UNC study supports role of circadian clock in response to chemotherapy
CHAPEL HILL For years, research has hinted that the time of day that cancer patients receive chemotherapy can impact their chances of survival. But the lack of a clear scientific explanation for this finding has kept clinicians from considering timing as a factor in treatment. Now, a new stud...New approach sheds light on ways Circadian disruption affects human health
Troy, N.Y. Growing evidence indicates that exposure to irregular patterns of light and darkness can cause the human circadian system to fall out of synchrony with the 24-hour solar day, negatively affecting human health but scientists have been unable to effectively study the relationship betwee...New research provides dynamic visualization of simplest circadian clock
Scientists have acquired a more dynamic picture of events that underlie the functions of a bacterial biological clock. New research published online March 13th by Cell Press in the journal Molecular Cell, shows how the simplest organism known to have a circadian clock keeps time and may enhance ou...Practice parameters discuss the evaluation, treatment of circadian rhythm sleep disorders
WESTCHESTER, Ill. Practice parameters published in the November 1 issue of the journal SLEEP are a guide to the appropriate assessment and treatment of circadian rhythm sleep disorders (CRSDs). The standards will have a positive impact on professional behavior, patient outcomes and possibly heal...Study Reveals Little-known Cell Networks Vital to Circadian Rhythm
Circadian rhythm is the basic 24-hour cycle that involves various behaviors, including sleeping and eating, in all living organisms. In mammals, the circadian clock is organized hierarchically in a series of multiple oscillators. At the top of this hierarchy, the suprachiasmatic nucleus (SCN), a r...Life Functions Governed by Circadian Rhythms-new Research
In a new study conducted by Colorado State University shows that circadian rhythms dominate all life function. The functions of all the genes in the mammals are according to this daily rhythm. It disproves the prior theory that only 10 to 15% of genes were affected by the natures clock. It was earl...Researchers Investigate Gene Linked With Circadian Liver Clock
Anyone who has experienced jet lag will understand the importance of a smooth-running circadian clock. Crossing time zones decouples our biological rhythms// from the natural cycle of light and dark we’re used to. We perceive light cues through retinal photoreceptors that relay signals to the supra...New Report Just Published: World Multiple Myeloma Therapeutics Market Report
...ake Over Kosan Biosciences II-47 Bristol and PDL BioPharma Enter into Agreement II-47 Gamida Cell Enters Into a Agreement with Amgen II-47 circadian Acquires Complete Stake in Vegenics II-48 Takeda Acquires Millennium Pharmaceuticals II-48 GlaxoSmithKline Forms Alliance with OncoMed for Dev...Cephalon Announces Positive Results from a Phase Three Study of NUVIGIL in Jet Lag Disorder
...ns and fatigue. Jet lag disorder is an acute circadian rhythm sleep disorder that results from rapid trav...once a person adjusts to the new local time. circadian rhythm sleep disorders are disruptions in a person...bility to sleep, stay awake and function normally. circadian rhythm sleep disorders can be caused by many facto...MicroRNAs grease the cell's circadian clockwork
Most of our cells possess an internal clock, a group of genes displaying a cyclic expression pattern that reaches a peak once a day. A large number of circadian genes are expressed by organs such as the liver, whose activity needs to be precisely regulated over the course of the day. A team of res...Two new studies on circadian rhythms
Hanover, NHDartmouth Medical School geneticists have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities, according to two studies published May 15. Research on the relationship between clocks and temperat...UNC study: Tinkering with the circadian clock can suppress cancer growth
CHAPEL HILL Researchers at the University of North Carolina at Chapel Hill have shown that disruption of the circadian clock the internal time-keeping mechanism that keeps the body running on a 24-hour cycle can slow the progression of cancer. The study disputes some of the most recent rese...Research finds that circadian rhythms dominate all life functions
New research from Colorado State University shows that the function of all genes in mammals is based on circadian -- or daily -- rhythms. The study, publishing in PLoS Computational Biology on June 15, refutes the current theory that only 10 percent to 15 percent of all genes were affected by natu...New fruit fly protein illuminates circadian response to light
Researchers at the University of Pennsylvania School of Medicine have identified a new protein required for the circadian response to light in fruit flies. The discovery of this protein ?named JET ?brings investigators one step closer to understanding the process by which the body's internal clock ...A resetting signal keeps circadian rhythm on track in Drosophila fruit flies
