AUA Foundation announces 2009 Research Scholar Program award winners

...ibility of Clear Cell Renal Cell Carcinoma Smitha Dutt, PhD, University of California, Davis School of Medicine Role of Trefoil Factor 1 (TFF1) in castration Resistant Prostate Cancer Amit Gupta, MD, MPH, Memorial Sloan-Kettering Cancer Center Significance of Prostate-Specific Antigen and Kallikrein 2 (h...

Poniard Pharmaceuticals Announces Appointment of Greg Weaver as Chief Financial Officer

...mulations. Clinical trials of intravenous picoplatin include a Phase 3 trial in small cell lung cancer and Phase 2 trials in metastatic colorectal and castration resistant prostate cancers (also known as hormone refractory prostate cancer), as well as a clinical trial of oral picoplatin in solid tumors. For add...

Why prostate cancer patients fail hormone deprivation therapy

...logical Institute. Since 1941, doctors have taken advantage of this dependency to battle prostate cancer by depriving patients of androgens, either by castration or chemical methods. For most patients, this hormone deprivation therapy causes tumors to shrink, sometimes dramatically. However, it's never a curetu...

Annual Congress European Association of Urology: highlights in Stockholm

...ning plenary sessions will focus on hot topics in prostate cancer. Providing the SIU lecture is Dr. Martin Gleave (Vancouver, Canada) who will discuss castration resistant prostate cancer with emphasis on new therapeutic approaches. Sub-plenary sessions will continue in the afternoon meetings focusing on androl...

Androgen Production Continues in Prostate Cancer Tumors

...tate cancer growth. Androgen therapy, which involves the use of surgical castration or medical castration with testosterone-blocking drugs, does extend survival time for patients, b...

How advanced prostate cancer becomes resistant to androgen-deprivation therapy

...g testosterone the hormone that fuels prostate-cancer growth via surgical castration (orchiectomy) or medical castration with testosterone-blocking drugs. While such therapy buys time for patients...

Revised AVMA Policy on Castrating and Dehorning Cattle Provides Additional Guidance for Managing Pain

...mation about identifying and ameliorating pain experienced by cattle during castration and dehorning. "Individual practitioners are encouraged to achieve pain m...ma.org/issues/policy/animal_welfare/dehorning_cattle.asp . Backgrounders on castration and dehorning have been compiled by the AVMA Animal Welfare Division and ar...

Did Medicare Reimbursement Changes Affect Prostate Cancer Treatment?

...a link between less drug therapy and more surgical castration MONDAY, April 7 (HealthDay News) -- In...s. Coincidentally or not, the use of surgery -- castration -- to accomplish that same goal started to increas...lly, the drug therapy -- sometimes called hormonal castration -- and surgery are virtually equivalent in their e...

Hormone refractory prostate cancers more likely to spread to other organs

...e resistant over time. These hormone refractory or castration resistant cancers can grow despite surgical or med...tor, Reiter said. We started noticing that the castration resistant prostate cancer models in the lab seemed...ised to find that it was not only overexpressed in castration resistant cancers but also in invasive cancers tha...

New research may show why some prostate cancer recurs after treatment

...ter becoming resistant to hormone suppression. Research in the field has focused on understanding the mechanisms used by these cancer cells to become castration resistant. Investigators Peter Nelson, M.D., Elahe Mostaghel, M.D., Ph.D., and Bruce Montgomery, M.D. from the Fred Hutchinson Cancer Research Cen...

Castration in Medical Technology

Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations

...prescribed for a reversible reduction of serum testosterone to the level of castration in adult men suffering from sexual deviations. Developed by Debiopharm, Moa...nd safety profile. Triptorelin decreased serum testosterone to the level of castration in all patients. Concurrent with the decrease in testosterone levels, the t...

Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations

...prescribed for a reversible reduction of serum testosterone to the level of castration in adult men suffering from sexual deviations. Developed by Debiopharm, Moa...nd safety profile. Triptorelin decreased serum testosterone to the level of castration in all patients. Concurrent with the decrease in testosterone levels, the t...

Salvacyl(R), Developed by Debiopharm, is Launched in two European Countries

...adotropin releasing hormone (GnRH) agonist analogue. The product will be prescribed for the reversible reduction of serum testosterone to the level of castration in order to lower sexual drive in adult men suffering from sexual deviations. "This is a great accomplishment for Debiopharm. Salvacyl(R) is th...

Interim Phase 1/2 Data of Ipilimumab in Prostate Cancer Presented at American Society of Clinical Oncology Annual Meeting

...Chicago. (Abstract #5004) "These initial data in patients with metastatic castration resistant prostate cancer demonstrated preliminary anti-tumor activity, inc...rapy is routinely used for palliative treatment in patients with metastatic castration resistant prostate cancer and bone metastases, and these data encourage fur...

