Carcinogenesis

A breakthrough in gastric carcinogenesis

Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chromosome instability (CIN) and genetic instability is one of the ...

Protein Targets for Carcinogenesis

Misfolded and disused proteins are eliminated by a cellular shredder called the proteasome. The cell labels the proteins it wants to dispose with Ubiquitin (Ub) in order to avoid the unwanted degradation of still needed proteins. Malfunctions in the ubiquitin-proteasome system can be fatal for the...

On the Heels of the Summer Meeting of the American Academy of Dermatology, Leading Dermatologist Weighs in on Sun Protection Myths and Facts

... surface year round and are known to penetrate deep within the skin. These rays can also pass through both clouds and windows and play a role in both carcinogenesis and photo-ageing. Having said that, I usually encourage my patients to wear sun protection on a daily basis as sunscreen remains the best defense aga...

Small Molecule Might Play Big Part in Lung Cancer

... disease, miR-21 was noticeably elevated in patients who had never smoked, according to researcher Dr. Curtis Harris, chief of the Laboratory of Human carcinogenesis at the U.S. National Cancer Institute. According to Harris, miR-21 is also elevated in tobacco-related adenocarcinoma, but to a lesser extent. Earl...

NASA Selects Four Proposals to Study Space Radiation Risks

...he proposals support the space radiation program element within NASA's Human Research Program. NASA is investing $28.4 million for research into carcinogenesis and central nervous system risks from spaceflight. Research from the peer-reviewed proposals during the five-year award period will pave the way for d...

Dream team targets key driver for breast, ovarian, endometrial cancers

...m from M. D. Anderson are Donald Berry, Ph.D., head of the Division of Quantitative Biology; Cheryl Lyn Walker, Ph.D., professor in the Department of carcinogenesis and the co-director of M. D. Anderson's Gynecology Specialized Program in Research Excellence; and Russell Broaddus, M.D., Ph.D. associate professor i...

The Center for the Biology of Chronic Disease Highlights Anti-Cancer Activities of the Food Extracts Quercetin, EGCG, Glycyrrhizin, and Trans-Cinnamaldehyde

... hepatocellular carcinoma. Oncology. 2002;62 Suppl 1:94-100. 2. Ikeda K, et al. A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients. Dig Dis Sci. 2006 Mar;51(3):603-9. Tran...

Cancer-obesity link discovery by MSU researchers could aid prevention efforts

...Mich., Fenton examined a key hormone found in fat tissue and thought to promote cancer. Her conclusions are published in a study today in the journal carcinogenesis . Leptin a fat cell-derived hormone regulating body energy is higher in obese individuals. Fenton's study is the first to demonstrate that, at hi...

JCI table of contents: March 23, 2009

...colorectal cancer. TITLE: Inhibition of 11-betahydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans AUTHOR CONTACT: Ming-Zhi Zhang Vanderbilt University Medical Center, Nashville, Tennessee, USA. Phone: (615) 343-1548; Fax: (...

Optical techniques show continued promise in detecting pancreatic cancer

...ths and measures them. An image sensor captures the result, then a computer analyzes the pattern of light scattering, looking for the "fingerprint" of carcinogenesis in the nanoarchitecture of the cells. The technology makes use of a biological phenomenon known as the "field effect," a hypothesis that suggests t...

Carcinogenesis in Medical Technology

SELECT TRIAL Used Selenomethionine Instead of High-Selenium Yeast, SelenoExcell(R) - Previous Research has Shown SelenoExcell(R) Supplementation to Reduce Lung, Colon and Prostate Cancers by as Much as 63%, Says Cypress Systems, Inc.

...m . The results of the SELECT TRIAL are consistent with previous animal studies. For example, Dr. David McCormick at the Experimental Toxicology and carcinogenesis Division, IIT Research Institute in Chicago found no effects with selenomethionine supplementation on the prevention of prostate cancer in rats (Eur U...

