Excess Cdk5 Enzyme Can Harm Brain
A research conducted by the Howard Hughes Medical Institute, the National Institute of Mental Health and the Harvard Medical School has revealed that a brain enzyme plays a prominent role// in maintaining and developing learning and memory. If the enzyme is present in high levels, then it can have ...
Protein can nurture or devastate brain cells, depending on its 'friends,' researchers find
...UT Southwestern research teams studied the protein cdk5
and discovered both helpful and detrimental mechan... mechanism of the helpful "Dr. Jekyll" side of the cdk5
protein, which is also thought to kill brain cells...thwestern, found yet another harmful action of the cdk5
protein. It can stunt learning and reduce motor co...
Alzheimer's disease as a case of brake failure?
.... The scientists focused on one particular kinase cdk5
termed "an atypical kinase" because they could fi...e it appears to be inert as a cell cycle promoter, cdk5
in the nervous system actually functions to hold t...e brain," Herrup said. "What we discovered is that cdk5
acts as a brake, not a driver."
Their latest la...
Recognizing outstanding young researchers
...to the learning processes in the brain. Fischers research on protein kinase cdk5
and on the activator protein p25, which continued while working as a postdo... is of particular importance. He was able to demonstrate, for instance, how cdk5
and p25 are capable of increasing learning ability over a short time period...
Brain Protein May Be a Clue to Autism
...g a brain protein called CASK and an enzyme called cdk5
may be part of the cause of autism and other brain...w a kinase (an enzyme that change proteins) called cdk5
interacts with CASK.
"We found that cdk5
is critical for recruiting CASK to do its job for ...
Parkinsons Disease Mechanism Identified
...the researchers analyzed neurons to determine that cdk5
regulates yet another enzyme called Prx2. This enz...rs found that treating neurons with MPTP activates cdk5
to switch off Prx2. Whats more, they found that ac...hey experimentally demonstrated that the action of cdk5
on Prx2 plays a pivotal role in the neuronal damag...
First Drug for Post-traumatic Stress Disorder
... (kinases are enzymes that change proteins) called cdk5
facilitates the extinction of fear learned in a pa...he current work, the MIT researchers looked at how cdk5
affects the ability to form and eliminate fear-related memories.
"Remarkably, inhibiting cdk5
facilitated extinction of learned fear in mice. Th...
Scientist Found New Mechanism for Brain Learning
...netically engineered mice to lack an enzyme called cdk5
in their brains by using the technique called cond...t, and worked out the new route.
works with another enzyme to break up a molecule c...earning.
The new research showed that when cdk5
is removed from the brain, the levels of NR2B sign...
Researchers Identify New Genetic Risk Factors for Type 2 Diabetes
...egulating insulin action.
CDKAL1. This gene codes for a protein called cdk5
regulatory subunit associated protein1-like1. The protein may affect the ac...in-producing cells, known as beta cells. In addition, excessive activity of cdk5
in the pancreas may lead to the degeneration of beta cells.
How neuronal activity leads to Alzheimer's protein cleavage
...ns to BACE domains. What is clear, however, is that the process is an active one, requiring a kinase called cdk5. Furthermore, treating neurons with a cdk5
inhibitor called roscovitine, which is currently in trials for cancer treatment, reduced APP's association with BACE microdomains and reduced APP clea...
'Smart' mice teach scientists about learning process, brain disorders
... poses a danger is a major goal.
In addition, cdk5
is heavily implicated in Alzheimer’s disease and a...s study was being able to "knock out" the gene for cdk5
only in the brain, and only when the mice were adu... together and actually applied it."
works with another enzyme to break up a molecule c...