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Caspase in Medical News

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

...," Bogyo said. Moreover, he said, new-generation drugs, some of them now in clinical trials, are designed specifically to turn on caspases. Because caspase activation is a very early event in apoptosis, monitoring it could speed clinicians' ability to determine whether, how and when these new drugs work, ...

Common anesthetic induces Alzheimer's-associated changes in mouse brains

...lls increased activation of the cell-death protein caspase and raised levels of BACE and gamma-secretase as p...s of control mice. Results at 6 hours showed that caspase levels were elevated and BACE had modestly increas...ce that received isoflurane. At 12 hours moderate caspase activation persisted, and BACE levels were even hi...

Clinical study shows biological and clinical activity in relapsed leukemia patients

....D., Professor of the Institute of Cell and Molecular Science at Barts and The London School of Medicine, today presented in an oral session "Clinical caspase Activation in CLL by GCS-100: a Phase 2 Study" at the 10th International Conference on Malignant Lymphoma (10-ICML). The promising interim results fr...

Loss of gene leads to protein splicing and buildup of toxic proteins in neurons

...rther discovered that this cleavage depends on the caspase 3 enzyme. Caspases cut other proteins and thus pla...to die when it needs to. It makes sense that these caspase might be activated when progranulin is mutated, Dr...w mutations in progranulin leads to an increase in caspase activity, he says. Progranulin could be acting a p...

Human C-reactive protein regulates myeloma tumor cell growth and survival

...ells. They demonstrated that CRP enhanced secretion of IL-6; binds activating Fcg receptors; activates PI3K/Akt, ERK, and NF-kB pathways; and inhibits caspase cascade activation induced by chemotherapy drugs. Further, CRP was shown to synergize with IL-6 in protecting myeloma cells from apoptosis. These ...

EpiCept Accelerates Development of Phase I Clinical Study for Cancer

...rnia, Moores Cancer Center, San Diego. EPC2407 belongs to a novel class of microtubulin inhibitors discovered by EpiCept. These compounds cause caspase activation, cell cycle arrest, and apoptotic death in cancer cells. The Phase I trial of EPC2407 is now being conducted in three U.S. cancer c...

Cells Re-Energize to Come Back From the Brink of Death

...ancerous. One of the requirements for apoptosis is activation of an enzyme called caspase. The St. Jude team discovered that a cell that lacks caspase activation and cannot undergo apoptosis increases the levels of an enzyme called GAPDH in order to counteract the backup program called caspase-indepe...

Breakthrough In The Identity Of Compounds That Encourage Stem Cell Growth

... up-regulated several molecules involved in cell cycling and growth, such as cyclins and epidermal growth factor receptor, and decreased those such as caspase 8 which play a role in apoptosis. LXA4 had the opposite effects. Source-Eurekalert VIK ...

Leading Biotech Companies Are Interested In Acquisition Of Smaller Companies

... reasons behind acquisition of Idun Pharmaceuticals, in the development of caspase modulators, which are proteins involved in apoptosis but that remains unpro...as a drug target. Pfizer says that it can quickly develop the potential for caspase targeting compounds, which Idun is developing for broad range of disorders ...
Caspase in Biological News

News tips from the Journal of Neuroscience

...d cell deathcould prevent neurodegeneration, Thompson and Brenowitz infused caspase inhibitors unilaterally into HVC, a song nucleus of white-crowned sparrows,...rger on the infused side. These results indicate that sustained infusion of caspase inhibitors can protect telencephalic neurons from programmed cell death, an...

Cells re-energize to come back from the brink of death

...ptosis, but if apoptosis fails because there is no caspase available, the backup program called caspase-indep...ch has shown that cells that become cancerous lack caspase and other proteins needed to support apoptosis aft...not only dodge death from apoptosis by eliminating caspase activation, but they also foil CIDC. “Our study so...

Harvard scientists identify compounds that stimulate stem cell growth in the brain

... up-regulated several molecules involved in cell cycling and growth, such as cyclins and epidermal growth factor receptor, and decreased those such as caspase 8 which play a role in apoptosis. LXA4 had the opposite effects. ...
Caspase in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...-406 is thought to mimic the activity of Smac (second mitochondria-derived activator of caspases) by binding to XIAP and preventing it from inhibiting caspase activation. Upon binding, AT-406 induces rapid degradation of cIAP-1/2 proteins and promotes apoptosis through activation of caspase-8 and the death-...

OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009

...elopment of a family of compounds known as caspase activators presently in preclinical research. As the caspase family of proteases plays essential roles in apoptosis, the caspase activators offer the potential for the dev...

OncoGenex Reports Third Quarter Financial Results

...development of a family of compounds known as caspase activators presently in preclinical research. As the caspase family of proteases plays essential roles in apoptosis, the caspase activators offer the potential for the develo...

Sonus Pharmaceuticals and OncoGenex Technologies complete business combination; OncoGenex Pharmaceuticals to commence trading on NASDAQ Capital Market today

...to the maximum tolerated dose; - CSP-9222 is a caspase activator presently in pre-clinical development. caspase activators consist of small molecules that have ...clinical development within 12-18 months. The caspase program was in-licensed in August 2008 throug...

