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Capsaicin in Medical News

NeurogesX Announces Resignation of Bruce A. Peacock from Board of Directors

... NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

NeurogesX and Astellas Enter Commercialization Agreement for Qutenza(TM)

...009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

Anesiva Announces Going Concern Opinion and Nasdaq Notice

...ialization of novel pharmaceutical products for pain management. The company's lead product candidate is Adlea, a novel small molecule formulation of capsaicin that is currently in development for the management of acute pain following orthopedic surgeries. Adlea has been shown in clinical trials to provide ...

Anesiva Announces Planned Rights Offering

...cialization of novel pharmaceutical products for pain management. The company's lead product candidate is Adlea, a novel small molecule formulation of capsaicin that is currently in development for the management of acute pain following orthopedic surgeries. Adlea has been shown in clinical trials to provide e...

NeurogesX Reports Fourth Quarter and Year-End 2008 Results

...io is led by its product candidate Qutenza(TM), a dermal high-concentration capsaicin patch designed to manage pain associated with peripheral neuropathic pain c... a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-199...

'Holy powder' ingredient makes membranes behave for better health

...ing to see whether other natural products, such as polyphenols (compounds found in many plant foods that are known to have antioxidant properties) and capsaicin (a pain reliever derived from hot peppers), interact with membranes in the same way as curcumin. ...

Chili Pepper Compound Can Bring Pain Relief

... capsaicin works on nerves to ease joint discomfort, scientis...the journal PLoS Biology , researchers found that capsaicin flips on nerve-ending receptors that sense both pa...ponsiveness range was shifted," Qin said. While capsaicin has been used in folk medicines for generations, k...

Sinus Buster Pepper Nasal Spray Moves Into Rite Aid Drug Stores

...l extract responsible for the heat of hot peppers. capsaicin has been shown to relieve a variety of sinus symptoms and headaches. Sinus Buster is the original capsaicin formula targeting nasal congestion, sinus pressure...incorporates natural Nettle extract along with the capsaicin to specifically target allergy symptoms. Both prod...

TorreyPines' NGX426, an Oral AMPA/Kainate Receptor Antagonist, Meets Primary Endpoints in Reducing Capsaicin-Induced Pain in Healthy Subjects

...red to placebo following intradermal injections of capsaicin in a human experimental model of cutaneous pain, h...n, subjects received two intradermal injections of capsaicin at 30 minutes and 120 minutes after administration...ned at specified intervals after each injection of capsaicin and measured by visual analog scale. The 9...

Some like it hot! Structure of receptor for hot chili pepper and pain revealed

...ed in this study was the heat of a chili pepper. It has been known for years that the burning sensation results from the action of a chemical known as capsaicin on TRPV1 found on the nerve cell membrane. TRPV1 is an ion channel, a tiny pore on the cell membrane that allows chemicals such as calcium to flux in ...
Capsaicin in Medical Technology

NeurogesX Initiates Dosing in Phase 1 Clinical Trial for NGX-1998 Capsaicin Liquid Formulation

SAN MATEO, Calif., July 11 /PRNewswire-FirstCall/ -- NeurogesX, Inc. (Nasdaq: NGSX ), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, announced the initiation of its Phase 1 clinical trial (study C203) of NGX-1998. The product candidate i...

NeurogesX Announces Preliminary Results of FDA-Requested Qutenza(TM) Study

... NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

NeurogesX Receives FDA Orphan Drug Designation for Qutenza(TM) for Treatment of Postherpetic Neuralgia

... drug designation for Qutenza(TM) (formerly NGX-4010), a high concentration capsaicin dermal patch for the management of neuropathic pain in patients with posthe... a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-199...

NeurogesX Announces Publication of Phase 3 Data for QUTENZA(TM) (NGX-4010) in Postherpetic Neuralgia (PHN) by The Lancet Neurology

...Neurology titled, "NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia...lication of Qutenza (n=206) or a low-concentration capsaicin control patch (n=196). Patients were required to h...uid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic...

Anesiva Announces FDA Approval of Supplemental New Drug Application to Expand Zingo(TM) Indication

...mmercialization of novel pharmaceutical products for pain management. Anesiva's lead product candidate is Adlea, a novel small molecule formulation of capsaicin that is currently in development for the management of acute pain following orthopedic surgeries. Adlea has been shown in clinical trials to provide e...

Anesiva Announces Adlea ACTIVE-1 Phase 3 Clinical Results, Ceasing of Zingo Commercial Operations and Restructuring

... than November 14, 2008. About Adlea Adlea is a highly purified form of capsaicin (derived from chili peppers) that acts on TRPV1 receptors, expressed most d...e product platform is based on Adlea, a novel small molecule formulation of capsaicin that is currently being evaluated in multiple clinical trials for the manag...

Anesiva Accelerates Its Transition to Specialty Pharma Pain Management Company

... double-blind, randomized, placebo-controlled Phase 3 Adlea trials, one in bunionectomy surgeries (the ACTIVE-1 trial -- Assessment of Highly Purified capsaicin To ImproVE Pain Management After Orthopedic Surgery), and one in total knee replacement surgeries (ACTIVE-2). The company continues to anticipate that...

Anesiva Commences Phase 2 Trial of Adlea(TM) in Arthroscopic Shoulder Surgery

... minimize the side effects associated with systemically administered analgesic drugs, such as opioids and NSAIDs. Adlea is a highly purified form of capsaicin (derived from chili peppers) that acts primarily on C-fiber neurons, which transmit long-term pain, by binding to and desensitizing the TRPV1 pain rec...

