DEET in Bug Spray Tied to Neural Damage in Mice
...arch institutions in France, say this is the first time a molecular target for DEET has been identified.
Interestingly, the class of drugs known as cholinesterase
inhibitors are used to treat Alzheimer's and can delay the decline of symptoms for up to a year.
Sanberg said the effects of DEET, like many chemic...
A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits
...ng about risk of dementia (63%).
Most respondents (70%) prescribe cholinesterase
inhibitors at least sometimes for this population, with memantine (39%) and "other" agents (e.g., vitamin E, gingko) prescribed less frequently. cholinesterase
inhibitors and memantine are FDA-approved drugs for Alzheimer's. Relatively...
Dementia drugs may put some patients at risk, Queen's study shows
...'s University Geriatrics professor Sudeep Gill.
inhibitors (Aricept, Exelon and Reminyl) are often...and his colleagues discovered that people who used cholinesterase
inhibitors were hospitalized for fainting almost t...wed heart-rate was 69 per cent more common amongst cholinesterase
inhibitor users. In addition, people taking the de...
Drug combinations key in treating neurodegenerative diseases
Alzheimer's treatment, for instance, should combine molecules that protect neurons from plaque buildup with approved therapies like cholinesterase
inhibitors, which treat cognition and memory loss, Dr. Buccafusco says.
Dr. Buccafusco also cited several novel drug candidates developed at the M...
Alzheimer's Drugs Also Treat Behavioral, Psych Problems
...s that examined the effectiveness of three popular cholinesterase
inhibitors in managing Alzheimer's patients' behav...tients have behavioral and psychological symptoms. cholinesterase
inhibitors boost levels of a brain chemical called...es we analyzed are encouraging and suggestive that cholinesterase
inhibitors are safe and effective alternatives," r...
Toxic Chemicals Blamed for Gulf War Illness
... causes," she said. One is a drug called pyridostigmine bromide, which is a cholinesterase
inhibitor that was given to the troops to protect them against nerve gas.
In addition, soldiers were exposed to pesticides that were also cholinesterase
inhibitors, Steele said. "The strongest evidence points to pyridostigmine b...
New Data Highlights Positive Results of Namenda (Memantine HCl) Once-Daily Extended-Release Formulation
...e Alzheimer's disease already being treated with a cholinesterase
inhibitor (donepezil, galantamine or rivastigmine)..., such as combination therapy with memantine and a cholinesterase
inhibitor, which can alleviate symptoms by providi...ntrolled trial of 677 outpatients already taking a cholinesterase
inhibitor was conducted in multiple centers in the...
RNA engineering to combat series of illnesses wins Kaye Award for Hebrew University dean
... succeeded in manipulating the RNA that translates cholinesterase
genes from DNA into the cholinesterase
proteins that control body-to-brain and brain-to b...n.
Prof. Soreq's invention of engineered human cholinesterase
and RNA-targeted agents to suppress its functionin...
Adding Light Eases Behavioral Problems of Dementia
...ognition, but also include strong effects on mood and functional limitations in activities of daily living."
The benefits may even surpass those of cholinesterase
inhibitors such as Aricept, which are commonly prescribed to limit cognitive decline in Alzheimer's patients, the authors stated.
Not only do indiv...
Cardiovascular Meds May Be Beneficial in Alzheimer's Disease, According to MedPredict Report
...s panel addresses other therapies in development for
symptomatic benefit in Alzheimer's, aimed at improving cognition and
physical symptoms, including cholinesterase
inhibitors, NMDA antagonists,
dimebolin, alpha-7 nicotinic acetylcholine agonists, and others.
Companies mentioned in this report: GE Healthcare, Av...
Cholinesterase in Medical Technology
deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders
...rently are a mainstay of therapy for
memory loss in early Alzheimer's disease, yet also benefiting long term
memory function in animal tests where the cholinesterase
deCODE has developed a broad proprietary platform for PDE4 modulators
that the company is applying to discover compounds...
Xalieve(TM) Gains Momentum as Calabar AB Launches a Phase II Repeated Dose Study in Dry Mouth Patients
... succeeding Phase III efficacy
Xalieve(TM) is a gel containing the cholinesterase
physostigmine. It is administered locally in the mouth where phys... company's product Xalieve(TM) is a locally
administered formulation of the cholinesterase
which has been shown to effectively increase saliv...
PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop
...on of free VX in the blood. At 7.5 hours the cholinesterase
activity of the plasma was approximately 27 fold greater than control.
Additionally, brain cholinesterase
levels were similar to previously
published data from untreated controls suggesting that non-pegylated rBChE
prevented the inhibition of these tissues...
Calabar AB Today Announced New Financing for Continuation of the Phase II Program in Patients With Dry Mouth
... "Dry mouth is
affecting millions of people every day and there is a great unmet need for
new drugs in this area."
The active drug, physostigmine, a cholinesterase
inhibitor, targets the
minor salivary glands with a direct local action, inducing a more
lubricating saliva. In previous phase II studies with single ...
Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease
...h.D., Associate Professor at the Karolinska Institutet in
"All of the approved Alzheimer's disease drugs operate by one of two
mechanisms -- cholinesterase
inhibition or NMDA-receptor antagonism," noted
Bengt Winblad, M.D., Ph.D., Head of the Karolinska Institutet's Alzheimer's
Disease Research Center. "T...