James Thomson plans to stay in Madison to study genesis of stem cells

...mple, they dont die easily. Viable embryonic stem cells have high levels of caspase 3/7, enzymes that break down proteins as part of a process called programme...t of the body. Yet the stem cells do not die, Thomson said, even though the caspase levels would kill most other cells. The reason is unknown. Once embryoni...

Promegas Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar

... Correlated measurement of an apoptosis marker (or caspase activity) and cell viability ... Promega Apo-ONE Homogeneous caspase 3/7 Assay, catalog no. G7790 D...ssion of 590 nm with the PHERAstar. The caspase reagents were then added to the plates with the Eq...

Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35)

...99. Purification and catalytic properties of human caspase family members. Cell Death and Differentiation 6....H. Kaufmann and W.C. Earnshaw. 1997. Caspases and caspase inhibitors. Trends Biochem. Sci. 22: 388393. .... 1997. Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal. Biochem...

Caspase-3 Activation - An Indicator of Apoptosis in Image-Based Assays

... We explored the use of the active form of caspase-3 for the detection of apoptotic events. This protease has been implicated as an effector caspase associated with the initiation of the death cascade and is therefore an important marker of the cells entry point into the apoptotic signaling pathway...

Use of the HitHunter EFC Chemiluminescent Detection Kits with LEADseeker Multimodality Imaging System

...h the LEADseeker Multimodality Imaging System. The caspase 3 and p38 MAPK binding assay kits were used as mod... 18-1140-71

HitHunter caspase 3 EFC Chemiluminescent 90-0028-02 ...ded by the kit manufacturer.

1.2 Prepare caspase 3 enzyme standard curve working dilutions in assay...

The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays

...r diclofenac for 4- and 21-h respectively. Staurosporine is a microbial alkaloid, a strong inhibitor of protein kinases, thought to work through JNK1, caspase proteases, AP-1, and NFκβ. It is an apoptotic inducer causing nuclear condensation (1, 2). Diclofenac is a non-steroidal anti-inflammatory ...
Caspase in Biological Products

ApoStat Intracellular Caspase Detection (FITC-VD-FMK) from R&D Systems

Description: Designed for flow cytometric applications intended to identify...
Company:R&D Systems

FAM POLY CASPASE FLICA ASSAY from AbD Serotec

Description: Request Info...
Company:AbD Serotec

CaspSCREEN Caspase Screening Kit from BioVision

Description: Detects caspase activation by flow cytometry....
Company:BioVision

CaspGLOW Red Caspase Staining Kit from BioVision

Description: Detects activated caspases in living cells. Simple/sensitive/straight-forward procedure takes only 30 minutes. Results can be analyzed by flow cytometry/fluorescence microscopy/fluorescence plate reader....
Company:BioVision

FAM Poly Caspase Assay Kit from B-Bridge International

Description: The Poly-Caspases FLICA Apoptosis Detection Kit contains a green fluorescent-labeled inhibitor, FAM-VAD-FMK, which is a carboxyfluorescein (FAM) derivative of valylalanylaspartic acid (VAD) fluoromethyl ketone (FMK), a potent inhibitor of caspase activity. When added to a population of cells, the ...
Company:B-Bridge International

SR POLY CASPASE FLICA ASSAY from AbD Serotec

Description: Request Info...
Company:AbD Serotec

Chaps Cell Extract Buffer (10X) from Cell Signaling Technology

Description:...Cell Extract Buffer can be used to lyse cells under nondenaturing conditions and is recommendedfor the preparation of cell lysates to be used with our caspase signaling pathway antibodies...
Company:Cell Signaling Technology

Rat Caspase-3 Active from BioVision

Description:... 1 unit is sufficient for 1 caspase activity assay....
Company:BioVision

Caspase Inhibitor Ac-DEVD-CHO, Unconjugated from Promega

Description:...-3/7 (DEVDase) activity. The concentration of inhibitor required to inhibit caspase activity must be determined empirically for each system. Ten micromolar inhibitor is sufficient to inhibit caspase activity in extracts of apoptotic THP-1 cells....
Company:Promega

Smac/DIABLO, Human, Recombinant, E. coli from Calbiochem

Description:...bull;Tag ® sequence was expressed in and purified from E. coli . Smac/DIABLO is released along with cytochrome c during apoptosis and promotes caspase activation through the neutralization of IAPs, including XIAP (Cat. No. PF137). Biological activity: IC 50 ~500-1500 nM to reverse the inhibition of ...
Company:Calbiochem

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Caspase in Biological Definition

Apoptosis

... caspase-8 directly activates other members of the caspase family, and triggers the execution of apoptosis; w...mitchondrial membrane permeable for the release of caspase activators. Just how BAX and BAK are controlled un...ore-forming domain. This results in the release of caspase activators, namely cytochrome c [11] , [12] ., b...
Caspase in Biological Dictionary

Caspase

Caspases , or cysteine-aspartic acid proteases, are a family of cysteine ... the apoptosome (regulated by cytochrome c and the Bcl-2 family) which activates caspase -9. ... An anti-apoptotic protein human survivin is a direct inhibitor of caspase -3 and -7" ... Caspase -2 i...

CAT assay

... dish. ... tube. 16. Store at -70 °C or proceed to CAT activity assay . ... Apoptosis can be mediated by mechanisms other than the traditional caspase ... Cathepsin Assay Kits. Cat . # Size. Price (USD) Data Sheet. Add to Cart ... ...
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