Genetic Variation Associated With Survival Advantage in African Americans With HIV
The research showed that African Americans with HIV who possess both a variation in the gene for the Duffy antigen receptor for chemokine
(DARC) and leukopenia have slower HIV-to-AIDS progression rates than HIV-infected European Americans with leukopenia. Previous studies showed that the...
ChemoCentryx to Present at The 9th World Congress on Inflammation in Tokyo, Japan
...re titled, "Treating Inflammation by Inhibition of chemokine
Receptors: Practical Requirements and Efficacy of ...developing drugs that selectively inhibit specific chemokine
and chemoattractant receptors in the treatment of ...g orally-administered therapeutics that target the chemokine
and chemoattractant systems in order to treat auto...
What is the mechanism of the chronic radiation enteritis?
... by expression of both the Th2-specific transcription factor GATA-3 and the chemokine
receptor CCR4 and by suppression of the Th1 cytokine IFN gamma/IP-10 throug... 50% reduction in the expression of the Th1 transcription factor T-bet, the chemokine
receptor CCXCR3, and the IFNgamma /STAT1 pathway. At the same time-point, t...
Researchers identify how binge drinking may drive heart disease
Several studies provide compelling evidence for a direct role of the monocyte chemoattractant protein-1 (MCP-1) receptor called chemokine
(C-C motif) receptor 2 (CCR2) in the rush of monocytes to blood vessel walls as part of atherosclerosis. CCR2 is a receptor, a protein that occurs on ...
Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
... his colleagues that demonstrates that the protein dachshund blocks metastasis in a mouse model and that this occurs through reduced production of the chemokine
IL-8," says Max Wicha, M.D., director of the University of Michigan Comprehensive Cancer Center in Ann Arbor. "Interestingly reduced dachshund and inc...
Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success
...; bcr-abl/abl (including mutated forms); B-FN
(ED-B fibronectin); carboxyanhydrase IX (CA IX); carcinoembryonic antigen
(CEA); cathepsin K (CTSK); C-C chemokine
receptor 4 (CCr4); CD105
(endoglin); CD13; CD19; CD20; CD22; CD25; CD3; CD30; CD33; CD38; CD4; CD40;
CD55; CD56; CD70; CD74; CD80; CD95 (fas); CD137 (...
Monogram Biosciences Announces Immediate Availability of Enhanced Sensitivity Trofile(TM) HIV Tropism Assay
...s a greater level of confidence that the Trofile assay is
selecting the most appropriate patients for CCR5 antagonist therapy.
Tropism refers to the chemokine
co-receptor on the surface of CD4+
cells that a particular variant of HIV uses to enter the cell. "R5"
variants use the CCR5 co-receptor, "X4" viruses...
Millennium Expands IBD Franchise with Addition of New Development Candidate
... - Company advances oral antagonist of CCR9, a chemokine
receptor believed to play a critical role in Crohn's disease -
CAMBRIDGE, Mass., March 17 /PRNewswire-FirstCall/ -- Millennium
Pharmacopeia to Present at The Roth 20th Annual OC Growth Stock Conference
...th respect to PS178990, including timing and expected outcomes of
such studies, Pharmacopeia's plans to develop PS031291, a product candidate
from its chemokine
receptor CCR1 program, Pharmacopeia's estimates of the
market opportunities for its product candidates, including PS433540,
PS178990 and PS031291, Pha...
The missing link between belly fat and heart disease?
...the same factors that regulate the inflammation that other researchers have seen in the naturally occurring fat deposits of obese mice specifically a chemokine
But because the fat was transplanted, the inflammation could be attributed directly to the fat, and not to overfeeding of the mice, ...
Chemokine in Medical Technology
Pharmacopeia Nominates Novel Chemokine Receptor Antagonist for Development
Company Also Provides Update on DARA Program's Ongoing Phase 2a Hypertension Study
PRINCETON, N.J., Feb. 11 /PRNewswire-FirstCall/ -- Pharmacopeia
(Nasdaq: PCOP ), an innovator in the discovery and development of novel
small molecule therapeutics, today announced...
PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference
...dy Demonstrated Efficacy of the Intestine-Specific chemokine
Receptor Antagonist CCX282-B (Traficet-EN) in Trea...gastrointestinal disease.
"Targeting the CCR9 chemokine
receptor represents a new and highly specific appr...
Traficet-EN is an orally-active inhibitor of the chemokine
receptor known as 'CCR9', which is selectively exp...
Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-CXCR4 Antibody, MDX-1338
...tion (FDA) for MDX-1338, for the treatment of patients with acute myelogenous leukemia (AML). MDX-1338 is a fully human antibody that targets CXCR4, a chemokine
receptor found on the surface of many cancer cells, including certain leukemias, lymphomas and other cancers. Preclinical laboratory experiments have ...
Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis
...ien, Chairman and CEO of Medarex. "These results show that by targeting the chemokine
IP-10 with our MDX-1100 antibody, we may be able to offer a potentially imp...100 is a fully human antibody that targets IP-10 (also known as CXCL-10), a chemokine
expressed in association with multiple inflammatory disease indications. Th...
Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer
...tibody proposed for therapeutic application in AML and ALL (Abstract #LB-150)
CXCR4 is a seven-transmembrane, G-protein-coupled receptor in the CXC chemokine
receptor family that is expressed on a variety of cancers including leukemias, lymphomas, breast, lung, colon, pancreatic, and ovarian cancer. In prec...
Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies
...ents of the Immune System -
- Studies Confirm Peregrine's PS-Targeting Antibodies Stimulate Dendritic Cell Maturation, Inflammatory Cytokine and chemokine
Release and Recruitment of Macrophages to Tumors -
DENVER and TUSTIN, Calif., April 21 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. ...
Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy
... diseases. CCL2-LPM selectively targets activated leukocytes expressing the chemokine
receptor CCR2 that are responsible for initiating and maintaining a variety... maintain a variety of inflammatory and autoimmune disorders. The CCL2-CCR2 chemokine
ligand-receptor axis plays a significant role in inflammatory kidney diseas...
Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack
...We believe that the effectiveness of these stem cells can be substantially improved through a targeting mechanism that involves the binding of the CXC chemokine
receptor 4 (found on these stem cells in the bone marrow but reduced after ex vivo expansion) with the stromal-derived factor-1 alpha ligand that is e...
Nventa Presents Findings on Proprietary Toll-like Receptor 3 (TLR3) Agonist, Poly-ICR, at World Vaccine Congress
-- Poly-ICR is stable and resistant to degradation by RNAses in human serum; -- Poly-ICR induces significant cytokine and chemokine
production; -- Poly-ICR matures dendritic cells, known as "the teachers of the immune system".
In addition to incorporating Poly-ICR into futur...
Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer
...mor activity in several cancer models and is currently in a Phase I
UNBS 5162 is anti-angiogenic in vivo, and has been shown to decrease
expression in experimental prostate cancers. UNBS 5162 is a
pan- antagonist of CXCL chemokines when administered in vitro chronically
at 1 M, which is...
Chemokine in Medical Definition
...try include CD44 , P-selectin (CD62P), and the chemokine
receptor CCR9. 
Following thymus entry, p... cell. The single positive T cells upregulate the chemokine
receptor CCR7, causing migration from the cortex ...elective thymus settling regulated by cytokine and chemokine
receptors. J Immunol. 2007 Feb 15;178(4):2008-17. ...
Chemokine in Medical Dictionary
...age characteristics. ... Macrophage -derived chemokine
ligand 22 (CCL22)) mediates its ... Macrophage -derived chemokine
is localized to thymic medullary epithelial cells ...
... proliferation, analyzing either PBMC (thymidine ... Ronen Alon Group Home Page ... units in lymphocyte transendothelial migration ... Scheme 5: chemokine
stimulated lymphocyte crawling via high affinity LFA-1 ... Britannica online encyclopedia article on lymphocyte (blood cell), type of leukocyt...
Chemokine in Biological News
Microbes and their hosts -- exploring the complexity of symbiosis in DNA and cell biology
...iosis. These include "The Oral Microbial Consortium's Interaction with the Periodontal Innate Defense System," which describes a process called "local chemokine
paralysis," in which the membership and characteristics of the bacterial community that populates the gingival crevice in the human mouth affect the a...
Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action
... completion of the first Phase I study with FX125L , an orally available small molecule which belongs to a new therapeutic class named Broad Spectrum chemokine
Inhibitors ( BSCIs ).
The Phase I, single ascending dose study was conducted in the United States. FX125L was well tolerated at all doses studied...
Major breakthrough in early detection and prevention of AMD
...ule also implicated in inflammatory processes is expressed on the surface of CNV vessels in humans but is absent from normal vascular tissue.
receptor is known to be a key player in the allergic inflammation process, but Dr. Ambati's studies have now identified CCR3 as a key marker of the CN...
UT Southwestern researchers probe kidney damage, protection in lupus
...rics; Dr. Peter Igarashi, professor of internal medicine; and Dr. Xin Zhou, professor of pathology. Researchers from the Universit Paris-Descartes and chemokine
Therapeutics, Canada, also participated.
New origin found for a critical immune response
...a TH1 response in laboratory mice that lacked this chemokine
with influenza viruses.
"We really thought ...es of mice, which were missing other chemokines or chemokine
receptors. They found that mice without the Ccr2 chemokine
receptor that controls the migration of inflammato...
Shades of 1918? New study compares avian flu with a notorious killer from the past
... ressortant strains were found to be highly virulent, they were outmatched by H5N1's rapid onset, overwhelming transcription induction of cytokine and chemokine
genes and headlong, sustained viral replication with wider distribution in the lungs. As Baskin notes, referring to the group's measurements of Tissue...
New discovery may lead to new class of allergy drugs
...fighter" cells from transforming into "seeker" dendritic cells, resulting in a heightened allergic response.
