Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs

A very small fraction of our genetic material--about 2%-- performs the crucial task scientists once thought was the sole purpose of the genome: to serve as a blueprint for the production of proteins, the molecules that make cells work and sustain life. This 2% of human DNA is converted into interm...

CSHL neuroscientists propose project to comprehensively map mammalian brain circuits

...elp address this knowledge gap, Mitra organized a series of meetings at the cshl Banbury Center in 2007 and 2008, from which this proposal grew. The neu...pect," says Jason Bohland, Ph.D., a postdoctoral neuroscience researcher at cshl and the paper's lead author, "it would be analogous to the multi-institutio...

CSHL scientists discover link between control of chromosome duplication and segregation

...or Orc1 seems to be separate from its duties in helping cells copy DNA. The cshl team found that a shortened version of Orc1 that lacked the ability to star...he original centriole pair from duplicating. In cells that lacked Orc1, the cshl scientists found that the centrioles were "disengaged" from the original, s...

CSHL scientists show how a protein that determines cell polarity prevents breast cancer

... understanding how cancer initiates," according to cshl Professor Senthil Muthuswamy, Ph.D., who headed th...or suppressor protein. Cells engineered by the cshl team to lack Scribble and overexpress Myc not only...and fast-growing breast epithelial tumors. The cshl team worked out the molecular players and specific...

Cold Spring Harbor science teams identify 13 new tumor-suppressor genes in liver cancer

...improve its diagnosis and treatment," according to cshl Professor Scott W. Lowe, Ph.D., the corresponding ...tor of the Human Cancer Genome Center at CSHL, and cshl Professors Gregory J. Hannon, Ph.D., W. Richard Mc...e genome via gene therapy. In other words, the cshl team's new strategy now makes it possible to rapid...

CSHL neuroscientists glimpse how the brain decides what to believe

...aboratory rats and reported this week in Nature by cshl Assistant Professor Adam Kepecs, Ph.D., in collaboration with Zachary F. Mainen, Ph.D., cshl Associate Professor and Group Leader in the Champa...our mere hunches," said Kepecs, who heads a lab at cshl devoted to uncovering neural circuitry underlying ...

CSHL scientists correlate enzyme expression levels with chemotherapy drug response

...nse "The method we developed is notable," said cshl Professor Scott W. Lowe, Ph.D., a leader of the re...king" with their targets. The research by the cshl team, which included Professors W. Richard McCombi... doxorubicin (sold under the name Adriamycin), the cshl team first sought to confirm its mechanism of acti...

Neuroscientists show insulin receptor signaling regulates structure of brain circuits

... development of neural circuits. This had never been demonstrated in living organisms until it was shown in experiments performed in the laboratory of cshl Professor Hollis Cline, Ph.D., and reported this week in the journal Neuron . These experiments, in Xenopus tadpoles, show that insulin receptor s...

Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce

...sooty mangabeys and macaques. The team included members of Dr. Skowronskis cshl lab and researchers at Stowers Institute for Medical Research in Kansas Cit...iral RNA to DNA. In their study, which consisted of several steps, the cshl team showed that when the vpx gene (the gene that encodes the Vpx protein) ...

CSHL scientists are part of consortium that sequences platypus genome

...by evolution over eons of time, said Dr. Hannon, a cshl professor. The evidence of how these innovations ... also have multiple sex chromosomes, he noted. cshl study shows small-RNA roles are conserved in platy...stems and protect their genetic material. The cshl team found certain small RNAs that were exclusive ...

CSHL in Medical Technology

J. Craig Venter, Ph.D. Receives Double Helix Medal from Cold Spring Harbor Laboratory

...ientific use on the Internet and for promoting awareness of the public health advantages of "personalized genomes." According to Dr. Bruce Stillman, cshl President, "The Double Helix Medals recognize individuals who have dedicated their lives to raising the awareness of the importance of genetics resear...

