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Cachexia in Medical News

Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes

...t also promotes fat breakdown in the liver. Cancer patients, too, might benefit from these findings. Many of them suffer from what is called tumor cachexia a life-threatening loss of weight that is associated with the development of fatty liver. "We have found first evidence suggesting that LSR is overpr...

New Blood Test Better Identifies Heart Failure Patients in ER

...physicians and critical care cardiologists," said Stefan D. Anker, M.D., Ph.D., co-principal investigator of the study and professor of cardiology and cachexia (malnutrition and wasting in the context of disease) research at Campus Virchow-Klinkum (Virchow Hospital) of the Charite Medical School, Berlin, Germ...

Strong Bodies Battle Better

...nal support of the cancer patient: issues and dilemmas. Crit Rev Oncol Hematol 2000;34(3):137-68. (5) Ottery FD. Supportive nutrition to prevent cachexia and improve quality of life. Sem Oncol 1995;22(2)Supp 3:98-111. ...

A common denominator of inflammations and fatty liver

...muscle mass are reduced, free fatty acids accumulate in the liver, and this eventually leads to fatty liver in affected patients. What is called tumor cachexia appears to be caused by signals emitted by the tumor itself. Despite vigorous searching, scientists have not yet been able to identify these degradati...

The Quigley Corporation Reports Fourth Quarter & 2007 Annual Results; Increases Investment to $6.5 million in Pharmaceutical R&D in 2007

...s for compounds against avian flu QR-441(a) and human influenza (QR-435). cachexia Treatment Compound - QR-443: Further positive results were obtained for the... atrophy, fatigue, weakness and decreased appetite. A preliminary follow up cachexia study, evaluating weight loss in mice concluded that QR-443 was as effectiv...

Explaining chemotherapy-associated nausea

...and hopefully more effective drug treatment regimens, said lead author Bart De Jonghe, PhD, a Monell physiologist. Anorexia (loss of appetite) and cachexia (a syndrome of physical wasting and weight loss) often accompany chemotherapy-induced symptoms of nausea and vomiting. These side effects can compromi...

Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting

...t dystrophin levels were reduced in the muscles of mice with cancer cachexia, and that two DGC proteins were altered. The researchers then showed that cachexia is accelerated in mice that lack dystrophin and develop cancer. Furthermore, they showed that they could prevent cancer wasting in the mice by causing...
Cachexia in Medical Technology

Vicus Therapeutics Records Last Patient Visit of Phase 2, VT-122 Trial for the Treatment of Cachexia in Patients With Advanced Lung Cancer

- Final study report expected in June 2008 - MORRISTOWN, N.J., April 30 /PRNewswire/ -- Vicus Therapeutics, LLC, a biopharmaceutical company focused on oncology supportive care, announced today the completion of the last patient visit in its study VT1-CAX-001, a Phase 2 trial of ...

Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA

...sentation is scheduled for 4:25 p.m. About Cancer cachexia and VT-122 Cancer cachexia results in severe wasting of muscle and connective... distressing conditions of advanced cancer. Severe cachexia is associated with extreme weakness, intolerance t...

American Society of Clinical Oncology (ASCO) Accepts New Data on AVR118 for Publication in 2007 Abstract Book

...cancer and other serious diseases. ADVR's lead product, AVR118 represents a new class of complex cytoprotective agents that target among other things, cachexia related disorders. AVR118 has also shown to have topical wound healing properties in animal models. Various degenerative conditions associated with ...

GTx Announces Ostarine Improved Insulin Resistance among Elderly Patients in a Recently Completed Phase II Clinical Trial

...starine(TM), a first-in-class selective androgen receptor modulator, or SARM. GTx plans to initiate a Phase IIb Ostarine(TM) clinical trial for cancer cachexia by the summer of 2007. GTx plans to initiate a Phase IIb Ostarine(TM) clinical trial for the treatment of chronic kidney disease and end stage renal d...

