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Cationic in Medical News

Nanoparticle-delivered 'Suicide' Genes Slowed Ovarian Tumor Growth

...kenau Institute for Medical Research. Sawicki and colleagues at the Massachusetts Institute of Technology evaluated the therapeutic efficacy of a cationic biodegradable beta-amino ester polymer as a vector for the nanoparticle delivery of a DNA encoding diphtheria toxin suicide gene. These nanoparticles ...

Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings

...5-log (99.999%) average reductions of common pathogens within the dressings. The active component of the dressings, a non-toxic high molecular weight cationic polymer - p-DADMAC - is patented for use in wound dressings and a variety of other fields by Quick-Med Technologies, Inc (QMDT.OB). Derma Sciences en...

Derma Sciences Gains FDA Clearance for Novel BIOGUARD(TM) Barrier Dressing with NIMBUS(R) Technology

....'s patented NIMBUS(R) (Novel Intrinsically Micro Bonded Utility Substrate) cationic biocide technology, licensed by Derma Sciences in 2007. This represents the...aching bond between the dressing substrate and the active agent. The NIMBUS cationic biocide is permanently bonded to the gauze, keeping it from depleting in th...

DiFUSION Technologies Announces Company Launch Focused on Surgical Site Infections (SSIs)

...focus of quality improvement as part of the 'pay for performance' initiative for hospitals, insurers and physicians." "The controlled delivery of cationic elements possible with our 'super silicate' open multiple promising applications from infection control to bone growth," said Dr. Gary Ghiselli, chair...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...al contraceptives, providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, and organic cationic transporter (OCT). Digoxin: Sitagliptin had a minimal effect on the pharmacokinetics of digoxin. Following administration of 0.25mg digoxin conco...

Juvaris BioTherapeutics, Inc. Announces the Appointment of Grant E. Pickering as Chief Executive Officer

...is BioTherapeutics is developing an immunotherapeutic product platform for the treatment of infectious diseases and cancers using lipid-DNA complexes. cationic lipids are formulated with non-coding DNA (plasmid) to create JVRS-100, a lipid-DNA complex, which as a single product will have utility in multiple i...

Bayer HealthCare and Juvaris BioTherapeutics Announce Major Licensing Agreement

...s was created in 2003 to develop an immunotherapeutic product platform for the treatment of infectious diseases and cancers using lipid-DNA complexes. cationic lipids are formulated with non-coding DNA (plasmid) to create the JuvImmune (JVRS-100) Immunostimulant, a lipid-DNA complex, which as a single product...

Vical Expands Clinical Testing of DNA Vaccine Against H5N1 Pandemic Influenza

...l development was provided under a previously-announced grant from the National Institutes of Health. About Vaxfectin(TM) Vaxfectin(TM) is a novel cationic lipid formulation optimized by Vical to increase the immune response to pDNA vaccines. Vaxfectin(TM) formulations have demonstrated safety and adjuvan...

Indian Scientists Identify Second Pancreatitis Gene

...her there was any link between the two and its role. In case of pancreatitis in the west, the disease is caused by the mutation of another gene - cationic trypsinogen - and this mutation is not found among the populations of tropical countries. "This underlines the need for conducting separate resea...

Popcorn Workers At Health Risk

...entrations in nonsmoking workers were significantly higher than those of the healthy nonsmoking control group, and sputum interleukin-8 and eosinophil cationic protein levels were higher in high-exposure workers than in low-exposure workers. These findings indicate that high exposure to popcorn flavorin...
Cationic in Medical Technology

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

...clinical trials in cancer. EP-100 is the first candidate from the Company's cationic Lytic Peptide (CLYP(TM)) platform technology. EP-100 is a targeted membrane...cals, Inc. is developing a new class of targeted anticancer drugs using its cationic Lytic Peptide (CLYP(TM)) platform technology. These drug candidates, called...

Novagali Pharma Completed a New Phase II With Cyclokat(R) in Dry Eye

...oprietary ophthalmic emulsion enabling an optimal penetration of Cyclosporine in tissues of the eye surface that benefit from Novasorb(R), Novagali(R) cationic emulsion technology. About Novagali Pharma : http://www.novagali.com Novagali Pharma is an ophthalmic pharmaceutical company that deve...

Novagali Pharma Presents Results of its Innovative Latanoprost Formulation for Glaucoma

...y ocular surface damages upon stress conditions. Nova21027 is a topical ocular BAK-free emulsion of latanoprost relying on Novasorb(R) patented cationic emulsions technology. The company achieved a product that present a safer profile than BAK-containing marketed products for glaucoma. This feature is ...

