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Chimeric in Medical News

Engineering chimeric polypeptides to illuminate cellular redox states

UIUC interdisciplinary team reports the design of chimeric polypeptides leading to development of noninvasive biosensors for potential application in biomedical research. Reduction/oxidation (redox) systems research is reaching a stage where domains that traditionally belonged to the physical s...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...ions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corporation is developing products that empower immune defens...

Immune Therapy May Aid Kids With Neuroblastoma

... of California, San Diego, and the school's Moores Cancer Center, said in a news release from the society. The new immune-based treatment -- called chimeric anti-GD2 antibody ch14.18 -- targets a key sugar-and-fat molecule lying on neuroblastoma cells called GD2. Left alone, the molecule inhibits the immun...

Nile Therapeutics Reports 2009 First Quarter Financial Results

...ase and other areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. A key component of the com...

Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009

...hat all three will be presented at this year's meeting" explained Bryan Leigh, MD, Chief Medical Officer at Tracon Pharmaceuticals. TRC105 is a chimeric IgG1 monoclonal antibody that binds CD105, a membrane receptor required for angiogenesis. By inhibiting new blood vessel formation, the antibody is e...

Device aims to decrease wait period for patients needing immunotherapy

...mulation and then genetically transferring desired messenger RNA (mRNA) into the T cells. The mRNA, once inside the T cells, produces a protein called chimeric antigen receptor (CAR), which allows the T cells to recognize and specifically kill tumor cells. The HitMeD device carries out this entire process. On...

Nile Therapeutics to Present at the 2009 BIO CEO & Investor Conference

...ease and other areas of unmet medical need. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile c...

Nile Therapeutics to Present at the 27th Annual J.P. Morgan Healthcare Conference

...and its clinical development programs for its lead compound, CD-NP, a novel chimeric peptide for the treatment of acute heart failure. About Nile Therapeut...efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure; 2NTX-99, a ...

CEL-SCI Launches Study to Determine Long Lasting Beneficial Effects of its Rheumatoid Arthritis Vaccine

...ctor T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). Therefore, it would appear that the L.E.A.P.S. construct represents a chimeric peptide with bi-functional behavior. CEL-SCI Corporation is developing products that empower immune defenses. Its lead product is Multikine(R) wh...

MaxCyte to Present Targeted Cancer Immunotherapy Product at 50th Annual Meeting of the American Society of Hematology

...ion on Monday, December 8, 2008 at 5:30 PM - 7:30 PM in Moscone Center, Hall A (Poster Board no.: III-976). The presentation will discuss how chimeric tumor-antigen receptor mRNA loaded peripheral blood mononuclear cells offer the potential to develop customizable, engineered outpatient transfusion m...
Chimeric in Medical Technology

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

...31, 1:00 PM to 4:00 PM, Level 2, West Hall D2 Neuroblastoma A phase III randomized trial of the chimeric anti-GD2 antibody ch14.18 with GM-CSF and IL2 as immunotherapy following dose intensive chemotherapy for high-risk neuroblastoma: Children's Oncology ...

CMC ICOS Biologics and Implicit Bioscience Ltd Announce IC14 Antibody Manufacturing Agreement and Patent License

...sepsis. ALI is a key factor on the pathway to mortality following severe influenza infection. About IC14 IC14 is a clinical stage recombinant chimeric monoclonal antibody which recognizes and blocks the function of human CD14, an essential component of the innate inflammatory response to bacterial in...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

...(panitumumab) they were highly active against KRAS-and BRAF-mutated human colorectal cancer cell lines(1). Recent clinical studies have shown that the chimeric monoclonal antibodies cetuximab(2,3) and panitumumab(3,4) are not active in colorectal cancer patients with tumor cells harboring mutations in KRAS an...

Nile Therapeutics Announces Dosing in Second Phase Ib Study of CD-NP in Heart Failure Patients

...ials are expected to be available in 2008. About CD-NP CD-NP is a novel chimeric natriuretic peptide in clinical development for an initial indication of ac...efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure; 2NTX-99, a ...

Nile Therapeutics Announces Dosing in Phase IIa Study of CD-NP in Heart Failure Patients

...e company's lead product candidate, CD-NP, a novel chimeric natriuretic peptide, in development for the treatm...ut CD-NP Nile's lead compound, CD-NP, is a novel chimeric natriuretic peptide in clinical development for an... lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of h...

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

...would normally inhibit T-cell function, and in addition, does not alter their cytolytic or tumor-killing properties." Dr. Jensen has developed novel chimeric immunoreceptors called "zetakines" that can be engineered into human immune cells to generate a population of cells that can specifically recognize an...

Raven Announces Initiation of a RAV12 Phase 2 Clinical Trial in Metastatic Pancreatic Cancer

...trial that involved 53 patients. Final analysis of the Phase 1/2a study will be available the third quarter of 2008. About RAV12 RAV12 is a novel, chimeric monoclonal antibody that is directed against a primate-specific glycotope (sugar structure) that is widely displayed on the surfaces of tumor cells, p...

