Pine bark reduces inflammatory marker CRP in osteoarthritis

Osteoarthritis (OA), a type of arthritis caused by the breakdown and loss of cartilage, affects more than 20 million Americans. While the most common prescription to treat OA is non-steroidal anti-inflammatory drugs (NSAIDs), many seek alternative treatments because of the side effects associated ...

New Evidence Found for CRP as an Independent Marker for Heart Disease, Stroke

A new study published in the New England Journal of Medicine lends further importance to the screening of C-reactive protein (CRP) in the detection of heart disease and stroke risk. Life Line Screening provides CRP screening along with glucose and cholesterol screenings. ...

Newer Blood Tests May Not Improve Heart Risk Assessment

...sociation between genetically controlled levels of crp and heart disease. "This study suggests that d... targeting specific reductions in plasma levels of crp are unlikely to be fruitful," the researchers concluded. The new studies do not say that crp is of no use in assessing heart risk, noted Dr. ...

Early treatment of systemic onset JIA with anakinra restores the IL-18 response

...ters such as fever, exanthema and arthritis resolved after 3 days. A rapid decrease in ESR (erythrocyte sediment rate; an indication of inflammation), crp (C reactive protein; a marker for inflammation), ferritin (a test of iron stores in the body) and sIL-2R (soluble interleukin 2 receptor) was observed...

IFX anti-TNF therapy associated with clinical benefit over 5 years in patients with active AS

...ho completed the trial under therapy (n=81) had no arthritis and 85% had no enthesitis. Over time, these patients also continued to show low or normal crp levels. Dr Frank Heldmann continues: "The EASIC cohort has been a success for European rheumatologists because the trial was directly organised and ...

Work Strife Stresses the Heart

... of physiological changes that go with this heightened state -- a raise in blood pressure, increased adrenaline and maybe inflammatory molecules, like crp are elevated with chronic stress," he explained. Dr. Matthew Lucks, a cardiologist at Scripps Memorial Hospital in La Jolla, Calif., said that "s...

Even modest exercise can reduce negative effects of belly fat

...er levels of C-reactive protein (CRP), less belly fat, and improved general fitness than the 'flex' group," said Ph.D. candidate Vieira. "The lower crp levels were partially mediated by the reduction in trunk fat," she explained. ...

Statin Might Help Fight Blood Clots in Veins

...at participants who had reductions in both LDL and crp levels had a reduction in vascular events that ran...ood, although some experts suspect the lowering of crp may explain the decline. "High crp also has been a risk factor for developing arteria...

Siemens Highlights Cardiac-Specific C-Reactive Protein (hsCRP) Test at ACC 2009

...ent issued by the FDA(1), not all high sensitivity crp (c-reactive protein) tests are cleared to identify...as differentiated as the Cardio Phase hs crp test, and cleared with the cardiac-specific claim ...L cholesterol levels (<130 mg/dL), but elevated crp levels (>2 mg/L), as determined by Siemens' BN ...

Study Finds Millions More May Benefit From Statins

...etermine how many Americans with low cholesterol (below 130 mg/dl) and high crp levels would benefit from taking statins, Michos and Hopkins cardiology pro... They concluded that 6.5 million older adults with low cholesterol and high crp might benefit from taking statins. That number would increase to 10 million...

CRP in Medical Technology

Isis Initiates Clinical Trial of CRP Drug

Reduction of CRP with ISIS 353512 could provide therapeutic benefit in cardiovascular, renal and inflammatory diseases CARLSBAD, Calif., Aug. 13 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today it has initiated a Phase 1 study of ISIS 353512, an...

CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 28, 2007 - CombinatoRx, Incorporated (NASDAQ: CRXX) today announced preliminary results of its randomized, blinded, placebo-controlled clinical trial of CRx-150 in patients with rheumatoid arthritis (RA). The trial compared CRx-150 plus a disease-modifying ant...

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

... ACR measurement factors included reported physician and patient global assessment of disease activity, patient reported pain score, and any change in crp in the patient's blood. The primary efficacy endpoint for the clinical trial was the percent of patients assigned to the R788 100 mg bid dose who were...

Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial

...th 6 data were unavailable, was considered a treatment failure (ACR non-responder). Disease Activity Scores are based on a 28 joint count and crp or an ESR at week 24 (depending on which was the qualifying biomarker). Safety Results The most common clinically meaningful drug-...

Arena Pharmaceuticals Announces Lorcaserin Data Demonstrating Highly Significant Categorical and Absolute Weight Loss and Improvements in Secondary Endpoints Associated with Cardiovascular Risk

... Glycemic Parameters: fasting glucose, fasting insulin and insulin resistance Inflammatory Markers of Cardiovascular Risk: high-sensitivity crp and fibrinogen Quality of Life, as assessed by the Impact of Weight Questionnaire - Lite, also improved to a significantly great...