Rexinoid Developed by NuRx Pharmaceuticals Shows Promise in Prevention, Treatment of Lung, Breast Cancer, Paper in Clinical Cancer Research Reports

...en used therapeutically. Rexinoids regulate cell proliferation, differentiation, and apoptosis pathways. Entitled "A New Rexinoid, NRX4204, Prevents carcinogenesis in Both Lung and Mammary Gland," the paper is based on a study that first evaluated the anti-inflammatory effects of NRX4204 and its growth-inhibitory...

Carcinogenesis in Medical Definition

Pathology

... - Radiation therapy - Immunotherapy - Experimental cancer treatment Misc. Tumor suppressor genes / oncogenes - Staging / grading - carcinogenesis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-related terms v • d • e Pa...

Ocular oncology

... - Radiation therapy - Immunotherapy - Experimental cancer treatment Misc. Tumor suppressor genes / oncogenes - Staging / grading - carcinogenesis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-related terms ...

Carcinogenesis in Biological News

'Normal' cells far from cancer give nanosignals of trouble

...from Northwestern and NorthShore University HealthSystem. "Our data provide a strong argument that these nanoscale changes are general phenomena in carcinogenesis and occur early in the process," says Vadim Backman, professor of biomedical engineering at the McCormick School of Engineering and Applied Science an...

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

...strin is an essential cofactor for Helicobacter -associated gastric corpus carcinogenesis in C57BL/6 mice," appears in the July 2009 issue of The American Journal o... of Helicobacter -induced stomach cancer, but may have distinct effects on carcinogenesis in different parts of the stomach. Takaishi et al suggest that "gastrin ...

Colon cancer screening technique shows continued promise in new study

...rs, and some of that light bounces back to sensors in the probe. A computer analyzes the pattern of light scattering, looking for the "fingerprint" of carcinogenesis in the nanoarchitecture of the cells. Researchers led by Vadim Backman, professor of biomedical engineering at the McCormick School of Engineering ...

Stem cell protein offers a new cancer target

...to specific cell types, was originally discovered to influence embryonic development in worms some 25 years ago. Development, stem cell generation and carcinogenesis are known to be closely related, but until last year's study connected LIN28 to let-7, it hadn't been clear how. "LIN28 is a fascinating protein ...

UCSB scientists show how certain vegetables combat cancer

...mental Biology, have shown how the healing power of these vegetables works at the cellular level. Their research is published in this month's journal carcinogenesis . "Breast cancer, the second leading cause of cancer deaths in women, can be protected against by eating cruciferous vegetables such as ca...

SNPs affect folate metabolism in study of Puerto-Rican adults

... some cancers, have been associated with diminished blood folate concentrations and abnormal folate metabolism. Crott, a scientist in the Vitamins and carcinogenesis Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts, and first author Lauren DeVos of Pennsylvania State University fo...

Breakthrough optical technology to assess colon cancer risk, accuracy

...rmality is cancer or not cancer," said Roy. "What we are doing is using optical technology to determine if we can assess risk through looking at field carcinogenesis [cancer formation]. The potential clinical applications include enhanced polyp detection during colonoscopy." "While the technology is still in the...

The dietary supplement genistein can undermine breast cancer treatment

...from the University of Illinois, Virginia Polytechnic and State University and the National Center for Toxicological Research, appears in the journal carcinogenesis . Aromatase inhibitors are a mainstay of breast cancer treatment in post-menopausal women. These drugs work by interfering with the enzyme aromatas...

Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold

...me batches of Roche's Viracept (nelfinavir mesylate) and demonstrated a clear threshold response at which DNA damage, the underlying mechanism for the carcinogenesis of EMS, occurs. The results of these animal studies, which can be translated to humans with high confidence, confirm that Viracept patients exposed t...

NCI grant launches clinical trials for colon cancer screening

...ers and some of that light bounces back to sensors in the probe. A computer analyzes the pattern of light scattering, looking for the "fingerprint" of carcinogenesis in the nanoarchitecture of the cells. "If you have a precancerous lesion in one part of the colon," said Backman, "even tissue that looks normal an...

