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Carboxyl in Medical Technology

Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP

...was discovered by researchers at Washington University in St. Louis and is based on a short amino acid sequence that occurs naturally in humans, the carboxyl terminal peptide (CTP). When attached to a therapeutic protein, CTP extends the time that the protein is active in the body. The potential utility of...

Study Published in Endocrinology Reports Potential of Modigene Technology to Extend Duration of Protein Drugs

...orted that researchers will publish a study in the October edition of the journal Endocrinology showing that erythropoietin (EPO) linked to Modigene's carboxyl terminal peptide (CTP) technology significantly increased the half-life of standard EPO in animal models.(1) The study, which assessed an early versio...

Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin

... Modigene's technology was discovered by researchers at Washington University in St. Louis, Missouri, and is based on a short amino acid sequence, the carboxyl Terminal Peptide (CTP). CTP occurs naturally in the human body, and when attached to a therapeutic protein, extends the time that such protein can las...
Carboxyl in Medical Dictionary

Protein S

... compounds made of amino acids arranged in a linear chain. The amino acids in a polymer chain are joined together by the peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.... Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium...

Amino acids

...mino acids , tryptophan and phenylalanine, are some of the most ... In chemistry, an amino acid is a molecule that contains both amine and carboxyl ... 4 Hydrophilic and hydrophobic amino acids ... Amino Acid | World of Genetics. Amino Acid summary with 3 pages of encyclopedia entr...
Carboxyl in Biological News

A new molecule discovered in the battle between plants and disease

...m Arabidopsis thaliana (G. Pearce, A. Huffaker, C.A. Ryan, submitted). The peptide is encoded by a gene at the locus At5g64900 and is derived from the carboxyl terminus of a 92 amino acid precursor, proAtPep1, a scenario commonly found in both animal and plant peptide precursors. No physiological role was kno...
Carboxyl in Biological Technology

PROLOR Biotech Awarded Two U.S. Patents for Its Longer-Acting Human Growth Hormone and Longer-Acting Erythropoietin

...OR's proprietary pharmaceutical compounds as well as certain associated methods. PROLOR's CTP technology is based on a short amino acid sequence, the carboxyl Terminal Peptide that occurs naturally in humans. When attached to a therapeutic protein, CTP extends the time that the protein is active in the body...

Modigene Awarded Second-Year Grant by Israeli Government to Support Development of Its Longer-Acting Human Growth Hormone

...was discovered by researchers at Washington University in St. Louis and is based on a short amino acid sequence that occurs naturally in humans, the carboxyl terminal peptide (CTP). When attached to a therapeutic protein, CTP extends the time that the protein is active in the body. The potential utility of...

Citrate appears to control buckyball clumping but environmental concerns remain

...discovered are similar to what happens intercellularly when human cells are exposed to C 60 , he said. We think citrate and other organic acids with a carboxyl group make C 60 more water soluble. Vikesland will present Effects of small molecular weight acids on C 60 aggregate formation and transport (ENV...

Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS

.... The average error of the mass measurement was +/- 0.03 Da (5 replicates). This measurement is more than would be required to differentiate between a carboxyl and an amide (one Da difference). All masses are monoisotopic since the resolution of the instrument was sufficient to resolve isotopes at these masse...

New Mammalian Two-Hybrid System Detects Protein-Protein Interactions

...anscriptional-activation domain of NF- k B p65 is located in its carboxyl terminus. 9 To determine the region of p65 that has the highest.... Amino acids 72 to 390 of murine p53 were fused in frame to the carboxyl (C) terminus of the GAL4-DNA binding domain (pBD-53), and amino ...
Carboxyl in Biological Products

MagSi-S-COOH 2 from MagnaMedics Diagnostics B.V.

Description:... MagSi uniform silica particles coated with a carboxyl group containing polymer, covalently attached to the bead surface....
Company:MagnaMedics Diagnostics B.V.

Tritirachium album Proteinase K from USB Corp.

Description:... active and stable endopeptidase used in a wide range of applications purified from the fungus T. album. It cleaves peptide bonds mainly following the carboxyl group of N-substituted hydrophobic aliphatic and aromatic amino acids (1) and is classified as a serine protease. Proteinase K is useful in purifying...
Company:USB Corp.
Carboxyl in Biological Definition

C-terminal end

... The C-terminal end refers to the extremity of a protein or polypeptide terminated by an amino acid with a free carboxyl group (COOH). See also N-terminal end . ...

Peptide bond

... A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H 2 O). This is a dehydration synthesis r...

Phospholipid

...thesis 2 Sphingomyelin 3 Amphiphatic character 4 See also 5 References Phosphoglycerides In phosphoglycerides, the carboxyl group of each fatty acid is esterified to the hydroxyl groups on carbon-1 and carbon-2. The phosphate group is attached to carbon-3 by an ester lin...

Polysaccharide

...ria possesing the enzyme are present in their gut. Acidic polysaccharides Acidic polysaccharides are a group of polysaccharides that contain carboxyl groups and/or sulfuric ester groups . ...
Carboxyl in Biological Dictionary

Proteins

...ompounds made of amino acids arranged in a linear chain. The amino acids in a polymer chain are joined together by the peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.... protein n. Any of a group of complex organic macromolecules that contain carbon, hydroge...

Protein

...ompounds made of amino acids arranged in a linear chain. The amino acids in a polymer chain are joined together by the peptide bonds between the carboxyl and amino groups of adjacent amino acid residues.... Proteins are broken down in the stomach during digestion by enzymes known as proteases...

Peptide Bond

... (amide bond ) is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amine group of the other molecule... The Genetic Code: RNA vs. Protein ... A peptide bond forms between the carboxyl group of one amino acid (amino acid 1 ... ...

N-terminus

...o C- terminus . When the protein is... The C- terminus of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C-terminal end on the right and write the sequence from N - to C- termi...

N Terminus

...o C- terminus . When the protein is... The C- terminus of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C-terminal end on the right and write the sequence from N - to C- termi...

C-terminus

... The C - terminus of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C -terminal end on the right and write the sequence from N- to C - ter...

Carboxyl Terminus

...nd of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptid...is article or section by expanding it. ... as the carboxyl - terminus , carboxy- terminus , C-terminal end, o...to the start of a protein or Deletion of the carboxyl - terminus had no effect on purple membrane (PM) ...

C Terminus

... The C - terminus of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C -terminal end on the right and write the sequence from N- to C - ter...

Amino Terminus

...o C- terminus . When the protein is... The C- terminus of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C-terminal end on the right and write the sequence from N- to C- terminu...

Amino acids

... In chemistry, an amino acid is a molecule containing both amine and carboxyl functional groups. These molecules are particularly important in biochemistry, where this term refers to alpha- amino acids with the general formul...
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