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Cofactor in Medical News

Patents Issued Covering Stable Tablet Formulation and Once Daily Dosing Regimen for Kuvan

...iet. The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

...human tissue both in culture and transplanted into mice show this appears the case for βarrestin2. First the team identified βarrestin2 as cofactor for androgen receptors. Next they found a reciprocal relationship: androgen receptor expression is low when βarrestin2 expression increases. That...

Biomarker associated with poor outcome in aggressive childhood cancer

...earch for additional components of the RA signaling pathway that might be linked to neuroblastoma. The researchers identified ZNF423 as a critical cofactor of RA-induced differentiation. Reduced expression of ZNF423 was led to a growth advantage and resistance to RA differentiation in neuroblastoma cells ...

A potential new target for treatment of hormone refractory prostate cancer

... AR transcriptional activity. "Our work suggests that ubiquitination of AR, and possibly other transcription factors, may function as the scaffold for cofactor recruitment to modulate transcriptional activity and specificity," concludes Dr. Qiu. "Targeting components of the ubiquitination machinery, such as R...

Long-term L-carnitine supplementation prevents development of liver cancer

...es; endogenous synthesis, in the liver and kidney, and from exogenous dietary sources such as red meat and dairy products. L-carnitine is an essential cofactor for the translocation of long chain fatty acids from the cytoplasmic compartment into mitochondria, where beta-oxidation enzymes are located for ATP p...

Redesigned protein accelerates blood clotting

...ore active protein by the time it hits the body, researchers said. Furthermore, when more stable factor VIII is converted into factor VIIIa, the VIIIa cofactor better holds onto the A2 domain, which is the reason that the current study found that more stable mutants increase clotting. In a recent paper in...

Experimental TB drug explodes bacteria from the inside out

...ed, conditions. With this new understanding of how the bacterial enzyme and cofactor act on PA-824 under low-oxygen conditions, Dr. Barry says, scientists can d...arch Foundation in San Diego. Because humans have neither the bacterial cofactor nor any enzymes equivalent to Ddn, PA-824 has no effect on human cells. Con...

ADVENTRX Pharmaceuticals Reports Second Quarter 2008 Financial Results and Business Update

...proved. As well, we announced response rate data from 2 separate studies of CoFactor(R), our third oncology product candidate. We continue to evaluate cofactor and expect to provide further updates with respect to the program as we gather additional data." Three-Month Period Ended June 30, 2008 Operating Re...

Fairview Specialty Pharmacy Signs Contract With BioMarin for Distribution of Kuvan(TM)

...et. The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential t...

BioMarin Re-Acquires Rights to Kuvan in Canada From Merck Serono

...et. The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential t...
Cofactor in Medical Technology

ADVENTRX Presents CoFactor Data at the 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO)

SAN DIEGO, June 3 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. (Amex: ANX ) announced today that it presented objective response rate and available safety data from the Company's Phase 2 clinical study of ANX-510, or CoFactor(R), for the treatment of advanced breast cancer at the ...

ADVENTRX to Present CoFactor Phase 2 Breast Cancer Data at the 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO)

SAN DIEGO, March 12 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. (Amex: ANX ) announced today that preliminary data from the Company's Phase 2 clinical study of ANX-510, CoFactor(R), for the treatment of advanced breast cancer has been accepted for presentation at the 2008 America...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

SAN DIEGO, Aug. 16 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. (Amex: ANX ) a biopharmaceutical research and development company focused on commercializing proprietary product candidates for the treatment of cancer and infectious diseases, today announced that the U.S. Food and D...

ADVENTRX to Present CoFactor Multiagent Therapy Data at AACR Annual Meeting

SAN DIEGO, March 29, 2007 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. , a biopharmaceutical research and development company focused on commercializing proprietary product candidates for the treatment of cancer and infectious diseases, announced today that results from preclin...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

... Dial in #: 617.801.6888 Replay Code: 73130467 About 6R-BH4 6R-BH4, commonly known as BH4 or tetrahydrobiopterin, is a naturally occurring enzyme cofactor that is required for numerous biochemical and physiologic processes, including the synthesis of nitric oxide (NO). NO has been shown to play a key pro...

ADVENTRX Announces Preliminary Response Rate Data From Discontinued Phase 3 Trial of CoFactor(R)

...ease rate and 4.8% progressive disease rate in the cofactor experimental arm compared to a 38.6% stable diseas... on investigators' assessments. In the study, both cofactor and 5-FU were administered as an i.v. bolus. Curre...ng treatment in this study, with 6 patients on the cofactor experimental arm and 4 patients on the leucovorin ...