Carcinogenesis in Biological Technology

Kosan Presents Preclinical Data on Novel Third-Generation Hsp90 Inhibitors at AACR

...haperone that acts to stabilize and/or activate a number of proteins required for cellular signaling pathways, including several known determinants of carcinogenesis such as HER2 (Erb2), B-Raf, c-Kit, Flt-3 and Raf-1. Hsp90 is effectively inhibited by benzoquinone ansamycins, such as geldanacmycin and its derivativ...

JCI table of contents: Dec. 3, 2007

...revention and treatment of UV lightinduced skin cancer. TITLE: CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice AUTHOR CONTACT: Mohammad Athar The University of Alabama at Birmingham, Birmingham, Alabama, USA. Phone: (205) 934-7554; Fax: (205) 934-...

Technology could enhance accuracy of breast biopsy

...ch as cell or nuclear size, as well as measurements of hemoglobin oxygenation, vascularity and cellular metabolic rate - all of which are hallmarks of carcinogenesis and can indicate whether the needle has hit the mark, she says. "These chemical and structural features are intrinsic inside tissue," she says. "T...

Sample Preparation Solutions for Cellular Protein Fractionation Poster, Rev A

...961219617 (1998) Bordier C, J Biol Chem 256, 16041607 (1981) Brown D and Rose J, Cell 68, 533544 (1992) Davidson JS et al., carcinogenesis 6, 645650 (1985) Dignam JD et al., Nucleic Acid Res 11, 14751489 (1983) Molloy MP et al., Eur J Biochem 267, 28712881 (2000) ...

Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer

...l. (1996) Mutat. Res. 369: 45-49. Ushijima, T., et al. (1994) carcinogenesis 15: 2805-2809. Okonogi, H., et al. (1997) Mutat. Res. 3...in. Biol. Res. 395: 81-108. Ushijima, T., et al. (1994) carcinogenesis 15: 2805-2809. * U.S. Patent No. 5,347,075 and 5,589,155; Eur...

Big Blue Rodent Cell Cultures for Mutagenesis Studies

...J., et al. (1994) Mutat. Res. 307: 461478. Rogers, B.J., et al. (1995) Mutat. Res. 327: 5766. Dycaico, M.J., et al. (1996) carcinogenesis 17: 23472356. Wyborski, D.L., Malkhosyan, S., Moores, J.C., Dycaico, M.J., and Short, J.M. (1994) Strategies 7: 5556. ...

Carcinogenesis in Biological Definition

Cancer

...eatic cancer , and mistletoe extract and chemotherapy for the treatment of solid tumors. Causes and pathophysiology Molecular biology carcinogenesis (meaning literally, the creation of cancer) is the process of derangement of the rate of cell division . Cancer is, ultimately, a disease of ge...

Mathematical biology

...n mathematical biology and links to related projects in various universities: Modelling of arterial disease [1] Modelling of neurons and carcinogenesis [2] Mechanics of biological tissues [3] Theoretical enzymology and enzyme kinetics [4] Cancer modelling and simulation [5] Swarm...

Carcinogenesis in Biological Dictionary

Peroxisome

...ptor to take it to the peroxisome . ... Perplexing Peroxisome Proliferators, Location: Main Section of EHP Online ... Peroxisome proliferator carcinogenesis remains a controversial subject among the ... Activation of Peroxisome Proliferator-Activated Receptors by Chlorinated Hydrocarbons and Endogenou...

Methylation

...hylation profiling is gaining momentum as an epigenetic approach for ... Epigenetic changes are rapidly gaining acceptance as co-conspirators in carcinogenesis fueling the demand for DNA methylation assays. If your body's methylation is not working at an optimal level it will translate ... What is met...

Exogenous DNA

...e. ... Plasmids are non-chromosomal DNA that code for proteins that ... The respective roles of endogenous versus exogenous DNA damage in carcinogenesis are discussed. ... Endogenous DNA damage occurs at a high frequency compared ... ...

DNA methylation

... protein 'packaging' of DNA help the cell 'read' and make sense ... Epigenetic changes are rapidly gaining acceptance as co-conspirators in carcinogenesis fueling the demand for DNA methylation assays. EcoSal is comprised of several hundred modules of information and ... Several reviews of DNA ...