Landmark trial to evaluate cardioprotective properties of insulin

BUFFALO, N.Y. -- The ability of insulin to limit heart-tissue damage during a heart attack will be tested in a landmark clinical trial led by Paresh Dandona, M.D., Ph.D., University at Buffalo Distinguished Professor in the departments of Medicine and Pharmacology and Toxicology in the UB School ...

Transdermal HRT not cardioprotective in postmenopausal women with Coronary Artery Disease

Transdermal hormone replacement therapy (HRT) does not reduce the risk of cardiac events in postmenopausal women with existing coronary artery disease (CAD). In the PHASE trial (Papworth HRT Atherosclerosis Study), researchers randomized 255 postmenopausal women with angiographically proven...

Transdermal HRT not cardioprotective in postmenopausal women with CAD

Transdermal hormone replacement therapy (HRT) does not reduce the risk of cardiac events in postmenopausal women with existing coronary artery disease (CAD). In the PHASE trial (Papworth HRT Atherosclerosis Study), researchers randomized 255 postmenopausal women with angiographically proven...

Overweight male teens with normal blood pressures showing signs of heart damage

...e. Overweight females in the group did not have elevated aldosterone levels or the associated heart damage, Dr. Raja says, noting that estrogen's cardioprotective effect may have made the difference. Blood and urine test are available to measure aldosterone levels, but they typically aren't measured unless a...

New study shows how spikes in nitrite can have

... studies by highlighting the importance of the dose-effect relationship for nitrite and the broad array of downstream targets possibly involved in its cardioprotective efficacy, the researchers concluded. ...

Fast Heart Rate Warns of Obesity, Diabetes

...mish in the study had a mutated form of the gene that limited production of the protein, and so they had low blood lipid levels. "It is an apparent cardioprotective mechanism," Pollin said. "It raises the hope that by decreasing production of APOC-3 it could potentially be therapeutic." It's possible that a dru...

Mini heart attacks lessen damage from major ones

...ng the pressure of blood returning from the body back into the heart. Early tests in a mouse model have confirmed that the new MRIG NO donor drugs are cardioprotective in-vivo, and do not cause system-wide vessel dilation side effects. Bruce Freeman, Ph.D., chair of the Department of Pharmacology & Chemical Biolo...

Naturally-occuring protein may be effective in limiting heart attack injury and restoring function

...en compared with no drug treatment. Additionally, they found that a single cardioprotective treatment with TPO did not increase platelet count. This novel finding suggests the cardioprotective actions of TPO are separate from its ability to increase platelet count. ...

Study shows cholesterol-lowering power of dietitian visits

...nitial visit. Although some patients may already be eating a relatively healthy diet, medical nutrition therapy can increase patients knowledge of cardioprotective foods and assist them in individualizing the guidelines to fit their preferences and lifestyle, says Weintraub. A significant number of patients reduc...

New data on hormone therapy must lead to re-evaluation of official guidelines

...demonstrated significant positive effect on bone density and reduction in fracture risk among hormone users. Estrogen has favorable metabolic and cardioprotective effects in healthy, young postmenopausal women. The results for the age group 5059 years in the WHI estrogen-alone arm support this claim. Estrogen sl...

cardioprotective in Medical Technology

New Cardioprotective Drug Could Provide Boost For Post-Bypass Surgery Heart Health

SOMERSET, N.J., April 5, 2007-- Stent thrombosis, restenosis and lifelong prescriptions. Millions of patients have discovered that the drug-coated stents used as part of their heart operations may be having more of a detrimental effect on their health than medical experts have ever publicly acknow...

Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained With Naproxen Sodium

...ning that there may be an interaction between ibuprofen and aspirin, which might render aspirin therapy less effective when used for its antiplatelet, cardioprotective effect. "This study is good news for the millions of Americans who currently use low-dose aspirin therapy, and also need safe, over-the-counter pain ...

Medicure's MEND-CABG Trial Results Published in Peer Reviewed Journal

...is of Medicure's positive MEND-CABG study. "We are pleased that our novel cardioprotective product MC-1 is being recognized by one of the leading cardiovascular surge... follow that of the Phase 2 MEND-CABG study. About MC-1 MC-1 is a novel cardioprotective compound that is being evaluated in the prevention of cardiac damage. Medic...

cardioprotective in Biological News

New research shows no link between aromatase inhibitors and cardiovascular problems

...ence about the impact of AIs on cardiovascular health is that tamoxifen has cardioprotective effects, explained Dr Monnier. Tamoxifen is an anti-oestrogen with known li... increase the incidence of fatal cardiovascular complications, but lack the cardioprotective effects of tamoxifen. These findings are important and very reassuring a...

A stronger heart with flavonoids

...ocyanins content of the traditional Mediterranean diet is much higher than that of the Western Diet, which might explain why the Mediterranean diet is cardioprotective says Michel de Lorgeril, cardiologist, head of the Grenoble group. However promising these results appear to be, researchers go easy on them. The cel...

A search for protection against chemotherapy cardiotoxicity

...ille Mousseau, head of the Department of Oncology. The research team, led by Christophe Ribuot, a professor of pharmacology, explored the beneficial cardioprotective effect afforded by recombinant human erythropoietin (rhEPO) against various stresses, through experimental and clinical investigations. This study is...

New research shows that flu is a trigger of heart attacks

...cardiac patients. If people can recognise that the flu vaccine has specific cardioprotective effects, then high-risk people will be more likely to make sure that they r... groups or under-developed countries who are not taking all the recommended cardioprotective medications due to their high cost or lack of access to proper medical care...

cardioprotective in Biological Technology

PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice

...day that positive preclinical results of its novel cardioprotective agent, GP531, were reported in a poster presentati...a second generation member of a novel new class of cardioprotective compounds known as adenosine regulating agents (AR...RAs, including GP531, have demonstrated impressive cardioprotective activity in preclinical models of ischemia/reperfu...

Resverlogix Board of Directors Update

...herosclerosis and vascular disorders such as Alzheimer's disease, vascular dementia, stroke, and Peripheral Artery Disease (PAD). ApoA-I, the critical cardioprotective protein of high-density lipoprotein (HDL) represent the bodies natural defense system against atherosclerosis by mediating reverse cholesterol transpo...

RVX-208 Exploratory Study Illustrates Early Potential for Alzheimer's Disease

...herosclerosis and vascular disorders such as Alzheimer's disease, vascular dementia, stroke, and Peripheral Artery Disease (PAD). ApoA-I, the critical cardioprotective protein of high-density lipoprotein (HDL) represent the bodies natural defense system against atherosclerosis by mediating reverse cholesterol transpo...

FDA Grants Resverlogix Approval to Commence a Phase 1 Clinical Trial for RVX-208

...X-208 in the USA. RVX-208 is a novel first-in-class small molecule that increases the production of ApoA-I and HDL. ApoA-I is regarded as the critical cardioprotective protein for the treatment of cardiovascular diseases. The Phase I clinical trial is taking place at a leading US contract research organization. The...

PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation

... Novel cardioprotective agent to move forward in Phase III development NEW YORK, Aug. 20 /PRNewsw...osine," said Robert L. Engler, M.D., one of the original discoverers of the cardioprotective effects of adenosine regulating agents (ARAs). "As such, we are optimistic ...