NeurogesX Announces Publication of NGX-4010 Phase 3 HIV-Neuropathy Study Results in Neurology

...urnal Neurology. The paper, titled, "Controlled Trial in High-Concentration capsaicin Patch for Treatment of Painful HIV Neuropathy," will appear in the June 10,... (HIV-DSP) receiving a single application of NGX-4010, a high-concentration capsaicin patch. In this trial, the primary endpoint was achieved with a statisticall...

TorreyPines Therapeutics Initiates Clinical Trial to Evaluate Analgesic Effect of Oral Prodrug of Tezampanel

...onstrate that the drug is well-tolerated at single doses up to and including 210 mg and that NGX426 is rapidly converted to tezampanel. Moreover, this capsaicin study, if successful, will enable us to further take advantage of the versatility of NGX426 and the overall tezampanel franchise." Subjects in the t...
Capsaicin in Medical Definition

Depolarization-induced suppression of inhibition

...an as-of-yet unknown cannabinoid receptor. Interestingly, some work has shown that anandamide can bind to the vannilloid receptor VR1, known as the capsaicin receptor. This receptor is present in the brain, and anandamide actions at this receptor may potentially contribute to DSE (Cristino et al. 2006, H...
Capsaicin in Biological News

New hybrid plants could prompt more prodigious pepper production in Southwest

...her yields of peppers with the size, shape, color, capsaicin (the active "heat" ingredient) level and nutrition...ing to the Agricultural Marketing Resource Center, capsaicin is already used as a "topical anti-arthritic and a... narcotic effect." Additional research indicates capsaicin may have cancer-fighting properties and facilitate...

New research reveals why chili peppers are hot

...th and protects the fruit from Fusarium. And while capsaicin deters local mammals, such as foxes and raccoons, ...bserved a clear correlation between high levels of capsaicin and low seed mortality due to fungal growth, Levey... as you move toward the poles," Levey said. The capsaicin in chilies, one of the first plants domesticated i...

Hot peppers really do bring the heat

...ocess by which cells convert energy into heat. capsaicin is the chemical in chili peppers that contributes ...nd sweating. Now, Yasser Mahmoud has found that capsaicin can create "heat" in a more direct manner by alter...een in hibernating animals. Mahmoud notes that capsaicin is the first natural compound known to augment the...

Too hot to handle! Scientists identify heat sensing regulator

...al mice. The team then exposed one hind paw to capsaicin and found that mice lacking Pirt did not lick thei...ervations suggest that Pirts action is specific to capsaicin and not other chemicals. To figure out whether...ous heat-108 degrees Fahrenheit-and some nerves to capsaicin and compared currents generated in each cell. Cell...

Detecting cold, feeling pain: Study reveals why menthol feels fresh

...of temperature sensation and pain. In 1997, the lab cloned the gene for the capsaicin receptor, the main pungent ingredient in some chili peppers (Nature, Oct. 2...ies of peppery food. (Science, April 14, 2000). The study demonstrated that capsaicin and noxious heat elicit the sensation of burning pain through activation of...

Tarantula venom and chili peppers target same pain sensor

...argets the heat sensor on nerve cells known as the capsaicin receptor, first cloned in 1997 in the Julius labor...ents have been developed that target them. The capsaicin receptor acts as a channel on the nerve surface. W...the tarantula Psalmopoeus cambridgei activated the capsaicin receptor, also called TRPV1, and the researchers i...

How taste response is hard-wired into the brain

...periments, the researchers engineered flies so that the hot pepper compound capsaicin would selectively switch-on either the sweet-detecting Gr5a neurons or the ...t pepper taste. The researchers found that flies engineered to recognize capsaicin on the sweet-tasting neurons were attracted to the chemical, while those th...
Capsaicin in Biological Technology

NeurogesX Submits NDA for NGX-4010 Dermal Capsaicin Patch for Treatment of Postherpetic Neuralgia (PHN)

Marketing Application Submitted on Schedule SAN MATEO, Calif., Oct. 22 /PRNewswire-FirstCall/ -- NeurogesX, Inc. (Nasdaq: NGSX ), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, announced today that it has submitted a new drug applicati...

NeurogesX Opens Investigational New Drug Application for Capsaicin Liquid Formulation NGX-1998

SAN MATEO, Calif., June 3 /PRNewswire-FirstCall/ -- NeurogesX, Inc. (Nasdaq: NGSX ), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, announced that it submitted an investigational new drug application (IND) to the U.S. Food and Drug Admin...

NeurogesX Reports Second Quarter 2009 Results

...009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

NeurogesX Announces New PDUFA Date for Qutenza(TM) New Drug Application

...9. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

NeurogesX to Hold Conference Call to Discuss Second Quarter 2009 Financial Results

...9. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

Anesiva Receives NASDAQ Delisting Staff Determination Letter

...cialization of novel pharmaceutical products for pain management. The company's lead product candidate is Adlea, a novel small molecule formulation of capsaicin that is currently in development for the management of acute pain following orthopedic surgeries. Adlea has been shown in clinical trials to provide e...

NeurogesX Added to Russell 3000 Index

...009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

NeurogesX Provides U.S. Regulatory Update for Qutenza(TM)

...009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

NeurogesX to Present at Needham Life Sciences Conference

...2009. NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 has completed three Phase 1 studies and NeurogesX is currently evaluating...

NeurogesX Receives European Commission Approval for Qutenza(TM)

...signed to locally deliver a high-concentration (8%) of the active substance capsaicin and to provide sustained relief from peripheral neuropathic pain. Followi... a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-199...
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