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Carbamazepine in Medical News

Epilepsy Drug Impairs Baby's Intelligence

...hildren exposed to the other medications. The average IQ for children exposed in the womb to lamotrigine was 101, for phenytoin it was 99, and for carbamazepine it was 98. Children exposed to valproate in the womb scored an average of 92 on the IQ test, according to the study. The researchers also found th...

Fish in U.S. Rivers Tainted With Common Medications

...Lopid), which researchers say had never before been found in wild fish; diltiazem (Cardizem), a medication that helps control high blood pressure; carbamazepine (Tegretol), a drug used for epilepsy and bipolar disorder; norfluoxetine, an active ingredient in the antidepressant fluoxetine (Prozac); the anti...

New research suggests common anti-seizure medications may increase risk of cardiovascular problems

...at will not adversely affect cardiovascular health. The study involved two of the most widely-prescribed anticonvulsants phenytoin (Dilantin) and carbamazepine (Tegretol, Carbatrol) which have potent effects on many enzymes in the body involved in different areas of metabolism. The researchers recruited 34...

Frost & Sullivan Lauds OVATION Pharmaceuticals for Its Business Model and Ability to Sustain Growth

...olubility issues plaguing others attempting to bring to market an intravenous (IV) reformulation of the oral antiepileptic carbamazepine, OVATION's IV carbamazepine has advanced into phase III clinical trials. As a cornerstone therapy for those who experience partial seizures, an IV formulation of this antiepilept...

FDA Adds Suicide Warning to Epilepsy Drugs

...efer them to psychiatrists," he added. In addition to clonazepam, phenytoin and topiramate, the drugs covered by the new FDA-mandated labeling are: carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR); clorazepate (Tranxene); divalproex sodium (Depakote, Depakote ER, Depakene); ethosuximide (Za...

FDA Advisers Don't Back 'Black Box' Warning for Epilepsy Drugs

...ll be a matter of discussion, Katz added. "We take the committee's recommendations very seriously," he said. The drugs reviewed by the FDA were: carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR), Felbamate (marketed as Felbatol), Gabapentin (marketed as Neurontin), Lamotrigine (marketed a...

FDA Advisers Don't Back Epilepsy Drug Warnings

...l be a matter of discussion, Katz added. "We take the committee's recommendations very seriously," he said. The drugs reviewed by the FDA were: carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR), Felbamate (marketed as Felbatol), Gabapentin (marketed as Neurontin), Lamotrigine (marketed a...

Epilepsy Drugs Can Cause Suicidal Tendencies, FDA Panel Finds

...man Sandy Walsh said at the time. "We have just come to the conclusion that it's time to alert health-care providers." The drugs under review were: carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR), Felbamate (marketed as Felbatol), Gabapentin (marketed as Neurontin), Lamotrigine (marketed a...

Epilepsy Drug Doesn't Prevent Migraines

...eadache Center at Maimonides Medical Center in New York City. "The results are not that surprising, as drugs with related mechanisms of action such as carbamazepine or phenytoin have never been found to be efficacious for migraine prophylaxis." The study was paid for by Novartis Pharmaceuticals Corp., maker of ...

FDA Warns Epilepsy Drugs May Raise Suicide Risk

...y, some of drug labels do list suicide or suicidal behavior as a side effect, but others don't, Walsh noted. The drugs included in the warning are: carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR), Felbamate (marketed as Felbatol), Gabapentin (marketed as Neurontin), Lamotrigine (marketed a...
Carbamazepine in Medical Technology

Data Demonstrates Long-Term Reduction In Seizure Frequency With Novel Once Daily Anti-Epileptic Zebinix(R)

... 3 studies. ESL is given orally once-daily. ESL can be used as an add-on to carbamazepine (one of the most commonly utilized therapies for partial onset seizures) or...t al. Efficacy and safety of eslicarbazepine acetate as add-on treatment to carbamazepine in patients with partial-onset seizures. Abstract presented at the 28th Int...