A Brandeis University study published this week in Nature shows for the first time that a molecular signal maintains coherence among brain clock cells that regulate daily activity of Drosophila melanogaster (fruit flies). The two key groups of neurons control morning and evening activity and are ma...A novel method to measure circadian cycles
Everyone knows morning people and late-night owls. The variation in individual circadian rhythms is an anecdotal as well as experimentally verified fact. But, until now, to systematically study circadian differences (and thereby hope to rout out the underlying genetic causes), scientists have had ...Temperature regulates circadian clock in zebrafish
The biological clock controls the circadian rhythms of a wide range of physiological and behavioral processes, from fluctuating hormone levels to sleep-wake cycles and feeding patterns. While it's well known that circadian clock elements sense and respond to light cycles, much less is known about h...Gene controlling circadian rhythms linked to drug addiction
The gene that regulates the body's main biological clocks also may play a pivotal role in drug addiction, researchers at UT Southwestern Medical Center have found. The Clock gene not only controls the body's circadian rhythms, including sleep and wakefulness, body temperature, hormone levels, bl...The circadian clock: Understanding nature's timepiece
A cluster of brain cells less than half the size of a pencil eraser tells you when to wake up, when to be hungry and when it's time to go to sleep. The same cells also cause you to be disoriented after you've flown across multiple time zones. The human circadian clock, comprised of about 20,000 ...Vanda Pharmaceuticals Reports First Quarter 2009 Results
...trating its efforts on the design and evaluation of clinical development options for tasimelteon, its compound for sleep and mood disorders, including circadian Rhythm Sleep Disorders. FINANCIAL DETAILS * Operating Expenses. First quarter 2009 R&D expenses of $2.3 million, cons...Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe
...n allows for the first time the restoration of the circadian rhythms of depressed patients.(1) Valdoxan:...anagement of depression through the restoration of circadian rhythms Valdoxan is the result of an advanc...C antagonist. As a result, Valdoxan resynchronises circadian rhythms that are profoundly disrupted in depressed...Genetic clock makers at UC San Diego publish their 'timepiece' in Nature
.... "Circadian clocks are hugely complicated. It's hard to know what the essential modules are, but based on our synthetic clock, it looks as though circadian clocks could have easily started as some kind of primitive negative feedback loop, with the positive loop coming later to regularize it," said Hasty. ...Nitec Pharma Expands Senior Management Team
... and pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is LodotraTM, a circadian cytokine modulator (CCMTM) based on a night time release formulation of prednisone, for the treatment of rheumatoid arthritis (RA) -addressing in part...Nitec's IND Application for Clinical Development With Lodotra Accepted by the FDA
...and pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is Lodotra(R), a circadian cytokine modulator for the treatment of rheumatoid arthritis (RA). Nitec was originally founded in 2004 as a spin-out of Merck KGaA. The Company is fi...Nitec Pharma AG Announces Appointments of CEO & CFO in Preparation for Launch of Lodotra(R)
...nd pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is Lodotra (R), a circadian cytokine modulator for the treatment of rheumatoid arthritis (RA). Nitec was originally founded in 2004 as a spin-out of Merck KGaA. The Company is fi...Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers
...ion, DNA repair and transcription, stress response, neuronal morphogenesis, cell surface receptor modulation, secretion, regulation, long-term memory, circadian rhythms and immune response. 2 Defects in ubiquitinmediated proteolysis are implicated in the pathogenesis of many human diseases, including a variet...NightOWL II LB 983 NC100 from BERTHOLD TECHNOLOGIES GmbH & Co. KG
Description:...ipped with an extreme sensitive camera to detect low level light in animals or plants in tumor research, infectious disease research, gene expression, circadian rhythm or Western blots. NightOWL is the only imager with a motor-driven camera inside the light-tight cabinet. This function allows close-up images o...NightOWL II LB 983 NC320 from BERTHOLD TECHNOLOGIES GmbH & Co. KG
Description:... Equipped with a very sensitive camera to detect low level light in animals or plants in tumor research, infectious disease research, gene expression, circadian rhythm, gels and Western blots. NightOWL is the only imager with a motor-driven camera inside the light-tight cabinet. This function allows close-up i...Porcine Leptin ELISA Kit from Diagnostic Systems Laboratories, Inc.
Description:...n this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short term,...