ADVENTRX Announces CoFactor(R) Phase 2b Clinical Trial Overall Survival Results

...erall survival from its Phase 2b clinical trial of cofactor for the treatment of first-line metastatic colorec...the leucovorin/5-FU arm. "In the Phase 2b study, cofactor was dosed at 60mg/m2 by infusion to provide as unb...d President of ADVENTRX. "Even while administering cofactor over hours instead of the more optimal 2 to 3 minu...

BioMarin Announces FDA Approval for Kuvan

...et. The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential t...

ADVENTRX Announces Completion of Patient Enrollment in Phase 2 Clinical Trial of CoFactor(R) for the Treatment of Advanced Breast Cancer

...d have greater insight into our ability to develop cofactor in breast cancer and other indications." The Pha...evaluate the safety and efficacy of treatment with cofactor plus 5-fluorouracil (5-FU) in advanced breast canc...metastatic disease. About ANX-510, or CoFactor cofactor is a folate-based biomodulator drug designed to re...

Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet

... PKU. The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Clinical data suggest that treatment with Kuvan results in significa...
Cofactor in Medical Products

Heparin Cofactor II

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Ristocetin Cofactor

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

AggRAM Analyzer

Description:... AggRAM, for platelet aggregation and ristocetin cofactor testing, couples a four-channel analyzer with the power of Windows-based software for unsurpassed testing flexibility. Up to two AggRAM modules can b...
Company:Helena Laboratories

Model 700 Whole Blood/Optical Lumi-Aggregometer

Description:...Model 700 Aggregometer also has the capability of performing the Ristocetin cofactor Assay for diagnosing patients with von Willebrands disease. The output can ...ted to either a strip chart recorder or to a Computer. AGGRO/LINK(8) and Vw cofactor Software packages are provided for the computer interface option. Wit...
Company:Chrono-log Corporation
Cofactor in Medical Dictionary

Vitamin B6

... Vitamin B6 is a water-soluble vitamin and is part of the vitamin B complex group. Pyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination,... ... Dietary Allowance for vitamin B6 for adults? When can a vitami...
Cofactor in Biological News

Rampant helper syndrome

...lying chemical reaction, a reduction, involves the cofactor known as F0 or F420 which is the tiny molecule dea...or Thomas Carell, however, has now shown that this cofactor is also common in eukaryotes, where it performs an...n involves the tiny molecule deazaflavin, known as cofactor F0 or...

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

...f gastrin play a key role in the development of Helicobacter -induced stomach cancer. The related report by Takaishi et al, "Gastrin is an essential cofactor for Helicobacter -associated gastric corpus carcinogenesis in C57BL/6 mice," appears in the July 2009 issue of The American Journal of Pathology . ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

...d enable infection. The synthesis of siderophores in M. tuberculosis and A. fumigatus requires special enzymes (hydroxylase) that are dependent on the cofactor flavin adenine dinucleotide (FAD). The function of these enzymes is essential to form the hydroxamate potion of the siderophore, which binds the iron ...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

...cs to slow the spread of infection inside the body. Akira Ono, Ph.D. The University of Michigan, Ann Arbor, MI $120,000 The role of PIP2 as a cofactor for HIV-1 assembly at the plasma membrane: After co-opting many cell proteins and processes in manufacturing its various parts, HIV assembles itself c...

Ireland Cancer Center researchers advance stem cell gene therapy

...ts in the blood) using Bax Inhibiting Peptides to rescue the damaged cells. Dr. Keith McCrae and colleagues presented that 2 glycoprotein is a cofactor in the process that dissolves blood clots through the use of the medical agent tPA. ...

NIH grants enable energy studies

... National Science Foundation and Monsanto also have supported the Kranz group during the past twenty years. Cytochrome c is a protein with the heme cofactor covalently attached to it. Cytochrome c is crucial for energy production in many bacteria and higher organisms, including humans and it is one of the...

Upgraded IMG 2.3 Data Management System released by DOE JGI to eager user community

... terms, pathways, and networks are used for improving the functional characterization of genes in ongoing studies related to carbohydrate utilization, cofactor biosynthesis, and methanogenesis. Responding to the needs of the DOE JGI user community, IMG 2.3 provides enhanced support through "MyIMG Annotatio...

MIT biologists solve vitamin puzzle

...uB-catalyzed synthesis is its cannibalization of a cofactor derived from another vitamin, B2. During the reaction, the B2 cofactor is split into more than two fragments, one of which becomes DMB. Normally, the B2-derived cofactor would assist in a reaction by temporarily holding ...

Scientists take 'snapshots' of enzyme action

... enzyme plus its cofactor, and the enzyme plus the cofactor plus the compound to be oxidized (the substrate). ...bstrate. "Our finding shows that the substrate and cofactor are binding to the enzyme alternately, not together," Swaminathan says. First, the cofactor (known as NADPH) binds to a molecule known as FAD,...