Isis and Collaborators Present New Research at the ATVB Annual Conference

...nimal models. "The potential to add an apoC-III inhibitor in the near-term to our cardiovascular pipeline, which already includes mipomersen, a crp inhibitor and a PCSK9 inhibitor is quite exciting," said Richard Geary, Ph.D., Senior Vice President of Development at Isis Pharmaceuticals. "Inhibit...

Sunesis Pharmaceuticals Announces Presentation of Voreloxin Clinical Data in Patients with Acute Myeloid Leukemia at the 50th Annual Meeting of the American Society of Hematology

...uration of response for patients achieving a CR or crp has not been reached. Grade 3 or highe... To date, of 18 evaluable patients, one achieved a crp and five are hypoplastic and are awaiting hematolo.... Nine of these 38 patients have achieved a CR or crp in voreloxin dose cohorts ranging from 20 to 90 mg...

Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows

...among the healthy elderly, he commented, "As family physicians, we are intended to [practice] preventive medicine." The combination of LDL <130 and crp >2 should be "the golden key" for receiving treatment. The JUPITER results, the G.P. continued, speak for themselves. "Billions of dollar...

Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds

...o offer a high- sensitivity C-reactive protein (CRP) test cleared by the U.S. Food and Drug Administration for cardiac risk stratification. The Cardio crp test helps physicians assess the risk a patient may have a heart attack based on CRP levels and other factors. Quest Diagnostics was also one of the f...

Sunesis Pharmaceuticals Initiates Phase 2 Clinical Trial of Voreloxin (SNS-595) in Acute Myeloid Leukemia

...0 mg/m2 or greater on a weekly dose schedule achieved bone marrow blast reductions to less than five percent, and five of those 13 achieved either CR, crp or complete remission with incomplete recovery of normal hematopoietic blood elements. Voreloxin was generally well tolerated, with a dose-limiting to...

CRP in Medical Products

Liquichek Elevated CRP Control

Description: Liquichek Elevated CRP Control is a liquid assayed serum control with elevated levels of C-Reactive Protein....
Company:Bio-Rad Laboratories

High-sensitive CRP Control

Description: The K-ASSAY hs-CRP Control Set is intended to be used as a consistent test sample of known concentrations for monitoring the performance of hs-CRP (high sensitive C-Reactive Protein) immunoturbimetric assays....
Company:Kamiya Biomedical Company

ASO / RF / CRP Control

Description: The K-ASSAY ASO / RF / CRP Control Set is intended to be used as a consistent test sample of known concentration for monitoring the performance of K-ASSAY Anti-Streptolysin O (ASO), Rheumatoid Factor (RF), and C-Reactive Protein (CRP) immunoturbidimetric assays....
Company:Kamiya Biomedical Company

High Sensitivity, CRP

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

High Sensitivity CRP

Description: IMMULITE and IMMULITE 1000 assays are designed for use with the IMMULITE and IMMULITE 1000, continuous random access immunoassay analyzers which offer simplicity in both design and operation. IMMULITE systems can be found in a wide variety of immunoassay testing environments around the world....
Company:Siemens Medical Solutions Diagnostics

ABX Micros CRP

Description: The most compact revolutionary innovation in hematology. 3 Part DIFF + CRP measurement on whole blood....
Company:Horiba ABX

N High Sensitivity CRP

Description: In vitro diagnostic reagents for the quantitative determination of C-reactive protein (CRP) in human serum as well as heparin- and EDTA- plasma by means of particle-enhanced Immunonephelometry using the BN Systems. In acute phase response, increased levels of a number of plasma proteins, including ...
Company:Dade Behring, Inc.

CRP (Complete Kit with Glass slides)

Description:... Latex agglutination slide test for the qualitative and semi-quantitative in vitro determination of crp in serum....
Company:Randox Laboratories Ltd.

CRP (Complete Kit with Disposible Cards)

Description:... Latex agglutination slide test for the qualitative and semi-quantitative in vitro determination of crp in serum....
Company:Randox Laboratories Ltd.

ABX Micros CRP200

Description:... First to USA-market, this revolutionary technology combines CBC and crp analysis for stat results of 17 parameters within 4.5 minutes!...
Company:Horiba ABX

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CRP in Medical Dictionary

WBC count

... WBC counts ? ... This spectrum of bone infections affects thousands of Americans every year ... Therefore, normal values of WBC count , crp level, or ESR cannot be used to rule ... ...

C-reactive protein

...earn about your heart disease risk and how the crp test can be a marker of the inflammation of arte... Test (CRP) Index. Glossary ... Describes the crp test ( c-reactive protein ), how it is used, when the crp test is ordered, and what the results of a...

CRP in Biological News

Will large amounts of soil carbon be released if grasslands are converted to energy crops?

... fate of carbon sequestered in the soil during the crp program by perennial grasses if the land is conver... and Ken Vogel indicate that no-till conversion of crp grasslands into grain crops or perennial biomass c...leased to the atmosphere if grasslands such as the crp grasslands are converted to energy crops and that ...

