Carcinoembryonic

Serum carcinoembryonic antigen level can reflect adrenal adenoma

The female patient, reported on the December 7 issue 45 of World J Gastroenterology, presented a rare case, with symptoms consistent with hyperadrenocorticism and hypercatecholaminism, and also had a Cushingoid appearance. The serum cortisol, dopamine and noradrenalin levels were elevated. Compute...

Many colorectal cancer survivors do not receive recommended follow-up care

...sis. The study investigators considered the screening guidelines to be fulfilled if a patient received two or more office visits per year, two or more carcinoembryonic antigen (CEA) tests per year, and at least one colonoscopy within three years. Overall, six in ten (60.2 percent) of patients received testing belo...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... ATP synthase [alpha] subunit; axl; Bap31; Bcl-xL; Bcl-2; bcr-abl/abl (including mutated forms); B-FN (ED-B fibronectin); carboxyanhydrase IX (CA IX); carcinoembryonic antigen (CEA); cathepsin K (CTSK); C-C chemokine receptor 4 (CCr4); CD105 (endoglin); CD13; CD19; CD20; CD22; CD25; CD3; CD30; CD33; CD38; CD4; CD40; ...

Immunotherapy: enlisting the immune system to fight cancer

...archers gave patients an intravenous dose of MFECP1, a recombinant fusion protein consisting of a fragment of an antibody raised against the substance carcinoembryonic antigen (CEA), which is produced by the cancer, and carboxypeptidase G2 (CPG2), an enzyme that activates a prodrug. Then, researchers gave patient...

Histochemistry is the golden standard in the diagnosis of carcinosarcomas

...n standard in the diagnosis of carcinosarcomas: epithelial component expressed positivity for cytokeratin 18, epithelial membranous antigen (EMA), and carcinoembryonic antigen (CEA). Chromogranin A positive epithelial cells could also be observed. The mesenchymal component had intensive staining for vimentin, althou...

Carcinoembryonic in Medical Technology

Immunomedics Announces Preclinical Therapy Results of SN-38 Immunoconjugate for Colorectal Cancer

...ated to labetuzumab was evaluated in two animal models of human colon cancer. Labetuzumab is a non-internalizing humanized antibody that binds to the carcinoembryonic antigen (CEACAM5) expressed by many solid cancers. The Company has conducted clinical trials with the naked and radiolabeled antibody in patients wit...

Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer

...a rapid decrease in plasma levels of calcitonin, a marker frequently elevated in MTC, and six of the seven patients had a decrease in the tumor marker carcinoembryonic antigen. All seven MTC patients remain on study. In addition, one patient with a neuroendocrine tumor has an unconfirmed partial response. In total, 1...

Updated Phase 1 Data for Exelixis' XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity

...lasma levels of calcitonin, a marker frequently elevated in medullary thyroid cancer, and six of the seven patients had a decrease in the tumor marker carcinoembryonic antigen (CEA). All seven MTC patients are still on study. In addition, one patient with a neuroendocrine tumor has an unconfirmed partial response. In...

Carcinoembryonic in Biological News

Plasma DNA level is a reliable marker of recurrent esophageal cancer, study finds

... for better selection of patients for adjuvant therapy, prediction of response to therapy and early intervention when the disease does recur. Although carcinoembryonic antigen (CEA) and plasma DNA are known to be elevated in patients with esophageal cancer and are higher in patients with metastatic disease, the sensi...

Nanowires can detect molecular signs of cancer, scientists find

...res conducting a small current with antibody receptors for certain cancer markers -- such as prostate specific antigen (PSA), PSA-a1-antichymotrypsin, carcinoembryonic antigen and mucin-1. When these telltale proteins come into contact with a receptor, it sparks a momentary change in conductance that gives a clear in...

Carcinoembryonic in Biological Technology

Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth

...d the publication of data in the peer-reviewed Journal of Immunotherapy (1) demonstrating the potent anti-tumor activity of a BiTE antibody binding to carcinoembryonic antigen (CEA) and to CD3 on T cells. Micromet and MedImmune are jointly developing MT111/MEDI-565, a CEA-specific BiTE, which is in pre-clinical devel...

Micromet to Present Six Posters on Progress of BiTE Antibodies at the Annual Meeting of American Association for Cancer Research

...n 'Immunology 5' on April 21, 2009, 8:00 AM in Hall B-F, poster section 12. Oberst, M. et al. (2009). In vitro pharmacological comparison of a carcinoembryonic antigen (CEA; CEACAM5; CD66e)/CD3 bispecific cynomolgus-reactive BiTE antibody (CyS111) biosimilar with the clinical candidate MEDI-565 (MT111). AACR ...

AMDL, Inc. Enters Into Collaboration Agreement to Advance Development of Its AMDL DR-70 (FDP) Cancer Test

...ue to undetected metastases.** Frequent surveillance of diagnosed patients is recommended, but current procedures have shortcomings. This includes the carcinoembryonic Antigen blood test currently used for surveillance of CRC, which suffers from poor sensitivity and specificity (i.e. the ability to determine if someo...

Purification of Murine IgG1 Using UNOsphere S and CHT Ceramic Hydroxyapatite Chromatography, Rev A

...his project. References Ford CH et al., Affinity purification of novel bispecific antibodies recognising carcinoembryonic antigen and doxorubicin, J Chromatogr B Biomed Sci and Appl 754, 427435 (2001) Godfrey MAJ et al., Assessment of th...