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Chondrocytes in Medical News

Protein level may serve as predictor of severe osteoarthritis

... VCAM-1 promotes leukocyte adhesion and homing to sites of inflammation. In chondrocytes (cartilage cells), VCAM-1 expression is induced by inflammatory cytokines (...ge or an inflammatory component in OA. Since it mediates the interaction of chondrocytes with immune cells, VCAM-1 may also contribute to immune-mediated cartilage ...

RTI Biologics Sees Expanded Surgeon User Base of Fresh OC Allografts

... undergone fresh osteochondral grafting by me several years before. As he is young and wants to continue an active lifestyle, fresh grafts with living chondrocytes provided the best opportunity for longevity of his knee." Fresh-stored OC allografts provide mature hyaline cartilage with attached bo...

JCI online early table of contents: June 12, 2008

...s that result in dwarfism. TITLE: Phosphorylation of GSK-3-beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes AUTHOR CONTACT: Hiroshi Kawaguchi University of Tokyo, Tokyo, Japan. Phone: 81-33815-5411 ext. 30473; Fax: 81-33818-4082; E-mail: kawaguchi-ort...

Cartilage regeneration '20,000 Leagues Under the Sea'

... study, Elder took small samples of cartilage from calves' knees, dissolved the ECM and isolated the living cartilage cells, or chondrocytes. The calf chondrocytes were used to create tissue-engineered cartilage. The engineered cartilage was placed into a chemical bath of growth factors and sealed inside soft pla...

Study shows pine bark naturally reduces osteoarthritis knee pain

...tory "master-switch" called NF-kappaB. Pycnogenol was shown to lower the sensitivity for NF-kappaB in humans last year. The cytokines released from chondrocytes recruits immune cells (leukocytes) to the joints where they cause more harm than good. Leukocytes release harmful substances such as free radicals an...

Indian radiologist spearheads cure for osteoarthritis sans surgery

...es forced movement of hydrogen protons and stimulates the cartilage called chondrocytes. "The trials have demonstrated that RFQMR stimulates the chondrocytes and initiates the regeneration process, reduces pain and increases mobility of the joints, thus reversing the negative cycle," Vasishta pointed out. ...

Another Potential Of Stem Cells Discovered: Used For Growing Cartilage

...ic and reconstructive surgery. The research, to be published in the journal Tissue Engineering, involved growing human embryonic stem cells with chondrocytes or cartilage cells, in Petri dishes in the laboratory in a specialized system that encouraged them to change into cartilage cells. When this was compa...
Chondrocytes in Medical Technology

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

...bone such as bone marrow, calcified bone and importantly, the growth plate. Our experiments have also shown that GALNS is taken up into human Morquio chondrocytes in vitro and reaches the lysosome to clear keratan sulfate." Chris Hendriksz, M.D., Consultant in Metabolic Disorders, Birmingham Children's Hosp...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

...hESC-derived islets for diabetes, and hESC-derived chondrocytes for arthritis and other orthopedic applications. ...d Dr. Greg Korbutt at the University of Alberta. chondrocytes for Orthopedic Applications Finally, Geron colla...rsity of Edinburgh reported the differentiation of chondrocytes from hESCs for use in the repair of diseased or in...
Chondrocytes in Medical Products

Osteocalcin IRMA Test

Description:...enous bone matrix [1,2,3]. Osteocalcin is synthesized by osteoblasts in bone, with a small amount produced by odontoblasts in dentin, and hypertrophic chondrocytes [1]. During bone formation, newly synthesized osteocalcin is incorporated into the extracellular bone matrix and a small fraction is released into cir...
Company:Diagnostic Systems Laboratories, Inc.

Osteocalcin ELISA Test

Description:...enous bone matrix [1,2,3]. Osteocalcin is synthesized by osteoblasts in bone, with a small amount produced by odontoblasts in dentin, and hypertrophic chondrocytes [1]. During bone formation, newly synthesized osteocalcin is incorporated into the extracellular bone matrix and a small fraction is released into cir...
Company:Diagnostic Systems Laboratories, Inc.
Chondrocytes in Biological News

Adult stem cell breakthrough

... originally devised for treating osteoarthritis by Professor Anthony Hollander at the University of Bristol. The donor trachea was then seeded with chondrocytes on the outside, using a novel bioreactor which incubates cells, developed at the Politecnico di Milano, Italy, allowing them to migrate into the tissu...

Stem cells offer cartilage repair hope for arthritis sufferers

... cells within articular cartilage of adults, which although it cannot become any cell in the body like full stem cells, has the ability to derive into chondrocytes - the cells that make up the bodys cartilage in high enough numbers to make treatment a realistic possibility. The team have even been able to identi...

