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CYP2D6 in Medical News

June 2009 Mayo Clinic Health Letter Highlights Probiotics, Carotid Artery and Breast Cancer Treatments

...l for 8 to 10 percent of women -- those who have an inactive variant of the cyp2d6 enzyme. Now, genetic markers from the blood can determine which women most ... Other effective treatment options are available for women with the variant cyp2d6 enzyme. Mayo Clinic Health Letter is an eight-page monthly newslette...

Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports

...he patient should be advised of the potential hazard to the fetus. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, cyp2d6 and CYP2C9. Dosage of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with...

Mayo Clinic researchers find tamoxifen's power comes from endoxifen

...onsible for converting tamoxifen to endoxifen. The cyp2d6 gene is present in different forms in different pe...ve shown that women with certain variations in the cyp2d6 gene - so-called "poor metabolizers" - have a sign... women who were poor metabolizers because of their cyp2d6 gene variant, there was little inhibition of cell ...

Other highlights in the April 29 JNCI

... The enzymes encoded by different variants of the cyp2d6 gene metabolize tamoxifen at different rates. For example, women who carry two copies of the cyp2d6 *4 allele have less endoxifen in their blood than ... who carry two copies of the wild-type allele for cyp2d6 . The lower serum concentration of endoxifen may m...

Scientific poster abstracts from the 24th annual meeting of the American Academy of Pain Medicine

...nic 119 Long-Term Safety of Fentanyl Buccal Tablet for the Treatment of Breakthrough Pain in Opioid-Tolerant Cancer Patients 120 The Impact of cyp2d6 Genetic Polymorphism on Postoperative MorphineConsumption 121 Comparing the Safety and Tolerability of Duloxetine for the Management of Diabetic P...

ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration

...ision of high-risk patients should accompany drug therapy. Physicians should advise patients to avoid alcohol while taking ABILIFY. Strong CYP3A4 or cyp2d6 inhibitors increase ABILIFY drug concentrations when used concomitantly. CYP3A4 inducers decrease ABILIFY drug concentrations when used concomitantly...

U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for Adolescent Patients With Schizophrenia

...ision of high-risk patients should accompany drug therapy. Physicians should advise patients to avoid alcohol while taking ABILIFY. Strong CYP3A4 or cyp2d6 inhibitors increase ABILIFY drug concentrations when used concomitantly. CYP3A4 inducers decrease ABILIFY drug concentrations when used concomitantly...

Vanda Pharmaceuticals to Present New Data on Iloperidone at the 2007 American Society of Human Genetics Annual Meeting

...th QT Prolongation during Iloperidone Treatment of Patients with Schizophrenia POSTER 1040 - Single-Nucleotide Polymorphisms in the cyp2d6 Gene Are Correlated with Iloperidone Drug Exposure Levels, Affecting the Degree of QTc Prolongation Associated with Il...

Medco, LabCorp Strike Strategic Agreement for Research on Personalized Medicine and Pharmacogenomics

... label about how the drug may not work as well in postmenopausal women taking it to prevent recurrence of breast cancer who carry a genetic variant of cyp2d6 of the cytochrome P450 gene family. Newer cancer drugs, such as Herceptin(R), Gleevec(R), Erbitux(R), Tarceva(R), and Iressa(R), now have a genetic or...

Tamoxifen Ineffective In Presence Of Genetic Variation in Breast Cancer

...rried a variant of this gene had low levels of the cyp2d6 enzyme. This in turn predisposed for a relapse of the breast cancer. cyp2d6 enzyme is responsible for the metabolization of ta... benefit from tamoxifen. "Our group has shown that cyp2d6 is responsible for activating tamoxifen to a metab...
CYP2D6 in Medical Technology

Popular Breast Cancer Drug Used with Certain Antidepressants Puts New Jersey Women at Risk

... been aware that certain antidepressants, known as cyp2d6 inhibitor drugs, block the activation of tamoxifen...are among a group of antidepressant drugs known as cyp2d6 inhibitors. These drugs prevent the cyp2d6 enzyme from working properly, and cause less of th...

New Study: Antidepressants Commonly Prescribed with Tamoxifen Put Women at Much Higher Risk for Recurrent Breast Cancer

...rtraline), and are among a group of drugs known as cyp2d6 inhibitors. Antidepressants are often prescribed ... tamoxifen are considered to be moderate to potent cyp2d6 inhibitors. Several other SSRIs examined in the study that are weak cyp2d6 inhibitors did not raise breast cancer recurrence ...

New Research Shows Antidepressants May Thwart Breast Cancer Treatment

... past few years, to give physicians and patients reason to question using certain antidepressants (and other types of medications that might block the cyp2d6 enzyme) together with tamoxifen." Tamoxifen has been used to successfully treat millions of women diagnosed with hormone-receptor-positive breas...

Three Clinical Studies of bioTheranostics Molecular Breast Cancer Diagnostics Presented at San Antonio Breast Cancer Symposium

...r patients." On Saturday, Matthew Goetz, M.D., from Mayo Clinic and colleagues from Austria presented data examining the predictive utility of cyp2d6 and the prognostic utility of the Theros Breast Cancer Index in women with breast cancer randomized to receive five years of treatment with tamoxifen ...

Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects

... side effects. The study was conducted at The Institute of Living of Hartford Hospital in collaboration with Genomas. The CYP2C9, CYP2C19 and cyp2d6 genes from the cytochrome P450 family were chosen for DNA typing because their common variants result in deficient metabolic capacity for many psychot...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...eevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, cyp2d6 and CYP2C9. Dosage of Gleevec should increase by at least 50%, and clinical...dicated dose. Tasigna is a competitive inhibitor of CYP3A4, CYP2C8, CYP2C9, cyp2d6 and UGT1A1. Since warfarin is metabolized by CYP2C9 and CYP3A4, it should b...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

...kidney and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, cyp2d6 and CYP2C9. Dosage of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with...

U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for the Acute Treatment of Manic and Mixed Episodes Associated With Bipolar I Disorder in Pediatric Patients (10 to 17 Years of Age)

...ion of high-risk patients should accompany drug therapy. Physicians should advise patients to avoid alcohol while taking ABILIFY. Strong CYP3A4 or cyp2d6 inhibitors increase ABILIFY drug concentrations when used concomitantly. CYP3A4 inducers decrease ABILIFY drug concentrations when used concomitantl...

Samaritan Announces Positive Data in Nonclinical (IND) In-Vitro Studies for Promising Alzheimer's Drug

...ive metabolites. In addition, positive results were reported where SP-233 was shown to have no CYP inhibition potential for CYP1A2, CYP2C9, CYP2C19, cyp2d6 and CYP3A4 suggesting that SP-233, is unlikely to cause, or alter the metabolism of co-administered drugs, and thus cause, a drug-drug interaction, wh...

Six-Week Investigational Study In Adults With Major Depressive Disorder Evaluates The Effectiveness of Adjunctive Aripiprazole Therapy With Antidepressants

...vise patients to avoid alcohol while taking aripiprazole. Both CYP3A4 and cyp2d6 are responsible for aripiprazole metabolism. Agents that induce CYP3A4 (eg,...learance and lower blood levels. Inhibitors of CYP3A4 (eg, ketoconazole) or cyp2d6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit aripiprazole elimina...
CYP2D6 in Biological News

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

SAN ANTONIO - Findings from a new study have prompted Mayo Clinic researchers to recommend CYP2D6 gene testing for postmenopausal women about to begin tamoxifen therapy. This data confirms that women with an inherited deficiency in the CYP2D6 gene, which is important for the metabolism of tamoxife...

Gene variation affects tamoxifen's benefit for breast cancer

...ommon genetic variant responsible for lowering the cyp2d6 enzyme, and found that women with this genetic var...of Clinical Oncology. "Our group has shown that cyp2d6 is responsible for activating tamoxifen to a metab...ts that women who inherit a genetic variant in the cyp2d6 gene appear to be at higher risk of relapse when t...
CYP2D6 in Biological Technology

Simultaneous Detection of CYP3A4, CYP2D6 and CYP2C9 Metabolites with a Single, Sensitive, LC/MS/MS Method

Jason S. Wood, Varian, Inc. Introduction Cytochrome P450s (CYPs) are heme-containing enzymes responsible for initial metabolism of xenobiotics within the human body 1 . CYPs are part of the Phase I (oxidative) metabolism within the body, which introduces a hydrophil...

Breast Cancer Patients Take DNA Test to Determine Best Treatment

...t cancer patients prescribed tamoxifen are missing cyp2d6 because of their DNA, and will fail tamoxifen trea... or over-the-counter medicines that interfere with cyp2d6 activity. Many classes of drugs, including anti-depressants, prevent cyp2d6 from converting tamoxifen into endoxifen. That's w...

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

...kidney and cardiac toxicity, and immunosuppression from long-term use. Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, cyp2d6 and CYP2C9. Dosage of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with...

U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) as the First Medication for Add-On Treatment of Major Depressive Disorder (MDD)

... use caution in patients at risk for aspiration pneumonia. Physicians should advise patients to avoid alcohol while taking ABILIFY. Strong CYP3A4 or cyp2d6 inhibitors increase ABILIFY drug concentrations when used concomitantly. CYP3A4 inducers decrease ABILIFY drug concentrations when used concomitantly...

Center for Molecular Medicine Only Regional Provider of Test Suggested in FDA Alert on Prescribing Codeine to Nursing Mothers

...g. The FDA advisory recommended physicians order a cyp2d6 genotyping test to determine how the patient will ...y than other people. Results from the FDA-approved cyp2d6 test, available at the CMM, tell a physician how r...mothers understand the critical need to complete a cyp2d6 test first in order to accurately determine how an...

Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System

...t A nucleotide at position 1934 (*4 allele) of the cyp2d6 gene. An analysis feature within the Opticon Monit...ts and psychotropic drugs. 1 The human cyp2d6 gene contains numerous Single Nucleotide Polymorph...nsive metabolizers (EMs) who metabolize cyp2d6 substrates normally, intermediate metabolizers ...
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