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Cleaving in Medical News

Novel role of protein in generating amyloid-beta peptide

...ACE1 and appears to 'scaffold' them into a structure." Kang explained that these three components must come together to result in the first cut or cleaving that leads to production of Aβ. To test this, the scientists knocked out RANBP9 in the cell, and discovered that 60% less Aβ was produced. ...

Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs

... signal was already embedded within the molecule, just ahead of the portion that later detached to form mascRNA. The molecular complex responsible for cleaving MALAT1 therefore knew precisely where to make its cut--right after the embedded signal--rather than at MALAT1's tail end. In this way, MALAT1 is effec...

Hopkins researchers discover new link to schizophrenia

...d psychiatric disorders and therefore may provide a new target for developing therapies. The BACE1 enzyme, for beta-site amyloid precursor protein cleaving enzyme, generates the amyloid proteins that lead to Alzheimers disease. The research team years ago suspected that removing BACE1 might prevent Alzhei...

Study Details New Molecular Approach to Preventing Alzheimer's

...t proposed methods of blocking beta-secretase, Simons said, is that they are designed to work outside of the affected brain cells. "This process of cleaving takes place inside cells," he said. "We have constructed an inhibitor which binds outside, on the cell membrane, and goes into the cell where the clea...

Lung damage in babies with congenital heart disease under study

...act of stretching the vessels increases TGF-1 and ultimately VEGF expression. The plasminogen system, which activates wound-healing, also is a player, cleaving TGF-1 so it gets released. In turn, the increased TGF-1 activates a signaling pathway that activates a plasminogen activator inhibitor. Endothelin,...

A major step toward a more targeted treatment for auto-immune diseases?

...(a protein that cleaves other proteins) and that A20 is the protein that is cut. In normal circumstances, A20 inhibits inflammatory reactions; and, by cleaving A20, MALT1 counteracts this inhibition, allowing the inflammation to progress freely. So, both proteins play very important parts in fine-tuning the i...

Protein Targets for Carcinogenesis

... inactivation. In other words they become unable to recognize and control ubiquitinated proteins. If needed the cell can re-activated them by cleaving the attached Ub. In this way the cell can quickly and dynamically react on external signals. The discovery provides the basis for novel therap...
Cleaving in Medical Products

ADAMTS13 Activity & Inhibitor (VWF Cleaving Protease)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Ceralas D15/810 10-Watt 810 nm Diode Laser

Description:...al maintenance or cooling. Like all biolitec lasers, the Ceralas D15/810 comes standard with several accessories, including goggles, handpieces, fiber cleaving and stripping tools, a foot pedal, and a carrying case. 60 watt version also available....
Company:biolitec, Inc.
Cleaving in Medical Dictionary

Pepsin

...to container, generate ... Pepsin is an enzyme produced in the stomach that splits proteins into peptones. ... Pepsin is most effective in cleaving the bonds of phenylalanine, tryptophan, and ... Effect of Pepsin on Laryngeal Stress Protein (Sep70, Sep53, and Hsp70) Response: ... Pepsin -In...
Cleaving in Biological News

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

...haracterized by accumulation and deposition of sticky clumps of A? protein. A? protein is generated from amyloid precursor protein (APP) by ?-site APP cleaving enzyme (BACE1). Previous research has suggested that BACE1 activity may play a key role in the initiation of AD pathogenesis and identified BACE1 as a...

Unicellular microRNA discovery

...,?says Dr. Qi. MicroRNAs (miRNAs) are a class of conserved, approximately 21-nucleotide long RNAs that regulate the expression of genes by either cleaving complementary mRNA targets or repressing their translation. MiRNAs have been identified in both plants and animals, acting as key regulators of multic...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...myloid precursor protein (APP) releasing the toxic beta amyloid fragments that clump together to form the sticky plaques. One of the enzymes doing the cleaving is called beta secretase or BACE1. And although the production of beta amyloid occurs in all brains, healthy brains are able to clear away excess a...

Medical molecules designed to respond to visible light that can penetrate tissue

... with Theralase Technologies Inc. to design molecular systems that use light that is in the therapeutic window. Starting with a complex with known DNA cleaving qualities, they changed the light absorber unit to one that responds to the red wavelength. "Investigations into polyazine supermolecular complexes...
Cleaving in Biological Technology

Sirnaomics Receives SBIR Grant from NIH/NCI for Its Multi-Targeted Lung Cancer siRNA Therapeutics

...y silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene function in basic research, drug discovery and clinical settings...

LI-COR Introduces Three IRDye(R) Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Protease Substrates

...ley. He notes that all three substrates have excellent water solubility. HIV-1 protease performs an essential step in the life cycle of HIV virus by cleaving Gag and Gas-Pol polyproteins into the constituent proteins that make up infectious virus particles. Anti-AIDS drugs targeting HIV-1 protease substanti...