Study Sheds Light on Medication Treatment Options for Bipolar Disorder

...s debilitating illness marked by severe mood swings between depression and mania, is usually treated with mood stabilizers such as lithium, valproate, carbamazepine or other medications that reduce mania. However, depression is more common than mania in bipolar disorder, and depressive episodes tend to last longer...
Carbamazepine in Biological News

Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage

... vulnerable to the potentially toxic interaction than others, Nelson says. This includes people who take certain anti-epileptic medications, including carbamazepine and phenobarbital, and those who take St. Johns Wort, a popular herbal supplement. These products have been shown to boost levels of the enzyme that p...

Gene variations explain drug dose required to control seizures

... action or metabolism of the anti-epileptic drugs, carbamazepine and phenytoin, to the drugs' clinical use. The stu...1,000 new cases diagnosed each year. Phenytoin and carbamazepine are important first-line anti-epileptic drugs that...ular treatment. Similarly, appropriate doses of carbamazepine take time to determine because of the drug's varia...
Carbamazepine in Biological Technology

Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union

...d by the QOLIE-31 score during a one year open label extension of the above 3 studies. ESL is given orally once daily. ESL can be used as an add-on to carbamazepine (one of the most commonly utilized therapies for partial onset seizures) or with other anti-epileptics. Clinical data The EU approval wa...

Multiple Vimpat(R) (lacosamide) Studies Presented at American Epilepsy Society Annual Meeting

...oncomitant AEDs at the time of study entry, mainly carbamazepine (35.2 percent), lamotrigine (31.2 percent), leveti...ncluded one to three concomitant AEDs: -- carbamazepine (36.5 percent seizure frequency reduction with Vim...eater reduction in seizure frequency): -- carbamazepine (37.4 percent responder rate with Vimpat(R) 400 mg...

Beyond Seizure Control in the Treatment of Epilepsy With New Anti-Epileptic Drug, Zebinix(TM)

...ngland Journal of Medicine 313:145-151, 1985. (14). Mattson, RH, Cramer, JA, et al, VA Cooperative Study Group. A comparison of valproate with carbamazepine for the treatment of partial seizures and secondarily generalized tonic-clonic seizures in adults. New England Journal of Medicine, 327:765-771, 1992....

Shire plc: IFRS Results for the Year Ending December 31, 2007

... year to December 31, 2007 were down 5% compared to the same period in 2006. This was primarily due to a comparable decline in the US extended release carbamazepine prescription market; CARBATROL's average market share remained constant. Sales of CARBATROL for the year to December 31, 2007 were US$72.3 million, ...

Shire plc: Excellent Performance Across All Areas of the Business and Accelerating New Product Sales Drive Revenue Growth of 36%

... year to December 31, 2007 were down 5% compared to the same period in 2006. This was primarily due to a comparable decline in the US extended release carbamazepine prescription market; CARBATROL's average market share remained constant. Sales of CARBATROL for the year to December 31, 2007 were $72.3 million, an...

IFRS Information - First Half of 2007

...onths ending June 30, 2007 were down 5% compared to the same period in 2006. This was primarily due to a comparable decline in the US extended release carbamazepine prescription market. Sales of CARBATROL for the six months to June 30, 2007 were $33.4 million, an increase of 10% compared to the same period in 200...

Validus Pharmaceuticals Expands Product Portfolio with Acquisition of Bipolar Drug: Equetro(R)

...er medication that contains carbamazepine, do not begin taking Equetro(R) without discussing this with your healthcare provider. Products that contain carbamazepine have been associated with rare but serious types of blood disorders. People with Bipolar Disorder have an increased risk for suicide. It is important ...

Practical Applications of HyperDSC in a Pharmaceutical Laboratory

...e form I and metastable form III. Figure 6 shows an experiment carried out at 500 C/min in which a very weak endotherm was detected for the melting of carbamazepine form III, a polymorph making up only 1% of the sample content. Analysis of a weak glass transition (Tg) The detect...
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