Master gene plays key role in blood sugar levels
...mice that lack steroid receptor-2 (SRC-2) a master regulator gene called a coactivator
fast for a day, their blood sugar levels plummet. If they go another day w...iency in a coactivator," O'Malley said.
He actually identified the first coactivator
SRC-1. His work with another called SRC-3 has led to better understanding ...
'Marathon mice' elucidate little-known muscle type
...archers produced mice with higher than normal levels of the transcriptional coactivator
PGC-1â in their skeletal muscles. Transcriptional coactivators work with ot...e activity of other genes. While earlier studies had found that the related coactivator
PGC-1â plays a role in determining muscle type, the role of PGC-1â wasn't k...
Scientists unlock mystery of embryonic stem cell signaling pathway
... both proliferative and differentiative. More specifically, IQ-1 blocks the coactivator
p300 from interacting with the protein ß-catenin; this prevents the stem ce...ific cell type. At the same time, IQ-1 enhances the interaction between the coactivator
CBP and ß-catenin, which signals the cells to keep dividing and to remain a...