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Choriomeningitis in Medical News

Transplant drug stimulates immune memory

... an abundance of T cells to fight an infection or respond to a vaccine. Araki had been examining rapamycin's effects in mice infected with lymphocytic choriomeningitis virus (LCMV). "Usually during the response to this virus, 90 percent of the CD8 T cells produced to fight an infection die after a few weeks. The m...

New arenavirus discovered as cause of hemorrhagic fever outbreak in South Africa and Zambia

...etic extracts of blood and liver from the victims and through unbiased high-throughput sequencing, is distantly related to Lassa virus and Lymphocytic choriomeningitis virus (LCMV). Characterization of the novel virus confirms the utility of unbiased high-throughput sequencing for pathogen discovery and provides a b...

Immune exhaustion driven by antigen in chronic viral infection

...cular frame supplied by other cells in the body -- called MHC (major histocompatibility complex) class I molecules. In mice infected by lymphocytic choriomeningitis virus (LCMV), T cells became more or less exhausted depending on how much properly framed viral protein was available. Insights from the research c...

Scientists confirm new virus responsible for deaths of transplant recipients in Australia

...n the organ donor and increasing titer of antibody in a recipient were used to implicate the virus as the cause of disease. The arenavirus lymphocytic choriomeningitis virus (LCMV) has been implicated in a small number of cases of disease transmission by organ transplantation, however, the newly discovered virus, whi...

New Genetic Technology IDs Virus That Killed Transplant Recipients

...ife." A previous transplant mystery, in which seven U.S. recipients died in 2003 and 2005, was eventually solved with identification of lymphocytic choriomeningitis virus (LCMV), which is carried by hamsters and other rodents. The newly identified arenavirus is related to LCMV. The previous identification "took...

JCI table of contents: Nov. 8, 2007

...acking either TNF-alpha or one of its receptors (TNFR1 and TNFR2) were found to mount strong antiviral CD8+ T cell responses targeting the lymphocytic choriomeningitis virus glycoprotein (GP). By contrast, CD8+ T cell responses targeting tumors engineered to express the same GP protein were abrogated in TNF-alphadefi...

Chronic infection persists by targeting stromal cell network in lymphoid organs

... week online in the Proceedings of the National Academy of Sciences. Using a mouse model, the scientists found that a chronic strain of lymphocytic choriomeningitis virus (LCMV) targeted a type of stromal cells in the lymphoid organs called fibroblastic reticular cells (FRC). In contrast, an acute strain of the v...

Unknown Virus Takes the Life of Three Transplant Patients

... few weeks following the transplant of organs from a 57 year old brain dead patient. According to experts, the virus closely resembled the lymphocytic choriomeningitis virus, which caused many transplant patients to die in the United States. Dr Mike Catton from the Victorian Infectious Disease Laboratory, said...

Pregnant Women Can Minimize Risk Of Rodent-Based Virus

... Pregnant women can minimize their risk of becoming infected with lymphocytic choriomeningitis virus (LCMV), an infectious agent carried by house mice// and other rodents that can cause severe brain damage in a fetus. The risk of LCMV tra...
Choriomeningitis in Medical Technology

Vaxiion Researchers Discover Novel Vaccine Delivery System in Collaboration with San Diego State University

..." said Kathleen McGuire, SDSU biology professor and co-author of the paper. In the study, the SDSU team created a vaccine against the lymphocytic choriomeningitis virus (LCMV), which causes a lethal form of meningitis in mice. The minicell vaccine protected 89 percent of immunized mice from death. "Through thi...
Choriomeningitis in Medical Products

Lymphocytic Choriomeningitis (LCM) Antibody by CF, CSF

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Lymphocytic Choriomeningitis (LCM) Antibody by CF

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Choriomeningitis in Biological News

Sticky protein helps reinforce fragile muscle membranes

...stroglycan in binding the membrane and the basal lamina, also may have clinical implications. The team showed that a virus called LCMV (Lymphocytic choriomeningitis virus), which binds tightly to alpha dystroglycan, also disrupts the basal lamina muscle membrane interaction and compromises the integrity of the mus...

Peering inside the skull of a mouse to solve meningitis mystery

...itical experiments that supported the unexpected findings of the study. A Disease Driven by the Immune System The scientists used lymphocytic choriomeningitis virus (LCMV), which is relatively harmless in humans with a healthy immune system. Other viruses that cause meningitis usually are associated with mil...

Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

... rearm T cells while generally reinvigorating them." The researchers made their discoveries in a mouse model of chronic infection with lymphocytic choriomeningitis virus. They had earlier found that a receptor known as programmed death-1 (PD-1) was highly expressed by exhausted T cells from chronically infected m...

Scripps research team sheds light on immune system suppression

... immune response in mice infected with lymphocytic choriomeningitis virus, pointing to potential new avenues for the d... Diego, worked with mice infected with lymphocytic choriomeningitis virus, a model Oldstone describes as a Rosetta Sto...'s findings is that while the initial lymphotcytic choriomeningitis virus effectively blocked interferon production, i...
Choriomeningitis in Biological Dictionary

Lymphocytes

...bility for ... Information about Lymphocytes in the free online English ... Lymphocytes . lymphocytic. lymphocytic choriomeningitis. lymphocytic choriomeningitis virus ... Lymphocytes are formed from lymphoblasts. ... Lymphocytes constitute 25-38% of the total white blood cells (WBCs) ... roughly 101...
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