Raven Announces Completion of Enrollment in the Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for the Treatment of Adenocarcinomas

... pancreatic cancer. An additional Phase 2 study employing RAV12 is planned to begin in the second half of this year. About RAV12 RAV12 is a novel, chimeric monoclonal antibody that is directed against a primate-specific glycotope (sugar structure) that is widely displayed on the surfaces of tumor cells, p...

Raven Announces Continued Enrollment of Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for Treatment of Adenocarcinomas

...CA; Georgetown University Medical Center in Washington, DC; and The University of Miami Medical Center in Miami, FL. About RAV12 RAV12 is a novel, chimeric monoclonal antibody that is directed against a primate-specific glycotope (sugar structure) that is widely displayed on the surfaces of tumor cells, p...

Raven Announces Phase 1 Clinical Trial Results of RAV12 Therapeutic Antibody for Treatment of Adenocarcinomas

...is planned for 2008. The recommended dose and schedule for Phase 2 clinical study of RAV12 is 0.75 mg/kg twice weekly. About RAV12 RAV12 is a novel, chimeric monoclonal antibody which is directed against a primate-specific glycotope (sugar structure) that is widely displayed on the surfaces of tumor cells, ...
Chimeric in Biological News

New chimeric mouse model for human liver diseases, drug testing

La Jolla, CA Cells cultured in the lab are like a fish out of water. Often, their behavior does not reflect their biological function within an entire organ or organism, which, for example, turns studying human liver cells into a big challenge. One way to get around the altered properties of ...

Activated stem cells in damaged lungs could be first step toward cancer

...the context of additional mutations, promote the development of cancerous or precancerous lesions from activated stem cells." The scientists used a chimeric mouse model, part wild-type and part with green fluorescent protein-tagged cells (GFP), so that the behavior of different populations of duplicating l...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

... towards my goal of a career in plant ecology. Annie Jeong, Barnard College Mentor: Kristen Shepard Analysis of the Spatial Orientation of chimeric and Male Floral Organs in Spergularia Marina I am a junior at Barnard College, majoring in Biology, with a Chemistry minor. This is my first year wo...

Synthetic virus supports a bat origin for SARS

...g domain that is critical for viral entry into human cells allowed the new chimeric SARS-like bat CoV to grow well in monkey cells (commonly used to study huma...ve from zero growth to very efficient growth in cells," Denison said. The chimeric virus also grew well in mouse cells modified to express the receptor for SA...

Yamanaka eliminates viral vector in stem cell reprogramming

...ocompromised mice. The resulting tumors contained a wide variety of cell types from all three germ layers. iPS cells injected into embryos resulted in chimeric mice with the injected cells contributing to almost all cell types. Still, other problems remain to be solved. The efficiency of the gene transfer...

Origen publishes in Nature a robust and versatile method for creating transgenic chickens

...aving greatly enhanced cancer killing activity compared to antibodies produced via conventional methods. "While that earlier research was done with chimeric chickens, it demonstrated the enormous opportunities that transgenic chickens hold as a therapeutics production system," said Robert Kay, Ph.D. Origen...

NIAID begins clinical trial of West Nile virus vaccine

...cluding mice, horses and American crows. Two other human WNV vaccines developed with NIAID support are currently in Phase I clinical trials. Called chimeric vaccines, these vaccines combine genes of the West Nile virus with genes of a closely related virus--yellow fever virus in the case of a vaccine devel...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...ece of human antibody (called IgG Fcg1) that docks to a cell receptor that can be recruited to stop allergic reactions. The investigators named the chimeric molecule GFD, or gamma Feline domesticus, for its human and feline parts, explains principal investigator Andrew Saxon, M.D., of UCLA. The cat allerge...
Chimeric in Biological Technology

Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor

Sylviane Komesli, Martine Page, and Patrick Dutartre Dpartement dImmunologie, Laboratoires Fournier S.A., France Abstract TGF- type I and type II receptors form ligand dependent heteromeric signaling complexes, in which transforming growth fact...

Nile Therapeutics, Inc. Announces Dosing of First Patient in Phase 2 Study of CD-NP for the Treatment of Acute Heart Failure

...ase and other areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile c...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...enerative disc disease. Exemplary genes include a chimeric variant of BMP-4 (chBMP4), which offers the potent... Cardium's Tissue Repair Company have shown that a chimeric variant of BMP-4 (chBMP4) enhances the properties ...Morphogenetic Protein (BMP) family. By creating a chimeric variant that further improves the BMP-4 construct,...

Nile Therapeutics, Inc. Completes $3.4 Million Private Placement

...ase and other areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile c...

Nile Therapeutics, Inc. To Raise $3.4 Million in Private Placement

...ase and other areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile c...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...ions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corporation is developing products that empower immune defens...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...ions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corporation is developing products that empower immune defens...