New Data Highlight Positive Results of Namenda(R) (memantine HCl) Once-Daily Extended-Release Formulation
Alzheimer's disease already being treated with a cholinesterase
(donepezil, galantamine or rivastigmine)..., such as
combination therapy with memantine and a cholinesterase
can alleviate symptoms by providi...ntrolled trial of 677 outpatients
already taking a cholinesterase
inhibitor was conducted in multiple centers
Memory Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Financial Results
...pulation, due primarily to an unusually large placebo response in the subgroup of monotherapy subjects. In the subgroup of subjects receiving cholinesterase
inhibitors, the change in ADAS-cog favored treatment over placebo and numeric improvements were seen in all of the four secondary endpoints. ...
Memory Pharmaceuticals Announces Results for Phase 2a Trial of MEM 1003 in Alzheimer's Disease
subjects and subjects on stable doses of cholinesterase
trial failed to meet its primary e...py subjects. In the subgroup of
subjects receiving cholinesterase
inhibitors, the change in ADAS-cog
favored treatme...e trend seen in the subgroup of
subjects receiving cholinesterase
inhibitors," said Stephen R. Murray,
M.D., Ph.D., ...
Medivation Announces Presentation of Full Top-Line Data From
Dimebon Six-Month Trial at Major International Alzheimer's Disease
tolerated in this study, with less than three percent incidence of
the gastrointestinal side effects that sometimes limit utilization
of approved cholinesterase
inhibitor drugs. Based on these data, I
look forward to participating in the planned Phase 3 trials of this
promising drug candidate."
The study of ...
Medivation Announces Presentation of New Subset Analyses From
Dimebon Phase 2 Alzheimer's Disease Trial at American Academy of
Neurology Annual Meeting
... year ended December 31, 2006, include more information
about factors that could affect the Company's financial and
(1) Birks, J. cholinesterase
inhibitors for Alzheimer's disease.
Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.:
CONTACT: Patrick Machado, Chief Finan...
Cholinesterase in Biological News
Queen's develops safe 'green' decontamination method
...sult seen in our testing of this method over the past five years.
Phosphorus-based chemical weapons, pesticides and related compounds act as acetyl cholinesterase
inhibitors, meaning they block nerve impulses, leading to paralysis, respiratory failure and eventually death.
The Queens scientists invented mild...
Computer-based 'games' enhance mental function in patients with Alzheimer's
...for community-dwelling persons with dementia in Barcelona, enrolled 46 people who were diagnosed with Alzheimer's disease. All were being treated with cholinesterase
inhibitors, the most common pharmacological treatment for Alzheimer's, for at least one year prior to enrolling in the study; all participants remaine...
Natural compound from 'pond scum' shows potential activity against Alzheimer's
...re is no cure for Alzheimer's at present, although cholinesterase
inhibitors have shown promise for delaying or prev...tocarboline, was shown to be a potent inhibitor of cholinesterase
-- a brain chemical thought to be important for me...ompound's potency is comparable to galanthamine, a cholinesterase
inhibitor already approved for the treatment of Al...
Cholinesterase in Biological Technology
Medivation Presents New Data on Dimebon's Novel Mechanism of Action
...rugs that focus on targets
implicated in cognition and memory loss, such as cholinesterase
these experiments, Dimebon was shown to be a weak cholinesterase
and additional data from binding assays showed that Dimebon did ...
New Report Provides Expert Analysis of Recent Advances and Setbacks in Parkinson's Disease Drug Development
-- Dopamine agonists, monoamine oxidase inhibitors;
-- Levodopa formulations, COMT inhibitors; and
-- Adenosine A2A receptor antagonists, cholinesterase
5-HT, anticonvulsants, antihypertensives, farnesyl transferase
Companies mentioned in this repor...
Medivation Reports Third Quarter 2008 Financial Results and Provides Corporate Update
... new Phase 3 studies in 2009 to seek further differentiation of Dimebon to include moderate-to-severe Alzheimer's disease, adjunctive use with cholinesterase
inhibitors, and twelve-month efficacy.
-- Received a Corporate Achievement Award from the Huntington's Disease Society of America (HDSA) for...
Forest Laboratories, Inc. Announces Positive Results of Memantine Study of Once-Daily Formulation
...tients with moderate to severe Alzheimer's disease currently treated
with a cholinesterase
inhibitor. The results indicate that patients treated
with memantine 28 mg ...domized, double-blind, placebo-controlled trial of 677 outpatients
taking a cholinesterase
inhibitor was conducted in multiple centers in
Argentina, Chile, Mexico, an...
Amarin Signs Agreement to Acquire Ester Neurosciences
...needed for breathing, a condition called myasthenic crisis. MG
occurs in all races, both genders, and at all ages.
Existing therapies for MG include cholinesterase
immunosuppressants and corticosteroids, plasma exchange and intravenous
immune globulin and surgical treatment (thymectomy). Cholinesteras...
Cholinesterase in Biological Definition
... bacteria that produce beta-lactamase resistant
Catalase : converts hydrogen peroxide to oxygen and water
Chitinase : breaks down chitin
Chymosin : better known as rennet, contained in the stomachs of many animals and causes milk to curdle
Chymotrypsin : can digest proteins
Cholinesterase in Biological Dictionary
...s also being ... Advertisement. Home Page > News & Publications > Journals > ... Physostigmine ( Synapton )* Phase 3 trials completed. cholinesterase
inhibitor. Xanomeline ... Prescription drugs starting with the letter S. Discuss one ... Synapton Physostigmine. New Discussion. Synarel Nafareli...