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Clozapine in Medical News

Schizophrenia Drug Got Bad Rap

... Less expensive clozapine might have saved thousands of lives, researchers s...dy suggests. Finnish researchers concluded that clozapine is associated with a lower death rate compared to ...tiapine (41 percent higher) and the lowest was for clozapine (26 percent lower). The study also found that l...

FDA Panel Snubs Seroquel as 1st Choice Depression Treatment

... Medicine . At the time, experts said that the overall odds of a heart problem for patients taking this class of medications -- which also includes clozapine (Clozaril), olanzapine (Zyprexa) and risperidone (Risperdal) -- were probably low, and the drugs remained appropriate for certain patients. Still, doc...

UT Southwestern researchers reveal how the brain processes important information

... current research focused on how dopamine operates on the cells associated with this type of memory formation. Dr. Greene, director of the National clozapine Coordinating Center at the Dallas Veterans Affairs Medical Center, and his research team isolated slices of the hippocampus region of the animals' bra...

Newer Antipsychotics Pose Cardiac Risk: Study

...t," Ray said. And patients should rarely, if ever, take the drugs to treat other conditions, he said. At issue are newer antipsychotic drugs -- clozapine (Clozaril), quetiapine (Seroquel), olanzapine (Zyprexa) and risperidone (Risperdal). Federal health officials have approved the use of the drugs to...

Most Newer Antipsychotics No Better Than Older Ones, Just Different

...toms, relapse rates, quality of life, and weight gain, among other measures. The analysis found four second-generation drugs, amisulpride (Solian), clozapine (Clozaril), olanzapine (Zyprexa) and risperidone (Risperdal) were more effective than first-generation drugs, with "small to medium effect sizes." ...

Comparison of antipsychotic treatments in adolescents with schizophrenia

...ments, the patients received treatment with either clozapine or high-dose olanzapine (doses that exceed the pac...n their symptoms. The researchers discovered that clozapine was approximately twice as likely to produce a tre...c medications, so the distinctive effectiveness of clozapine in this study could be very important. Dr. Kumr...

Drug Risks Must Be Balanced Against Benefits, Researchers

...f six drugs: smallpox vaccine; antihistamines for the treatment of allergies for four months out of every year; aspirin for cardiovascular protection; clozapine to treat schizophrenia; Tysabri, a multiple-sclerosis drug; and Vioxx, the now-retired painkiller. These were then compared to various non-dru...

Scientists Uncover Cause of Antipsychotic Drug Weight Gain

...overact, the Johns Hopkins team injected mice with clozapine (Clozaril), which, with olanzapine (Zyprexa) and r... do poorly on conventional drugs. Mice given clozapine showed quadrupled AMPK activity compared to activi...he drug, AMPK activity and appetite, the team gave clozapine to mice genetically engineered without a histamine...

Old Anti-psychotic Drugs Are Equally Good

...althcare costs. Atypical antipsychotics like risperidone, quetiapine, clozapine and olanzapine, cost a lot more, at least ten times more than their precurs...ed by the NHS, confirms previous findings that one new antipsychotic called clozapine was most effective in treating advanced schizophrenia. Jo Loughran, w...

Brain changes in schizophrenia to be analyzed

... will compare the effect of six-month administration of two antipsychotic drugs used commonly in the treatment of schizophrenia and bipolar disorder – clozapine (Clozaril) and haloperidol (Haldol) – in monkeys. B The purpose of the monkey studies will be to: 1. Better understand the effects of the two drug...
Clozapine in Medical Technology

ACADIA Pharmaceuticals' Schizophrenia Programs to Be Presented at the 2007 International Congress on Schizophrenia Research

...e and no adverse effect in the Novel Object Recognition assay. In contrast, clozapine impaired performance in both these assays. The pro-cognitive effects of ACP...as a receptor profile that is distinct from and potentially advantageous to clozapine and other atypical antipsychotic agents. About ACP-103 ACP-103 is a sma...

Avanir Pharmaceuticals Presents IEED Prevalence and Updated Zenvia Long-Term Safety Data at AAN Annual Meeting

...em, cardiovascular disorders, inflammation and infectious diseases. Avanir currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who fail to respond adequately to standard schizophrenic drug treatments. FazaClo is also in...

AVANIR Pharmaceuticals to Present Zenvia Phase III Data in Diabetic Peripheral Neuropathic Pain at Second International Congress on Neuropathic Pain

...em, cardiovascular disorders, inflammation and infectious diseases. AVANIR currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who fail to respond adequately to standard drug treatments for schizophrenia. FazaClo is als...

AVANIR Pharmaceuticals Presents Zenvia Phase III Data in Diabetic Peripheral Neuropathic Pain at International Congress on Neuropathic Pain

...em, cardiovascular disorders, inflammation and infectious diseases. AVANIR currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who fail to respond adequately to standard drug treatments for schizophrenia. FazaClo is als...
Clozapine in Biological News

New treatment mechanisms for schizophrenia

....S. Food and Drug Administration have had, at their core, a single treatment mechanism, the blockade of the dopamine D2 receptor. The introduction of clozapine in the 1980s suggested a potential that other brain targets might complement the blockade of dopamine D2 receptors to treat symptoms that failed to re...

How schizophrenia develops: Major clues discovered

... The researchers also showed, in mice, that antipsychotic medications like clozapine appear to correct this epigenetic flaw. This raises the possibility of dev... because it can lead to more effective treatments with fewer side effects. clozapine and other current antipsychotic medications are effective for many patients...
Clozapine in Biological Technology

Azur Pharma and Elan Corporation (NYSE: ELN) Sign Agreement to Develop a Once-Daily Clozapine

DUBLIN, November 10 /PRNewswire/ -- Azur Pharma Limited ("Azur") today announced that it has entered into an agreement to develop and commercialise once-daily formulations of clozapine using Elan Corporation plc's ("Elan")(NYSE: ELN ) proprietary drug delivery technologies, including its NanoC...
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