ACS PressPac -- Dec. 10, 2008

...umans. Although promising as an anti-cancer agent, ceramide also is insoluble in the blood stream making deliv...icles (CPNPs). The particles are soluble and with ceramide encapsulated with the calcium phosphate, effectively make ceramide soluble. With...

Nontoxic nanoparticle can deliver and track drugs

... at Penn State College of Medicine, have optimized ceramide for both cancer and vascular disease. Their grou...using human vascular smooth muscle cells in vitro, ceramide encapsulated in calcium phosphate nanoparticles re... by up to 80 percent at a dose 25 times lower than ceramide administered freely, without damaging the cells. ...

Case Western Reserve and Penn State investigators inhibit corneal inflammation

...ound that when delivered in nano-sized packages reduces corneal haze, corneal thickening and inflammation. These nano-sized packages permit the use of ceramide as an eye drop. Drs. Pearlman and Kester are working towards human trials with this reagent. Inflammation and corneal infections are potential si...

Synthetic molecules hold promise for new family of anti-cancer drugs

...les developed by Dagan and Gatt are derivatives of ceramide (a member of the sphingolipid family). ceramide induces programmed cell death (apoptosis) in a variety of cancer cells. The natural levels of ceramide in cancer cells are generally too low to induce a ...

New Genetic Studies Carried Out in Cancer Therapy

...o a wide range of chemotherapeutic drugs. Although ceramide has been associated with apoptosis for some time, .... In this study, decreased expression of a ceramide transport protein, COL4A3BP, sensitized cancer cel...xel-induced prolonged mitotic arrest may result in ceramide accumulation and initiation of apoptosis, while in...

Lipid Plays Big Role in Embryonic Development

... They found that in the first few days of life, ceramide helps stem cells line up to form the primitive ect...l College of Georgia. Probably 90 percent of ceramide gathers at the top or apical end of these early st...own, a head and foot of the cell, and that is what ceramide most likely regulates,” says Dr. Bieberich. “Cell ...

Ceramide Directs Stem Cells in Embryo

... They found that in the first few days of life, ceramide helps stem cells line up to form the primitive ect...l College of Georgia. Probably 90 percent of ceramide gathers at the top or apical end of these early st...own, a head and foot of the cell, and that is what ceramide most likely regulates,' says Dr. Bieberich. 'Cell ...

Ceramide can target and kill cancer cells

...ed their techniques on mice for successful results. However injecting ceramide in the usual way into the blood stream can have severe toxic results. Scien...ature, and disrupts the mitochondria of the cells. In mice these bundles of ceramide targets and destroys only breast cancer cells, leaving the surrounding cell...

Ceramide in Biological News

Neuronal conduction of excitation without action potentials based on ceramide production

Researchers from the Laboratoire de Physiologie Neurovg tative (CNRS-INRA-Universit Paul C zanne), the Laboratoire de Chimie Biologique Applique (INRA-Universit Paul Czanne) and from the D partement Lipoprotines et M diateurs Lipidiques (INSERM, Hopital Purpan Toulouse), and in particular Profes...

Breast cancer cells recycle to escape death by hormonal therapy

...r protein Rb and low levels of the lipid ceramide. ceramide is vital but causes cell death at high levels. MCG...sity of Georgia showed in 2003 that high levels of ceramide kill cells that are unnecessary to the developing ...w studies will further explore the roles of Rb and ceramide in breast cancer survival during macroautophagy an...

Story ideas from the Journal of Lipid Research

...PC-5, and K6PC-9 may be used to treat skin diseases arising from abnormal growth of skin cells, the scientists concluded. Article: Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation , by Yoo Bin Kwon, Chang Deok Kim, Jong-Kyung You...

Ceramide in Biological Technology

LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43)

...oxicity test based on calcein AM release. Human Immunology 37: 264-270 (1993). 5. Hausner, J. M. L., Buehrer, B. M., and Bell, R. M. Role of ceramide in mitogenesis induced by exogenous sphingoid bases. J. Biol. Chem. 269: 6803-6809 (1994). 6. Jacobson, M. D., Weil, M. and Raff, M. C. Role...

Ceramide in Biological Definition

Phospholipid

... is sphingosine , an amino alcohol formed from palmitate and serine . The amino terminal is acylated with a by a long-chain acyl CoA to yield ceramide . Subsequent substitution of the terminal hydroxyl group by phosphatidyl choline forms sphingomyelin. Sphingomyelin is present in all eukaryotic ...

Signal transduction

...second messenger molecules One group of lipophilic second messenger molecules consists of inositol triphosphate and diacylglycerol . Others are ceramide and lysophosphatic acid . Nitric oxide (NO) as second messenger The gas nitric oxide is a free radical which diffuses through the plasm...