Will The Combination Of Calcitriol and Docetaxel Work ?
Researchers from Canada, United States and Europe are registering men with advanced prostate cancer //for a study involving a treatment that combines chemotherapy with high-dose of Calcitriol, a naturally occurring active form of vitamin D.
This clinical trial will test whether specially formul...
Nephrologists Indicate High Interest in AMAG Pharmaceuticals' Newly Approved Feraheme According to Latest BioTrends Report
...ket share. Hectorol PO also declined year over year, but together these newer analogues still account for roughly half of the CKD patient share while calcitriol
remains the market share leader.
The next wave of TreatmentTrends(R): US Nephrology will field in late August in tandem with surveys directed...
Product Shifts are Occurring in the Renal Anemia and Bone and Mineral Metabolism Markets According to the Most Recent TreatmentTrends(R): US Nephrology Report from BioTrends Research Group
...ar. Abbott's Zemplar continues to hold the position of market leader among hemodialysis patients, and in a shift from the same quarter last year when calcitriol
was the market leader in CKD, Zemplar now holds that position. Nephrologists report that barriers to increased use of both Zemplar and Genzyme's Hect...
Study helps clarify role of vitamin D in cancer therapy
...nstead of spreading.
To delve into the mechanism, the team dosed colon cancer cells with calcitriol, the metabolically active version of vitamin D. calcitriol
triggered a surge of calcium into the cells and the subsequent switching on of RhoARhoGTPases, which have been implicated in the cytoskeletal changes ...
Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model
...rated advantages over two marketed
vitamin D hormone replacement therapies, calcitriol
(Zemplar(R)), the latter currently being the most widely u...at the ASN demonstrate that CTA018 is at least 10 times
more effective than calcitriol
and paricalcitol in activating the VDR, and
over 7 times more effective in ...
Vitamin D Use Linked to Lower Mortality in Kidney Patients
... compared with those not on the drug. Those taking calcitriol
were also less likely to develop end-stage renal d...h advanced chronic kidney disease (CKD) often take calcitriol
to treat elevated levels of parathyroid hormone (h...Seattle, said in a prepared statement.
use was linked to a 20 percent reduction in the li...
OHSU Cancer Institute researcher identifies protein that helps predict prostate cancer survival
...n patients enrolled in the ASCENT study, a large Phase 2 clinical trial that evaluated treatment with docetaxel and DN-101, a high dose formulation of calcitriol
or docetaxel with placebo. This analysis included patients from both groups. The analyses were supported by Novacea Inc., the sponsor of the ASCENT st...
Deficiency in Vitamin D Increases the Risk of Cancer
...I recently initiated a clinical trial of high-dose calcitriol
(vitamin D) replacement in individuals with high r...ative and pro-differentiative effects of high-dose calcitriol
treatment in in vitro and in vivo models. In the l...ta and limited clinical data strongly suggest that calcitriol
and other vitamin D analogues have a role in the s...
Sunshine Vitamin for Prostate Cancer
...ention and treatment. Their focus is on the most potent form of vitamin D – calcitriol
– which has many roles in how the body's immune system reacts to challenges...ighting disease. In the clinics, studies are trying to determine if linking calcitriol
with chemotherapy will be a new treatment option for patients diagnosed wit...
Prostate Cancer Preventable By Vitamin D Analogs
...ancer Institute was meant to examine the effect of calcitriol
and two analogs, QW-1624-F2-2 and paricalcitol, on...s prostate cancer as the mice age, found that both calcitriol
and QW slowed the progression of prostate cancer a...ment. Additionally, chronic treatment of mice with calcitriol
reduced tumour burden, although side-effects manif...
Could vitamin D save us from radiation?
...d by the rocks on which we stand and the skies above us. He points out that calcitriol
is involved in cell cycle regulation and control of proliferation, cellular...as programmed cell death (apoptosis and autophagy) and antiangiogenesis.
is the form of vitamin D that activates the body's Vitamin D Receptor (VDR)...
Vitamin D: New way to treat heart failure?
...important results," Simpson says.
After 13 weeks, the researchers found that the heart failure-prone rats on the high-salt diet that were given the calcitriol
treatment had significantly lower levels of several key indicators of heart failure than the untreated high-salt diet rats in the study. The treated r...
BioTrends Releases TreatmentTrends(TM): US Nephrology, an Ongoing Syndicated Publication Providing Insight into Physician Perceptions and Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism
...has been relatively stable from a market share perspective as Abbott's Zemplar continues to hold its position as the leader in the dialysis market and calcitriol
continues to hold this position in CKD. Use of Amgen's Sensipar has also been relatively stable, although Nephrologists continue to report an expecte...
BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism
...y Lowers PTH", "Supported by Clinical Data", and
"Well-Tolerated". Zemplar and Hectorol receive significantly higher ratings
than Amgen's Sensipar and calcitriol
on "Improves Mortality" and
"Well-Tolerated" whereas Sensipar receives significantly higher ratings
than all vitamin D products on "Efficacy". While S...
Fontus Pharmaceuticals Acquires Nephrology and Endocrinology Drug from Roche Laboratories Inc.
...lite of vitamin D available and is active in regulating the
absorption of calcium from the gastrointestinal tract and its utilization
in the body. The calcitriol
in ROCALTROL is believed to be the active
hormone which exerts vitamin D activity in the body. ROCALTROL improves
calcium absorption in patients who h...
BioTrends Releases Two Publications - TreatmentTrends(TM): Nephrologists and TreatmentTrends(TM): Renal Dietitians - Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism
...ity." Zemplar continues to
dominate in dialysis with 72% market share and Nephrologists project
Zemplar to take the market leader position in CKD from calcitriol
next three months. Both Nephrologists and Renal Dietitians report that
their primary reason for prescribing Amgen's Sensipar is to lower calciu...