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Cholinesterase in Medical News

DEET in Bug Spray Tied to Neural Damage in Mice

...arch institutions in France, say this is the first time a molecular target for DEET has been identified. Interestingly, the class of drugs known as cholinesterase inhibitors are used to treat Alzheimer's and can delay the decline of symptoms for up to a year. Sanberg said the effects of DEET, like many chemic...

A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits

...ng about risk of dementia (63%). Most respondents (70%) prescribe cholinesterase inhibitors at least sometimes for this population, with memantine (39%) and "other" agents (e.g., vitamin E, gingko) prescribed less frequently. cholinesterase inhibitors and memantine are FDA-approved drugs for Alzheimer's. Relatively...

Dementia drugs may put some patients at risk, Queen's study shows

...'s University Geriatrics professor Sudeep Gill. cholinesterase inhibitors (Aricept, Exelon and Reminyl) are often...and his colleagues discovered that people who used cholinesterase inhibitors were hospitalized for fainting almost t...wed heart-rate was 69 per cent more common amongst cholinesterase inhibitor users. In addition, people taking the de...

Drug combinations key in treating neurodegenerative diseases

...roTherapeutics. Alzheimer's treatment, for instance, should combine molecules that protect neurons from plaque buildup with approved therapies like cholinesterase inhibitors, which treat cognition and memory loss, Dr. Buccafusco says. Dr. Buccafusco also cited several novel drug candidates developed at the M...

Alzheimer's Drugs Also Treat Behavioral, Psych Problems

...s that examined the effectiveness of three popular cholinesterase inhibitors in managing Alzheimer's patients' behav...tients have behavioral and psychological symptoms. cholinesterase inhibitors boost levels of a brain chemical called...es we analyzed are encouraging and suggestive that cholinesterase inhibitors are safe and effective alternatives," r...

Toxic Chemicals Blamed for Gulf War Illness

... causes," she said. One is a drug called pyridostigmine bromide, which is a cholinesterase inhibitor that was given to the troops to protect them against nerve gas. ...llness." In addition, soldiers were exposed to pesticides that were also cholinesterase inhibitors, Steele said. "The strongest evidence points to pyridostigmine b...

New Data Highlights Positive Results of Namenda (Memantine HCl) Once-Daily Extended-Release Formulation

...e Alzheimer's disease already being treated with a cholinesterase inhibitor (donepezil, galantamine or rivastigmine)..., such as combination therapy with memantine and a cholinesterase inhibitor, which can alleviate symptoms by providi...ntrolled trial of 677 outpatients already taking a cholinesterase inhibitor was conducted in multiple centers in the...

RNA engineering to combat series of illnesses wins Kaye Award for Hebrew University dean

... succeeded in manipulating the RNA that translates cholinesterase genes from DNA into the cholinesterase proteins that control body-to-brain and brain-to b...n. Prof. Soreq's invention of engineered human cholinesterase and RNA-targeted agents to suppress its functionin...

Adding Light Eases Behavioral Problems of Dementia

...ognition, but also include strong effects on mood and functional limitations in activities of daily living." The benefits may even surpass those of cholinesterase inhibitors such as Aricept, which are commonly prescribed to limit cognitive decline in Alzheimer's patients, the authors stated. Not only do indiv...

Cardiovascular Meds May Be Beneficial in Alzheimer's Disease, According to MedPredict Report

...s panel addresses other therapies in development for symptomatic benefit in Alzheimer's, aimed at improving cognition and physical symptoms, including cholinesterase inhibitors, NMDA antagonists, dimebolin, alpha-7 nicotinic acetylcholine agonists, and others. Companies mentioned in this report: GE Healthcare, Av...
Cholinesterase in Medical Technology

deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders

...rently are a mainstay of therapy for memory loss in early Alzheimer's disease, yet also benefiting long term memory function in animal tests where the cholinesterase inhibitors are ineffective. deCODE has developed a broad proprietary platform for PDE4 modulators that the company is applying to discover compounds...

Xalieve(TM) Gains Momentum as Calabar AB Launches a Phase II Repeated Dose Study in Dry Mouth Patients

... succeeding Phase III efficacy study. Xalieve(TM) is a gel containing the cholinesterase inhibitor physostigmine. It is administered locally in the mouth where phys... company's product Xalieve(TM) is a locally administered formulation of the cholinesterase inhibitor physostigmine, which has been shown to effectively increase saliv...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

...on of free VX in the blood. At 7.5 hours the cholinesterase activity of the plasma was approximately 27 fold greater than control. Additionally, brain cholinesterase levels were similar to previously published data from untreated controls suggesting that non-pegylated rBChE prevented the inhibition of these tissues...

Calabar AB Today Announced New Financing for Continuation of the Phase II Program in Patients With Dry Mouth

... "Dry mouth is affecting millions of people every day and there is a great unmet need for new drugs in this area." The active drug, physostigmine, a cholinesterase inhibitor, targets the minor salivary glands with a direct local action, inducing a more lubricating saliva. In previous phase II studies with single ...

Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease

...h.D., Associate Professor at the Karolinska Institutet in Sweden. "All of the approved Alzheimer's disease drugs operate by one of two mechanisms -- cholinesterase inhibition or NMDA-receptor antagonism," noted Bengt Winblad, M.D., Ph.D., Head of the Karolinska Institutet's Alzheimer's Disease Research Center. "T...

