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Circadian in Medical News

UNC study supports role of circadian clock in response to chemotherapy

CHAPEL HILL For years, research has hinted that the time of day that cancer patients receive chemotherapy can impact their chances of survival. But the lack of a clear scientific explanation for this finding has kept clinicians from considering timing as a factor in treatment. Now, a new stud...

Don't Disturb Your Circadian Rhythm This Black Friday 'Sleep In, Nap Later,' says Specialty Sleep Association

NEW YORK, Nov. 13 /PRNewswire/ -- Are you one of those shoppers who wake up at 4am on Black Friday? Not this year, stresses the non-profit Specialty Sleep Association (SSA). "It is important not to disturb your circadian rhythm and to maintain your regular sleep schedule," notes Dale Read, P...

New approach sheds light on ways Circadian disruption affects human health

Troy, N.Y. Growing evidence indicates that exposure to irregular patterns of light and darkness can cause the human circadian system to fall out of synchrony with the 24-hour solar day, negatively affecting human health but scientists have been unable to effectively study the relationship betwee...

New research provides dynamic visualization of simplest circadian clock

Scientists have acquired a more dynamic picture of events that underlie the functions of a bacterial biological clock. New research published online March 13th by Cell Press in the journal Molecular Cell, shows how the simplest organism known to have a circadian clock keeps time and may enhance ou...

Practice parameters discuss the evaluation, treatment of circadian rhythm sleep disorders

WESTCHESTER, Ill. Practice parameters published in the November 1 issue of the journal SLEEP are a guide to the appropriate assessment and treatment of circadian rhythm sleep disorders (CRSDs). The standards will have a positive impact on professional behavior, patient outcomes and possibly heal...

Study Reveals Little-known Cell Networks Vital to Circadian Rhythm

Circadian rhythm is the basic 24-hour cycle that involves various behaviors, including sleeping and eating, in all living organisms. In mammals, the circadian clock is organized hierarchically in a series of multiple oscillators. At the top of this hierarchy, the suprachiasmatic nucleus (SCN), a r...

Life Functions Governed by Circadian Rhythms-new Research

In a new study conducted by Colorado State University shows that circadian rhythms dominate all life function. The functions of all the genes in the mammals are according to this daily rhythm. It disproves the prior theory that only 10 to 15% of genes were affected by the natures clock. It was earl...

Researchers Investigate Gene Linked With Circadian Liver Clock

Anyone who has experienced jet lag will understand the importance of a smooth-running circadian clock. Crossing time zones decouples our biological rhythms// from the natural cycle of light and dark we’re used to. We perceive light cues through retinal photoreceptors that relay signals to the supra...

-Contrave(R) Obesity Research Phase 3 Program Meets Co-Primary and Key Secondary Endpoints; Exceeds FDA Efficacy Benchmark for Obesity Treatments-

...o patients, who tended to experience a slight decrease (approximately 2 mm Hg) from baseline. Contrave treatment did not appear to disrupt the normal circadian pattern of blood pressure. There was a slight increase in pulse (approximately 1 beat per minute) in Contrave patients compared to placebo patients, ...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...ake Over Kosan Biosciences II-47 Bristol and PDL BioPharma Enter into Agreement II-47 Gamida Cell Enters Into a Agreement with Amgen II-47 circadian Acquires Complete Stake in Vegenics II-48 Takeda Acquires Millennium Pharmaceuticals II-48 GlaxoSmithKline Forms Alliance with OncoMed for Dev...
Circadian in Medical Technology

Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals' Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet

ROCKVILLE, Md., Dec. 1 /PRNewswire-FirstCall/ -- Vanda Pharmaceuticals Inc. (Nasdaq: VNDA ) reports publication in The Lancet , one of the world's leading medical journals, results of clinical trials of its novel circadian regulator, experimental compound tasimelteon (VEC-162). The publication...

Cephalon Announces Positive Results from a Phase Three Study of NUVIGIL in Jet Lag Disorder

...ns and fatigue. Jet lag disorder is an acute circadian rhythm sleep disorder that results from rapid trav...once a person adjusts to the new local time. circadian rhythm sleep disorders are disruptions in a person...bility to sleep, stay awake and function normally. circadian rhythm sleep disorders can be caused by many facto...

Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia

...weeks. The mechanism of action of tasimelteon as a circadian regulator gives Vanda the opportunity to explore its use for the treatment of circadian rhythm sleep disorders as well as chronic primary ...ic primary insomnia. "These results suggest that circadian misalignment may play an important role in the pat...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...ic but undergoes natural variations which follow a circadian pattern. Highest levels are reached during the mor...diac symptoms. A large study has revealed a marked circadian periodicity in the onset of myocardial infarction ... and plasma that make up the blood. Circadian: a circadian rhythm is a roughly 24-hour cycle in the physiolog...

Phase IIIb Clinical Data Validate the Overall and Cardiovascular Safety Profile of Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) in Patients with Type 2 Diabetes

... decades of preclinical and clinical research have focused on investigating circadian neuroendocrine regulation of metabolism, particularly in relation to metabo... as a single timed (morning) daily dose, Cycloset(TM) is believed to act on circadian neuronal activities within the hypothalamus to reset abnormally elevated hy...
Circadian in Medical Products

Leptin IRMA Test

Description:...n this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short term,...
Company:Diagnostic Systems Laboratories, Inc.

Leptin ELISA Test

Description:...n this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short term,...
Company:Diagnostic Systems Laboratories, Inc.

TSH ELISA Test

Description:...evels occurs with a subsequent rapid decline over several hours [3]. Postnatal secretion of TSH is relatively age- and sex-independent and occurs in a circadian pattern with a nadir in the late afternoon and a peak at approximately midnight. Measurement of serum TSH levels have been used in the diagnostic eval...
Company:Diagnostic Systems Laboratories, Inc.

TSH IRMA Test

Description:...evels occurs with a subsequent rapid decline over several hours [3]. Postnatal secretion of TSH is relatively age- and sex-independent and occurs in a circadian pattern with a nadir in the late afternoon and a peak at approximately midnight. Measurement of serum TSH levels have been used in the diagnostic eval...
Company:Diagnostic Systems Laboratories, Inc.

Cortisol RIA Test

Description:...in urine in an unbound (free) form. Cortisol levels follow a ACTH-dependent circadian rhythm with peak levels in the early morning and a nadir at night. Increased amounts of ACTH and cortisol are also secreted independently of the circadian rhythm in response to physical and psychological stress [4,5]. Elevated cor...
Company:Diagnostic Systems Laboratories, Inc.

Cortisol EIA Kit

Description:... Cortisol is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is secreted with a circadian periodicity, and peaks just prior to waking in the morning. Cortisol is often elevated in major depressive disorder, certain forms of hypertension, st...
Company:Cayman Chemical
Circadian in Medical Definition

Ultradian

...be individual stages of sleep that occur within intervals of an organism's circadian rhythm , and especially to refer to the 90 minute ultradian cycle in human ...ote-on-4-hr-ultradian-cycle.html (Dr. Claudio Stampi is a sleep expert). circadian Rhythms factor in Rapid-Cycling Bipolar Disorder. [4] Barrios C, Chaudh...
Circadian in Medical Dictionary

Circadian

A circadian rhythm is a roughly-24-hour cycle in the biochemical, physiological or behavioral processes of living entities, including plants, animals, fungi and cyanobacteria . The term " circadian ", coined by Franz Halberg,... A circadian rhythm is a roughly-24-hour cycle in the...

Vitamin B12

.... ... Selective impaired absorption of vitamin B12 due to intrinsic factor deficiency. ... Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a ... Recipes, nutrition and food guidelines for healthy eating and ... home > health & living center > nutri...

Urea Cycle

...re shown below. ... Feature article describes urea cycle disorders, their diagnosis, and treatment. ... Hereditary urea cycle abnormality. circadian Rhythm - Definition of ... Urea cycle disorders are a group of inherited conditions of amino acid ... Infants and children with a urea cy...

Sleeping problems

... Learn about a variety of sleep problems including circadian rhythm disorder, insomnia, snoring, sleep apnea, narcolepsy and others. Learn about different sleep problems and the symptoms associated ...

Irregular sleep

...h brain ... Featuring clear descriptions of sleep disorders and treatments, the site also ... Irregular sleep -wake rhythm is one of several circadian rhythm disorders. ... Irregular sleep -wake syndrome - Overview, Irregular sleep -wake syndrome involves different and disorganized per...

Insomnia

...bility Insomnia , Insomnia is the inability to sleep when sleep should normally occur. ... Insomnia may stem from a disruption of the body's circadian rhythm, an internal ... List of 487 disease causes of Insomnia , patient stories, diagnostic guides, medical books excerpts online about Inso...