"Our study reveals a new role for the chemokine
eotaxin in controlling immune cell types at the site of allergic reaction," said Nigel Stevenson, a researcher involved in the study. "These findings ...
The Burnham buzz
...and colleagues have determined that a biologically active molecule called a chemokine
promotes the spread of tumors, particularly in breast cancer. Dr. Roth believes that compounds that block the chemokine
may be potential cancer therapies. However, existing small molecules that b...
New synthetic form of protein holds promise to stop cancer spread
...that inhibits cell migration.
"This was exciting because it was genuinely unexpected," says Dr. Volkman. "It was the strongest suggestion yet that chemokine
dimers might really be active participants in directing the migration of white blood cells and possibly other kinds of cells."
Dr. Volkman says the ...
Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
... a couple of days of the initial infection. It also turns out that only a fraction of the available white blood cells are capable of recognizing these chemokine
messages. Discovering that this response occurs rapidly, and that only a specific subset of white blood cells can recognize these messages, helps prov...
Chemokine in Biological Technology
Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice
San Diego-Based Carolus Therapeutics Focuses on Discovery and Development of Anti-Inflammatory Drugs Based on Collaborators' Findings at RWTH Aachen University in Germany
SAN DIEGO, Jan. 5 /PRNewswire/ -- Research published in Nature Medicine shows that the disruption of the interactions be...
ChemoCentryx Demonstrates Recently Discovered Chemokine Receptor CXCR7 is Essential in Tumor Growth
Characterization of Receptor's Central Role in Cancer is Published in the Proceedings of the National Academy of Sciences
MOUNTAIN VIEW, Calif., Sept. 26 /PRNewswire/ -- ChemoCentryx, Inc., a
clinical-stage biopharmaceutical company focused on discovering, developing
The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System
Key words: CXCR2 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads
Chemo-attractant cytokines (chemokines) are low molecular weight, pro-inflammatory cytokines with potent leukocyte activation and/or chemotactic activ...
Funxional Successfully Completes Initial Clinical Trial of FX125L, an Anti-Inflammatory Drug With a Novel Mechanism of Action
...ul completion of the first Phase
I study with FX125L, an orally available small molecule which belongs to a
new therapeutic class named Broad Spectrum chemokine
The Phase I, single ascending dose study was conducted in the United
States. FX125L was well tolerated at all doses studied...
ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week
...g inflammatory bowel diseases by blocking the CCR9 chemokine
receptor. Targeting the CCR9 chemokine
receptor represents a novel approach for the treat...dy Demonstrated Efficacy of the Intestine-Specific chemokine
Receptor Antagonist CCX282-B (Traficet-EN) in Trea...
ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist
...tectural similarities between the C5a receptor and chemokine
receptors, ChemoCentryx researchers successfully a...r degeneration (AMD). C5aR is one of four defined chemokine
and chemoattractant receptor targets covered under...g orally-administered therapeutics that target the chemokine
and chemoattractant systems in order to treat auto...
Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS
...HO, over 2.7 million people were infected with HIV in 2007. There are now over 33 million people living with HIV and AIDS worldwide.
CCR5 is the chemokine
receptor that HIV uses as a co-receptor to gain entry into immune cells. CCR5 is perhaps the most important of the known co-receptors for HIV, since ...
Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic
...DS/WHO, over 2.7 million people were infected
with HIV in 2007. There are now over 33 million people living with HIV and
CCR5 is the chemokine
receptor that HIV uses as a co-receptor to gain
entry into immune cells. CCR5 is perhaps the most important of the known
co-receptors for HIV, since t...
ChemoCentryx Advances Second Orally Available CCR9 Antagonist CCX025 Into Clinical Development
...idifies Company's Leadership Position in Targeting chemokine
Receptor CCR9 for Gastrointestin...ond orally
administered compound that inhibits the chemokine
receptor known as CCR9.
Structurally distinct from...ressed by
inflammatory T cells. Targeting the CCR9 chemokine
receptor represents a
novel approach for the treat...
Researchers decode viral process that prepares cells for HIV infection
... analyzed CD4 T-cells taken from blood and infected with HIV. The researchers found that when HIV binds to the cell surface, it uses a molecule called chemokine
coreceptor CXCR4 to send a signal that activates a cell protein known as cofilin. The protein is then used to cut through the cortical actin cytoskele...
Chemokine in Biological Products
Chemokine in Biological Dictionary
...ts for storing and reading out Memory T cell For other uses, see Memory cell . ... Central memory TCM cells express L-selectin and the chemokine
receptor CCR7, ... The concept of cell memory came to Browne 25 years ago through her spirit guide, Francine. ... Whatever isn't caused by c...
...oxic substances ... Eosinophils circulate in the bloodstream. ... Eosinophils help destroy cancer cells. ... The Role of Eosinophils in the chemokine
Network of Allergy ... Further stimulated by interleukin-5 (IL-5) they develop into eosinophils . ... Eosinophils are cytotoxic, releasing the c...