Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes
...lt in net destruction of the tumor it is fundamentally changing the tumor into one that is predominantly comprised of chemosensitive cells rather than chemoresistant
The findings also appear to give scientists a way to more quickly evaluate future vaccine-related research.
"The demonstration that the ...
Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
...ort-circuit signals that trigger cancer cell death.
We consider that the capacity of NV-128 to trigger caspase-independent cell death, in otherwise chemoresistant
ovarian cancer cells, opens new possibilities for the use of NV-128 as a potential addition to conventional chemotherapy targeting ovarian cancer cell...
FASgen Diagnostic Tests Identify Ovarian Cancer Progression and Apoptosis
...rian Serous Carcinomas and its Potential Diagnostic and
Therapeutic Role in chemoresistant
Disease," presented the data from
studies conducted at the Johns Hopkins On... cancers previously announced
by FASgen. FAS is thus a promising target for chemoresistant
About FASgen Diagnostics, LLC and FASgen, I...
Supratek Pharma Inc. announced today that under the Special Protocol
...s, doxorubicin. SP1049C has been
shown, in pre-clinical and clinical development, to have much higher
efficacy and a novel mechanism of action against chemoresistant
which the original drug is inactive. SP1049C has also obtained an Orphan
Drug designation from the FDA for the treatment of esophageal carci...
New Ovarian Cancer Drug Trial Under Way
... of the drug phenoxodiol when combined with weekly doses of the chemotherapy drug carboplatin. Phenoxodiol is believed to help chemotherapy drugs kill chemoresistant
cancer cells by removing factors in the cells that block the killing action of chemotherapy. Phenoxodiol has not yet been approved for use by the U.S....
Genes That Allow Brain Cancer-Causing Stem Cells to Resist Treatment Identified
...dars-Sinai appear in the Dec. 2 issue of the journal Molecular Cancer. The researchers describe genes and mechanisms that give cancer stem cells their chemoresistant
properties. They also allude to ongoing research aimed at developing methods for readily distinguishing cancer stem cells from normal neural stem cell...
Chemoresistant in Medical Technology
In Vitro and In Vivo Data Show Alfacell's Onocanse is Active
Against Naive and Chemoresistant Neuroblastoma Cells
Pre-Clinical Results Demonstrate Potential of ONCONASE for
Treatment of Neuroblastoma
BLOOMFIELD, N.J., June 27, 2007 /PRNewswire-FirstCall/ --
Alfacell Corporation today announced that new data show ONCONASE,
the company's lead drug candidate, is active against naive and
A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol
carcinoma. Eur J Gynaecol Oncol. 2005;26(4):386-90. About Phenoxodiol Phenoxodiol is believed to help chemotherapy drugs, such as
carboplatin, kill chemoresistant
cancer cells by removing factors in the
cells that block the killing action of chemotherapy. Phenoxodiol appears to selectively inhibit the pro-survi...
First Patient Enrolled in Europe in Ovature Phase III Ovarian Cancer Trial
...athways leads to prevention of phosphorylation of key
anti-apoptotic proteins such as XIAP. Loss of activity of these proteins
restores the ability of chemoresistant
tumour cells to undergo apoptosis in
response to chemotherapy. The putative molecular target for phenoxodiol is
a tumour-specific protein, accounting ...
New Research Results Show That Investigational Drug Phenoxodiol
Targets Cancer Protein, Causing Cancer Cell Death
...athways leads to prevention of phosphorylation
of key anti-apoptotic proteins such as XIAP. Loss of activity of
these proteins restores the ability of chemoresistant
to undergo apoptosis in response to chemotherapy. The putative
molecular target for phenoxodiol is a tumor-specific protein,
Introgen and Clinical Collaborators to Report New Results with
Advanced-Stage Cancer Therapies at Upcoming Medical Meetings
...:30 - 11:30 a.m. at Washington State
Convention Center during symposium titled "Cancer: Hot Topics in
Cancer Gene Therapy"
-- MDA-7 (INGN-241) Kills chemoresistant
Cancer Cells and
Restores Chemosensitivity to Cisplatin, Abstract #197: Presentation
during "Cancer: Apoptosis and Suicide" poster session on Thurs.,
Investigational Drug Cediranib (AZD2171) Shows Promise in Patients
With Recurrent Glioblastoma (GBM)
...ercent (18 out of 27 patients).(3) The most common toxicities were
fatigue, hypertension, diarrhea, and voice alteration.
"Renal cell carcinoma is a chemoresistant
disease which has
traditionally been difficult to treat, resulting in poor prognosis
for patients hence these early data are encouraging," commented