Hypothalamus

... hypothalamus links the nervous system to the endocrine system via the ... The hypothalamus also controls body temperature, hunger, thirst, and circadian cycles. ... Encyclopedia article about hypothalamus . Information about hypothalamus in the Columbia Encyclopedia, Computer Desktop Encycloped...
Circadian in Biological News

MicroRNAs grease the cell's circadian clockwork

Most of our cells possess an internal clock, a group of genes displaying a cyclic expression pattern that reaches a peak once a day. A large number of circadian genes are expressed by organs such as the liver, whose activity needs to be precisely regulated over the course of the day. A team of res...

Two new studies on circadian rhythms

Hanover, NHDartmouth Medical School geneticists have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities, according to two studies published May 15. Research on the relationship between clocks and temperat...

UNC study: Tinkering with the circadian clock can suppress cancer growth

CHAPEL HILL Researchers at the University of North Carolina at Chapel Hill have shown that disruption of the circadian clock the internal time-keeping mechanism that keeps the body running on a 24-hour cycle can slow the progression of cancer. The study disputes some of the most recent rese...

Research finds that circadian rhythms dominate all life functions

New research from Colorado State University shows that the function of all genes in mammals is based on circadian -- or daily -- rhythms. The study, publishing in PLoS Computational Biology on June 15, refutes the current theory that only 10 percent to 15 percent of all genes were affected by natu...

New fruit fly protein illuminates circadian response to light

Researchers at the University of Pennsylvania School of Medicine have identified a new protein required for the circadian response to light in fruit flies. The discovery of this protein ?named JET ?brings investigators one step closer to understanding the process by which the body's internal clock ...

A resetting signal keeps circadian rhythm on track in Drosophila fruit flies

A Brandeis University study published this week in Nature shows for the first time that a molecular signal maintains coherence among brain clock cells that regulate daily activity of Drosophila melanogaster (fruit flies). The two key groups of neurons control morning and evening activity and are ma...

A novel method to measure circadian cycles

Everyone knows morning people and late-night owls. The variation in individual circadian rhythms is an anecdotal as well as experimentally verified fact. But, until now, to systematically study circadian differences (and thereby hope to rout out the underlying genetic causes), scientists have had ...

Temperature regulates circadian clock in zebrafish

The biological clock controls the circadian rhythms of a wide range of physiological and behavioral processes, from fluctuating hormone levels to sleep-wake cycles and feeding patterns. While it's well known that circadian clock elements sense and respond to light cycles, much less is known about h...

Gene controlling circadian rhythms linked to drug addiction

The gene that regulates the body's main biological clocks also may play a pivotal role in drug addiction, researchers at UT Southwestern Medical Center have found. The Clock gene not only controls the body's circadian rhythms, including sleep and wakefulness, body temperature, hormone levels, bl...

The circadian clock: Understanding nature's timepiece

A cluster of brain cells less than half the size of a pencil eraser tells you when to wake up, when to be hungry and when it's time to go to sleep. The same cells also cause you to be disoriented after you've flown across multiple time zones. The human circadian clock, comprised of about 20,000 ...

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Circadian in Biological Technology

Respironics Acquires Apollo Light Systems, Inc., Expands into Circadian Rhythm Device-Based Therapy Market

MURRYSVILLE, Pa., Oct. 2 /PRNewswire/ - Respironics, Inc. (Nasdaq: RESP) today announced that it has acquired 100% of the outstanding shares of Apollo Light Systems, Inc., a 20-year-old, privately held company and a leading manufacturer of light therapy systems for melatonin suppression and ci...

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

...in adults. Vanda will also present two posters on tasimelteon at APA. Tasimelteon is an investigational compound in development for the treatment of circadian rhythm sleep disorders, including transient insomnia caused by jet lag. The following two posters discussing data from Fanapt(TM) clinical trials...

Vanda Pharmaceuticals Reports First Quarter 2009 Results

...trating its efforts on the design and evaluation of clinical development options for tasimelteon, its compound for sleep and mood disorders, including circadian Rhythm Sleep Disorders. FINANCIAL DETAILS * Operating Expenses. First quarter 2009 R&D expenses of $2.3 million, cons...

Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe

...n allows for the first time the restoration of the circadian rhythms of depressed patients.(1) Valdoxan:...anagement of depression through the restoration of circadian rhythms Valdoxan is the result of an advanc...C antagonist. As a result, Valdoxan resynchronises circadian rhythms that are profoundly disrupted in depressed...

