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Chaperone in Medical News

Chemical chaperone could open door to treatment of neurological disorder

An unexpected finding turned out to be a clue leading researchers at Washington University School of Medicine in St. Louis to propose a new treatment approach for Niemann-Pick disease, a rare, deadly neurodegenerative disorder. To overcome the genetic defect in Niemann-Pick disease, the resear...

Slices of living brain tissue are helping scientists identify new stroke therapies

...located within the endoplasmic reticulum of cells, which controls protein synthesis and regulates calcium levels. When needed, the receptors appear to chaperone these proteins to the cell powerhouse, or mitochondria. In his studies, Dr. Kirov is testing to see whether these sigma receptor ligands inhibit anoxi...

USC researchers identify novel approach for suppressing prostate cancer development

...f cancer and isolate drugs that inhibit GRP78, Lee says. "To our knowledge, this is the first demonstration that inactivation of a specific molecular chaperone from the mouse prostate epithelial cells can potently block prostate cancer development and suppress the activation of AKT, which is a protein kinase ...

Researchers aim to over-stress already taxed mantle cell lymphoma cells

...sed-out machinery," Dr. Bhalla said. To help push cancer cells over the edge, the researchers are inhibiting hsp90, so the cells lose the molecular chaperone function required to maintain their fast pace. This also puts more stress on the endoplasmic reticulum. Independently hsp90 inhibitors are known to se...

'Healthy Fat' Chemical Aids Body's Metabolism

... metabolic problems, like diabetes and heart disease, normally linked to a long-term, high-fat diet. In these mice, whose fat cells lacked proteins to chaperone the fat to their normal storage cells, palmitoleate production was much higher. The excess palmitoleate signaled the muscles and the liver to improve ...

JCI online early table of contents: July 1, 2008

...eutic targets for the treatment of congenital hypothyroidism. TITLE: The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone AUTHOR CONTACT: Peter Arvan University of Michigan, Ann Arbor, Michigan, USA. Phone: (734) 936-5006; Fax: (734) 936-6684; Email: parvan@umich.e...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators

...fornia, is investigating the molecular mechanism by which the Hsp90 protein chaperone affects the folding of substrate proteins. The effect of Hsp90 on folding is important because this chaperone activates a wide variety of proteins that are over-expressed in cancerous c...

United Nations Environment Programme and Bayer Corporation Announce North American Winners of International Children's Painting Competition

...ther five UNEP regions of Africa; Asia and the Pacific; West Asia; Latin America and the Caribbean; and Europe. As second prize winner, Ms. Yu and a chaperone will receive an all- expense-paid trip, courtesy of Bayer, to the Chicago Botanic Garden, host venue of the North American World Environment Day celeb...

MU researchers find clue to cataract formation

...t an increasing rate. As the number of small peptides increases in the eye, chaperone activity starts to decrease, resulting in less cleansing activity inside th...velop cataracts. There are a variety of causes that lead to the decrease of chaperone activity, and the presence of these small peptides accelerates the process,...

HSP90: New point of view on melanoma of the eye, at the MUHC

...target Heat Shock Protein 90 (HSP90). HSP90 is already a therapeutic target in many other types of cancer. In fact, this protein, which is called a chaperone because it guides the actions of other proteins, is at the centre of many metabolic pathways. By disrupting HSP90s functioning, it is possible to affe...
Chaperone in Medical Technology

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

...jointly develop Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders, Amigal,...a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules tha...d commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under t...

Amicus Therapeutics Announces Issuance of New Plicera(TM) Composition of Matter Patent

...r our development programs and our pharmacological chaperone technology platform." Plicera is currently be...d commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under t...a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules tha...

Amicus Therapeutics Suspends Enrollment for Phase 2 Clinical Trial of AT2220 for Pompe Disease

... Shire plc, to develop and commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under the agreement, Shire recei...nes for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and...

Amicus Therapeutics Announces Positive Progress of Three Lead Clinical Programs and General Outlook for 2009

...GT, and the growing breadth of our pharmacological chaperone technology platform, we feel this progress sets th...opriate for Pompe patients who are not amenable to chaperone monotherapy. Amicus expects to announce additional...a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules tha...

