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Centromere in Medical News

Researchers solve first structure of a key to intact DNA inheritance

...he scientists capture the first structure ever solved of a segrosome complex that partitions and divides DNA. A protein called ParR connects with a centromere DNA site, a round string of DNA repeats in the plasmid, to form the segrosome complex, which then completes itself by attracting filaments of another ...
Centromere in Medical Products

Fluorescent HEp-2000 ANA

Features:...y-to-read mitotic cells Clear pattern identification Ready-to-use pattern controls and conjugates Positive pattern controls for: - homogeneous - centromere - SS-A/Ro - speckled - nucleolar Titratable control referenced to the WHO standard 66/233 for ANA...
Company:Immuno Concepts N.A. Ltd.
Centromere in Biological News

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

...le), from the centre of the cell to the poles. The centromere is the area of the chromosome that directs this at...ement along the protein track. The location of the centromere on the chromosome is marked by the presence of a p...nts of the cell to orchestrate the assembly of the centromere was not understood - until now. Using a newly...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

...these components," explains Joshua-Tor, "there has been a longstanding debate over how the RITS complex initially gets recruited to the regions at the centromere that are destined to become heterochromatin." At first, scientists thought that the siRNA molecules acted as guides to recruit RITS. After latchin...

Centromeres cross over, a lot

...exes called shelterins and by DNA methylation. The centromere has no shelterin, but it is methylated. Knockdown ... methyltransferases increased recombination at the centromere by about 50%, and decreased centromere length, possibly because of misalignment between r...

Exploring the dark matter of the genome

...'s centromeres and telomeres. In a typically bow-tie-shaped chromosome, the centromere is the knot. Centromeres play a crucial role in controlling chromosome dupl..." -- that is, from one end of the chromosomes to the other -- including the centromere in the middle." Obtaining a more complete picture of the sequence of hetero...

Regulating the nuclear architecture of the cell

...res -- chromatin structures best known for limiting, by their diminishing length, how many times a cell can replicate. Heterochromatin also flanks the centromere in the central region of the chromosome, the chromatin structure that plays a crucial role in chromosome segregation during cell division. What other ...

One-dimensional diffusion accelerates molecular motors

...y Prof. Jonathon Howard and Stefan Diez at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden. The motor protein MCAK (Mitotic centromere Associated Kinesin) goes into action at the end of microtubules where it disassembles them. This is in contrast to most other motor proteins, which tr...

15-year hunt finds cause of pseudothalidomide syndrome

... together, ensuring that the two copies are lined up together at the center of the dividing cell. Once lined up, tiny molecular "motors" attach to the centromere of each copy and pull the original and the new copy away from each another as division proceeds. However, in cells from people with Roberts syndrom...

Found: Missing sequence of the human Y chromosome

...nome Research that they have successfully cloned and characterized a previously intractable DNA sequence: a 554-kilobase-pair genomic segment near the centromere of the human Y chromosome. This sequence contains eight putatively active genes that could be implicated in sex-associated height differences and gona...
Centromere in Biological Technology

Rice Centromere, Supposedly Quiet Genetic Domain, Surprises

... significant step," says Jiang. "This is the first centromere to be sequenced at this level for any higher organism." The centromere of rice, says Jiang, lent itself to sequencing bec... a surprise, says Jiang. The newly discovered rice centromere genes, whose functions are unknown, belie the idea...
Centromere in Biological Products

LNA-ISH Cytogenetics - Human centromere alpha satelliteISH probes from Exiqon

Description: Exiqons LNA technology enables sensitive, fast and specific detection of chromosomal sequences directly on intact chromosomes. Short hybridisation time ( Works on fixed cells and chromosome spreads Multiplex capability Available with different tags Pre-validated probes Probes available w...
Company:Exiqon
Centromere in Biological Definition

Centromere

The centromere is a region of a eukaryotic chromosome where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis . It is also the site of the primary constriction visible in microscopy images of chromo...

Barr body

...hromosome (Y or W). Mechanism Mammalian X-chromosome inactivation is initiated from the X inactivation centre or Xic , usually found near the centromere . The centre contains twelve genes, seven of which code for proteins , five for untranslated RNAs , of which only two are known to play an active ro...

Chromatin

...evels of DNA condensation. (1) Single DNA strand. (2) Chromatin strand ( DNA with histones ). (3) Condensed chromatin during interphase with centromere . (4) Condensed chromatin during prophase . (Two copies of the DNA molecule are now present) (5) Chromosome during metaphase . Two distinct ty...