Nile Therapeutics CD-NP Clinical Program for Acute Heart Failure Released From Clinical Hold by FDA

...d to be completed by the end of 2009. About CD-NP CD-NP is a novel chimeric natriuretic peptide in clinical development for the treatment of acute hear...efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, ...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

...tions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corporation is developing products that empower immune defens...

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

...tions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corporation is developing products that empower immune defen...
Chimeric in Biological Products

GenoStat Inducible Expression System from Upstate

Description:...able of repeated on/off expression kinetics. This degree of control is mediated by the highly specific interaction between the GenoStat Ligand and the chimeric bipartite nuclear receptor complex. Gene expression levels are easily manipulated higher or lower by simply increasing or decreasing the concentration...
Company:Upstate
Chimeric in Biological Definition

Lipase

... pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig. Structure 4:1363-74. ... pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig. Structure 4:1363-74. ...

Monoclonal antibody

... Monoclonal antibodies for cancer treatment 2.2 chimeric and humanized antibodies 2.3 FDA approved monoc...ure below shows all these possibilities: chimeric and humanized antibodies One problem in medical...rt of the mouse antibody is used, one talks about chimeric antibodies or humanized antibodies . Another ap...
Chimeric in Biological Dictionary

Recombinant clone

...xamples ... a plasmid ( which is then called a cloning factor) . If the recombinant plasmid ... 1.1 Cloning and relation to plasmids. 1.2 chimeric plasmids ... The use of cloning is interrelated with Recombinant DNA in classical biology, as ... Recombinant DNA Technology or DNA Cloning ...

Gastrula

... Gastrula was a planet in the Outer Rim Territories. ... Gastrula was created by Jim Anderson for his comic strip Bungo n' Rusti Get ... ... chimeric zebrafish embryos by transplantation at the blastula or gastrula stage. ... chimera, zebrafish embryo, gastrula , blastula, targeted, transplanta...

Fusion Protein

... Fusion proteins, AKA chimeric proteins, are proteins created through the joining of two or more genes which originally coded for separate proteins. Translation of this fusion g...
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(Date:7/10/2014)... As the use of electronic health record becomes widespread ... implementation of the Affordable Care Act, the quantity of ... analytic purposes will also dramatically increase. Additionally, experts ... that analyze large quantities of data for the purpose ... the value of patient care a process that ...
(Date:7/10/2014)... (HealthDay News) -- Teens who are sensitive to light ... develop emotional symptoms such as anxiety and depression, a ... that may exacerbate issues teens experience after concussion may ... making decisions about when to return to play and ... study authors Lisa Koehl and Dong Han, of the ...
(Date:7/10/2014)... HealthDay Reporter THURSDAY, July 10, 2014 (HealthDay ... of calorie information on menus, if it,s available, to decide ... study. Women in particular review the menu labeling, said ... the U.S. Centers for Disease Control and Prevention. ... help choose their meal, compared with just under half of ...
(Date:7/10/2014)... captured with a microchip-based device developed at the Massachusetts ... the MGH Cancer Center can be cultured to establish ... In the July 11 issue of Science , ... accurately reflect a tumor,s genetic mutation over time and ... can culture cells from the blood that represent those ...
(Date:7/10/2014)... Human Services (HHS) has announced a three-year grant to ... totaling $4.7 million to support a new national model ... , Titled "Evidence-Conformant Oncology Care," the project will ... care for adult cancer patients with late-stage disease, significant ... , "We believe that the best cancer ...
Breaking Medicine News(10 mins):Health News:Six cases where big data can reduce healthcare costs 2Health News:Six cases where big data can reduce healthcare costs 3Health News:Six cases where big data can reduce healthcare costs 4Health News:Some Teens May Face Emotional Problems After Concussion 2Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 2Health News:60 Percent of Diners Use Calorie Labeling When Posted: CDC 3Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 2Health News:Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells 3Health News:UH Case Medical Center awarded $4.7 million grant from HHS 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 3
(Date:7/10/2014)... overfishing in the English Channel has resulted in the ... left fishermen ,scraping the barrel, for increasing amounts of ... haddock and many other species at the head of ... removed from the area completely., These are some of ... at Plymouth University, in association with international non-profit research ...
(Date:7/10/2014)... at NJIT,s business incubator, received a $1.4 million federal ... use to staunch bleeding during brain surgery. , Surgeons ... the natural bio-polymer solutions in the gel will cohere ... , The gel can shorten an intracranial surgery ... time for the patient,s skull to be open and ...
(Date:7/10/2014)... that Courtney Aldrich, Ph.D., will head the brand-new, ... editor-in-chief. With the first issue slated for publication ... a growing demand for a place to publish ... is to develop a journal focused on diseases ... that advances the field and lays the foundation ...
Breaking Biology News(10 mins):Overfishing in the English Channel leaves fisherman scraping the bottom of the barrel 2Overfishing in the English Channel leaves fisherman scraping the bottom of the barrel 3A start-up at NJIT develops bleeding-control gel for brain surgery 2ACS Infectious Diseases: Unique chemistry journal names editor 2
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