Amicus Therapeutics Announces Second Quarter 2008 Financial Results

...hich is the third product from our pharmacological chaperone platform to enter Phase 2 development. We also suc...T combination treatment in Pompe patients. Other chaperone Programs: Amicus is accelerating its investment ...a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules tha...

Amicus Therapeutics Announces Successful Completion of End of Phase 2 Meeting With FDA for Amigal in Fabry Disease

...ompany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and traff...

Anavex presents neuroprotective effects of Anavex 1-41 at the International Conference on Alzheimer's Disease 2008

...d protect nerve cells from death." The Anavex Life Sciences presentation is entitled: "Neuroprotective effects of activators/agonists of the sigma-1 chaperone protein against amyloid toxicity in a mouse mode". The authors are: Tanguy Maurice (1), Vanessa Villard (1), Johann Meaner (1), Emetine Keller (1), Fa...

Michael J. Fox Foundation Awards $2.4 Million for Validation of Nine Promising Therapeutic Targets for Parkinson's Disease

...ients and researchers," said Katie Hood, CEO of The Michael J. Fox Foundation. "But to attract an industry sponsor with the resources and expertise to chaperone it through optimization, preclinical work and ultimately clinical testing, that target needs a critical mass of evidence behind it, demonstrating that...

Amicus Therapeutics Begins Phase 2 Clinical Trial of AT2220 in Pompe Disease

...a and Europe. AT2220 is the third compound based on Amicus' pharmacological chaperone technology platform to enter Phase 2 clinical development. "We look forwa...nes for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and...

Amicus Therapeutics Presents Data from Clinical Ex Vivo Response Study and Phase 1 Studies of AT2220

...gest Majority of Pompe Patients May Be Amenable to chaperone Therapy CRANBURY,...patients may be treatable with our pharmacological chaperone AT2220," said John F. Crowley, President and CEO o...a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules tha...
Chaperone in Biological News

Sidestepping cancer's chaperone

WORCESTER, Mass. Cancerous tumors are wildly unfavorable environments. Struggling for oxygen and nutrients while being bombarded by the bodys defense systems, tumor cells in fact require sophisticated adaptations to survive and grow. For decades, scientists have sought ways to circumvent these ad...

Protein handlers should be effective treatment target for cancer and Alzheimer's

... Mivechi, director of the MCG Center for Molecular chaperone Biology/Radiobiology and Cancer Virology. Ever... know whether ramping up the activity of molecular chaperone can essentially make them act young again and halt...for example, when they remove a specific molecular chaperone they find Alzheimer's-like disease accelerates dra...

New study reveals the protein that makes phosphate chains in yeast

...at in yeast a protein called Vtc4p is responsible for the production of polyphosphates. Vtc4p is part of a protein complex called vacuolar transporter chaperone complex (VTC) that is usually found in the membranes of vacuoles pouches in which cells store molecules for later use, transport or destruction. ...

In scientific first, Einstein researchers correct decline in organ function associated with old age

...amaged proteins. After finding such a protein, the chaperone ferries it towards one of the cell's many lysosome... membrane-bound sacs filled with enzymes. When the chaperone and its cargo "dock" on a receptor molecule on the...es. In previous work, Dr. Cuervo found that the chaperone surveillance system, in particular, becomes less e...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

...ients and researchers," said Katie Hood, CEO of The Michael J. Fox Foundation. "But to attract an industry sponsor with the resources and expertise to chaperone it through optimization, preclinical work and ultimately clinical testing, that target needs a critical mass of evidence behind it, demonstrating that...

Researchers reveal insights into hidden world of protein folding

...rtually all proteins have to be folded-some in complex configurations-in order to function properly, and many are known to require a molecule called a chaperone to fold them. Frydman estimates that perhaps 10 percent of the proteins needing chaperones must have one that, like TRiC, is part of the subset called...

Biophysical Society announces new and notable symposium speakers

...posium Speakers and Information: The Effect of chaperone SecB on MBP Folding: A Single-molecule Study. Sa...nducted the first experimental study to show how a chaperone affects a protein folding pathway. The chaperone was shown to interfere specifically with some fold...

