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CYP3A4 in Medical News

New Once-Daily RYZOLT(TM) (tramadol HCl extended-release tablets) Now Available in the U.S.

...MAOIs, and triptans, with drugs which impair metabolism of serotonin (including MAOIs), and with drugs which impair metabolism of tramadol (CYP2D6 and cyp3a4 inhibitors). This may occur within the recommended dose. Do not prescribe RYZOLT for patients who are suicidal or addiction-prone. Like oth...

Astellas Launches Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia

...d risk of adverse events. Vaprisol is contraindicated in patients with hypovolemic hyponatremia. In addition, coadministration of Vaprisol with potent cyp3a4 inhibitors, such as ketoconazole, itraconazole, clarithromycin, ritanovir, and indinavir, is contraindicated. Solutions containing dextrose may be con...

Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports

...d of the potential hazard to the fetus. Gleevec is metabolized by the cyp3a4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6 and CYP2C9. Dosage of Gleev... should be carefully monitored, in patients receiving Gleevec with a potent cyp3a4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... Drugs known to prolong the QT interval and strong cyp3a4 inhibitors should be avoided. Patients should avoi... drugs known to prolong the QT interval and strong cyp3a4 inhibitors. Use caution in patients with hepatic i...longing drugs and strong inhibitors or inducers of cyp3a4 should be avoided as they may affect serum concent...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...utamide, and glimepiride) which, like glyburide, are primarily eliminated by CYP2C9. Simvastatin: Single-dose pharmacokinetics of simvastatin, a cyp3a4 substrate, was not meaningfully altered in subjects receiving multiple daily doses of sitagliptin. Therefore, sitagliptin is not an inhibitor of CYP3A...

New IDSA Clinical Practice Guidelines Recommend NOXAFIL(R) (Posaconazole) for Antifungal Prophylaxis in Certain High-Risk Patients

.... The most commonly reported serious adverse events in refractory OPC patients included fever (13%) and neutropenia (10%). Coadministration with the cyp3a4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine, is contraindicated since this may result in increased plasma conc...

Photo: New Data Show Gleevec(R) Halts Progression to Advanced Stages of Life-Threatening Form of Leukemia in Sixth Year of Treatment

..., and immunosuppression from long-term use. Gleevec is metabolized by the cyp3a4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, and CYP2C9. Dosage of Glee... should be carefully monitored, in patients receiving Gleevec with a potent cyp3a4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that...

Wyeth Receives Honors at the 2007 Scrip Awards

..., phosphorus decreased (18%) and triglycerides increased (44%). Strong inducers of CYP3A4/5 (e.g., dexamethasone, rifampin) and strong inhibitors of cyp3a4 (e.g., ketoconazole, atazanavir) may decrease and increase concentrations of the major metabolite of TORISEL, respectively. If alternatives cannot be ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

...nhibitory activity in plasma. Potent inhibitors of cyp3a4 can raise the plasma levels of HMG-CoA reductase i...juice contains one or more components that inhibit cyp3a4 and can increase the plasma concentrations of drug...he use of lovastatin concomitantly with the potent cyp3a4 inhibitors itraconazole, ketoconazole, erythromyci...

ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration

...cians should advise patients to avoid alcohol while taking ABILIFY. Strong cyp3a4 or CYP2D6 inhibitors increase ABILIFY drug concentrations when used concomitantly. cyp3a4 inducers decrease ABILIFY drug concentrations when used concomitantly. Com...
CYP3A4 in Medical Technology

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

...rt of therapy with Afinitor and periodically thereafter. Strong or moderate cyp3a4 or P-glycoprotein inhibitors should be avoided. An increase in the dose of Afinitor is recommended when co-administered with a strong cyp3a4 inducer. Live vaccinations and close contact with those who have received l...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...or and periodically thereafter. Strong or moderate cyp3a4 or P-glycoprotein inhibitors should be avoided. An... is recommended when co-administered with a strong cyp3a4 inducer. Live vaccinations and close contact with ... long-term use. Gleevec is metabolized by the cyp3a4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, a...

Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib

...rt of therapy with Afinitor and periodically thereafter. Strong or moderate cyp3a4 or P-glycoprotein inhibitors should be avoided. An increase in the dose of Afinitor is recommended when co-administered with a strong cyp3a4 inducer. Live vaccinations and close contact with those who have received l...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

...gs known to prolong the QT interval and strong cyp3a4 inhibitors should be avoided. Patients should avoi... drugs known to prolong the QT interval and strong cyp3a4 inhibitors. Use caution in patients with hepatic i...longing drugs and strong inhibitors or inducers of cyp3a4 should be avoided as they may affect serum concent...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...g-term use. Gleevec is metabolized by the cyp3a4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6 an...itored in patients receiving Gleevec with a potent cyp3a4 inducer such as rifampin or phenytoin. Examples of... Drugs known to prolong the QT interval and strong cyp3a4 inhibitors should be avoided. Patients should avoi...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

..., and immunosuppression from long-term use. Gleevec is metabolized by the cyp3a4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6 and CYP2C9. Dosage of Gleev... should be carefully monitored, in patients receiving Gleevec with a potent cyp3a4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that...

New Data Show TORISEL Improves Progression-Free Survival for Patients With Relapsed/Refractory Mantle Cell Lymphoma

..., phosphorus decreased (18%) and triglycerides increased (44%). Strong inducers of CYP3A4/5 (e.g., dexamethasone, rifampin) and strong inhibitors of cyp3a4 (e.g., ketoconazole, atazanavir) may decrease and increase concentrations of the major metabolite of TORISEL, respectively. If alternatives cannot be ...

New Analyses Presented at ASCO Reaffirmed Efficacy and Safety of TORISEL in Patients With Advanced Kidney Cancer

..., phosphorus decreased (18%) and triglycerides increased (44%). Strong inducers of CYP3A4/5 (e.g., dexamethasone, rifampin) and strong inhibitors of cyp3a4 (e.g., ketoconazole, atazanavir) may decrease and increase concentrations of the major metabolite of TORISEL, respectively. If alternatives cannot be ...

Wyeth Initiates INTORACT -- A New Clinical Trial to Examine TORISEL Plus Avastin for First-Line Treatment of Advanced Kidney Cancer

... phosphorus decreased (18%), and triglycerides increased (44%). Strong inducers of CYP3A4/5 (e.g., dexamethasone, rifampin) and strong inhibitors of cyp3a4 (e.g., ketoconazole, atazanavir) may decrease and increase concentrations of the major metabolite of TORISEL, respectively. If alternatives cannot be ...

Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting

... Drugs known to prolong the QT interval and strong cyp3a4 inhibitors should be avoided. Patients should avoi... drugs known to prolong the QT interval and strong cyp3a4 inhibitors. Use caution in patients with hepatic i...longing drugs and strong inhibitors or inducers of cyp3a4 should be avoided as they may affect serum concent...
CYP3A4 in Biological Technology

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

..., and immunosuppression from long-term use. Gleevec is metabolized by the cyp3a4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6 and CYP2C9. Dosage of Gleev... should be carefully monitored, in patients receiving Gleevec with a potent cyp3a4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that...

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

...rom long-term use. Gleevec is metabolized by the cyp3a4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, a...tored, in patients receiving Gleevec with a potent cyp3a4 inducer such as rifampin or phenytoin. Examples of... Drugs known to prolong the QT interval and strong cyp3a4 inhibitors should be avoided. Patients should avoi...

U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD)

...cians should advise patients to avoid alcohol while taking ABILIFY. Strong cyp3a4 or CYP2D6 inhibitors increase ABILIFY drug concentrations when used concomitantly. cyp3a4 inducers decrease ABILIFY drug concentrations when used concomitantly. Com...

FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML

...dministration. Drug Interactions: Dasatinib is a cyp3a4 substrate. Drugs that may increase dasatinib concentrations are: Strong cyp3a4 inhibitors (e.g., ketoconazole, itraconazole, clar...oncomitant use of dasatinib and drugs that inhibit cyp3a4 should be avoided. If systemic administration of a...
CYP3A4 in Biological Dictionary

Tetracycline

... interactions. ... Tetracycline , a "broad-spectrum" antibiotic, is ... cyp3a4 substrates: Tetracycline may increase the levels/effects of cyp3a4 ... Avoid antacids, iron, or dairy products within 2 hours of taking tetra...

Deamination

...alian ... C-to-U deamination of nuclear mRNA is a highly restricted process in ... www.ihop-net. ... For deamination , data supported a role for cyp3a4 and CYP2C19. ... and B also catalyzed sertraline deamination with comparable K(m) values ... ... of T/G mispairs that arise in non-replicating DN...
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Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
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