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Cathepsin in Medical News

Cathepsin B increases apoptosis in fulminant hepatic failure

...apoptosis in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis is involved in the..., the research examined the protective effect of a cathepsin B inhibitor (CA-074Me) on fulminant hepatic failur...Hospital of Harbin Medical University investigated cathepsin B expression changes in the liver of fulminant hep...

Drug blocks two of world's deadliest emerging viruses

...he chloroquine molecule appears to block the action of a key enzyme, called cathepsin L, which is essential to the virus's growth and maturation. Without this en...vade, but cannot cause disease. Several other zoonotic viruses depend on cathepsin L -- most notably, Ebola. "Our findings, and our methods, could easily be a...

Drug blocks 2 of world's deadliest emerging viruses

...he chloroquine molecule appears to block the action of a key enzyme, called cathepsin L, which is essential to the virus's growth and maturation. Without this en...vade, but cannot cause disease. Several other zoonotic viruses depend on cathepsin L -- most notably, Ebola. "Our findings, and our methods, could easily be a...

Genetic disorder sheds light on enzyme's role in bone metabolism

.... It is caused by deficiency of an enzyme known as cathepsin K which hampers osteoclasts (the cells that break ...poor bone resorption and dense, brittle bones. cathepsin K's role in bone metabolism has largely been studi...oped psoriatic arthritis. Since the patient lacked cathepsin K due to her condition, researchers hypothesized t...

Merck's odanacatib increased BMD over 2 years at key fracture sites in Phase IIB study

...treatment option for osteoporosis." Odanacatib selectively inhibits the cathepsin K enzyme believed to play a central role in osteoclastic bone resorption, p...icularly in the degradation of the protein component of bone. Inhibition of cathepsin K is a novel approach to the treatment of osteoporosis that differs from th...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...xl; Bap31; Bcl-xL; Bcl-2; bcr-abl/abl (including mutated forms); B-FN (ED-B fibronectin); carboxyanhydrase IX (CA IX); carcinoembryonic antigen (CEA); cathepsin K (CTSK); C-C chemokine receptor 4 (CCr4); CD105 (endoglin); CD13; CD19; CD20; CD22; CD25; CD3; CD30; CD33; CD38; CD4; CD40; CD55; CD56; CD70; CD74; C...

Receptor protein appears to be key in breakdown of kidney filtration

...hanisms involved in proteinuria, including the activity of an enzyme called cathepsin L, reported earlier this year by members of the same research team. We are...w in two directions to better understand the relationship between uPAR and cathepsin L and to conduct a clinical trial with small molecules blocking uPAR or alp...

The most important candidate genes for pancreatic stone formation

...nvestigated the interaction between the reg1 gene and the established susceptibility genes for TCP, such as pancreatic secretory trypsin inhibitor and cathepsin B (encoded by SPINK1 and CTSB respectively). On testing the hypothesis in a large cohort of ethnically matched TCP patients and normal individuals...

Indian Scientists Identify Second Pancreatitis Gene

...ientists have discovered a second candidate gene - cathepsin B - responsible for the fatal tropical calcific pa...er research led to the discovery of another gene - cathepsin B - that causes the same disease. According ...journal GUT in its online edition, the mutation of cathepsin B works like a trigger for trypsinogen to become a...

Enzyme for treatment of arthritis

... joint inflammations in conditions like // arthritis. An enzyme called cathepsin G can regulate the ability of the immune cells to secrete chemicals that wi...e process of inflammatory conditions that can lead to arthritis. The enzyme cathepsin G attracts accumulation of immune cells that can lead to damage of the tiss...
Cathepsin in Biological News

University of Minnesota study refutes belief that black men have more aggressive prostate cancer

...troying membranes that keep cells in place. Called cathepsin B, the enzyme, if unchecked, carves out an escape ...s of a substance, known as stefin A, that inhibits cathepsin B. The ratio of the two substances in slices of pr...gressive ones are characterized by a high ratio of cathepsin B to stefin A. Results showed that the ratios w...

Enzyme shreds Alzheimer's protein

...ue that is one of the hallmarks of Alzheimer's disease (AD), researchers have found. They said their findings in mice suggest that the protein, called cathepsin B (CatB), is a key part of a protective mechanism that may fail in some forms of AD. Also, they said their findings suggest that drugs to enhance CatB...

Study finds adult stem cells can replicate

...edicine in St. Louis shows that an enzyme known as cathepsin G regulates the ability of immune cells known as n...udy appears in the June 2005 issue of Immunity. cathepsin G, which is made by the neutrophils it regulates, ...inhibits proteases, so scientists who try to block cathepsin G's role in inflammation will already have an exte...

Enzyme's newly discovered role may make it target for arthritis treatment

...edicine in St. Louis shows that an enzyme known as cathepsin G regulates the ability of immune cells known as n...udy appears in the June 2005 issue of Immunity. cathepsin G, which is made by the neutrophils it regulates, ...inhibits proteases, so scientists who try to block cathepsin G's role in inflammation will already have an exte...

Scientists discover how Ebola virus infects cells

...lls before exposing them to Ebola virus. When one specific cellular enzyme, cathepsin B, was inhibited, the infectivity of Ebola virus dropped to near zero. An accessory role is played by another cellular enzyme, cathepsin L, the scientists determined. Inhibitors of cathepsins are already under...
Cathepsin in Biological Technology

VisEn Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent

...of its new Cat-K FAST (TM) imaging agent for measuring and monitoring cathepsin K activity associated with disease progression and therapeutic response in vivo . cathepsin K expression is well known as a key biomarker and therapeutic target in a r...

Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology

...cate that carfilzomib has minimal activity on proteases other than the proteasome. In contrast, bortezomib targets several serine proteases including cathepsin G, an enzyme whose inhibition may play a role in neuropathic pain. Proteolix researchers believe that these observations may translate into a differe...

Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results

...yment from Johnson & Johnson Pharmaceutical Research and Development, LLC (J&JPRD) triggered by J&JPRD's selection of a compound targeting the cathepsin S enzyme as a development candidate emerging from a collaboration with Sunesis. -- Lesley A. Stolz, Ph.D., joined Sunesis in November 2007 as Vic...

Sunesis Pharmaceuticals Announces Milestone Payment from Inflammation Collaboration

... by J&JPRD's selection of a compound targeting the cathepsin S enzyme as a development candidate. Under the ter.... "We believe that a small molecule inhibitor of cathepsin S will provide a useful approach to treating certa...D., Vice President of Research at Sunesis. About cathepsin S ...
Cathepsin in Biological Products

Sheep Anti-Human CATHEPSIN G Polyclonal Antibody, Unconjugated from AbD Serotec

Description: SHEEP ANTI HUMAN CATHEPSIN G...
Company:AbD Serotec

Human Cathepsin D from Calbiochem

Description: Lyophilized. Lyophilized from 2 mM sodium phosphate buffer, pH 6.5. Cathepsin D from human liver. Cathepsin D is a major lysosomal aspartyl protease in mammalian cells produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse an...
Company:Calbiochem
Cathepsin in Biological Dictionary

CAT assay

...ube. 16. Store at -70 °C or proceed to CAT activity assay . ... Apoptosis can be mediated by mechanisms other than the traditional caspase ... cathepsin Assay Kits. Cat . # Size. Price (USD) Data Sheet. Add to Cart ... ...
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