First high-res 3D structures of mammalian HSP90 protein solved

...nally, the work shows for the first time how members of the hsp90 family of chaperone proteins can differ from each other, while still being part of the same ove...ies GRP94s place in this family and has already stimulated interest in this chaperone as a drug target. This understanding would allow for the long-term developm...

NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins

...gate the protective effects in flies, mammalian cells and mice of so-called chaperone proteins, which work to make sure that other proteins take on their proper ...ey intend to use their flies to determine whether other possibly protective chaperone proteins work as well. Next, theyll check any promising leads with experime...

In mice, drug protects against diabetes and atherosclerosis

...ccess after a decade of intense efforts to achieve with a chemical what has been observed in mice and humans carrying the gene variant. The lipid chaperone protein aP2 acts as a signal in cells, setting off a chain of inflammatory and metabolic responses to consumption of fatty foods. Some of those effect...
Chaperone in Biological Technology

Amicus Therapeutics Announces Second Quarter 2009 Financial Results

...oughout the remainder of 2009. Preclinical chaperone Programs Amicus continues to invest in res...to assess the potential for applying its versatile chaperone technology platform to the treatment of a broad ra...jointly develop Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders: Amigal,...

Amicus Therapeutics Announces Second Quarter 2009 Financial Results Release Date

...ompany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and traff...

Amicus Therapeutics to Present at the Bank of America and Merrill Lynch 2009 Health Care Conference on May 13, 2009

...ompany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and traff...

Amicus Therapeutics Announces First Quarter 2009 Financial Results Release Date

...ompany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and traff...

Amicus Therapeutics to Present at the 16th Annual Future Leaders in the Biotech Industry Conference

...mpany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and traff...

Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting

... Shire plc, to develop and commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under the agreement, Shire recei...nes for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and...

Publication of Shire plc's Annual Report 2008

...nt and preclinical studies. Pharmacological chaperone Technology In November 2007 Shire entered i...rally administered, small molecule pharmacological chaperone being jointly developed for the treatment of Pompe...AMIGAL, PLICERA and AT-2220, three pharmacological chaperone compounds for lysosomal storage disorders in marke...

Amicus Therapeutics to Present at the Cowen and Company 29th Annual Healthcare Conference on March 17, 2009

...mpany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and traff...

Safer nanoparticles spotlight tumors, deliver drugs

...s report. The cancer drug doxorubicin will stick to the pores and slowly escape as the silicon dissolves. "The goal is to use the nanoparticles to chaperone the drug directly to the tumor, to release it into the tumor rather than other parts of the body," Sailor said. Targeted delivery would allow docto...

Amicus Therapeutics Announces Change to Board of Directors

...ompany developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and traff...
Chaperone in Biological Definition

Signal transduction

...ing together in a complex called aporeceptor complex , which also contains chaperone proteins (also known as heatshock proteins or Hsp s). The Hsp s are ... These receptors are located in the nucleus and are not accompanied by chaperone proteins . In the absence of hormone, they bind to their specific DNA seque...
Chaperone in Biological Dictionary

Ribosomal RNA

...structure of a ribosomal RNA operon from Escherichia coli. ... Nearly a third of the 34 large ribosomal subunit proteins displayed RNA chaperone activity. ... wind their way through ribosomal RNA , acting to cement together ... ... and LSU (large subunit) ribosomal RNA sequences. ... ...

Metaphase

...imated, click the image. • The centrosomes are at opposite poles of the cell. ... Separase is kept inactive until late metaphase by an inhibitory chaperone called securin. ... In plant cells, a cell plate forms where the metaphase plate had been. ... ...

Chaperone Proteins

...er are performing their normal biological... chaperone ( protein ), a protein that assists the non-covalent folding/unfolding ... chaperone , a small molecule which stabilizes the correct folding of a protein ... The major chaperone classes are 40-kDa heat shock protein (HSP40; t...

Chaperone protein

...er are performing their normal biological... chaperone ( protein ), a protein that assists the non-covalent folding/unfolding ... chaperone , a small molecule which stabilizes the correct... protein ... Protein -folding Diseases and chaperone Biology ... length of the polyglutamine expansion...
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