Cardiolipin

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

...itor that prevents a major symptom of the disease- cardiolipin deficiency. "Our research has established a causal role of cardiolipin deficiency in the pathogenesis of Barth syndrome and identified an important enzyme in cardiolipin degradation called iPLA2-VIA as a potential target...

Nearly a century later, new findings support Warburg theory of cancer

...rain tumors, specifically a complex lipid known as cardiolipin (CL). They reported their findings in the Decembe...e Journal of Lipid Research . Abnormalities in cardiolipin can impair mitochondrial function and energy produ...Thomas N. Seyfried and Jeffrey Chuang compared the cardiolipin content in normal mouse brain mitochondria with CL...

Abnormal fat metabolism underlies heart problems in diabetic patients

...y means heart fat, and the term was coined because cardiolipin was first discovered in beef hearts and is one of ...isorder Barth syndrome held a key to identifying cardiolipin decrease in diabetic hearts. Children born with Ba...oducing enough cardiolipin. The connection between cardiolipin and heart disease in Barth syndrome led the Washin...

Cardiolipin in Biological Definition

Mitochondrion

...ratio (more than 3:1 by weight, which is about 1 protein for 15 phospholipids). Additionally, the inner membrane is rich in a an unusual phospholipid, cardiolipin , which is usually characteristic of bacterial plasma membranes . The outer mitochondrial membrane contains numerous integral proteins called ...

Mitochondrion

...ratio (more than 3:1 by weight, which is about 1 protein for 15 phospholipids). Additionally, the inner membrane is rich in a an unusual phospholipid, cardiolipin , which is usually characteristic of bacterial plasma membranes . The outer mitochondrial membrane contains numerous integral proteins called ...