Long-sought protein structure may help reveal how 'gene switch' works

...(cAMP) receptor protein, or CRPin its "off" state. crp is the "binding site" (attachment point) for cAMP,...the signal to throw the switch. This "on" state of crp then turns on the genes that help a microbe surviv...gulated. The biochemical puzzle surrounding the crp switch is the mechanism by which the protein binds...

Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease

...dy looking at vitamins C and E and their impact on crp levels. She pointed out that the Brigham and Women...id not screen study participants for elevations in crp - defined by the American Heart Association as 1 m..., participants who did not start out with elevated crp levels saw no benefit from vitamin C supplementati...

AIDS-related cognitive impairment exists in two separate forms

... for Cancer Research. The Serological Markers TIMP-1, PAI-1, MASP-2 and crp are Independent Predictors of Colorectal Cancer-Specific Death: Abstract No...d. The protein markers included in the test - TIMP-1, PAI-1, MASP-2, and crp - are related to tissue remodeling, angiogenesis, and inflammation. The tes...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

... for Cancer Research. The Serological Markers TIMP-1, PAI-1, MASP-2 and crp are Independent Predictors of Colorectal Cancer-Specific Death: Abstract No...d. The protein markers included in the test - TIMP-1, PAI-1, MASP-2, and crp - are related to tissue remodeling, angiogenesis, and inflammation. The tes...

New drug could reduce tissue damage after heart attack

...shed in the journal Nature, suggest that targeting crp may produce both immediate and long-term clinical benefits following a heart attack. crp is normally present at trace levels in the blood b...such as rheumatoid arthritis and Crohn's disease. crp levels also rise dramatically after a heart attack...

Gene expression profile helps predict chemotherapy response in ovarian cancer patients

... defined by the absence of disease at the time of second-look surgery. The crp also confirmed the importance of genes such as BAX in this process, which r...ch as paclitaxel. The authors then went on to compare the results of the crp and the OCPP. "We found that together these two gene profiles [CRP and OCPP...

CRP in Biological Technology

Sunesis Reports Financial Results for the Second Quarter 2009

...n dose of 80 mg/m2 or higher. Five of 14 of these patients achieved a CR or crp for an overall CR or crp rate of 36 percent, which compares favorably relative to expected remission...

Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress

...y of Hematology (ASH) meeting in late 2008, included complete remissions (CRs) in 1 of 3 patients with ALL and 10 of 44 patients with AML (9 CRs and 1 crp - complete remission without full platelet recovery). Some of these remissions occurred at dose levels as low as one-third to one-half of the maximum...

Recombinant C-Reactive Protein

... the company pays close attention to the clinical research community to stay ahead of their demands for acute phase proteins like C-Reactive Protein crp . Lee Biosolution now has canine, rat, human and recombinant c-reactive protein. Press Release Contact Information: Burton Lee Pres...

Martek Announces First Quarter 2009 Financial Results

...tor. There was a corresponding increase in the concentration of anti-inflammatory matrix metalloproteinase. The authors noted that the reduction of crp was similar to that seen with statins. Overall, the authors concluded that supplemental DHA may lessen the inflammatory response. Martek's life'sDH...

Sunesis Pharmaceuticals Provides Year-End Clinical Update on Voreloxin

...e was 17 percent, which compares favorably to standard induction chemotherapy. Data on the median duration of response for patients achieving a CR or crp in Schedule A is not yet available. With Schedule B, 72 mg/m2 of voreloxin weekly for two weeks, Sunesis is exploring if the therapeutic inde...

Human clinical study demonstrates superior Neptune Krill Oil NKO(R) pharmacokinetic profile

... and anti-inflammatory benefits of Neptune phospholipids, namely increasing HDL ("good cholesterol") and decreasing LDL ("bad cholesterol") as well as crp ("C-reactive protein", an inflammatory marker), and as such strengthening their position in cardiovascular management. "This is a very important c...

Isis Reports Financial Results and Highlights for Third Quarter of 2008

...ipomersen, we have bolstered our cardiovascular franchise with the addition of a new drug targeting PCSK9 and the initiation of clinical trials on our crp inhibitor. This year we and our partners have presented encouraging Phase 2 data on our antisense drugs in cardiovascular disease, cancer and multiple...

Corgenix Receives Third U.S. Patent on AtherOx(R) Technology

...rmation, and the immunoassay method for measuring these complexes in blood. crp is an inflammatory protein that has been associated with risk of cardiovascular disease. High levels of crp can be found in many inflammatory and infectious disorders, but oxLDL/CRP c...

Isis Reports Financial Results and Highlights for Second Quarter of 2008

...olesterol patients -- Present liver imaging safety data on mipomersen -- Initiate Phase 1 clinical study on ISIS 353512, Isis' drug targeting crp for the treatment of cardiovascular, renal and inflammatory diseases -- Report Phase 2 study data in type 2 diabetics treated with ISIS 113715 ...