Juvaris BioTherapeutics Announces Cooperative Research and Development Agreement With The Centers for Disease Control and Prevention

...s was created in 2003 to develop an immunotherapeutic product platform for the treatment of infectious diseases and cancers using lipid-DNA complexes. cationic lipids are formulated with non-coding DNA (plasmid) to create the JuvImmune Immunostimulant, a lipid-DNA complex, which as a single product will have ...

Cutanea Announces Promising Phase II Results in Rosacea with Omiganan

...ntrations and in all trials conducted, omiganan was found to be safe, well tolerated and non-irritating with no evidence of systemic absorption. While cationic antimicrobial peptides, such as Omiganan, are well known for their antimicrobial properties, recent research has shown that they also may play a role ...

Novagali Pharma Announces Positive Vekacia Clinical Results From Pivotal Phase III Trial in Vernal Keratoconjunctivitis

...ine A for the treatment of VKC. Vekacia(R) is a topical Cyclosporine A cationic emulsion enabling an efficient and unmatched-level drug absorption in tissu...ry enthusiastic about the confirmation of the high potential of Novasorb(R) cationic emulsion technology through the development of Vekacia(R) and its successfu...

Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis

...(R): Vekacia(R) is a Cyclosporine A ophthalmic product intended for patients suffering from vernal keratoconjunctivitis. Vekacia(R) is a proprietary cationic emulsion enabling an efficient and unmatched-level drug absorption in tissues of the eye leading to optimal therapeutic efficacy. About Novagali Pha...
Cationic in Medical Products

Eosinophil Cationic Protein

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Cationic in Biological News

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

...nkenau Institute for Medical Research. Sawicki and colleagues at the Massachusetts Institute of Technology evaluated the therapeutic efficacy of a cationic biodegradable beta-amino ester polymer as a vector for the nanoparticle delivery of a DNA encoding diphtheria toxin suicide gene. These nanoparticles ...

Tips from the journals of the American Society for Microbiology

...hen the body responds to foreign pathogens at an early stage of infection. cationic antimicrobial peptides (known for their antibacterial, antifungal, antivira...ch kills microorganisms. In a previous study researchers developed the cationic antimicrobial peptide L5 out of antibacterial proteins from Sarcophaga per...

Researchers from the UGR use a bacterium to obtain biopreservatives from food

...ind new antimicrobial agents because of the stronger resistance acquired by bacteria. Researcher Sánchez Hidalgo points out that natural antimicrobial cationic peptides such as bacteriocins "represent a good alternative." Bacteriocins are proteins that are biologically active against members of the same ...

Honey helps problem wounds

...00 courses of disease over the next few months. The next step planned is comparative studies with other therapeutic methods such as the very expensive cationic silver dressings. 'These too are an effective anti-bacterial method,' says Dr. Arne Simon. 'However, it is not yet clear whether the silver released f...

'Cookbook recipes' would cure disease with nontoxic DNA delivery systems

...tively charged DNA molecules and have been used for DNA delivery, but these cationic molecules are often toxic to cells, Wong said. An alternative is to use nat...l arrangements." Utilizing naturally occurring anionic lipids instead of cationic lipids "creates a whole hierarchy of interactions and a much richer range o...
Cationic in Biological Technology

Novagali Pharma Announces FDA Clearance of IND for Phase III of Catioprost(R), its Cationic Emulsion of Latanoprost in Patients With Glaucoma

EVRY, France, May 5 /PRNewswire/ -- Novagali Pharma, a French pharmaceutical ophthalmic company, announces today that the Company's Investigational New Drug Application (IND) to conduct a Phase III clinical trial of Catioprost(R) (Nova21027), for the treatment of glaucoma has been granted by t...

Frost & Sullivan Recognizes Novagali Pharma for Innovation in Ophthalmic Therapies

...ntra-ocular platform offers improvements over existing implant technology in treating challenging diseases of the eye's posterior." Novasorb is a cationic emulsion technology platform being investigated to treat dry eye, glaucoma, allergies, and anterior uveitis. As the effective treatment of surface ocu...

DiFUSION Technologies Completes Successful Testing of Antimicrobial Spinal Implant

...robial coatings which do not fight infection past the first 48 hours. Our technology provides antimicrobial protection for 4 weeks due to 'controlled cationic release'," said Dr. Hyun Bae, a member of DiFUSION's scientific advisory board and a board-certified orthopaedic surgeon in Santa Monica, California, ...

Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008

...ry and development of novel antibiotics against multidrug-resistant Gram-negative bacteria. The NAB compounds are polymyxin derivatives that have less cationic charges than the polymyxins currently in clinical use. This difference is believed to result in reduced nephrotoxicity of the novel compounds. For mor...