Preclinical Study Finds Protease Inhibitor-Resistant HIV May Have Reduced Potential to Develop Resistance to Panacos' Bevirimat

...hat appeared in PI-resistant virus was located at the CA-SP1 junction and has been observed previously in bevirimat resistance generation studies. The cshl conference presentation concluded that bevirimat resistance may be less likely to arise in PI-resistant HIV strains. Dr. Graham P. Allaway, Panacos'...

CSHL in Biological News

Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds

Cold Spring Harbor, NY -- A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated the mechanism by which a signaling protein found throughout the brain controls the maturation and strength of excitatory synapses, the tiny gaps across which the majority of neurons communi...

CCNY, CSHL biologists find birdsong of isolates reverts to norm over several generations

AUDIO: This recording demonstrates the progression from isolate song to "wild-type " song in two tutoring lineages and also in the isolate colony. ...

Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants

Cold Spring Harbor, N.Y. -- A key item in the developmental agenda of a plant leaf is the establishment of an axis that makes a leaf's top half distinct from its bottom half. This asymmetry is crucial for the leaf's function: it ensures that the leaf develops a flattened blade that is optimized fo...

Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants

Cold Spring Harbor, N.Y. -- A key item in the developmental agenda of a plant leaf is the establishment of an axis that makes a leaf's top half distinct from its bottom half. This asymmetry is crucial for the leaf's function: it ensures that the leaf develops a flattened blade that is optimized fo...

Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage

Although post-reproductive life in humans is often associated with decline and a loss of powers, an analogous state in certain cells -- called senescence -- is proving to be one of ironic potency. Scientists at Cold Spring Harbor Laboratory (CSHL) today reported that a particular class of senesce...

Leemor Joshua-Tor, PhD, CSHL biologist and WSBS dean, is named an HHMI Investigator

Leemor Joshua-Tor, Ph.D., a CSHL professor and Dean of the Watson School of Biological Sciences, has been named a Howard Hughes Medical Institute (HHMI) Investigator. Dr. Joshua-Tor, a structural biologist whose work is known and respected worldwide, is one of 56 new HHMI Investigators select...

iPlant Kickoff Conference at CSHL begins tackling plant biology's grand challenges

Cold Spring Harbor Laboratory will host the inaugural conference of the iPlant Collaborative, an NSF-funded, $50 million project to create a virtual center in cyberspace for plant sciences researchers and students. The kickoff conference, titled "Bringing Plant and Computing Scientists Together to...

New edition of a classic molecular biology textbook from CSHL Press and Benjamin Cummings

A new edition of the most widely used undergraduate textbook in molecular biology, Molecular Biology of the Gene , has just been released. It incorporates the latest in research and technological advances while retaining the distinctive characteristics of earlier editions that have made this a s...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

...se math theorem with concepts from cryptology, the cshl scientists have devised "DNA Sudoku." The strategy...ce more than a hundred thousand DNA samples," says cshl Professor Gregory Hannon, Ph.D., a genomics expert...c diseases a process known as genotyping. The cshl team has already begun to explore this possibility...

Songbird study from CSHL, CCNY provides concrete measure of biology's impact on culture

...Feher took up the experimental challenge, raising songbirds in soundproof boxes and collecting audio and video recordings of their subjects. Mitra and cshl postdoctoral fellow Haibin Wang in turn analyzed these recordings, comprising a large dataset of several terabytes, which show that the innate song of...

CSHL in Biological Dictionary

RNA Splicing

...equences within exons that stimulate messenger RNA splicing . ... Cold Spring Harbor Laboratory is a research and educational institution. ... cshl Researchers Show RNA Splicing Factor May Be New Target for Cancer Therapy ... Textbook Reference - Figure 14.10, p. 289 ... This process of ...

Regulatory sequence

...ee that regulatory sequences are genes, they have an effect on the ... Analysis of genomic regulatory sequences . Andrew D Smith. Zhang Lab, cshl ... do we want to analyze regulatory sequences ? 6. What about finding the functional ... Get PARS - Regulatory sequence analysis tool at Sou...