GTx Announces Presentation of Ostarine and Acapodene Data at 2007 ASCO Annual Meeting

...starine(TM), a first-in-class selective androgen receptor modulator, or SARM. GTx plans to initiate a Phase IIb Ostarine(TM) clinical trial for cancer cachexia in non-small cell lung cancer patients in June of 2007. GTx plans to initiate a Phase IIb Ostarine(TM) clinical trial for the treatment of chronic kid...

Second Successful Quigley QR-443 Study Suggests Method of Action Relevant to Broad Range of Chronic Inflammatory Diseases - Human Study to Follow -

...act metabolic imbalances and chronic inflammation. cachexia is an extremely debilitating and life threatening,...corded and blood being drawn prior to the onset of cachexia and then at the peak of cachexia which marked the end of the experiment. There was ...
Cachexia in Medical Definition

Cachexia

Name of Symptom / Sign : Cachexia Classifications and external resources ICD - 10 R64 ICD - 9 799.4 Cachexia ( pronounced [kəˈkɛksiə] ) is loss of weight , muscle atrophy , fatigue, weakness and significant loss of appetite in someone who is not actively ...

Muscle atrophy

...own as atrophy , including: inactivity, as seen when a cast is put on a limb, or upon extended bedrest (which can occur during a prolonged illness); cachexia - which is a "body-wasting" syndrome that is a co-morbidity of cancer and Congestive Heart Failure ; Chronic Obstructive Pulmonary Disease ; burn...
Cachexia in Medical Dictionary

Cachexia

Cachexia is loss of weight, muscle atrophy, fatigue, weakness and significant loss of appetite in someone who is not actively trying to lose weight. The formal definition of cachexia is the loss of body mass that cannot be reversed nutritionally; even if you supplement... Cachexia i...
Cachexia in Biological Technology

Advanced Viral Announces Phase IIb Wound Healing Trial for AVR123

...ther things, some of the most problematic symptoms associated with clinical cachexia or the so called wasting syndrome. In addition, AVR118 and AVR123 have also...roperties in animal models. Various degenerative conditions associated with cachexia such as cancer, HIV-AIDS and chronic inflammation are potential disease tar...

Vicus Therapeutics Announces Participation at 15th International Molecular Medicine Tri-Conference

...ations with an initial focus on cachexia. Vicus' lead combination product candidate, VT-122, is in Phase 2 clinical trials for the treatment of cancer cachexia in patients with advanced lung cancer. Additionally, Vicus has preclinical-stage combination product candidates being evaluated for the treatment of o...

Vicus Therapeutics to Present at the BMO Capital Markets Focus on Healthcare Conference

...ve responses to cancer and its treatment. Vicus' lead combination product candidate, VT-122, is in Phase 2 clinical trials for the treatment of cancer cachexia in patients with advanced lung cancer. Additionally, Vicus has preclinical-stage combination product candidates being evaluated for the treatment of o...

Vicus Therapeutics' Chief Executive Officer to Participate in BIOTECH 2007 Expert Panels

...ve responses to cancer and its treatment. Vicus' lead combination product candidate, VT-122, is in Phase 2 clinical trials for the treatment of cancer cachexia in patients with advanced lung cancer. Additionally, Vicus has preclinical-stage combination product candidates being evaluated for the treatment of o...

Introducing Strativa Pharmaceuticals

...-- launched its first product, Megace(R) ES, in July 2005. Megace ES (megestrol acetate) oral suspension is indicated for anorexia (loss of appetite), cachexia (severe malnutrition), and/or an unexplained, significant weight loss in patients with acquired immunodeficiency syndrome (AIDS). Megace ES generated ...

Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA

...sentation is scheduled for 4:25 p.m. About Cancer cachexia and VT-122 Cancer cachexia results in severe wasting of muscle and connective... distressing conditions of advanced cancer. Severe cachexia is associated with extreme weakness, intolerance t...
Cachexia in Biological Definition

Cancer

... (enlarged liver ), bone pain, fracture of affected bones and neurological symptoms. Systemic symptoms : weight loss , poor appetite and cachexia (wasting), excessive sweating ( night sweats ), anemia , and specific paraneoplastic phenomena , i.e. specific conditions that are due to an acti...
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