MIGENIX Reports First Quarter Fiscal 2009 Financial Results

...DEVELOPMENT PROGRAMS Omiganan 1% gel (Omigard(TM)/CPI-226/MX-226; topical cationic peptide; prevention of catheter-related infections): Cadence Pharmaceutical...e completed after positive CLIRS trial results. Omiganan (CLS001; topical cationic peptide; treatment of dermatological diseases): Cutanea Life Sciences ("Cut...

Senesco Signs a Supply Agreement for Polyplus-transfection's Delivery System

...HT (RNA Interference Technology as Human Therapeutic Tool). Polyplus-transfection recently extended its field of expertise to the development of new cationic oligonucleotides, ZNA (Zip Nucleic Acid), for molecular biology and diagnostics. For more information, visit: http://www.polyplus-transfection.com ...

Novagali Pharma Announces the Launch of Cationorm(R)

... The Innovative cationic Emulsion for the Treatment of Dry Eye Symptoms ... in France of its first product Cationorm(R). This cationic emulsion is an innovative approach to treat dry ey... the patients suffering from dry eye symptoms. The cationic emulsion reproduces the tear mechanisms of action ...

MIGENIX Reports Third Quarter Fiscal Year 2008 Financial Results

...DEVELOPMENT PROGRAMS Omiganan 1% gel (Omigard(TM)/CPI-226/MX-226; topical cationic peptide; prevention of catheter-related infections): A pivotal Phase III st...ion of a partnership is uncertain at this time. Omiganan (CLS001; topical cationic peptide; treatment of dermatological diseases): Based on positive results f...

Nastech Assigns Intellectual Property Related to the Development of RNA-Based Therapeutics to its Subsidiary, MDRNA, Inc.

... includes: -- the building blocks for drugs, including novel nucleotides, cationic lipids, and formulations; -- the RNA drug cargo, i.e., RISC and Dice...ns and Methods for Complexes of Nucleic Acids and Organic Cations -- cationic Peptides for siRNA Intracellular Delivery -- Formulations for Intracellul...

MIGENIX Reports Second Quarter Fiscal Year 2008 Financial Results

...DEVELOPMENT PROGRAMS Omiganan 1% gel (Omigard(TM)/CPI-226/MX-226; topical cationic peptide; prevention of catheter-related infections): A pivotal Phase III st...inst HCV, continues in other key jurisdictions. Omiganan (CLS001; topical cationic peptide; treatment of dermatological diseases): Cutanea Life Sciences, Inc....
Cationic in Biological Products

PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection

Description:...tracellular proteins in living cells with antibodies without fixation, eliminating the time and effort of fixing cells. PULSin contains a proprietary cationic lipid that noncovalently complexes with many proteins including antibodies. Complexes are internalized via anionic cell-adhesion receptors present on ...
Company:Polyplus Transfection

PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection

Description:...tracellular proteins in living cells with antibodies without fixation, eliminating the time and effort of fixing cells. PULSin contains a proprietary cationic lipid that noncovalently complexes with many proteins including antibodies. Complexes are internalized via anionic cell-adhesion receptors present on ...
Company:Polyplus Transfection

Mito Casp from BACHEM

Description:...c and bind covalently to the active caspases within the cells. At the same time the mitochondrial membrane potential is visualized by a cell-permeable cationic red fluorescent dye which is accumulated by the mitochondria of healthy but not apoptotic cells. The kit can be used in conjunction with other antibod...
Company:BACHEM

Cation Exchange ProteinChip Arrays from Ciphergen

Description:... to rapidly capture, purify and characterize proteins directly on the chip. cationic arrays bind proteins through electrostatic interaction of positively charge...ip WCX2: is a weak cation exchange array with a carboxylate surface to bind cationic proteins. The negatively charged carboxylate groups on the surface of the W...
Company:Ciphergen

APO LOGIX - JC-1 Mitochondrial Membrane Potential Detection Kit from BACHEM

Description:...measured by the change in the membrane potential (YD). Loss of mitochondrial YD is indicative of apoptosis and can be detected by a unique fluorescent cationic dye, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzamidazolocarbocyanin iodide, commonly known as JC-1. Application: Fluorescence via flow cytometry,...
Company:BACHEM
Cationic in Biological Dictionary

Oligodeoxyribonucleotide

... in chronically infected H9 cells, was fluorescently labeled to ... ... modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic ... oligodeoxyribonucleotide is associated with sensitization of human laryngeal ... Oligodeoxyribonucleotide probe accessibility on a thre...

Hyperpolarization

...ventral part of the pedunculopontine ... The membrane hyperpolarization persisted for ... ... blocking h currents ( hyperpolarization -activated cationic currents) with ... is consistent with Cs+-induced hyperpolarization under a current-clamp condition. ... Neurons expressing a strong hyperpolari...
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