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Chemoresistant in Medical News

Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes

...lt in net destruction of the tumor it is fundamentally changing the tumor into one that is predominantly comprised of chemosensitive cells rather than chemoresistant cells." The findings also appear to give scientists a way to more quickly evaluate future vaccine-related research. "The demonstration that the ...

Drug compound leads to death of ovarian cancer cells resistant to chemotherapy

...ort-circuit signals that trigger cancer cell death. We consider that the capacity of NV-128 to trigger caspase-independent cell death, in otherwise chemoresistant ovarian cancer cells, opens new possibilities for the use of NV-128 as a potential addition to conventional chemotherapy targeting ovarian cancer cell...

FASgen Diagnostic Tests Identify Ovarian Cancer Progression and Apoptosis

...rian Serous Carcinomas and its Potential Diagnostic and Therapeutic Role in chemoresistant Disease," presented the data from studies conducted at the Johns Hopkins On... cancers previously announced by FASgen. FAS is thus a promising target for chemoresistant and recurrent ovarian cancer. About FASgen Diagnostics, LLC and FASgen, I...

Supratek Pharma Inc. announced today that under the Special Protocol

...s, doxorubicin. SP1049C has been shown, in pre-clinical and clinical development, to have much higher efficacy and a novel mechanism of action against chemoresistant tumors in which the original drug is inactive. SP1049C has also obtained an Orphan Drug designation from the FDA for the treatment of esophageal carci...

New Ovarian Cancer Drug Trial Under Way

... of the drug phenoxodiol when combined with weekly doses of the chemotherapy drug carboplatin. Phenoxodiol is believed to help chemotherapy drugs kill chemoresistant cancer cells by removing factors in the cells that block the killing action of chemotherapy. Phenoxodiol has not yet been approved for use by the U.S....

Genes That Allow Brain Cancer-Causing Stem Cells to Resist Treatment Identified

...dars-Sinai appear in the Dec. 2 issue of the journal Molecular Cancer. The researchers describe genes and mechanisms that give cancer stem cells their chemoresistant properties. They also allude to ongoing research aimed at developing methods for readily distinguishing cancer stem cells from normal neural stem cell...
Chemoresistant in Medical Technology

In Vitro and In Vivo Data Show Alfacell's Onocanse is Active Against Naive and Chemoresistant Neuroblastoma Cells

Pre-Clinical Results Demonstrate Potential of ONCONASE for Treatment of Neuroblastoma BLOOMFIELD, N.J., June 27, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation today announced that new data show ONCONASE, the company's lead drug candidate, is active against naive and chemoresistant neuroblast...

A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol

... carcinoma. Eur J Gynaecol Oncol. 2005;26(4):386-90. About Phenoxodiol Phenoxodiol is believed to help chemotherapy drugs, such as carboplatin, kill chemoresistant cancer cells by removing factors in the cells that block the killing action of chemotherapy. Phenoxodiol appears to selectively inhibit the pro-survi...

First Patient Enrolled in Europe in Ovature Phase III Ovarian Cancer Trial

...athways leads to prevention of phosphorylation of key anti-apoptotic proteins such as XIAP. Loss of activity of these proteins restores the ability of chemoresistant tumour cells to undergo apoptosis in response to chemotherapy. The putative molecular target for phenoxodiol is a tumour-specific protein, accounting ...

New Research Results Show That Investigational Drug Phenoxodiol Targets Cancer Protein, Causing Cancer Cell Death

...athways leads to prevention of phosphorylation of key anti-apoptotic proteins such as XIAP. Loss of activity of these proteins restores the ability of chemoresistant tumor cells to undergo apoptosis in response to chemotherapy. The putative molecular target for phenoxodiol is a tumor-specific protein, accounting fo...

Introgen and Clinical Collaborators to Report New Results with Advanced-Stage Cancer Therapies at Upcoming Medical Meetings

...:30 - 11:30 a.m. at Washington State Convention Center during symposium titled "Cancer: Hot Topics in Cancer Gene Therapy" -- MDA-7 (INGN-241) Kills chemoresistant Cancer Cells and Restores Chemosensitivity to Cisplatin, Abstract #197: Presentation during "Cancer: Apoptosis and Suicide" poster session on Thurs., ...

Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)

...ercent (18 out of 27 patients).(3) The most common toxicities were fatigue, hypertension, diarrhea, and voice alteration. "Renal cell carcinoma is a chemoresistant disease which has traditionally been difficult to treat, resulting in poor prognosis for patients hence these early data are encouraging," commented P...
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