Leukemic cells find safe haven in bone marrow

...vital nutrient, the researchers reported. Mesenchymal cells give rise to a variety of different tissues, such as osteoblasts (bone-building cells) and chondrocytes (cartilage-building cells), and form the nurturing environment where normal blood cells and leukemic cells grow. "Leukemic cells that resist as...

Cellular traffic backups implicated in skeletal malformations

...cells that form the fish's cartilaginous skeleton. chondrocytes secrete proteins like collagen into the extracellu...e gene is supposedly active in all cells, just why chondrocytes are the only cell type affected by the mutation re...mains unclear. "The fact that it affects only chondrocytes is very strange," Knapik said. One possibilit...

Scientists use stem cells to grow cartilage

...artilage it may be possible to avoid the need for a joint replacement for some time." The research involved growing human embryonic stem cells with chondrocytes or cartilage cells, in Petri dishes in the laboratory in a specialised system that encouraged them to change into cartilage cells. When this was compa...
Chondrocytes in Biological Technology

ArunA Biomedical Announces Commercial Release of its Human Embryonic Stem Cell Derived Mesenchymal Cells

... Unlike human bone marrow and other tissue derived mesenchymal cells, ArunA's hMC cells have the unique ability to differentiate into osteoblasts and chondrocytes but not adipocytes, making them a unique tool for research and drug discovery directed at areas such as Osteoporosis." The CELL-EZ hMC(TM) cell l...

ISTO Technologies to Present at OneMedPlace Emerging Company Finance Conference

...ncludes DeNovo(R) ET, engineered cartilage to repair and restore joint function in the knee, NuQu(TM), a cell-based injectable formulation of juvenile chondrocytes for nucleus regeneration of the spinal disc and InQu(R), an osteobiologic bone graft Substitute and extender. About ISTO ISTO Technolog...

Positive Preclinical Data on Cell Therapy for Spinal Disc Repair Presented at 23rd Annual Meeting of the North American Spine Society

... treatment of degenerative intervertebral disc. In these pre-clinical studies, the disc nucleus from adult pigs was removed and replaced with juvenile chondrocytes in a protein gel carrier. "We are encouraged by the results of the UCSF preclinical studies and we believe ISTO's cell-based therapy may offer a bre...

Frost & Sullivan Acknowledges ISTO Technologies' Role in Developing Advanced Biologic Products for Bone Healing

...pipeline includes NuQu(TM), a cell-based injectable formulation of juvenile chondrocytes for nucleus regeneration of the spinal disc," notes Ishwarakrishnan. "In ad...tion in the knee, NuQu(TM), a cell-based injectable formulation of juvenile chondrocytes for nucleus regeneration of the spinal disc and InQu(R), an osteobiologic b...

ISTO Technologies Granted Key Patent for Cartilage Cell Expansion by the United States Patent Office

...n vitro, and can no longer produce functional cartilage tissue. To circumvent this problem, ISTO's scientific team has developed a process for growing chondrocytes without the loss of phenotype, thereby providing a commercially viable number of cartilage cells for clinical applications. "This is a significant pa...

Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples

...sed in and secreted from malignant melanomas and chondrocytes [2, 3]. As MIA expression in chondrocytes is dep... Cell culture Human primary chondrocytes derived from articular cartilage were cultivated...2 at 37 C, then split 1:2 at 80 % confluency. As chondrocytes spontaneously dedifferentiate in cell culture, r...

Roche Diagnostics Corporation

...arations Tools for Proteomic Science II Quantitation of the Protein MIA as a Marker for chondrocytes in Research Samples A Further Step in Understanding Apoptosis Direct Detection of PARP Cleavage Det...
Chondrocytes in Biological Products

CnC (Cn402-05) from European Collection of Cell Cultures (ECACC)

Description:... Canine chondrocytes (CnC) (500,000 cells)...
Company:European Collection of Cell Cultures (ECACC)
Chondrocytes in Biological Definition

Cartilage

...ve tissue . Cartilage is composed of cells called chondrocytes which are dispersed in a firm gel-like ground sub...ed of cells , fibers and a matrix. Cells chondrocytes are the only cells found in cartilage. They are r...the matrix. The matrix immediately surrounding the chondrocytes is referred to as the territorial matrix and sta...
Chondrocytes in Biological Dictionary

Cartilage

... existing within many joints. It is composed of specialized cells called chondrocytes that produce a large amount of extracellular matrix composed of collagen ...lieve the pain and inflammation of ... Cartilage is composed of cells, chondrocytes (2-5% of the tissue volume only) ... Cartilage is an avascular tissue ...
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