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

...stosterone -- the hormone that fuels prostate-cancer growth -- via surgical castration (orchiectomy) or medical castration with testosterone-blocking drugs. While such therapy buys time for patients...

Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology

...ata of Ipilimumab in Prostate -- "Phase 1 trial of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration resistant prostate cancer (mCRPC)" (Abstract #5004, New Targeted Strategies for Patients with Prostate Cancer Session) -- Oral presentation be...

Medivation's MDV3100 Demonstrates Substantial PSA Reductions in First Patient Groups Treated in Phase 1-2 Hormone Refractory Prostate Cancer Trial

...ion. "While these results are still preliminary, the declines in PSA observed at these lowest doses are encouraging and provide proof of concept that castration resistant prostate cancers can still be sensitive to alternative hormone therapies like MDV3100," said the study's principal investigator Howard Scher...

AEterna Zentaris Reports Positive Results with Cetrorelix in BPH for Japanese Phase 2a Trial

...bility profile Reduction of testosterone concentration was maintained above castration level Japanese partner Shionogi initiates Phase 2b trial QUEBEC CITY, Marc...f testosterone concentration in blood, which did not reach or remain at the castration level. Additionally, none of the dosage regimens tested caused a suppressio...

Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR Annual Meeting Late-Breaking Clinical Trials Session

...below: Inhibition of androgen synthesis results in a high response rate in castration refractory prostate cancer: A Phase II clinical trial The Phase I/II tria...sible CYP450c17 enzyme inhibitor appears to have activity in post-docetaxel castration refractory prostate cancer patients The Phase II trial is being conducted...

Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at AUA Annual Meeting

...e of Cancer Research in an oral presentation entitled, "Abiraterone acetate, an inhibitor of androgen synthesis, has significant antitumor activity in castration resistant prostate cancer." The Phase I/II trial of CB7630 was conducted at The Institute of Cancer Research and at The Royal Marsden NHS Foundation ...

Castration in Medical Dictionary

Castration

Castration is any action, surgical, chemical, or otherwise, by which a male loses the functions of the testicles and penis. In common usage the term is usually applied to males, although as a medical term it is applied to... The Castration of Uranus: fresco by Vasari & Cristofano Gherar...

Oophorectomy

... case of non-human animals, it is also called spaying and is a form of sterilization. Removal of the ovaries in women is the biological equivalent of castration in males, and the term is occasionally... Oophorectomy is often necessary ... When an oophorectomy is done before a woman's natural age of .....

Castration in Biological News

Veterinarians developing model to help producers, vets make cattle more comfortable

...trument similar to a pedometer are a few of the tools K-State researchers are using to measure discomfort in cattle undergoing two routine procedures, castration and dehorning. Hans Coetzee, assistant professor of clinical sciences, is working with David Anderson, professor of clinical sciences, and Brad Whi...

Castration in Biological Technology

AEterna Zentaris Presents Data Supporting Evaluation of AEZS-108 in Prostate Cancer at ASCO Meeting

... - In virtually all patients with prostate cancer, tumor cells appear to express LHRH receptors; - Even tumors persisting or relapsing after castration or prolonged hormonal treatment with LHRH agonists retain the expression of LHRH receptors; - The continued expression of these recept...

Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology

...tate "Initial Phase 2 experience of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration resistant prostate cancer (mCRPC)" (Abstract #5138, Genitourinary Cancer - Prostate Session) S. Slovin - General poster from 2:00 p.m. to 6:00 p.m. lo...

Poniard Pharmaceuticals to Present at the BIO CEO & Investor Conference

...mulations. Clinical trials of intravenous picoplatin include a Phase 3 trial in small cell lung cancer and Phase 2 trials in metastatic colorectal and castration resistant prostate cancers (also known as hormone refractory prostate cancer), as well as a clinical trial of oral picoplatin in solid tumors. For add...

Poniard Pharmaceuticals to Present Data from Phase 2 Clinical Trials of Picoplatin in Colorectal and Prostate Cancers

...Symposium in San Francisco. In February, updated data from the ongoing Phase 2 trial of picoplatin in patients with metastatic hormone refractory (or castration resistant) prostate cancer will be presented at ASCO's Genitourinary (GU) Cancers Symposium in Orlando, Fla. Presentation details are as follo...

Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons*

... in rats. 7 In addition, the density of ADH nerve fibers is higher in male rats than in female rats. 8 ADH nerve-fiber density can be reduced by castration and restored to normal density following testosterone replacement therapy. 9 hNT Neurons and Alzheimers Disease Another topic in neurogener...