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Calmodulin in Medical News

Lead With a Poisonous Electron Shield

...alcium cation in the human body. A calcium ion binds to seven ligands at the active centers of the enzyme. If one of the four possible calcium ions of calmodulin is replaced by lead, the lead ion remains roughly heptacoordinated, but this active center becomes distorted and inefficient; the three remaining site...

Altered Sodium Channel Function Linked to Heart Failure

...els are predisposed to life-threatening VTs. So, because a protein known as calmodulin regulates Na+ channel function, and expression and activity of the calmodulin effector CaMKII is upregulated in humans with heart failure, Maier and coll...

Researchers Identify Key Step in Cocaine-Induced Heart Enlargement, Sudden Death

...icine at the Haley VA Hospital. Using heart muscle cells from adult rats, Dr. Henning and his colleagues found that cocaine activates the enzyme calmodulin kinase II (CaMK), which increases calcium within the heart muscle cells. The increase in calcium appears to be a key step in prompting the accumulatio...
Calmodulin in Biological News

Enzyme doesn't act alone in atrial fibrillation

...ularly." Researchers knew that an enzyme called calmodulin kinase II is overactive in several heart diseases ...ease in heart rate is a very specific activator of calmodulin kinase II. The research team found that mice with ...tion. When they used a drug to block activity calmodulin kinase II, and the mices' heart rates were raised,...

Rare disease provides clues about enzyme role in arrhythmias

...to a calcium-sensing enzyme already known to play a role in irregular heartbeats and other critical functions. The researchers showed that the enzyme, calmodulin kinase II (CaM kinase II), contributes to arrhythmia in an extremely rare disease called Timothy syndrome and that inhibiting the enzyme prevents irre...

Like eavesdropping at a party

...cine has discovered how the calcium sensor protein calmodulin can gauge both the local flow of calcium, in throu...medical engineering at Hopkins. "It turns out that calmodulin is doing a similar thing, sensing the calcium comi...gh distant channels across the cell." Normally, calmodulin is positioned right near each calcium channel. Sev...

Uncharged organic molecule can bind negatively charged ions

...molecules) out of a solution and hold onto them. Chelators play a valuable role in both nature and laboratory settings. For example, the human protein calmodulin not only grabs positively charged calcium ions out of the solution surrounding it, it also influences cell processes according to how many calcium ion...

Lead with a poisonous electron shield

...alcium cation in the human body. A calcium ion binds to seven ligands at the active centers of the enzyme. If one of the four possible calcium ions of calmodulin is replaced by lead, the lead ion remains roughly heptacoordinated, but this active center becomes distorted and inefficient; the three remaining site...

UNC scientists discover new role for protein as fundamental inhibitor of cell movement

..."CIB1 is very similar to the protein calmodulin, which binds to a host of other proteins and regulates numerous cell functions, the fact that CIB1 and calmodulin are so similar could suggest that CIB1 may play multiple roles in multiple cell types." "Our study of CIB1 is still very much in its early days, bu...
Calmodulin in Biological Technology

Identification of Low-Level Oxidation Products in Calmodulin Using NanoSpray Ion Trap Mass Spectrometry

Andreas Hhmer, Helen Tran, and William S. Hancock Protein Oxidation The data presented here can be acquired using any Thermo Finnigan LCQTMion trap mass spectrometer with MS n capab...

The Bio-Rad Silver Stain, Rev E

...eveloper detects proteins not initially visualized; for example, calmodulin 51, 56, 57 Universality Stains gels of various com...ification of the catalytic subunit of brain adenylate cyclase: a calmodulin binding protein of 135 kDa, Proc Natl Acad Sci USA 82, 6736-6740...

Mammalian and Bacterial Expression in One Vector

...earchers can fuse their target gene to the small calmodulin binding peptide (CBP) affinity tag located downstr...agenes Affinity CBP fusion detection kit and calmodulin Affinity Resin, respectively. The new pDual expr...described in the manual supplied with the kit. The calmodulin affinity resin with adsorbed GFP-CBP fu...

Highly Active and Removable AffinityTagged Lambda Phosphatase

...n, Stratagene's novel Lambda Phosphatase is readily removable; binding to calmodulin affinity resin completely eliminates lambda phosphatase activity. By usin...sphatase activity was specifically removed by treatment with Stratagene's calmodulin (CaM) Affinity Resin. The efficiency of removing lambda phosphatase activ...

Expression and Purification of Recombinant Proteins That Have Native Amino Acid Sequence

...from crude cell lysates with a single pass through calmodulin affinity resin. 1,2 The CBP purification system... Lysates were prepared, incubated with calmodulin affinity resin, applied to a disposable... 3 shows the induced and uninduced sample, the calmodulin affinity resin flowthrough fraction dep...

Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini

...de cell lysates to apparent homogeneity, as determined by visual inspection of silver-stained PAGE gels after a single pass over calmodulin (CaM) affinity resin 4 (data not shown). A series of reactions containing various amounts of recombinant EK was incubated at ro...

Yeast Protein Production System Features High Yields and One-Step Purification

...ting the cells and growing them in EMM broth without thiamine for approximately 18 hours. Figure 2 The chicken calmodulin gene was inserted into the pESP-1 vector and expressed in S. pombe. Figure 2 shows the cell lysate samples derived from repres...

High-Level Protein Expression, One-Column Purification, and FLAG Epitope Tagging in E. coli

...articular interest to scientists who wish to use calmodulin affinity-purified proteins to study protein-prot... 1 because of its high affinity for immobilized calmodulin (K d =10 -9 ). CBP fusion proteins are bound to and eluted from calmodulin affinity matrices at neutral pH using gentle buf...

New Yeast Cloning System for Producing Proteins with Native Amino Acid Sequences

...nant proteins include human Elk1, Krs2, MEK1 WT and the chicken calmodulin gene product. The yields for GST-Elk1 and GST-Krs2 fusion protei...e approximately 4 mg per liter (data not shown). The GST-chicken calmodulin recombinant protein produced approximately 12 mg per liter of fu...

A New C-Terminal GST Vector for Protein Production in S. pombe

...pitope. Expression and Purification of Chicken calmodulin The chicken calmodulin gene was inserted into the Nde I and BamH I site...ene for protein expression and purification. The calmodulin gene primers were designed such that the calmoduli...
Calmodulin in Biological Products

Rabbit Anti-Human S100 A6 Ab-9 Polyclonal Antibody, Unconjugated from Lab Vision

Description:... S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the ant...
Company:Lab Vision

ProtoArray Yeast PPI Kit from Invitrogen

Description:...ation Purification Module, Biotinylation Assessment Module, 30 l (2 mg/ml) streptavidinconjugate Alexa Fluor(r) 647, and 40 l (0.5 mg/ml) biotinylated calmodulin kinase. The ProtoArray Buffer Module A contains 30 ml of 30% BSA, 400 l 1M DTT. The ProtoArray Buffer Module B contains blocking and probing buffers, ...
Company:Invitrogen
Calmodulin in Biological Definition

Long-term potentiation

... ^ PMID 10545144 ^ Malenka RC, Kauer JA, Perkel DJ, Mauk MD, Kelly PT, Nicoll RA, Waxham MN (1989) "An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation.". Nature 340 (6234), 554-7. ^ Sweatt JD (1999) "Toward a molecular explanation fo...

Signal transduction

... best studied interactions of Ca 2+ with a protein is the regulation of calmodulin by Ca 2+ . calmodulin itself can regulate other proteins, or be part of a larger protein (for exa...
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