Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimer's disease

... diabetes and Alzheimer's disease onset and progression. Dr. Pasinetti and colleagues found that a gene known as proliferator-activated receptor coactivator 1 - (PGC-1 ), a key regulator of glucose content currently investigated as a potential therapeutic target for type-2 diabetes, is also decreased in A...

Coactivator in Biological News

Master gene plays key role in blood sugar levels

...mice that lack steroid receptor-2 (SRC-2) a master regulator gene called a coactivator fast for a day, their blood sugar levels plummet. If they go another day w...iency in a coactivator," O'Malley said. He actually identified the first coactivator SRC-1. His work with another called SRC-3 has led to better understanding ...

'Marathon mice' elucidate little-known muscle type

...archers produced mice with higher than normal levels of the transcriptional coactivator PGC-1â in their skeletal muscles. Transcriptional coactivators work with ot...e activity of other genes. While earlier studies had found that the related coactivator PGC-1â plays a role in determining muscle type, the role of PGC-1â wasn't k...

Scientists unlock mystery of embryonic stem cell signaling pathway

... both proliferative and differentiative. More specifically, IQ-1 blocks the coactivator p300 from interacting with the protein ß-catenin; this prevents the stem ce...ific cell type. At the same time, IQ-1 enhances the interaction between the coactivator CBP and ß-catenin, which signals the cells to keep dividing and to remain a...

Coactivator in Biological Technology

ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System Target Validation and Identification of Novel Disease Indications

...ceptor Activity". CARM1 (coactivator-associated arginine methyltransferase) methylates many proteins that modulate transcriptional regulation and is a coactivator of gene transcription for ESR1. Pelp1 (Proline-, glutamic acid-, leucine-rich protein 1) is a scaffold protein that may mediate the rapid cellular pro...

Coactivator in Biological Products

Rabbit Anti-Nuclear Receptor Coactivator 2 (NCOA2) Polyclonal Antibody, Agarose Conjugated from Novus Biologicals

Description: Rabbit polyclonal antibody to NCOA2 [Agarose Immobilized]...
Company:Novus Biologicals