Chromatid

... After they have been pulled apart by the mitotic spindle , chromatids are called "chromosomes". Sister chromatids are joined at a point called the centromere . In non-gametic, non-dividing human cells, there are 23 pairs of chromosomes, thus 46 chromosomes. When it is ready to divide, each chromosome will r...

Chromosome

...ical parts of the chromosome after S phase . (2) centromere . The point where the two chromatids touch, and wh...ed in the cell's nucleus. Each chromosome has one centromere , with one or two arms projecting from the centrom...which is never expressed. It is located around the centromere and usually contains repetitive sequences. Facu...

Chromosomal crossover

...i, the result can be a duplication of genes on one chromosome and a deletion of these on the other. If they break and rejoin on opposite sides of the centromere , the result can be one chromosome being lost during cell division . If homologous chromosome are not perfectly aligned an unequal crossover may oc...

Meiosis

...ernal gamete nuclei come together and pair up. They have same lengths, same centromere positions and in most cases same number of genes arranged in linear order. ...whole centromeres , lining up the bivalents along the equator so that each centromere is equidistant above and below the equator. The lining along the equator is...

Mitosis

...ome in the cell. Identical chromosomes (called sister chromosomes) are attached to each other at a DNA element present on every chromosome called the centromere . A protein called cohesin acts as a glue joining two sister chromosomes (a.k.a. sister chromatids) along their lengths. When chromosomes are paired ...

Mitotic spindle

...the spindle is formed by the centrosomes as they move apart. Some of the spindle's microtubules attach to the kinetochores that assemble on the centromere portion of the chromosomes and then pull the chromosomes into alignment along the center of the spindle. Once all the chromosomes are aligned wi...

Prophase

...ome in the cell. Identical chromosomes (called sister chromosomes) are attached to each other at a DNA element present on every chromosome called the centromere . When chromosomes are paired up and attached, each individual chromosome in the pair is called a chromatid , while the whole unit (confusingly) ...
Centromere in Biological Dictionary

Centromere

A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come in contact. It is involved in cell division as the point of mitotic spindle. centromere ( ) n. The most condensed and constricted region of a chromosome, to whic...

Metacentric

...rtical distance between a ship's center of gravity and its metacenter, for metacentric adj. Of or relating to a metacenter. Genetics. Having the centromere in the median position so that the arms are of equal length metacentric . Definition from Wiktionary, a free dictionary. Jump to: navigation, s...

Locus

... or intense concentration: "the cunning exploitation of loci of Locus (genetics) Short and long arms Chromosome components: (1) Chromatid (2) centromere (3) Short arm (4) Long arm Example of bands In the fields of home | products & services | news | contact us | careers. Copyright © 2008 Locus ...

Loci

... videos, listen to free streaming mp3s, & read Loci's blog. Locus (genetics) Short and long arms Chromosome components: (1) Chromatid (2) centromere (3) Short arm (4) Long arm Example of bands In the fields of loci [L.] plural of locus . ... Why does linkage between loci tend to decrease ...

Kilobase

..... Scientists report that they have successfully cloned and characterized a previously intractable, 554- kilobase -pair genomic segment near the centromere of the human Y ... Inverse polymerase chain reaction (Inverse PCR) is a variant of the polymerase ... One limitation of conventional PCR is ...

Interkinesis

...ce in mitosis, except no ... ... five centromeric signals can be detected per interkinesis nucleus (Fig. 6B,C) ... We found only one separated centromere in 88 scored smg7 interkinesis nuclei. ... ...

Heterozygous

...imilar alleles at corresponding chromosomal loci; ... One strand of a replicated chromosome as ... A single strand by itself with it's own centromere is a chromosome and not a chromatid. ... heterozygous ... A simple kind of learning involving a loss of sensitivity to ... heterozygous (het...

Daughter Chromosome

...r spirem, and ... Offers a pictorial tour of the process of cell division. ... the onset of anaphase, each daughter chromosome possesses one centromere and one ... Brief review of mitosis, a comparison with meiosis and step-by-step walk ... Telophase—the groups of daughter chromosomes are gr...

Acrocentric

...l centromere; "an acrocentric chromosome" ... centromere ( ) n. The most condensed and constricted region o...l including ... acrocentric adj. Having the centromere located near one end of the chromosome so that ...ocentric /ac·ro·cen·tric/ (-sen'trik) having the centromere toward ... Acrocentric . Definition(s) ... De...

Acentric

...confuse this word ... Acentric - Definition of Acentric at Dictionary.com a free online dictionary ... ACENTRIC - 3 dictionary ... lacking a centromere < acentric chromosomes> ... ...
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