Chloroquine

Discovery of variations in resistance to sulfadoxine across Africa

...mostly in sub-Saharan Africa. Until recently, treatment in Africa relied on chloroquine and sulfadoxine-pyrimethamine. Unfortunately, parasites have developed resi... Scientists have discovered that the mutations that caused resistance to chloroquine and pyrimethamine originated in Asia and spread into Africa in the late 197...

Drug blocks two of world's deadliest emerging viruses

...f infection by Hendra and Nipah. "The fact that chloroquine is safe and widely used in humans means that it ma...terfere with its development at various stages. chloroquine does not prevent Hendra or Nipah virus from entering the cell. Instead, the chloroquine molecule appears to block the action of a key enzy...

Drug blocks 2 of world's deadliest emerging viruses

...f infection by Hendra and Nipah. "The fact that chloroquine is safe and widely used in humans means that it ma...terfere with its development at various stages. chloroquine does not prevent Hendra or Nipah virus from entering the cell. Instead, the chloroquine molecule appears to block the action of a key enzy...

Study: Delaying evolution of drug resistance in malaria parasite possible

...novel and highly effective anti-malarials that can be plugged into the recommended strategy of deploying multiple therapies." In the past century, chloroquine and sulfadoxine-pyrimethamine were widely used to combat malaria, but the parasites eventually evolved resistance leading to the drugs' failure. Artem...

Discovery of key malaria proteins could mean sticky end for parasite

... treated using drugs that kill the parasites. However, as the parasites evolve, they have become increasingly resistant to existing treatments such as chloroquine and mefloquine, and there is some evidence of increasing resistance against even the most effect and newest treatments, artemisinin derivatives such a...

International health experts to enlist the public in war on African malaria

... first-line malaria treatment in the many African countries where drug-resistant strains of the disease have dramatically reduced the effectiveness of chloroquine and sulfadoxine / pyrimethane. Tanzania is one of the countries where ACT (artemisinin in combination with artemether-lumefantrine) has had excelle...

Malaria Drug Promising Against Cancer

... 60-year-old drug chloroquine eliminated certain malignancies in mice, researche...althDay News) -- A common anti-malaria drug called chloroquine can also prevent the development of certain types ...he January print edition. "Our study shows that chloroquine inhibits the final steps of a pathway that is requ...

You can teach an old dog new tricks: anti-malarial prevents cancer in mice

...Jupiter, have indicated that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two...gy study suggesting that malarial prophylaxis with chloroquine diminished the incidence of Burkitt lymphoma. In the study, chloroquine was shown to inhibit the development of Myc-induce...

JCI table of contents: Dec. 20, 2007

...Jupiter, have indicated that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two...gy study suggesting that malarial prophylaxis with chloroquine diminished the incidence of Burkitt lymphoma. In the study, chloroquine was shown to inhibit the development of Myc-induce...

JCI table of contents: Oct. 18, 2007

...terium Pseudomonas aeruginosa, infection with which is a major complication for individuals with CF. This study provides strong support for the use of chloroquine (which counteracts high levels of TGN acidity) to treat CF, something that is currently being tested in clinical trials, and identifies furin inhibito...

Chloroquine in Biological News

New papers offer insights into process of malarial drug resistance

...the Thailand/Cambodian border multiple drug-resistant strains of the disease are becoming commonplace. With the previously mainstay antimalarial drug chloroquine nearly ineffective due to drug resistance and traditional public health approaches such as mosquito netting offering uneven results, two new papers by...

Breast cancer cells recycle to escape death by hormonal therapy

...ing center of the reorganized cell gets acidic and chloroquine increases pH. "If you add this particular inhibito...2007 in The Journal of Clinical Investigation that chloroquine increased death of suicide-resistant lymphoma cell...reated with chemotherapy. Dr. Schoenlein will give chloroquine along with an antiestrogen and measure cell death....

New way to make malaria medicine also first step in finding new antibiotics

...'s population is at risk of malaria, and an estimated 247 million cases led to nearly 881,000 deaths in 2006." Resistance to classic drugs such as chloroquine and sulphadoxine-pyrimethamine is on the rise, and mosquitoes also are developing resistance to insecticides. "In my opinion malaria is the bigge...

American Society for Microbiology honors Thomas E. Wellems

...e that was very successful in the 1950s, has dramatically increased death rates from malaria in Africa and Asia. Dr. Wellems was able to identify the chloroquine transporter and develop a diagnostic test, which has made serious impacts on malaria treatment. Among other important findings, Wellems has published...

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

...e Pacific than from all enemy fire, Roepe said. The Germans first invented chloroquine (CQ), a synthetic version of quinine, which quickly became the treatment of...when it is growing inside the red cell. These changes affect how drugs like chloroquine enter the parasite, and how efficiently they bind to pre-crystalline heme. ...

Reducing malarial transmission in Africa

...occur in Africa, mostly in young children. One of the greatest challenges facing Africa in the fight against malaria is drug resistance; resistance to chloroquine (CQ), the cheapest and most widely used antimalarial, is common throughout Africa, and resistance to sulfadoxine-pyrimethamine (SP), the first-develop...

Chloroquine in Biological Definition

Malaria

...n the prophylactic of choice for malaria. The development of quinacrine , chloroquine , and primaquine in the 20th century reduced the reliance on quinine. ...ns. Certain strains of Plasmodium have recently developed resistance to chloroquine which has been the first line of treatment in many countries, thus complica...