Misdiagnosis of cataplexy

Cataplexy, transient episodes of bilateral muscle weakness with areflexia provoked by emotions, is a state highly specific to narcolepsy. Cataplexy is diagnosed based on clinical interview. Two screening tools have been // developed recently but their usefulness has been limited because of length o...

Jazz Pharmaceuticals to Present Data From First Phase III Study of Sodium Oxybate in Patients With Fibromyalgia

..., approved by the FDA for the treatment of excessive daytime sleepiness and cataplexy (the sudden loss of muscle tone) in adult patients with narcolepsy. The Ame...the European Medical Evaluation Agency for the treatment of narcolepsy with cataplexy in adult patients. Most commonly reported adverse drug reactions in narcole...

Researcher IDs Narcolepsy as Autoimmune Disease

... but sudden bursts of sleep during the day. The condition, which affects about one in 2,000 people, also causes poor nighttime sleep patterns and even cataplexy -- a sudden loss of muscle tone and strength. "This is a very important finding," sleep disorder expert Merrill Mitler, program director at the U.S...

Narcolepsy is an autoimmune disorder, Stanford researcher says

... a model for other diseases." Narcolepsy affects about one in 2,000 people and is characterized by daytime drowsiness, irregular sleep at night and cataplexy a sudden loss of muscle tone and strength. Mignot and others showed in the late 1990s that the disease stems from a lack of hypocretin, a hormone tha...

Treating sleep disorders in people with traumatic brain injury may not eliminate symptoms

...e of a sleep disorder, while 23 percent (13) had OSA, 7 percent (4) had periodic limb movements in sleep (PLMS), 5 percent (3) had narcolepsy without cataplexy and 3 percent (2) had post-traumatic hypersomnia. Participants underwent objective evaluation by overnight polysomnography to detect the presence of...

Potential dangers faced by narcoleptics who use nicotine outlined in new abstract

.... Narcolepsy patients who smoke may have more trouble quitting because of increased sleepiness. The role of nicotine to self-medicate sleepiness and cataplexy merits more study, said Dr. Krahn. Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably during the day. It also include...

Changes in narcoleptics' skin, core body temperatures affect their vigilance and sleepiness

... Neuroscience in Amsterdam, and Leiden University Medical Center in The Netherlands, focused on eight patients who were diagnosed with narcolepsy with cataplexy and suffered from excessive daytime sleepiness. The subjects vigilance was measured using the Psychomotor Vigilance Task, and their sleepiness was as...

Lower metabolism, eating behavior possibly explain the cause of overweight in narcolepsy

...trols were overweight. Overall, narcoleptics had lower metabolism than controls. Only typical narcoleptic patients (those with narcolepsy with clear cataplexy and with suspected hypocretin deficiency) tended to eat less than controls. Plasma glucose, cortisol, thyroid and sex hormone levels did not differ b...

Cataplexy During Status Cataplecticus Resembles REM Sleep

... cataplexy is a sudden temporary loss of muscle tone in the b...f intense emotional states like laughter or anger. cataplexy is one of the symptoms of// narcolepsy, which is a...iving. A study has led to the discovery that cataplexy during status cataplecticus partially resembles no...

Cataplexy in Medical Technology

Jazz Pharmaceuticals and UCB Announce Second Phase III Study of Sodium Oxybate in Patients With Fibromyalgia Meets Primary Endpoints

...icals in the U.S. for the treatment of excessive daytime sleepiness and cataplexy (the sudden loss of muscle tone) in adult patients with narcolepsy. The A...pe , where it is approved by the EMEA for the treatment of narcolepsy with cataplexy in adult patients under a license from Jazz Pharmaceuticals. Most commonly ...

Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia

...oved by the FDA for the treatment of excessive daytime sleepiness (EDS) and cataplexy (the sudden loss of muscle tone) in adult patients with narcolepsy. The Ame...opean Medical Evaluation Agency (EMEA) for the treatment of narcolepsy with cataplexy in adult patients. Most commonly reported adverse drug reactions in narcole...

Jazz Pharmaceuticals, Inc. Completes Enrollment in Second of Two Phase III Clinical Trials of Sodium Oxybate to Treat Fibromyalgia

...nd GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA for the treatment of excessive daytime sleepiness (EDS) and cataplexy (the sudden loss of muscle tone) in adult patients with narcolepsy. The American Academy of Sleep Medicine recommends sodium oxybate as a standard of...

Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia

...nd GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA for the treatment of excessive daytime sleepiness (EDS) and cataplexy (the sudden loss of muscle tone) in adult patients with narcolepsy. The American Academy of Sleep Medicine recommends sodium oxybate as a standard of ...

Jazz Pharmaceuticals, Inc. Announces Final Patient Has Completed Phase III Clinical Trial of Sodium Oxybate to Treat Fibromyalgia

...oxybate is the active ingredient in Xyrem(R), a Jazz Pharmaceuticals product approved by the FDA for the treatment of excessive daytime sleepiness and cataplexy (the sudden loss of muscle tone) in patients with narcolepsy. Sodium oxybate has not been approved for the treatment of fibromyalgia. About Fibromya...

Jazz Pharmaceuticals, Inc. Completes Enrollment in First of Two Phase III Clinical Trials of Sodium Oxybate to Treat Fibromyalgia

...ts who complete one of the two pivotal Phase III trials. Sodium oxybate is approved by the FDA for the treatment of excessive daytime sleepiness and cataplexy (the sudden loss of muscle tone) in patients with narcolepsy. Sodium oxybate has not been approved for the treatment of fibromyalgia. About Fibromya...

Cataplexy in Medical Dictionary

Narcolepsy

...narcolepsy lead quickly to a cure? ... The cause of narcolepsy without cataplexy is still under investigation. ... To understand Narcolepsy , one must ...ents with narcolepsy should try to take three or more short naps on a ... cataplexy occurs in about two-thirds of narcolepsy patients. ... Narcolepsy a...

Cataplexy in Biological News

Genetic study confirms the immune system's role in narcolepsy

...study, which appears today in Nature Genetics , focused on narcolepsy with cataplexy a sudden loss of muscle tone that can cause a person to collapse, with or ...as stimulant drugs for combating daytime sleepiness and antidepressants for cataplexy are only able to control symptoms, and do not address the underlying loss o...

What happens when we sleep

...wake state. These neurons are active in the waking state and turn off during sleep and in their absence, animals and humans experience narcolepsy with cataplexy or sudden loss of mucle tone. However, the role of MCH neurons was until now, unclear. Evidence from earlier knockout studies suggested that MCH neuro...