Sirnaomics Receives SBIR Grant from NCI For Its Multi-Targeted Cancer siRNA Therapeutics

...y silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene function in many basic research, drug discovery and clinical set...

A phonon floodgate in monolayer carbon

...he spatial distribution of the electronic states. The Crommie group's experiments used exfoliated graphene, individual flakes made by mechanically cleaving a sheet of atoms from a larger chunk of carbon. The group attached electrodes to both the graphene flake and an underlying substrate consisting of a c...

Sirnaomics and GRL Establish Partnership for the Development of Two Multi-Targeted RNAi Therapeutics Products

...y silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene functions in basic research, drug discovery and clinical setting...

Sirnaomics Received Multiple Government Fundings For Its Multi-Targeted siRNA Therapeutics Programs

...y silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene function in many basic research, drug discovery and clinical set...

Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini

...ic acid) 4 lysine. This cleavage produces fusion proteins that have native amino termini following removal of N-terminal tags by cleaving with EK ( figure 1 ). In the past, the use of EK for fusion protein cleavage was hampered by the generally poor quali...

Restriction Endonucleases Undergo Rigorous QC Testing to Ensure Optimal Performance

...ts might include other site-specific endonucleases that produce unwanted DNA fragments, exonucleases that destroy the integrity of the cut site by cleaving nucleotides from the resultant 5 or 3 termini of the fragments, and phosphatases that inhibit ligation reactions by removing the 5 phospha...
Cleaving in Biological Products

GeneRacer 3' Nested Primer from Invitrogen

Description:...for improved amplification of the full-length 5 end from long and complex mRNA. The RNase H portion of SuperScript II RT has been inactivated to avoid cleaving mRNA during cDNA synthesis. This increases the size and yield of cDNA. SuperScript II RT is more thermostable than wild-type RTS. This enables reverse...
Company:Invitrogen

AcTEV Protease from Invitrogen

Description:...ble than native TEV protease, resulting in long-term activity. AcTEV Protease specifically recognizes a seven amino acid (Glu-Asn-Leu-Tyr-Phe-Gln-Gly, cleaving between Gln and Gly), making it useful for removing affinity tags from fusion proteins (1,2). For proper cleavage, the protein of interest is expresse...
Company:Invitrogen
Cleaving in Biological Definition

Anaphase

...hase-to-anaphase transition. At this point the Anaphase Promoting Complex (APC) becomes activated. This terminates metaphase (M-phase) activity by cleaving and inactivating the M-phase cyclin required for the function of M-phase cyclin dependent kinases (M-Cdks). It also cleaves securin , a protein tha...

Apoptosis

...sic pathways have in common the activation of central effectors of apoptosis , a group of cysteine proteases called caspases , which carry out the cleaving of both structural and functional elements of the cell, resulting in the previously described morphological changes. Biochemical execution Ca...

DNA

...d. The task of unknotting topologically linked strands of DNA falls to enzymes known as topoisomerases . Some of these enzymes unknot circular DNA by cleaving two strands so that another double-stranded segment can pass through. Unknotting is required for the replication of circular DNA as well as for variou...

Proteome

... gel are proteins that have migrated to specific locations. The mass spectrometer has augmented proteomics. Mass mapping identifies a protein by cleaving it into short peptides and then deduces the protein's identity by matching the observed peptide masses against a sequence database . Tandem mass spe...
Cleaving in Biological Dictionary

S1 nuclease

...bstrate is single-stranded, it can also occasionally introduce single-stranded breaks in double-stranded... A nuclease is an enzyme capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids. Older publications may use terms such as "polynucleotidase" or ...

Phosphodiester Bond

...d . ... enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. ... ... ends of RNA and DNA polymers, cleaving the last phosphodiester bond in a chain. ... The endonucleases cleave phosphodiester bonds of DNA or RNA at positions other ... DNA Replica...

Nuclease

... A nuclease is an enzyme capable of cleaving the phosphodiester bonds between the nucleotide ...nucleic ... A nuclease is an enzyme capable of cleaving the ... nuclease general term for enzymes t...hat catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller Nuclease R...

Exonuclease

... Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end of a polynucleotide chain. A hydrolyzing reaction occurs that breaks phosphodiester bonds at either the 3’ or 5...

Concatemer

...process, known under the name of concatemer chain reaction (CCR) [White et al. ... site concatemer , we demonstrated that AP endo was capable of cleaving ... structure written above, while concatemer refers to double ... It is not composed of interlocked circles and may be a long linear concatem...

Blastomeres

...ed into several blastomeres that do not ... Some blastomeres differentiate and form an embryonic epidermis and an ... b Three signal positive cleaving blastomeres in the syncytial mass (arrowhead) ... Contribution of Cells Derived from Dextran-Labeled Blastomeres in Blastocysts ... Cells deriv...
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