New Data Highlight Positive Results of Namenda(R) (memantine HCl) Once-Daily Extended-Release Formulation

...e Alzheimer's disease already being treated with a cholinesterase inhibitor (donepezil, galantamine or rivastigmine)..., such as combination therapy with memantine and a cholinesterase inhibitor, which can alleviate symptoms by providi...ntrolled trial of 677 outpatients already taking a cholinesterase inhibitor was conducted in multiple centers in the...

Memory Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Financial Results

...pulation, due primarily to an unusually large placebo response in the subgroup of monotherapy subjects. In the subgroup of subjects receiving cholinesterase inhibitors, the change in ADAS-cog favored treatment over placebo and numeric improvements were seen in all of the four secondary endpoints. ...

Memory Pharmaceuticals Announces Results for Phase 2a Trial of MEM 1003 in Alzheimer's Disease

...notherapy subjects and subjects on stable doses of cholinesterase inhibitors. The trial failed to meet its primary e...py subjects. In the subgroup of subjects receiving cholinesterase inhibitors, the change in ADAS-cog favored treatme...e trend seen in the subgroup of subjects receiving cholinesterase inhibitors," said Stephen R. Murray, M.D., Ph.D., ...

Medivation Announces Presentation of Full Top-Line Data From Dimebon Six-Month Trial at Major International Alzheimer's Disease Conference

...well tolerated in this study, with less than three percent incidence of the gastrointestinal side effects that sometimes limit utilization of approved cholinesterase inhibitor drugs. Based on these data, I look forward to participating in the planned Phase 3 trials of this promising drug candidate." The study of ...

Medivation Announces Presentation of New Subset Analyses From Dimebon Phase 2 Alzheimer's Disease Trial at American Academy of Neurology Annual Meeting

... year ended December 31, 2006, include more information about factors that could affect the Company's financial and operating results. (1) Birks, J. cholinesterase inhibitors for Alzheimer's disease. Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD005593. CONTACT: Patrick Machado, Chief Finan...
Cholinesterase in Biological News

Queen's develops safe 'green' decontamination method

...sult seen in our testing of this method over the past five years. Phosphorus-based chemical weapons, pesticides and related compounds act as acetyl cholinesterase inhibitors, meaning they block nerve impulses, leading to paralysis, respiratory failure and eventually death. The Queens scientists invented mild...

Computer-based 'games' enhance mental function in patients with Alzheimer's

...for community-dwelling persons with dementia in Barcelona, enrolled 46 people who were diagnosed with Alzheimer's disease. All were being treated with cholinesterase inhibitors, the most common pharmacological treatment for Alzheimer's, for at least one year prior to enrolling in the study; all participants remaine...

Natural compound from 'pond scum' shows potential activity against Alzheimer's

...re is no cure for Alzheimer's at present, although cholinesterase inhibitors have shown promise for delaying or prev...tocarboline, was shown to be a potent inhibitor of cholinesterase -- a brain chemical thought to be important for me...ompound's potency is comparable to galanthamine, a cholinesterase inhibitor already approved for the treatment of Al...
Cholinesterase in Biological Technology

Medivation Presents New Data on Dimebon's Novel Mechanism of Action

...rugs that focus on targets implicated in cognition and memory loss, such as cholinesterase inhibition. In these experiments, Dimebon was shown to be a weak cholinesterase inhibitor, and additional data from binding assays showed that Dimebon did ...

New Report Provides Expert Analysis of Recent Advances and Setbacks in Parkinson's Disease Drug Development

... -- Dopamine agonists, monoamine oxidase inhibitors; -- Levodopa formulations, COMT inhibitors; and -- Adenosine A2A receptor antagonists, cholinesterase inhibitors, AMPA, 5-HT, anticonvulsants, antihypertensives, farnesyl transferase inhibitors. Companies mentioned in this repor...

Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update

... new Phase 3 studies in 2009 to seek further differentiation of Dimebon to include moderate-to-severe Alzheimer's disease, adjunctive use with cholinesterase inhibitors, and twelve-month efficacy. -- Received a Corporate Achievement Award from the Huntington's Disease Society of America (HDSA) for...

Forest Laboratories, Inc. Announces Positive Results of Memantine Study of Once-Daily Formulation

...tients with moderate to severe Alzheimer's disease currently treated with a cholinesterase inhibitor. The results indicate that patients treated with memantine 28 mg ...domized, double-blind, placebo-controlled trial of 677 outpatients taking a cholinesterase inhibitor was conducted in multiple centers in Argentina, Chile, Mexico, an...

Amarin Signs Agreement to Acquire Ester Neurosciences

...needed for breathing, a condition called myasthenic crisis. MG occurs in all races, both genders, and at all ages. Existing therapies for MG include cholinesterase inhibitors, immunosuppressants and corticosteroids, plasma exchange and intravenous immune globulin and surgical treatment (thymectomy). Cholinesteras...
Cholinesterase in Biological Definition

Enzyme

... bacteria that produce beta-lactamase resistant Catalase : converts hydrogen peroxide to oxygen and water Chitinase : breaks down chitin cholinesterase Chymosin : better known as rennet, contained in the stomachs of many animals and causes milk to curdle Chymotrypsin : can digest proteins ...
Cholinesterase in Biological Dictionary

Synapton

...s also being ... Advertisement. Home Page > News & Publications > Journals > ... Physostigmine ( Synapton )* Phase 3 trials completed. cholinesterase inhibitor. Xanomeline ... Prescription drugs starting with the letter S. Discuss one ... Synapton Physostigmine. New Discussion. Synarel Nafareli...
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