Evolutionary conservation of a mechanism of longevity from worms to mammals

...ifespan in mice. The gene clk-1 in the worm, as well as mclk1 in mice, encodes an enzyme necessary for the biosynhesis of ubiquinone, an essential cofactor in numerous redox reactions such as mitochondrial respiration. Though lack of the mclk1 gene results in embryonic lethality, the authors were able to...
Cofactor in Biological Technology

Bio/Data Corporation Launches vW Select(TM) - The World's First and Only Complete Ristocetin CoFactor Assay

vW Select Significantly Reduces Laboratory Variability and Provides Clinicians with More Reliable Test Results HORSHAM, Pa., June 30 /PRNewswire/ -- Today, Bio/Data Corporation announced the launch of vW Select(TM), the world's first all-in-one Ristocetin CoFactor Assay. vW Select is the firs...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

SAN DIEGO, Aug. 16 /PRNewswire-FirstCall/ -- ADVENTRX Pharmaceuticals, Inc. (Amex: ANX ) a biopharmaceutical research and development company focused on commercializing proprietary product candidates for the treatment of cancer and infectious diseases, today announced that the U.S. Food and D...

Kuvan Receives Priority Review Status From Health Canada

... The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. ...

BioMarin Receives Notice of Allowance for Once Daily Dosing Patent for Kuvan

... The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. ...

ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results

...es related to ANX-514 and a $0.2 million increase in personnel costs, offset by a $5.4 million decrease in external clinical trial expenses related to cofactor and ANX-530 and a $0.3 million decrease in non-cash, stock-based compensation expenses. R&D expenses for 2008 included non-cash, stock-based comp...

Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant

...ation onset time from baseline to week 24. About 6R-BH4 6R-BH4, commonly known as BH4 or tetrahydrobiopterin, is a naturally occurring enzyme cofactor that is required for numerous biochemical and physiologic processes, including the synthesis of nitric oxide (NO). NO has been shown to play a key pro...

ADVENTRX Pharmaceuticals Reports Third Quarter 2008 Financial Results and Business Update

...nal clinical trial expenses related to ANX-530 and cofactor and a $0.1 million decrease in share-based compens...ment in our discontinued Phase 3 clinical trial of cofactor was stopped, however, patients currently receiving cofactor in this trial will continue to receive treatment. ...

Data to Be Presented at 58th Annual Meeting of The American Society of Human Genetics

...diet. The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential t...

ADVENTRX Announces Restructuring and Cost Reduction Initiatives

...any discontinued active work on all product candidates other than ANX-530 and ANX-514, including its CoFactor(R) program. Patients currently receiving cofactor will continue to receive treatment. With respect to ANX-530 and ANX-514, until the Company has secured additional funding, it anticipates focusing pri...

Kuvan Receives Positive Opinion From CHMP for European Approval

...et. The active ingredient in Kuvan, sapropterin dihydrochloride, is the synthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential t...
Cofactor in Biological Products

Ligase, T4 DNA from USB Corp.

Description:...Tris-HCl, (pH 7.8), 6.7mM MgCl 2 , 10mM DTT, 66M ATP and 3.3M radiolabeled pyrophosphate. Incubation is at 37C for 20 min. Note: ATP is an essential cofactor for the reaction. This contrasts with E. coli DNA Ligase which requires NAD. Unit Definition: One Weiss unit is the amount of enzyme required to conve...
Company:USB Corp.
Cofactor in Biological Definition

Flavin

...rm of FADH 2 , it is one of the cofactors that can transfer electrons to the electron transfer chain . FAD Flavin adenine dinucleotide is a cofactor in the enzymes D-amino acid oxidase, glucose oxidase, and xanthine oxidase . FADH / FADH 2 FADH and FADH 2 are reduced forms of FAD. F...

Flavin

...rm of FADH 2 , it is one of the cofactors that can transfer electrons to the electron transfer chain . FAD Flavin adenine dinucleotide is a cofactor in the enzymes D-amino acid oxidase, glucose oxidase, and xanthine oxidase . FADH / FADH 2 FADH and FADH 2 are reduced forms of FAD. F...
Cofactor in Biological Dictionary

Cofactors

... A cofactor is a non-protein chemical compound that is bound...red "helper molecules/ions" that... cofactor (linear algebra), the signed minor of a matrix ... cofactor (biochemistry), a substance that needs to be pres...

Coenzymes

... A cofactor is a non-protein chemical compound that is bound to a protein and is required for the protein's biological activity. These proteins are comm...
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