An adjuvant chemotherapeutic agent in gastric cancer therapy
Peritoneal carcinomatosis can be thought of as a series of events that together form a peritoneal metastatic cascade. The peritoneal stromal tissue appears to be a friendly host for tumour proliferation, providing a rich source of growth factors and chemokines known to be involved in tumour metast...A new chemotherapeutic target for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a major health problem worldwide. Currently, the only chance for obtaining a cure in patients with HCC is by either a surgical resection or liver transplantation. However, many HCCs with scattered tumors cannot be operated on. In such patients, effective alternati...Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers
Dr. Christopher Counter and colleagues at the Duke University Medical Center have identified IL6 as a new target in the battle against Ras-induced cancers . Ras is a key intracellular messenger protein that directs, among other things, cell growth and proliferation. Over-expression of the Ras ...Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer
... "We are eager to advance Bezielle to Phase 2 clinical testing as the drug continues to have an improved safety profile over currently available chemotherapeutic agents, and shows encouraging clinical activity in a cohort of women who have been heavily pretreated for metastatic breast cancer," said Dr. Mary Tag...RI Hospital first in country to enroll patient in new study for recurrent chest wall breast cancer
...called the DIGNITY Study. The study will investigate the effectiveness of a chemotherapeutic agent, ThermoDox, used in conjunction with mild hyperthermia (a form of hea...e DIGNITY study that will test 100 patients nationally with an encapsulated chemotherapeutic agent called ThermoDox combined with hyperthermia treatment. ThermoDox is a...Research identifies successful new treatment for Hodgkin's lymphoma, reduces long-term risks
...based treatment algorithm. Only nine weeks of chemotherapy were required in 63 percent of our patients. This study has shown conclusively that the new chemotherapeutic treatment of ABVE-PC simultaneously provides high efficacy and reduces the cumulative doses of chemotherapy and radiation. We believe this represents ...Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows
... apoptosis light up, but not the healthy surrounding tissues. The potential for practical payoffs is significant, Bogyo said. Radiotherapy and many chemotherapeutic selectively damage DNA in rapidly replicating cells, dramatically boosting the amount of apoptotic death happening in tumors. Some experimental models...Alfacell Provides Shareholder Update
...hat there are specific chemotherapy resistance genes which not only are present in untreated mesotheliomas but also become over expressed when certain chemotherapeutic agents, including platinum, are used in the first line therapy of cancer. These genes, known as the multidrug resistance (MDR) gene1 and the multidrug...Pocket Guide to Colorectal Cancer Drugs and Treatment
Features:...logy, and trends; staging and primary surgical management; adjuvant therapy; and treatment of advanced disease Specific information about each of the chemotherapeutic agents used in systemic treatment as adjuvant therapy of treatment of advanced disease is presented for both the nurse and patient/family The referen...Protein handlers should be effective treatment target for cancer and Alzheimer's
...ould be used for limited periods to avoid trading cancer for an increased risk of neurodegenerative disease or vice versa. "A lot of drugs, such as chemotherapeutic agents, can kill cancer but they also kill normal tissue. That is a limiting factor. We are looking for better drugs," she says. The MCG center is...Tumor growth and chemo response may be predicted by mathematical model
... whether a prescribed drug will reach the tumor in sufficient quantities to kill the malignant cells. "We seek to improve the precision of prescribing chemotherapeutic drugs, since it is sometimes hard to tell which will work and which will not, and what the optimal dose is for a particular patient," said Hermann Fri...TGen researchers discover possible way to block the spread of deadly brain tumors
... ensure that all of the invading tumor cells are gone, even when surgery is followed by radiation treatments and conventional anti-cancer drugs. "A chemotherapeutic treatment which targets these migrating cells would therefore have significant ramifications on patient survival," said Dr. Jennifer M. Eschbacher, a ...Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
...the future, scientists may be able to use these crystal structures to design chemicals that block P-glycoprotein's activity and restore sensitivity to chemotherapeutic agents." Solving the Structure The team, which included scientists from Texas Tech University Health Sciences Center as well as Scripps Resear...Updated formula measures kidney function more accurately
...termine if such a formula will apply to children and infants with higher levels of kidney function, so that any harm that might come from antibiotics, chemotherapeutic drugs and dehydration can be minimized in these populations as well." ...UNC study: Tinkering with the circadian clock can suppress cancer growth
...ernal clock of each cancer cell to render it more vulnerable to attack with chemotherapeutic drugs. "Adjusting the clock in this way could certainly be a new targe...hat is when a particular enzyme system one that can reverse the actions of chemotherapeutic drugs is at its lowest levels in the body. ...Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer
...t a particular woman has a high probability of not responding to an anthracyclin-based therapy, this clinician may consider prescribing an alternative chemotherapeutic regimen. Moreover, this study suggests that predicting how individual patients might respond to chemotherapy could be possible, which raises hopes th...Scattered light rapidly detects tumor response to chemotherapy
...r cell samples, researchers can determine if cancer cells are responding to chemotherapeutic agents within a matter of hours. Most chemotherapy drugs work by forcing... number of cells in a short time. "Now, oncologists typically judge if a chemotherapeutic agent is working by looking for shrinkage in the tumor using imaging techni...New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome
...t agent reaches the tumor, we can predict how much of a clinically approved chemotherapeutic will reach the tumor, allowing physicians to personalize the dose and predi...roved chemotherapy drug, liposomal doxorubicin. Results showed that the chemotherapeutic drug slowed the progress of the tumor. The variability in uptake of the con...TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
...of oxygen). The drug candidate may provide an opportunity to treat slowly dividing tumor cells within hypoxic regions that generally evade traditional chemotherapeutic agents and ultimately contribute to relapse," Dr. Weiss said. Phase 1 and Phase 1/2 trials are underway to investigate the safety and activity of ...The Breast Cancer Therapeutics Market in Australia
...ent. These therapies are specifically designed to target cancer cells, while minimizing the adverse effects on normal cells when compared to cytotoxic chemotherapeutic drugs. New offerings must constitute therapies that will improve quality of life and survival rates if they are to thrive in this highly competitive m...Cynvec to Present at The 2009 New York Venture Summit
...ol of Medicine, Cynvec is developing its lead product, CYN 101, to be used as a single agent or in combination with cytotoxics, monoclonal antibodies, chemotherapeutic agents and radiation. CYN 101 is a replication defective, apoptotic RNA vector that has shown tumor eradication and highly significant survival rates ...Laboratory Test May Predict Effectiveness of ERBITUX(R) for Individual Colorectal Cancer Patients
...for response would be of great clinical utility. ChemoFx(R) is a test that measures an individual cancer patient's probable tumor response to various chemotherapeutic and biologic agents -- providing both sensitivity and resistance information. As such, ChemoFx(R) provides valuable insights that can help guide phys...Micromet Presents Update at ASCO 2009 on a Phase 1b Combination Study of Adecatumumab and Docetaxel
...and autoimmune diseases, presented data from a clinical trial investigating its anti-EpCAM human antibody adecatumumab (MT201) in combination with the chemotherapeutic docetaxel in patients with metastatic breast cancer (MBC) at the annual meeting of the American Society of Clinical Oncology (ASCO) held in Orlando, F...Access Pharmaceuticals Announces the European Launch of MuGard(TM) by its European Partner, SpePharm
...s targeted to breast cancer; Prodrax(R), a non-toxic prodrug which is activated in the hypoxic zones of solid tumors to kill cancer cells; Alchemix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an HDAC inhibitor and diffe...