxel-refractory prostate cancer who were treated with the same docectaxel/prednisone/AT-101 regimen(2). A rigorous definition of ref...