Genetic clock makers at UC San Diego publish their 'timepiece' in Nature

.... "Circadian clocks are hugely complicated. It's hard to know what the essential modules are, but based on our synthetic clock, it looks as though circadian clocks could have easily started as some kind of primitive negative feedback loop, with the positive loop coming later to regularize it," said Hasty. ...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

...lood pressure is not static but undergoes natural variations which follow a circadian pattern. Highest levels are reached during the morning, which then decline ...ood vessels, and the cells and plasma that make up the blood. Circadian: a circadian rhythm is a roughly 24-hour cycle in the physiological processes of living ...

Nitec Pharma Expands Senior Management Team

... and pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is LodotraTM, a circadian cytokine modulator (CCMTM) based on a night time release formulation of prednisone, for the treatment of rheumatoid arthritis (RA) -addressing in part...

Nitec's IND Application for Clinical Development With Lodotra Accepted by the FDA

...and pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is Lodotra(R), a circadian cytokine modulator for the treatment of rheumatoid arthritis (RA). Nitec was originally founded in 2004 as a spin-out of Merck KGaA. The Company is fi...

Nitec Pharma AG Announces Appointments of CEO & CFO in Preparation for Launch of Lodotra(R)

...nd pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is Lodotra (R), a circadian cytokine modulator for the treatment of rheumatoid arthritis (RA). Nitec was originally founded in 2004 as a spin-out of Merck KGaA. The Company is fi...

Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers

...ion, DNA repair and transcription, stress response, neuronal morphogenesis, cell surface receptor modulation, secretion, regulation, long-term memory, circadian rhythms and immune response. 2 Defects in ubiquitinmediated proteolysis are implicated in the pathogenesis of many human diseases, including a variet...
Circadian in Biological Products

NightOWL II LB 983 NC100 from BERTHOLD TECHNOLOGIES GmbH & Co. KG

Description:...ipped with an extreme sensitive camera to detect low level light in animals or plants in tumor research, infectious disease research, gene expression, circadian rhythm or Western blots. NightOWL is the only imager with a motor-driven camera inside the light-tight cabinet. This function allows close-up images o...
Company:BERTHOLD TECHNOLOGIES GmbH & Co. KG

NightOWL II LB 983 NC320 from BERTHOLD TECHNOLOGIES GmbH & Co. KG

Description:... Equipped with a very sensitive camera to detect low level light in animals or plants in tumor research, infectious disease research, gene expression, circadian rhythm, gels and Western blots. NightOWL is the only imager with a motor-driven camera inside the light-tight cabinet. This function allows close-up i...
Company:BERTHOLD TECHNOLOGIES GmbH & Co. KG

Porcine Leptin ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:...n this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short term,...
Company:Diagnostic Systems Laboratories, Inc.
Circadian in Biological Definition

Photobiology

...dy of the effects of light on living organisms . The field encompasses many biological phenomena, including photosynthesis , visual processing , circadian rhythms , and ultraviolet radiation effects. There are numerous professional societies devoted to the study of photobiology, the largest of which ar...
Circadian in Biological Dictionary

Urea cycle

...e or more of the ... Feature article describes urea cycle disorders, their diagnosis, and treatment. ... Hereditary urea cycle abnormality. circadian Rhythm - Definition of ... ...

Photobiology

...ntific study of the interactions of light and living organisms. The field includes the study of photosynthesis, photomorphogenesis, visual processing, circadian rhythms, bioluminescence, and ultraviolet radiation effects. The division between ionizing radiation and nonionizing radiation is typically consider...

Optic lobes

...ranslation of Optic lobe . ... Optic lobe Definition. Find Definitions For Any Word.Get Your Free ... The bilaterally paired optic lobe circadian pacemakers of the cricket Gryllus ... medulla bilateral neurons, connecting the medulla areas of the two optic lobes . ... optic lobes o...

Hypothalamus

...l items. The hypothalamus is a small area at the base of the brain, weighing ... 2 Inputs to the hypothalamus . 3 Homeostatic, allostatic, and circadian control systems ... Hypothalamus . You don't need to be Editor-In-Chief to add or edit content to WikiDoc. ... Review articles on Hypothalamus . ...

Hepatocytes

...ligament. hepatodynia ... Novel in vitro system for primary culture of hepatocytes ... hepatocytes and the desynchronization and damping of circadian rhythm. ... ... liver transplantation, transplanted hepatocytes must proliferate efficiently ... Recently, small hepatocytes and oval cells ...
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(Date:9/18/2014)... millions of Americans to undertake jaunts into the countryside each ... longer within a century, according to new research. , Climate ... the United States as summer temperatures linger later into the ... Ecology and Biogeography . For instance, the paper birch ... New Hampshire could change color one to three weeks ...
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